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We trained a model to predict PR from complete blood count (CBC) scattergrams. A genome-wide association study of this phenotype in 29 806 blood donors identified 21 distinct associations implicating 20 genes, of which 6 have been identified previously. The effect size estimates were significantly correlated with estimates from a study of flow cytometry\u2013measured PR and a study of a phenotype of in\u00a0vitro thrombus formation. A genetic score of PR built from the 21 variants was associated with the incidence rates of myocardial infarction and pulmonary embolism. Mendelian randomization analyses showed that PR was causally associated with the risks of coronary artery disease, stroke, and venous thromboembolism. Our approach provides a blueprint for\u00a0using phenotype imputation to study the determinants of hard-to-measure but biologically important hematological traits.<\/jats:p>","DOI":"10.1182\/blood.2023021100","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T17:45:07Z","timestamp":1693417507000},"page":"1895-1908","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":12,"title":["A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease risk"],"prefix":"10.1182","volume":"142","author":[{"given":"Hippolyte","family":"Verdier","sequence":"first","affiliation":[{"name":"1Institut Pasteur, CNRS UMR 3751, Decision and Bayesian Computation, Universit\u00e9 Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Thomas","sequence":"additional","affiliation":[{"name":"2Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5406-6353","authenticated-orcid":false,"given":"Joana","family":"Batista","sequence":"additional","affiliation":[{"name":"2Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5721-1050","authenticated-orcid":false,"given":"Carly","family":"Kempster","sequence":"additional","affiliation":[{"name":"2Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom"},{"name":"3Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"McKinney","sequence":"additional","affiliation":[{"name":"2Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1132-1059","authenticated-orcid":false,"given":"Nicholas","family":"Gleadall","sequence":"additional","affiliation":[{"name":"2Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom"},{"name":"4National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Danesh","sequence":"additional","affiliation":[{"name":"5British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"},{"name":"6Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom"},{"name":"7British Heart Foundation Centre of Research Excellence, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"},{"name":"8Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom"},{"name":"9Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5523-511X","authenticated-orcid":false,"given":"Andrew","family":"Mumford","sequence":"additional","affiliation":[{"name":"10School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom"},{"name":"11South West National Health Service Genomic Medicine Service Alliance, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2848-5121","authenticated-orcid":false,"given":"Johan W. 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