{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T09:18:33Z","timestamp":1792919913223,"version":"4.5.0"},"reference-count":14,"publisher":"American Society of Hematology","issue":"20","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,16]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>Defining prognostic variables in T-lymphoblastic lymphoma (T-LL) remains a challenge. AALL1231 was a Children\u2019s Oncology Group phase 3 clinical trial for newly diagnosed patients with T acute lymphoblastic leukemia or T-LL, randomizing children and young adults to a modified augmented Berlin-Frankfurt-M\u00fcnster backbone to receive standard therapy (arm A) or with addition of bortezomib (arm B). Optional bone marrow samples to assess minimal residual disease (MRD) at the end of induction (EOI) were collected in T-LL analyzed to assess the correlation of MRD at the EOI to event-free survival (EFS). Eighty-six (41%) of the 209 patients with T-LL accrued to this trial submitted samples for MRD assessment. Patients with MRD &amp;lt;0.1% (n\u00a0= 75) at EOI had a superior 4-year EFS vs those with MRD \u22650.1% (n\u00a0= 11) (89.0%\u00a0\u00b1 4.4% vs 63.6%\u00a0\u00b1 17.2%; P\u00a0= .025). Overall survival did not significantly differ between the 2 groups. Cox regression for EFS using arm A as a reference demonstrated that MRD EOI \u22650.1% was associated with a greater risk of inferior outcome (hazard ratio, 3.73; 95% confidence interval, 1.12-12.40; P\u00a0= .032), which was independent of treatment arm assignment. Consideration to incorporate MRD at EOI into future trials will help establish its value in defining risk groups. CT# NCT02112916.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1182\/blood.2023021184","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T17:57:43Z","timestamp":1709920663000},"page":"2053-2058","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":18,"title":["MRD at the end of induction and EFS in T-cell lymphoblastic lymphoma: Children\u2019s Oncology Group trial AALL1231"],"prefix":"10.1182","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1140-1139","authenticated-orcid":false,"given":"Robert J.","family":"Hayashi","sequence":"first","affiliation":[{"name":"1Division of Pediatric Hematology\/Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1790-2679","authenticated-orcid":false,"given":"Michelle L.","family":"Hermiston","sequence":"additional","affiliation":[{"name":"2Pediatric Hematology Oncology, University of California, San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7414-3969","authenticated-orcid":false,"given":"Brent L.","family":"Wood","sequence":"additional","affiliation":[{"name":"3Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7373-8987","authenticated-orcid":false,"given":"David T.","family":"Teachey","sequence":"additional","affiliation":[{"name":"4Division of Pediatric Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children\u2019s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-3478","authenticated-orcid":false,"given":"Meenakshi","family":"Devidas","sequence":"additional","affiliation":[{"name":"5Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8913-8035","authenticated-orcid":false,"given":"Zhiguo","family":"Chen","sequence":"additional","affiliation":[{"name":"6Department of Biostatistics, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5782-9547","authenticated-orcid":false,"given":"Robert D.","family":"Annett","sequence":"additional","affiliation":[{"name":"7Department of Pediatrics, University of New Mexico, Albuquerque, NM"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9709-3415","authenticated-orcid":false,"given":"Barbara L.","family":"Asselin","sequence":"additional","affiliation":[{"name":"8Division of Pediatric Hematology\/Oncology, Department of Pediatrics, Golisano Children's Hospital, University of Rochester, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5690-0855","authenticated-orcid":false,"given":"Keith","family":"August","sequence":"additional","affiliation":[{"name":"9Division of Pediatric Hematology\/Oncology, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Cho","sequence":"additional","affiliation":[{"name":"10Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Wisconsin Institute for Medical Research, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly P.","family":"Dunsmore","sequence":"additional","affiliation":[{"name":"11Department of Pediatrics, Virginia Tech Carilion School of Medicine, Roanoke, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0752-2701","authenticated-orcid":false,"given":"Jason Lawrence","family":"Freedman","sequence":"additional","affiliation":[{"name":"12Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0322-8882","authenticated-orcid":false,"given":"Paul J.","family":"Galardy","sequence":"additional","affiliation":[{"name":"13Department of Pediatric Hematology and Oncology, Mayo Clinic, Rochester, 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Children's Hospital, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Lam","sequence":"additional","affiliation":[{"name":"17Miller Children's and Women\u2019s Hospital, Long Beach, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-1802","authenticated-orcid":false,"given":"Yoav H.","family":"Messinger","sequence":"additional","affiliation":[{"name":"18Division of Pediatric Hematology\/Oncology, Department of Pediatrics, Children's Hospitals and Clinics of Minnesota, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney R.","family":"Miles","sequence":"additional","affiliation":[{"name":"19Division of Hematopathology, Department of Pathology, ARUP Institute for Clinical and Experimental Pathology, University of Utah, Primary Children's Hospital, Salt Lake City, 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