{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:20:06Z","timestamp":1784298006968,"version":"3.55.0"},"reference-count":37,"publisher":"American Society of Hematology","issue":"9","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8,29]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>Adult hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow (BM) hematopoietic niche, which regulates HSPC quiescence, self-renewal, and commitment in a demand-adapted manner. Although the complex BM niche is responsible for adult hematopoiesis, evidence exists for simpler, albeit functional and more accessible, extramedullary hematopoietic niches. Inspired by the anecdotal description of retroperitoneal hematopoietic masses occurring at higher frequency upon hormonal dysregulation within the adrenal gland, we hypothesized that the adult adrenal gland could be induced into a hematopoietic-supportive environment in a systematic manner, thus revealing mechanisms underlying de novo niche formation in the adult. Here, we show that upon splenectomy and hormonal stimulation, the adult adrenal gland of mice can be induced to recruit and host functional HSPCs, capable of serial transplantation, and that this phenomenon is associated with de novo formation of platelet-derived growth factor receptor \u03b1\/leptin receptor (PDGFR\u03b1+\/LEPR+\/\u2013)\u2013expressing stromal nodules. We further show in CXCL12\u2013green fluorescent protein reporter mice that adrenal glands contain a stromal population reminiscent of the CXCL12-abundant reticular cells, which compose the BM HSPC niche. Mechanistically, HSPC homing to hormonally induced adrenal glands was found dependent on the CXCR4\u2013CXCL12 axis. Mirroring our findings in mice, we found reticular CXCL12+ cells coexpressing master niche regulator FOXC1 in primary samples from human adrenal myelolipomas, a benign tumor composed of adipose and hematopoietic tissue. Our findings reignite long-standing questions regarding hormonal regulation of hematopoiesis and provide a novel model to facilitate the study of adult-specific inducible hematopoietic niches, which may pave the way to therapeutic applications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1182\/blood.2023020875","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T17:57:02Z","timestamp":1715363822000},"page":"964-976","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":11,"title":["Inducible CXCL12\/CXCR4\u2013dependent extramedullary hematopoietic niches in the adrenal\u00a0gland"],"prefix":"10.1182","volume":"144","author":[{"given":"Fr\u00e9d\u00e9rica","family":"Schyrr","sequence":"first","affiliation":[{"name":"1Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland"},{"name":"2Laboratory of Regenerative Hematopoiesis, Swiss Institute for Experimental Cancer Research and Institute of Bioengineering, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Alonso-Calleja","sequence":"additional","affiliation":[{"name":"1Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland"},{"name":"2Laboratory of Regenerative Hematopoiesis, Swiss Institute for Experimental Cancer Research and Institute of Bioengineering, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3147-4623","authenticated-orcid":false,"given":"Anjali","family":"Vijaykumar","sequence":"additional","affiliation":[{"name":"3Department of Medical Oncology and Hematology, Comprehensive Cancer Center, University of Z\u00fcrich and University Hospital Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2982-3273","authenticated-orcid":false,"given":"Jessica","family":"Sordet-Dessimoz","sequence":"additional","affiliation":[{"name":"4Histology Core Facility, School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Gebhard","sequence":"additional","affiliation":[{"name":"5Centre vaudois anorexie boulimie, Espace CHUV Service de psychiatrie de liaison, D\u00e9partement de psychiatrie, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4874-9937","authenticated-orcid":false,"given":"Rita","family":"Sarkis","sequence":"additional","affiliation":[{"name":"1Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland"},{"name":"2Laboratory of Regenerative Hematopoiesis, Swiss Institute for Experimental Cancer Research and Institute of Bioengineering, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1880-8538","authenticated-orcid":false,"given":"Charles","family":"Bataclan","sequence":"additional","affiliation":[{"name":"1Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ferreira Lopes","sequence":"additional","affiliation":[{"name":"1Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Oggier","sequence":"additional","affiliation":[{"name":"2Laboratory of Regenerative Hematopoiesis, Swiss Institute for Experimental Cancer Research and Institute of Bioengineering, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-516X","authenticated-orcid":false,"given":"Laurence","family":"de Leval","sequence":"additional","affiliation":[{"name":"6Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Nombela-Arrieta","sequence":"additional","affiliation":[{"name":"3Department of Medical Oncology and Hematology, Comprehensive Cancer Center, University of Z\u00fcrich and 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