{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:22:16Z","timestamp":1792027336964,"version":"4.4.0"},"reference-count":86,"publisher":"American Society of Hematology","issue":"18","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>The population of survivors of childhood leukemia who reach adulthood is growing due to improved therapy. However, survivors are at risk of long-term complications. Comprehensive follow-up programs play a key role in childhood leukemia survivor care. The major determinant of long-term complications is the therapeutic burden accumulated over time. Relapse chemotherapy, central nervous system irradiation, hematopoietic stem cell transplantation, and total body irradiation are associated with greater risk of long-term complications. Other parameters include clinical characteristics such as age and sex as well as environmental, genetic, and socioeconomic factors, which can help stratify the risk of long-term complications and organize follow-up program. Early diagnosis improves the management of several late complications such as anthracycline-related cardiomyopathy, secondary cancers, metabolic syndrome, development defects, and infertility. Total body irradiation is the treatment associated with worse long-term toxicity profile with a wide range of complications. Patients treated with chemotherapy alone are at a lower risk of long-term complications, although the optimal long-term follow-up remains unclear. Novel immunotherapies and targeted therapy are generally associated with a better short-term safety profile but still require careful long-term toxicity monitoring. Advances in understanding genetic susceptibility to long-term complications could enable tailored therapeutic strategies for leukemia treatment and optimized follow-up programs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2023019804","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T16:42:08Z","timestamp":1705423328000},"page":"1795-1806","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":23,"title":["How I treat long-term survivors of childhood acute leukemia"],"prefix":"10.1182","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6327-0898","authenticated-orcid":false,"given":"Paul","family":"Saultier","sequence":"first","affiliation":[{"name":"1Department of Pediatric Hematology, Immunology and Oncology, Aix Marseille Universit\u00e9, APHM, INSERM, INRAe, C2VN, La Timone Children\u2019s Hospital, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Michel","sequence":"additional","affiliation":[{"name":"2Department of Pediatric Hematology, Immunology and Oncology, Aix Marseille Universit\u00e9, APHM, CERESS, La Timone Children\u2019s Hospital, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"15","key":"2024050215203327300_bib1","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1056\/NEJMsa060185","article-title":"Chronic health conditions in adult survivors of childhood cancer","volume":"355","author":"Oeffinger","year":"2006","journal-title":"N\u00a0Engl J Med"},{"issue":"19","key":"2024050215203327300_bib2","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1093\/jnci\/djn310","article-title":"Cause-specific late mortality among 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study","volume":"100","author":"Mertens","year":"2008","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"12","key":"2024050215203327300_bib3","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1182\/blood-2007-10-117150","article-title":"Twenty-five\u2013year follow-up among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study","volume":"111","author":"Mody","year":"2008","journal-title":"Blood"},{"issue":"7","key":"2024050215203327300_bib4","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/pbc.24134","article-title":"Abdominal aortic calcification in young adult survivors of childhood acute lymphoblastic leukemia: results from the St. Jude Lifetime Cohort study","volume":"59","author":"Gurney","year":"2012","journal-title":"Pediatr Blood Cancer"},{"issue":"17","key":"2024050215203327300_bib5","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"issue":"29","key":"2024050215203327300_bib6","first-page":"3418","article-title":"Reduced morbidity and mortality in survivors of childhood acute lymphoblastic leukemia: a report from the childhood cancer survivor study","volume":"38","author":"Dixon","year":"2020","journal-title":"J\u00a0Clin Orthod"},{"issue":"17","key":"2024050215203327300_bib7","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1182\/blood-2010-09-304899","article-title":"Prevalence and risk factors of the metabolic syndrome in adult survivors of childhood leukemia","volume":"117","author":"Oudin","year":"2011","journal-title":"Blood"},{"issue":"4","key":"2024050215203327300_bib8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3324\/haematol.2017.176123","article-title":"Prevalence and characteristics of metabolic syndrome in adults from the French childhood leukemia survivors\u2019 cohort: a comparison with controls from the French population","volume":"103","author":"Oudin","year":"2018","journal-title":"Haematologica"},{"issue":"12","key":"2024050215203327300_bib9","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.3324\/haematol.2016.148908","article-title":"Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study","volume":"101","author":"Saultier","year":"2016","journal-title":"Haematologica"},{"key":"2024050215203327300_bib10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1530\/EC-18-0497","article-title":"Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia","volume":"8","author":"Visentin","year":"2019","journal-title":"Endocr Connect"},{"issue":"6","key":"2024050215203327300_bib11","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1038\/s41409-020-01180-y","article-title":"Testosterone deficiency in men surviving childhood acute leukemia after treatment with hematopoietic stem cell transplantation or testicular radiation: an L.E.A. study","volume":"56","author":"Lopez","year":"2021","journal-title":"Bone Marrow Transplant"},{"issue":"6","key":"2024050215203327300_bib12","first-page":"880","article-title":"Biomarkers predictive of metabolic syndrome and cardiovascular disease in childhood cancer survivors","volume":"12","author":"Romano","year":"2022","journal-title":"J\u00a0Pers Med"},{"issue":"11","key":"2024050215203327300_bib13","doi-asserted-by":"crossref","first-page":"e13312","DOI":"10.1111\/obr.13312","article-title":"Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review","volume":"22","author":"Pluimakers","year":"2021","journal-title":"Obes Rev"},{"issue":"13","key":"2024050215203327300_bib14","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/cncr.29153","article-title":"Genetic and clinical factors associated with obesity among adult survivors of childhood cancer: a report from the St. Jude Lifetime Cohort","volume":"121","author":"Wilson","year":"2015","journal-title":"Cancer"},{"issue":"2","key":"2024050215203327300_bib15","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s12185-012-1236-1","article-title":"The glucocorticoid receptor gene polymorphism N363S predisposes to more severe toxic side effects during pediatric acute lymphoblastic leukemia (ALL) therapy","volume":"97","author":"Eipel","year":"2013","journal-title":"Int J Hematol"},{"issue":"8","key":"2024050215203327300_bib16","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1038\/s41591-022-01902-3","article-title":"Genetic risk score enhances the risk prediction of severe obesity in adult survivors of childhood cancer","volume":"28","author":"Sapkota","year":"2022","journal-title":"Nat Med"},{"issue":"3","key":"2024050215203327300_bib17","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/1097-0142(19910801)68:3<600::AID-CNCR2820680326>3.0.CO;2-F","article-title":"Epipodophyllotoxin-related leukemia. Identification of a new subset of secondary leukemia","volume":"68","author":"Whitlock","year":"1991","journal-title":"Cancer"},{"issue":"12","key":"2024050215203327300_bib18","first-page":"130","article-title":"Large population analysis of secondary cancers in pediatric leukemia survivors","volume":"6","author":"Yavvari","year":"2019","journal-title":"Children (Basel)"},{"key":"2024050215203327300_bib19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.14694\/EdBook_AM.2015.35.57","article-title":"Early detection of cancer: past, present, and future","author":"Schiffman","year":"2015","journal-title":"Am Soc Clin Oncol Educ Book"},{"issue":"4","key":"2024050215203327300_bib20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1200\/JCO.20.02529","article-title":"Total body irradiation or chemotherapy conditioning in childhood ALL: a multinational, randomized, noninferiority phase III study","volume":"39","author":"Peters","year":"2021","journal-title":"J\u00a0Clin Oncol"},{"issue":"2","key":"2024050215203327300_bib21","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1182\/blood-2007-07-099283","article-title":"Increased risk of breast cancer among survivors of allogeneic hematopoietic cell transplantation: a report from the FHCRC and the EBMT-Late Effect Working Party","volume":"111","author":"Friedman","year":"2008","journal-title":"Blood"},{"issue":"21","key":"2024050215203327300_bib22","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1200\/JCO.2013.54.4601","article-title":"Breast cancer after chest radiation therapy for childhood cancer","volume":"32","author":"Moskowitz","year":"2014","journal-title":"J\u00a0Clin Oncol"},{"issue":"4","key":"2024050215203327300_bib23","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/bjh.13148","article-title":"Incidence and risk factors for cataract after haematopoietic stem cell transplantation for childhood leukaemia: an LEA study","volume":"168","author":"Horwitz","year":"2015","journal-title":"Br J Haematol"},{"issue":"1","key":"2024050215203327300_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/bjh.12598","article-title":"Prevalence and risk factors of cataract after chemotherapy with or without central nervous system irradiation for childhood acute lymphoblastic leukaemia: an LEA study","volume":"164","author":"Alloin","year":"2014","journal-title":"Br J Haematol"},{"issue":"6","key":"2024050215203327300_bib25","first-page":"747","article-title":"Late thyroid complications in survivors of childhood acute leukemia","volume":"101","author":"Oudin","year":"2016","journal-title":"An L.E.A. study. Haematologica"},{"issue":"2","key":"2024050215203327300_bib26","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1182\/blood.V86.2.825.bloodjournal862825","article-title":"Role of busulfan and total body irradiation on growth of prepubertal children receiving bone marrow transplantation and results of treatment with recombinant human growth hormone","volume":"86","author":"Giorgiani","year":"1995","journal-title":"Blood"},{"key":"2024050215203327300_bib27","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/1471-2431-14-236","article-title":"Final height and body mass index in adult survivors of childhood acute lymphoblastic leukemia treated without cranial radiotherapy: a retrospective longitudinal multicenter Italian study","volume":"14","author":"Bruzzi","year":"2014","journal-title":"BMC Pediatr"},{"issue":"6","key":"2024050215203327300_bib28","doi-asserted-by":"crossref","first-page":"378.e1","DOI":"10.1016\/j.jtct.2023.02.019","article-title":"Ovarian function and spontaneous pregnancy after hematopoietic stem cell transplantation for leukemia before puberty: an L.E.A. cohort study","volume":"29","author":"Chabut","year":"2023","journal-title":"Transplant Cell Ther"},{"issue":"4","key":"2024050215203327300_bib29","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.fertnstert.2022.12.040","article-title":"The uterine volume is dramatically decreased after hematopoietic stem cell transplantation during childhood regardless of the conditioning regimen","volume":"119","author":"Courbiere","year":"2023","journal-title":"Fertil Steril"},{"issue":"5","key":"2024050215203327300_bib30","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/bmt.2014.3","article-title":"Health status of childhood leukemia survivors who received hematopoietic cell transplantation after BU or TBI: an LEA study","volume":"49","author":"Bernard","year":"2014","journal-title":"Bone Marrow Transplant"},{"issue":"11","key":"2024050215203327300_bib31","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/j.bbmt.2015.07.025","article-title":"Long-term morbidity and mortality in children with chronic graft-versus-host disease classified by national institutes of health consensus criteria after allogeneic hematopoietic stem cell transplantation","volume":"21","author":"Inagaki","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"2024050215203327300_bib32","doi-asserted-by":"crossref","first-page":"808103","DOI":"10.3389\/fped.2022.808103","article-title":"Management of chronic Graft-vs.-Host disease in children and adolescents with ALL: present status and model for a personalised management plan","volume":"10","author":"Sobkowiak-Sobierajska","year":"2022","journal-title":"Front Pediatr"},{"issue":"suppl 1","key":"2024050215203327300_bib33","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1182\/blood-2023-178121","article-title":"Chronic graft-versus-host disease in long-term survivors of childhood leukemia [abstract]","volume":"142","author":"Saultier","year":"2023","journal-title":"Blood"},{"issue":"2","key":"2024050215203327300_bib34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/MPH.0000000000000209","article-title":"Health status and quality of life of long-term survivors of childhood acute leukemia: the impact of central nervous system irradiation","volume":"37","author":"Benadiba","year":"2015","journal-title":"J\u00a0Pediatr Hematol Oncol"},{"issue":"2","key":"2024050215203327300_bib35","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/1096-911X(200008)35:2<91::AID-MPO1>3.0.CO;2-G","article-title":"Changes in body mass index and prevalence of overweight in survivors of childhood acute lymphoblastic leukemia: role of cranial irradiation","volume":"35","author":"Sklar","year":"2000","journal-title":"Med Pediatr Oncol"},{"issue":"31","key":"2024050215203327300_bib36","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.1200\/JCO.2007.10.8464","article-title":"Neuropsychological outcomes from a randomized trial of triple intrathecal chemotherapy compared with 18 Gy cranial radiation as CNS treatment in acute lymphoblastic leukemia: findings from Dana-Farber Cancer Institute ALL Consortium Protocol 95-01","volume":"25","author":"Waber","year":"2007","journal-title":"J\u00a0Clin Oncol"},{"issue":"7","key":"2024050215203327300_bib37","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1200\/JCO.1992.10.7.1095","article-title":"Long-term survivors of leukemia treated in infancy: factors associated with neuropsychologic status","volume":"10","author":"Mulhern","year":"1992","journal-title":"J\u00a0Clin Oncol"},{"issue":"1","key":"2024050215203327300_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0360-3016(92)90976-O","article-title":"Prophylactic cranial irradiation dose effects on late cognitive function in children treated for acute lymphoblastic leukemia","volume":"22","author":"Halberg","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"suppl","key":"2024050215203327300_bib39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/ijc.10348","article-title":"Prophylactic cranial irradiation of acute lymphoblastic leukemia in childhood: outcomes of late effects on pituitary function and growth in long-term survivors","volume":"96","author":"Hata","year":"2001","journal-title":"Int J Cancer"},{"issue":"1","key":"2024050215203327300_bib40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0022-3476(05)81537-9","article-title":"Final height after treatment for childhood acute lymphoblastic leukemia: comparison of no cranial irradiation with 1800 and 2400 centigrays of cranial irradiation","volume":"123","author":"Sklar","year":"1993","journal-title":"J\u00a0Pediatr"},{"issue":"18","key":"2024050215203327300_bib41","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1200\/JCO.2007.14.9088","article-title":"Osteonecrosis in adult survivors of childhood cancer: a report from the childhood cancer survivor study","volume":"26","author":"Kadan-Lottick","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"issue":"31","key":"2024050215203327300_bib42","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1200\/JCO.2011.37.3217","article-title":"Prospective study on incidence, risk factors, and long-term outcome of osteonecrosis in pediatric acute lymphoblastic leukemia","volume":"29","author":"te Winkel","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"issue":"4","key":"2024050215203327300_bib43","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.clml.2015.12.009","article-title":"Treatment of Osteonecrosis in Children and Adolescents With Acute Lymphoblastic Leukemia","volume":"16","author":"Heneghan","year":"2016","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"11","key":"2024050215203327300_bib44","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3324\/haematol.2016.147595","article-title":"Osteonecrosis in children with acute lymphoblastic leukemia","volume":"101","author":"Kunstreich","year":"2016","journal-title":"Haematologica"},{"issue":"5","key":"2024050215203327300_bib45","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1080\/08880018.2023.2168810","article-title":"Symptomatic osteonecrosis in French survivors of childhood and adolescent leukemia: a clinical and MRI study of LEA cohort","volume":"40","author":"Huault","year":"2023","journal-title":"Pediatr Hematol Oncol"},{"issue":"15","key":"2024050215203327300_bib46","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1182\/blood-2015-05-643601","article-title":"Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia","volume":"126","author":"Karol","year":"2015","journal-title":"Blood"},{"issue":"11","key":"2024050215203327300_bib47","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1182\/blood.2020008471","article-title":"Genetics of osteonecrosis in pediatric acute lymphoblastic leukemia and general populations","volume":"137","author":"Yang","year":"2021","journal-title":"Blood"},{"issue":"13","key":"2024050215203327300_bib48","doi-asserted-by":"crossref","first-page":"14545","DOI":"10.1002\/cam4.5980","article-title":"Current perspectives of cardio-oncology: epidemiology, adverse effects, pre-treatment screening and prevention strategies","volume":"12","author":"Bychowski","year":"2023","journal-title":"Cancer Med"},{"key":"2024050215203327300_bib49","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev-pharmtox-022823-035521","article-title":"Anthracycline toxicity: light at the end of the tunnel?","volume":"64","author":"Cejas","year":"2024","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2024050215203327300_bib50","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fcvm.2020.00026","article-title":"Cardiotoxicity of anthracyclines","volume":"7","author":"Cardinale","year":"2020","journal-title":"Front Cardiovasc Med"},{"issue":"6","key":"2024050215203327300_bib51","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1001\/jamaoncol.2018.6634","article-title":"Derivation of anthracycline and anthraquinone equivalence ratios to doxorubicin for late-onset cardiotoxicity","volume":"5","author":"Feijen","year":"2019","journal-title":"JAMA Oncol"},{"key":"2024050215203327300_bib52","doi-asserted-by":"crossref","first-page":"b4606","DOI":"10.1136\/bmj.b4606","article-title":"Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort","volume":"339","author":"Mulrooney","year":"2009","journal-title":"BMJ"},{"issue":"14","key":"2024050215203327300_bib53","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1001\/archinternmed.2010.233","article-title":"Cardiac function in 5-year survivors of childhood cancer: a long-term follow-up study","volume":"170","author":"van der Pal","year":"2010","journal-title":"Arch Intern Med"},{"issue":"11","key":"2024050215203327300_bib54","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/sj.bmt.1705652","article-title":"Impact of cumulative anthracycline dose, preparative regimen and chronic graft-versus-host disease on pulmonary and cardiac function in children 5 years after allogeneic hematopoietic stem cell transplantation: a prospective evaluation on behalf of the EBMT Pediatric Diseases and Late Effects Working Parties","volume":"39","author":"Uderzo","year":"2007","journal-title":"Bone Marrow Transplant"},{"issue":"5","key":"2024050215203327300_bib55","doi-asserted-by":"crossref","first-page":"e186","DOI":"10.3324\/haematol.2014.116574","article-title":"Late cardiomyopathy in childhood acute myeloid leukemia survivors: a study from the L.E.A. program","volume":"100","author":"Barlogis","year":"2015","journal-title":"Haematologica"},{"issue":"12","key":"2024050215203327300_bib56","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1200\/JCO.22.02423","article-title":"Dexrazoxane and long-term heart function in survivors of childhood cancer","volume":"41","author":"Chow","year":"2023","journal-title":"J\u00a0Clin Oncol"},{"issue":"4","key":"2024050215203327300_bib57","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/cncr.33974","article-title":"Late health outcomes after dexrazoxane treatment: a report from the Children\u2019s Oncology Group","volume":"128","author":"Chow","year":"2022","journal-title":"Cancer"},{"issue":"13","key":"2024050215203327300_bib58","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1200\/JCO.2011.34.8987","article-title":"Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children\u2019s Oncology Group","volume":"30","author":"Blanco","year":"2012","journal-title":"J\u00a0Clin Oncol"},{"issue":"3","key":"2024050215203327300_bib59","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1016\/S1470-2045(14)70409-7","article-title":"Recommendations for cardiomyopathy surveillance for survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group","volume":"16","author":"Armenian","year":"2015","journal-title":"Lancet Oncol"},{"issue":"23","key":"2024050215203327300_bib60","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1016\/j.jacc.2015.04.013","article-title":"Comprehensive echocardiographic detection of treatment-related cardiac dysfunction in adult survivors of childhood cancer: results from the St. Jude lifetime cohort study","volume":"65","author":"Armstrong","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"17","key":"2024050215203327300_bib61","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1161\/CIR.0b013e3182a88099","article-title":"Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association","volume":"128","author":"Lipshultz","year":"2013","journal-title":"Circulation"},{"issue":"2","key":"2024050215203327300_bib62","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.tmrv.2011.07.007","article-title":"Donor testing and risk: current prevalence, incidence, and residual risk of transfusion-transmissible agents in US allogeneic donations","volume":"26","author":"Zou","year":"2012","journal-title":"Transfus Med Rev"},{"issue":"1","key":"2024050215203327300_bib63","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/bmt.2016.205","article-title":"Prevalence and risk factors of iron overload after hematopoietic stem cell transplantation for childhood acute leukemia: a LEA study","volume":"52","author":"Sirvent","year":"2017","journal-title":"Bone Marrow Transplant"},{"issue":"8","key":"2024050215203327300_bib64","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.3109\/10428194.2012.750724","article-title":"Trends in transfusion burden among long-term survivors of childhood hematological malignancies","volume":"54","author":"Nottage","year":"2013","journal-title":"Leuk Lymphoma"},{"issue":"8","key":"2024050215203327300_bib65","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/bmt.2008.370","article-title":"Height growth during adolescence and final height after haematopoietic SCT for childhood acute leukaemia: the impact of a conditioning regimen with BU or TBI","volume":"43","author":"Bernard","year":"2009","journal-title":"Bone Marrow Transplant"},{"issue":"4","key":"2024050215203327300_bib66","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jpeds.2006.11.036","article-title":"Decreased adult height in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study","volume":"150","author":"Chow","year":"2007","journal-title":"J\u00a0Pediatr"},{"issue":"2","key":"2024050215203327300_bib67","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/bmt.2011.78","article-title":"Fertility after allogeneic haematopoietic stem cell transplantation in childhood and adolescence","volume":"47","author":"Borgmann-Staudt","year":"2012","journal-title":"Bone Marrow Transplant"},{"issue":"8","key":"2024050215203327300_bib68","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.bbmt.2017.04.017","article-title":"Survival and late effects after allogeneic hematopoietic cell transplantation for hematologic malignancy at less than three years of age","volume":"23","author":"Vrooman","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1","key":"2024050215203327300_bib69","doi-asserted-by":"crossref","first-page":"e518","DOI":"10.1038\/bcj.2016.129","article-title":"Late effects in survivors of infantile acute leukemia: a study of the L.E.A program","volume":"7","author":"Gandemer","year":"2017","journal-title":"Blood Cancer J"},{"issue":"3","key":"2024050215203327300_bib70","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/cncr.31065","article-title":"Long-term sequelae in survivors of childhood leukemia with Down syndrome: a childhood cancer survivor study report","volume":"124","author":"Goldsby","year":"2018","journal-title":"Cancer"},{"issue":"1","key":"2024050215203327300_bib71","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/bjh.15495","article-title":"Outcome of haematopoietic stem cell transplantation in dyskeratosis congenita","volume":"183","author":"Fioredda","year":"2018","journal-title":"Br J Haematol"},{"issue":"2","key":"2024050215203327300_bib72","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nrc2587","article-title":"Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype","volume":"9","author":"Barnett","year":"2009","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"2024050215203327300_bib73","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1200\/JCO.2017.75.5215","article-title":"TP53 germline variations influence the predisposition and prognosis of B-cell acute lymphoblastic leukemia in children","volume":"36","author":"Qian","year":"2018","journal-title":"J\u00a0Clin Oncol"},{"issue":"7","key":"2024050215203327300_bib74","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1158\/1078-0432.CCR-16-0610","article-title":"Somatic and Germline TP53 alterations in second malignant neoplasms from pediatric cancer survivors","volume":"23","author":"Sherborne","year":"2017","journal-title":"Clin Cancer Res"},{"issue":"9","key":"2024050215203327300_bib75","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1182\/bloodadvances.2019000839","article-title":"Subsequent neoplasms and late mortality in children undergoing allogeneic transplantation for nonmalignant diseases","volume":"4","author":"Kahn","year":"2020","journal-title":"Blood Adv"},{"issue":"22","key":"2024050215203327300_bib76","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1002\/cncr.29609","article-title":"Longitudinal smoking patterns in survivors of childhood cancer: an update from the Childhood Cancer Survivor Study","volume":"121","author":"Gibson","year":"2015","journal-title":"Cancer"},{"issue":"10","key":"2024050215203327300_bib77","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/cncr.34701","article-title":"Loss to follow-up of minorities, adolescents, and young adults on clinical trials: A report from the Children\u2019s Oncology Group","volume":"129","author":"Puthenpura","year":"2023","journal-title":"Cancer"},{"issue":"5","key":"2024050215203327300_bib78","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s11764-020-00968-7","article-title":"Neighborhood deprivation index is associated with weight status among long-term survivors of childhood acute lymphoblastic leukemia","volume":"15","author":"Oluyomi","year":"2021","journal-title":"J\u00a0Cancer Surviv"},{"issue":"suppl 1","key":"2024050215203327300_bib79","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1182\/blood-2022-157345","article-title":"Cardiac and vascular risks are the essential parameters for long-term surveillance of lower risk childhood acute leukemia survivors [abstract]","volume":"140","author":"Saultier","year":"2022","journal-title":"Blood"},{"key":"2024050215203327300_bib80","doi-asserted-by":"crossref","first-page":"205","DOI":"10.14694\/EdBook_AM.2014.34.205","article-title":"Models of cancer survivorship health care: moving forward","author":"Oeffinger","year":"2014","journal-title":"Am Soc Clin Oncol Educ Book"},{"issue":"32","key":"2024050215203327300_bib81","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.1200\/JCO.2009.23.4278","article-title":"Transition of care for young adult survivors of childhood and adolescent cancer: rationale and approaches","volume":"28","author":"Freyer","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"issue":"1","key":"2024050215203327300_bib82","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11764-020-00920-9","article-title":"Transition from pediatric to adult follow-up care in childhood cancer survivors-a systematic review","volume":"15","author":"Otth","year":"2021","journal-title":"J\u00a0Cancer Surviv"},{"issue":"18","key":"2024050215203327300_bib83","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1016\/j.ejca.2014.10.007","article-title":"Growth deceleration in children treated with imatinib for chronic myeloid leukaemia","volume":"50","author":"Millot","year":"2014","journal-title":"Eur J Cancer"},{"issue":"4","key":"2024050215203327300_bib84","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jpeds.2011.03.046","article-title":"Distinct impact of imatinib on growth at prepubertal and pubertal ages of children with chronic myeloid leukemia","volume":"159","author":"Shima","year":"2011","journal-title":"J\u00a0Pediatr"},{"key":"2024050215203327300_bib85","unstructured":"FDA investigating serious risk of T-cell malignancy following BCMA-directed or CD19-directed autologous chimeric antigen receptor (CAR) T cell immunotherapies. Accessed 31 December 2023. https:\/\/www.fda.gov\/vaccines-blood-biologics\/safety-availability-biologics\/fda-investigating-serious-risk-t-cell-malignancy-following-bcma-directed-or-cd19-directed-autologous."},{"issue":"9","key":"2024050215203327300_bib86","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.bbmt.2019.05.005","article-title":"Gonadal function after busulfan compared with treosulfan in children and adolescents undergoing allogeneic hematopoietic stem cell transplant","volume":"25","author":"Faraci","year":"2019","journal-title":"Biol Blood Marrow Transplant"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/doi\/10.1182\/blood.2023019804\/2223742\/blood_bld-2023-019804-c-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/doi\/10.1182\/blood.2023019804\/2223742\/blood_bld-2023-019804-c-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T11:21:20Z","timestamp":1714648880000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/143\/18\/1795\/514593\/How-I-treat-long-term-survivors-of-childhood-acute"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,2]]},"references-count":86,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2024,5,2]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2023019804","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,2]]}}}