{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:48:46Z","timestamp":1740134926068,"version":"3.37.3"},"reference-count":10,"publisher":"American Society of Hematology","issue":"12","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9,21]]},"DOI":"10.1182\/blood.2023021385","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T15:34:29Z","timestamp":1695310469000},"page":"1032-1034","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":0,"title":["New targeted therapy for hemophilia"],"prefix":"10.1182","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0108-4077","authenticated-orcid":false,"given":"Roger J. S.","family":"Preston","sequence":"first","affiliation":[{"name":"Royal College of Surgeons in Ireland University of Medicine and Health Sciences and Children\u2019s Health Ireland Crumlin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"234","reference":[{"issue":"12","key":"2023092115342139100_bib1","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1182\/blood.2023020005","article-title":"Safety and efficacy of an anti\u2013human APC antibody for prophylaxis of congenital factor deficiencies in preclinical models","volume":"142","author":"Jiang","year":"2023","journal-title":"Blood"},{"issue":"5","key":"2023092115342139100_bib2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/MOH.0000000000000726","article-title":"The protein C pathways","volume":"29","author":"Leon","year":"2022","journal-title":"Curr Opin Hematol"},{"issue":"1","key":"2023092115342139100_bib3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1182\/blood-2016-05-718635","article-title":"Design and characterization of an APC-specific serpin for the treatment of\u00a0hemophilia","volume":"129","author":"Polderdijk","year":"2017","journal-title":"Blood"},{"issue":"3","key":"2023092115342139100_bib4","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1182\/bloodadvances.2021005257","article-title":"An engineered activated factor V for the prevention and treatment of acute traumatic coagulopathy and bleeding in mice","volume":"6","author":"Chumappumkal Joseph","year":"2022","journal-title":"Blood Adv"},{"issue":"12","key":"2023092115342139100_bib5","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1182\/blood-2017-09-800326","article-title":"Targeting anticoagulant protein S to improve hemostasis in hemophilia","volume":"131","author":"Prince","year":"2018","journal-title":"Blood"},{"issue":"1","key":"2023092115342139100_bib6","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1038\/s41467-020-16720-9","article-title":"Targeted\u00a0inhibition of activated protein C by\u00a0a non-active-site inhibitory antibody to treat hemophilia","volume":"11","author":"Zhao","year":"2020","journal-title":"Nat Commun"},{"issue":"11","key":"2023092115342139100_bib7","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1182\/bloodadvances.2021006214","article-title":"Blocking human protein C anticoagulant activity improves clotting defects of hemophilia mice expressing human protein C","volume":"6","author":"Jiang","year":"2022","journal-title":"Blood Adv"},{"issue":"1","key":"2023092115342139100_bib8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41467-017-00169-4","article-title":"Activated protein C protects from GvHD via PAR2\/PAR3 signalling in regulatory T-cells","volume":"8","author":"Ranjan","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"2023092115342139100_bib9","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1073\/pnas.0807594106","article-title":"Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells","volume":"106","author":"Yang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2023092115342139100_bib10","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1160\/TH13-11-0967","article-title":"Activated protein C based therapeutic strategies in chronic diseases","volume":"111","author":"Bock","year":"2014","journal-title":"Thromb Haemost"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/142\/12\/1032\/2077516\/blood_bld-2023-021385-c-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/142\/12\/1032\/2077516\/blood_bld-2023-021385-c-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T15:34:35Z","timestamp":1695310475000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/142\/12\/1032\/497856\/New-targeted-therapy-for-hemophilia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,9,21]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2023021385","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"type":"print","value":"0006-4971"},{"type":"electronic","value":"1528-0020"}],"subject":[],"published":{"date-parts":[[2023,9,21]]}}}