{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T10:49:07Z","timestamp":1793875747714,"version":"4.7.0"},"reference-count":53,"publisher":"American Society of Hematology","issue":"12","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,21]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>The World Health Organization (WHO) classification of hematolymphoid tumors and the International Consensus Classification (ICC) of 2022 introduced major changes to the definition of chronic myelomonocytic leukemia (CMML). To assess its qualitative and quantitative implications for patient care, we started with 3311 established CMML cases (according to WHO 2017 criteria) and included 2130 oligomonocytosis cases fulfilling the new CMML diagnostic criteria. Applying both 2022 classification systems, 356 and 241 of oligomonocytosis cases were newly classified as myelodysplastic (MD)-CMML (WHO and ICC 2022, respectively), most of which were diagnosed as myelodysplastic syndrome (MDS) according to the WHO 2017 classification. Importantly, 1.5 times more oligomonocytosis cases were classified as CMML according to WHO 2022 than based on ICC, because of different diagnostic criteria. Genetic analyses of the newly classified CMML cases showed a distinct mutational profile with strong enrichment of MDS-typical alterations, resulting in a transcriptional subgroup separated from established MD and myeloproliferative CMML. Despite a different cytogenetic, molecular, immunophenotypic, and transcriptional landscape, no differences in overall survival were found between newly classified and established MD-CMML cases. To the best of our knowledge, this study represents the most comprehensive analysis of routine CMML cases to date, both in terms of clinical characterization and transcriptomic analysis, placing newly classified CMML cases on a disease continuum between MDS and previously established CMML.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1182\/blood.2023021199","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T21:05:02Z","timestamp":1702069502000},"page":"1139-1156","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":27,"title":["Comparing malignant monocytosis across the updated WHO and ICC classifications of 2022"],"prefix":"10.1182","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-1956","authenticated-orcid":false,"given":"Francis","family":"Baumgartner","sequence":"first","affiliation":[{"name":"1Munich Leukemia Laboratory, Munich, Germany"},{"name":"2Department of Hematology, Oncology, and Cancer Immunology, Campus Benjamin Franklin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"3Berlin Institute of Health at Charit\u00e9-Universit\u00e4tsmedizin Berlin, BIH Biomedical Innovation Academy, Berlin Institute of Health at Charit\u00e9 (Junior) (Digital) Clinician Scientist Program, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Baer","sequence":"additional","affiliation":[{"name":"1Munich Leukemia Laboratory, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-7735","authenticated-orcid":false,"given":"Stefanos","family":"Bamopoulos","sequence":"additional","affiliation":[{"name":"2Department of Hematology, Oncology, and Cancer Immunology, Campus Benjamin Franklin, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"3Berlin Institute of Health at Charit\u00e9-Universit\u00e4tsmedizin Berlin, BIH Biomedical Innovation Academy, Berlin Institute of Health at Charit\u00e9 (Junior) (Digital) Clinician Scientist Program, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1321-0114","authenticated-orcid":false,"given":"Edward","family":"Ayoub","sequence":"additional","affiliation":[{"name":"1Munich Leukemia Laboratory, Munich, Germany"},{"name":"4Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marietta","family":"Truger","sequence":"additional","affiliation":[{"name":"1Munich Leukemia Laboratory, Munich, 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