{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:01:14Z","timestamp":1793944874928,"version":"4.8.0"},"reference-count":60,"publisher":"American Society of Hematology","issue":"10","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,7]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>A major hurdle in adoptive T-cell therapy is cell exhaustion and failure to maintain antitumor responses. Here, we introduce an induced pluripotent stem cell (iPSC) strategy for reprogramming and revitalizing precursor exhausted B-cell maturation antigen (BCMA)-specific T cells to effectively target multiple myeloma (MM). Heteroclitic BCMA72-80 (YLMFLLRKI)\u2013specific CD8+ memory cytotoxic T lymphocytes (CTL) were epigenetically reprogrammed to a pluripotent state, developed into hematopoietic progenitor cells (CD34+ CD43+\/CD14\u2212 CD235a\u2212), differentiated into the T-cell lineage and evaluated for their polyfunctional activities against MM. The final T-cell products demonstrated (1) mature CD8\u03b1\u03b2+ memory phenotype, (2) high expression of activation or costimulatory molecules (CD38, CD28, and 41BB), (3) no expression of immune checkpoint and senescence markers (CTLA4, PD1, LAG3, and TIM3; CD57), and (4) robust proliferation and polyfunctional immune responses to MM. The BCMA-specific iPSC\u2013T cells possessed a single T-cell receptor clonotype with cognate BCMA peptide recognition and specificity for targeting MM. RNA sequencing analyses revealed distinct genome-wide shifts and a distinctive transcriptional profile in selected iPSC clones, which can develop CD8\u03b1\u03b2+ memory T cells. This includes a repertoire of gene regulators promoting T-cell lineage development, memory CTL activation, and immune response regulation (LCK, IL7R, 4-1BB, TRAIL, GZMB, FOXF1, and ITGA1). This study highlights the potential application of iPSC technology to an adaptive T-cell therapy protocol and identifies specific transcriptional patterns that could serve as a biomarker for selection of suitable iPSC clones for the successful development of antigen-specific CD8\u03b1\u03b2+ memory T cells to improve the outcome in patients with MM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1182\/blood.2023020528","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T20:21:20Z","timestamp":1698438080000},"page":"895-911","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":14,"title":["Differentiation of BCMA-specific induced pluripotent stem cells into rejuvenated CD8\u03b1\u03b2+ T cells targeting multiple myeloma"],"prefix":"10.1182","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8922-9703","authenticated-orcid":false,"given":"Jooeun","family":"Bae","sequence":"first","affiliation":[{"name":"1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"2Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Kitayama","sequence":"additional","affiliation":[{"name":"1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"2Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-2464","authenticated-orcid":false,"given":"Zach","family":"Herbert","sequence":"additional","affiliation":[{"name":"1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"2Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4877-8503","authenticated-orcid":false,"given":"Laurence","family":"Daheron","sequence":"additional","affiliation":[{"name":"3Harvard Stem Cell Institute, Harvard University, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1060-9218","authenticated-orcid":false,"given":"Keiji","family":"Kurata","sequence":"additional","affiliation":[{"name":"1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"2Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derin B.","family":"Keskin","sequence":"additional","affiliation":[{"name":"1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"2Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Livak","sequence":"additional","affiliation":[{"name":"1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"2Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqiang","family":"Li","sequence":"additional","affiliation":[{"name":"1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"2Harvard Medical School, Boston, MA"},{"name":"4Broad Institute of MIT and Harvard, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mubin","family":"Tarannum","sequence":"additional","affiliation":[{"name":"1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"2Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwan","family":"Romee","sequence":"additional","affiliation":[{"name":"1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"2Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Samur","sequence":"additional","affiliation":[{"name":"1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"2Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil C.","family":"Munshi","sequence":"additional","affiliation":[{"name":"1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"2Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2291-4586","authenticated-orcid":false,"given":"Shin","family":"Kaneko","sequence":"additional","affiliation":[{"name":"5Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5526-4669","authenticated-orcid":false,"given":"Jerome","family":"Ritz","sequence":"additional","affiliation":[{"name":"1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"2Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth C.","family":"Anderson","sequence":"additional","affiliation":[{"name":"1Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"2Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"3","key":"2024030716204126700_bib1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3390\/cancers12030683","article-title":"Adoptive cell therapy - harnessing antigen-specific T cells to target solid tumours","volume":"12","author":"Chru\u015bciel","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"10","key":"2024030716204126700_bib2","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1007\/s00262-019-02395-9","article-title":"T\u00a0cell engineering for adoptive T\u00a0cell therapy: safety and receptor avidity","volume":"68","author":"D\u2019Ippolito","year":"2019","journal-title":"Cancer Immunol Immunother"},{"issue":"6","key":"2024030716204126700_bib3","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1080\/14712598.2020.1727436","article-title":"CAR T cells and checkpoint inhibition for the treatment of glioblastoma","volume":"20","author":"Shen","year":"2020","journal-title":"Expert Opin Biol Ther"},{"issue":"7","key":"2024030716204126700_bib4","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.ccell.2021.06.012","article-title":"The role of exhaustion in CAR T cell therapy","volume":"39","author":"Delgoffe","year":"2021","journal-title":"Cancer Cell"},{"key":"2024030716204126700_bib5","doi-asserted-by":"crossref","first-page":"1034257","DOI":"10.3389\/fcell.2022.1034257","article-title":"Mechanisms of CAR T cell exhaustion and current counteraction strategies","volume":"10","author":"Zhu","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"2024030716204126700_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13045-018-0629-x","article-title":"T\u00a0cell senescence and CAR-T cell exhaustion in hematological malignancies","volume":"11","author":"Kasakovski","year":"2018","journal-title":"J\u00a0Hematol Oncol"},{"issue":"4","key":"2024030716204126700_bib7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41408-021-00459-7","article-title":"CAR-T cell therapy: current limitations and potential strategies","volume":"11","author":"Sterner","year":"2021","journal-title":"Blood Cancer J"},{"issue":"1","key":"2024030716204126700_bib8","doi-asserted-by":"crossref","first-page":"100826","DOI":"10.1016\/j.currproblcancer.2021.100826","article-title":"CAR T-cell therapy for B-cell lymphoma","volume":"46","author":"Denlinger","year":"2022","journal-title":"Curr Probl Cancer"},{"issue":"9","key":"2024030716204126700_bib9","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1038\/s41375-019-0414-z","article-title":"Selective targeting of multiple myeloma by B cell maturation antigen (BCMA)-specific central memory CD8+ cytotoxic T lymphocytes: immunotherapeutic application in vaccination and adoptive immunotherapy","volume":"33","author":"Bae","year":"2019","journal-title":"Leukemia"},{"issue":"1","key":"2024030716204126700_bib10","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.stem.2012.11.002","article-title":"Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation","volume":"12","author":"Nishimura","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"1","key":"2024030716204126700_bib11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.stem.2012.12.006","article-title":"Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8(+) T cells","volume":"12","author":"Vizcardo","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"5","key":"2024030716204126700_bib12","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0092-8674(03)00393-3","article-title":"The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells","volume":"113","author":"Mitsui","year":"2003","journal-title":"Cell"},{"issue":"5858","key":"2024030716204126700_bib13","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.1151526","article-title":"Induced pluripotent stem cell lines derived from human somatic cells","volume":"318","author":"Yu","year":"2007","journal-title":"Science"},{"issue":"4","key":"2024030716204126700_bib14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.stem.2020.09.014","article-title":"Pluripotent stem cell-based cell therapy-promise and challenges","volume":"27","author":"Yamanaka","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"6","key":"2024030716204126700_bib15","doi-asserted-by":"crossref","first-page":"e0221721","DOI":"10.1128\/jvi.02217-21","article-title":"Sustainable antiviral efficacy of rejuvenated HIV specific cytotoxic T lymphocytes generated from induced pluripotent stem cells","volume":"96","author":"Miki","year":"2022","journal-title":"J\u00a0Virol"},{"issue":"9","key":"2024030716204126700_bib16","first-page":"1310","article-title":"Induced pluripotent stem cell-derived rejuvenated cytotoxic T lymphocyte therapy for Epstein-Barr virus-associated lymphomas: application to clinical practice","volume":"63","author":"Ando","year":"2022","journal-title":"Rinsho Ketsueki"},{"issue":"1","key":"2024030716204126700_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11523-017-0538-x","article-title":"The role of B-cell maturation antigen in the biology and management of, and as a potential therapeutic target in, multiple myeloma","volume":"13","author":"Sanchez","year":"2018","journal-title":"Target Oncol"},{"issue":"6","key":"2024030716204126700_bib18","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/bjh.14145","article-title":"Evaluation of B cell maturation antigen as a target for antibody drug conjugate mediated cytotoxicity in multiple myeloma","volume":"174","author":"Lee","year":"2016","journal-title":"Br J Haematol"},{"issue":"5","key":"2024030716204126700_bib19","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.clml.2018.02.015","article-title":"Multiple myeloma: clinical updates from the American Society of Hematology annual meeting, 2017","volume":"18","author":"Terpos","year":"2018","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"4","key":"2024030716204126700_bib20","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/bjh.15116","article-title":"Investigational agents in immunotherapy: a new horizon for the treatment of multiple myeloma","volume":"181","author":"Varga","year":"2018","journal-title":"Br J Haematol"},{"issue":"8","key":"2024030716204126700_bib21","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1038\/s41596-019-0195-x","article-title":"RNase H-dependent PCR-enabled T-cell receptor sequencing for highly specific and efficient targeted sequencing of T-cell receptor mRNA for single-cell and repertoire analysis","volume":"14","author":"Li","year":"2019","journal-title":"Nat Protoc"},{"issue":"1","key":"2024030716204126700_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"12","key":"2024030716204126700_bib23","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"5","key":"2024030716204126700_bib24","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat Biotechnol"},{"issue":"1","key":"2024030716204126700_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12859-018-2139-9","article-title":"VIPER: visualization pipeline for RNA-seq, a Snakemake workflow for efficient and complete RNA-seq analysis","volume":"19","author":"Cornwell","year":"2018","journal-title":"BMC Bioinformatics"},{"key":"2024030716204126700_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"2024030716204126700_bib27","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.stem.2021.08.002","article-title":"Human inducible pluripotent stem cells: realization of initial promise in drug discovery","volume":"28","author":"Kleiman","year":"2021","journal-title":"Cell Stem Cell"},{"issue":"1","key":"2024030716204126700_bib28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s12015-011-9263-5","article-title":"Specific gene signatures and pathways in mesodermal cells and their derivatives derived from embryonic stem cells","volume":"8","author":"Doss","year":"2012","journal-title":"Stem Cell Rev Rep"},{"key":"2024030716204126700_bib29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ceb.2019.07.012","article-title":"Mesoderm specification and diversification: from single cells to emergent tissues","volume":"61","author":"Ferretti","year":"2019","journal-title":"Curr Opin Cell Biol"},{"issue":"6","key":"2024030716204126700_bib30","doi-asserted-by":"crossref","first-page":"109992","DOI":"10.1016\/j.celrep.2021.109992","article-title":"Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy","volume":"37","author":"Bachireddy","year":"2021","journal-title":"Cell Rep"},{"issue":"1","key":"2024030716204126700_bib31","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s42003-023-04631-6","article-title":"CD83 expression characterizes precursor exhausted T cell population","volume":"6","author":"Wu","year":"2023","journal-title":"Commun Biol"},{"issue":"1-2","key":"2024030716204126700_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-1759(03)00265-5","article-title":"Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation","volume":"281","author":"Betts","year":"2003","journal-title":"J\u00a0Immunol Methods"},{"issue":"18","key":"2024030716204126700_bib33","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1182\/blood-2010-03-273953","article-title":"Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin","volume":"116","author":"Tewary","year":"2010","journal-title":"Blood"},{"issue":"1","key":"2024030716204126700_bib34","doi-asserted-by":"crossref","first-page":"36850421997273","DOI":"10.1177\/0036850421997273","article-title":"A\u00a0review of the mechanism of DDIT4 serve as a mitochondrial related protein in tumor regulation","volume":"104","author":"Ding","year":"2021","journal-title":"Sci Prog"},{"issue":"12","key":"2024030716204126700_bib35","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1002\/2211-5463.13013","article-title":"GDF15 knockdown suppresses cervical cancer cell migration in\u00a0vitro through the TGF-\u03b2\/Smad2\/3\/Snail1 pathway","volume":"10","author":"Li","year":"2020","journal-title":"FEBS Open Bio"},{"issue":"3","key":"2024030716204126700_bib36","first-page":"443","article-title":"The role of GOLPH3L in the prognosis and NACT response in cervical cancer","volume":"8","author":"Feng","year":"2017","journal-title":"J\u00a0Cancer"},{"issue":"5","key":"2024030716204126700_bib37","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1530\/ERC-15-0063","article-title":"Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy","volume":"22","author":"Hedrick","year":"2015","journal-title":"Endocr Relat Cancer"},{"issue":"38","key":"2024030716204126700_bib38","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.3748\/wjg.v27.i38.6387","article-title":"Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer","volume":"27","author":"Safe","year":"2021","journal-title":"World J Gastroenterol"},{"issue":"2","key":"2024030716204126700_bib39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1158\/2767-9764.CRC-21-0073","article-title":"Nuclear receptor 4A2 (NR4A2\/NURR1) regulates autophagy and chemoresistance in pancreatic ductal adenocarcinoma","volume":"1","author":"Zarei","year":"2021","journal-title":"Cancer Res Commun"},{"issue":"6","key":"2024030716204126700_bib40","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41416-020-01226-4","article-title":"Inhibition of interferon-signaling halts cancer-associated fibroblast-dependent protection of breast cancer cells from chemotherapy","volume":"124","author":"Broad","year":"2021","journal-title":"Br J Cancer"},{"key":"2024030716204126700_bib41","doi-asserted-by":"crossref","first-page":"144223","DOI":"10.1016\/j.gene.2019.144223","article-title":"The roles and regulation of TBX3 in development and disease","volume":"726","author":"Khan","year":"2020","journal-title":"Gene"},{"key":"2024030716204126700_bib42","doi-asserted-by":"crossref","first-page":"771773","DOI":"10.3389\/fcell.2021.771773","article-title":"Colloidal self-assembled patterns maintain the pluripotency and promote the hemopoietic potential of human embryonic stem cells","volume":"9","author":"Lin","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"2024030716204126700_bib43","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1038\/s41467-019-11100-4","article-title":"Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes, and adipocytes throughout life","volume":"10","author":"Pineault","year":"2019","journal-title":"Nat Commun"},{"issue":"4","key":"2024030716204126700_bib44","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/s41385-019-0173-1","article-title":"IRF4-dependent dendritic cells regulate CD8+ T-cell differentiation and memory responses in influenza infection","volume":"12","author":"Ainsua-Enrich","year":"2019","journal-title":"Mucosal Immunol"},{"issue":"9","key":"2024030716204126700_bib45","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.4049\/jimmunol.170.9.4475","article-title":"Phosphatidylinositol 3-kinase regulates the CD4\/CD8 T cell differentiation ratio","volume":"170","author":"Rodr\u00edguez-Borlado","year":"2003","journal-title":"J\u00a0Immunol"},{"issue":"9","key":"2024030716204126700_bib46","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s41423-019-0357-3","article-title":"Variants of innate CD8+ T cells are associated with Grip2 and Klf15 genes","volume":"17","author":"Jo","year":"2020","journal-title":"Cell Mol Immunol"},{"issue":"10","key":"2024030716204126700_bib47","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1084\/jem.20070731","article-title":"Increased IL-12 inhibits B cells\u2019 differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts","volume":"205","author":"Kim","year":"2008","journal-title":"J\u00a0Exp Med"},{"issue":"1","key":"2024030716204126700_bib48","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13045-019-0746-1","article-title":"Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies","volume":"12","author":"Wang","year":"2019","journal-title":"J\u00a0Hematol Oncol"},{"issue":"4","key":"2024030716204126700_bib49","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"issue":"22","key":"2024030716204126700_bib50","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1002\/1873-3468.12389","article-title":"Origin of the hematopoietic system in the human embryo","volume":"590","author":"Julien","year":"2016","journal-title":"FEBS Lett"},{"issue":"20","key":"2024030716204126700_bib51","doi-asserted-by":"crossref","first-page":"dev193037","DOI":"10.1242\/dev.193037","article-title":"Human yolk sac-like haematopoiesis generates RUNX1-GFI1- and\/or GFI1B-dependent blood and SOX17-positive endothelium","volume":"147","author":"Bruveris","year":"2020","journal-title":"Development"},{"issue":"30","key":"2024030716204126700_bib52","doi-asserted-by":"crossref","first-page":"27491","DOI":"10.1074\/jbc.M500555200","article-title":"Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface","volume":"280","author":"Wooldridge","year":"2005","journal-title":"J\u00a0Biol Chem"},{"issue":"5548","key":"2024030716204126700_bib53","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1126\/science.1063564","article-title":"T\u00a0cell responses modulated through\u00a0interaction between CD8alphaalpha and the nonclassical MHC\u00a0class I molecule, TL","volume":"294","author":"Leishman","year":"2001","journal-title":"Science"},{"issue":"8","key":"2024030716204126700_bib54","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/s41590-021-00982-6","article-title":"Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory","volume":"22","author":"Tonnerre","year":"2021","journal-title":"Nat Immunol"},{"issue":"8","key":"2024030716204126700_bib55","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nmeth.2510","article-title":"Hematopoietic progenitor cell lines with myeloid and lymphoid potential","volume":"10","author":"Redecke","year":"2013","journal-title":"Nat Methods"},{"issue":"1","key":"2024030716204126700_bib56","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/imr.13057","article-title":"Epigenetics and CD8+ T cell memory","volume":"305","author":"Montacchiesi","year":"2022","journal-title":"Immunol Rev"},{"issue":"12","key":"2024030716204126700_bib57","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1007\/s00277-021-04615-8","article-title":"Early and late stage MPN patients show distinct gene expression profiles in CD34+ cells","volume":"100","author":"Baumeister","year":"2021","journal-title":"Ann Hematol"},{"issue":"2","key":"2024030716204126700_bib58","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3892\/or.2020.7888","article-title":"Involvement of Blnk and Foxo1 in tumor suppression in BCR-ABL1-transformed pro-B cells","volume":"45","author":"Zhang","year":"2021","journal-title":"Oncol Rep"},{"issue":"11","key":"2024030716204126700_bib59","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.devcel.2021.04.027","article-title":"VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway","volume":"56","author":"Jiang","year":"2021","journal-title":"Dev Cell"},{"issue":"10","key":"2024030716204126700_bib60","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.3390\/ijms22105282","article-title":"Understanding LAG-3 signaling","volume":"22","author":"Chocarro","year":"2021","journal-title":"Int J Mol Sci"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/143\/10\/895\/2217129\/blood_bld-2023-020528-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/143\/10\/895\/2217129\/blood_bld-2023-020528-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T16:22:19Z","timestamp":1709828539000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/143\/10\/895\/498485\/Differentiation-of-BCMA-specific-induced"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,3,7]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2023020528","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,7]]}}}