{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:25:31Z","timestamp":1789442731661,"version":"build-2803163510"},"reference-count":23,"publisher":"American Society of Hematology","issue":"14","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4,4]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>Distinct diagnostic entities within BCR::ABL1-positive acute lymphoblastic leukemia (ALL) are currently defined by the International Consensus Classification of myeloid neoplasms and acute leukemias (ICC): \u201clymphoid only\u201d, with BCR::ABL1 observed exclusively in lymphatic precursors, vs \u201cmultilineage\u201d, where BCR::ABL1 is also present in other hematopoietic lineages. Here, we analyzed transcriptomes of 327 BCR::ABL1-positive patients with ALL (age, 2-84 years; median, 46 years) and identified 2 main gene expression clusters reproducible across 4 independent patient cohorts. Fluorescence in situ hybridization analysis of fluorescence-activated cell-sorted hematopoietic compartments showed distinct BCR::ABL1 involvement in myeloid cells for these clusters (n\u00a0= 18\/18 vs n\u00a0= 3\/16 patients; P\u00a0&amp;lt; .001), indicating that a multilineage or lymphoid BCR::ABL1 subtype can be inferred from gene expression. Further subclusters grouped samples according to cooperating genomic events (multilineage: HBS1L deletion or monosomy 7; lymphoid: IKZF1-\/- or CDKN2A\/PAX5 deletions\/hyperdiploidy). A novel HSB1L transcript was highly specific for BCR::ABL1 multilineage cases independent of HBS1L genomic aberrations. Treatment on current German Multicenter Study Group for Adult ALL (GMALL) protocols resulted in comparable disease-free survival (DFS) for multilineage vs lymphoid cluster patients (3-year DFS: 70% vs 61%; P\u00a0= .530; n\u00a0= 91). However, the IKZF1-\/- enriched lymphoid subcluster was associated with inferior DFS, whereas hyperdiploid cases showed a superior outcome. Thus, gene expression clusters define underlying developmental trajectories and distinct patterns of cooperating events in BCR::ABL1-positive ALL with prognostic relevance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1182\/blood.2023021752","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T18:17:45Z","timestamp":1703787465000},"page":"1391-1398","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":32,"title":["Developmental trajectories and cooperating genomic events define molecular subtypes of <i>BCR<\/i>::<i>ABL1<\/i>-positive ALL"],"prefix":"10.1182","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1487-9437","authenticated-orcid":false,"given":"Lorenz","family":"Bastian","sequence":"first","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"},{"name":"2Clinical Research Unit \u201cCATCH ALL\u201d (KFO 5010\/1), Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Beder","sequence":"additional","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1581-2020","authenticated-orcid":false,"given":"Malwine J.","family":"Barz","sequence":"additional","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"},{"name":"2Clinical Research Unit \u201cCATCH ALL\u201d (KFO 5010\/1), Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Bendig","sequence":"additional","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"},{"name":"2Clinical Research Unit \u201cCATCH ALL\u201d (KFO 5010\/1), Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Bartsch","sequence":"additional","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"},{"name":"2Clinical Research Unit \u201cCATCH ALL\u201d (KFO 5010\/1), Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5083-9838","authenticated-orcid":false,"given":"Wencke","family":"Walter","sequence":"additional","affiliation":[{"name":"3MLL Munich Leukemia Laboratory, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Wolgast","sequence":"additional","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"},{"name":"2Clinical Research Unit \u201cCATCH ALL\u201d (KFO 5010\/1), Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1044-1355","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Br\u00e4ndl","sequence":"additional","affiliation":[{"name":"4Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany"},{"name":"5Department of Psychiatry and Psychotherapy, University Hospital Schleswig Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3661-1183","authenticated-orcid":false,"given":"Christian","family":"Rohrandt","sequence":"additional","affiliation":[{"name":"5Department of Psychiatry and Psychotherapy, University Hospital Schleswig Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6672-3787","authenticated-orcid":false,"given":"Bj\u00f6rn-Thore","family":"Hansen","sequence":"additional","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina M.","family":"Hartmann","sequence":"additional","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"},{"name":"2Clinical Research Unit \u201cCATCH ALL\u201d (KFO 5010\/1), Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Iben","sequence":"additional","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"},{"name":"2Clinical Research Unit \u201cCATCH ALL\u201d (KFO 5010\/1), Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Das Gupta","sequence":"additional","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"},{"name":"2Clinical Research Unit \u201cCATCH ALL\u201d (KFO 5010\/1), Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Denker","sequence":"additional","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5041-1954","authenticated-orcid":false,"given":"Johannes","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"6Department of Evolutionary Ecology and Genetics, Zoological Institute, Christian Albrechts University, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1103-4196","authenticated-orcid":false,"given":"Michael","family":"Wittig","sequence":"additional","affiliation":[{"name":"7Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9609-4643","authenticated-orcid":false,"given":"Guranda","family":"Chitadze","sequence":"additional","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"},{"name":"2Clinical Research Unit \u201cCATCH ALL\u201d (KFO 5010\/1), Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Neumann","sequence":"additional","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"},{"name":"2Clinical Research Unit \u201cCATCH ALL\u201d (KFO 5010\/1), Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8134-1054","authenticated-orcid":false,"given":"Folker","family":"Schneller","sequence":"additional","affiliation":[{"name":"8Medical Clinic and Polyclinic of Klinikum rechts der Isar of Technical University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Fiedler","sequence":"additional","affiliation":[{"name":"9Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Steffen","sequence":"additional","affiliation":[{"name":"10Department of Medicine II, Hematology\/Oncology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9331-5145","authenticated-orcid":false,"given":"Matthias","family":"Stelljes","sequence":"additional","affiliation":[{"name":"11Department of Medicine A\u2013Hematology, Hemostaseology, Oncology, Pulmonology, University Hospital Muenster, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Faul","sequence":"additional","affiliation":[{"name":"12Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology, and Rheumatology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8833-5793","authenticated-orcid":false,"given":"Stefan","family":"Schwartz","sequence":"additional","affiliation":[{"name":"13Department of Hematology, Oncology and Tumor Immunology (Campus Benjamin Franklin), Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"14German Cancer Research Center and German Cancer Consortium, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-8430","authenticated-orcid":false,"given":"Franz-Josef","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"4Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany"},{"name":"5Department of Psychiatry and Psychotherapy, University Hospital Schleswig Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Cario","sequence":"additional","affiliation":[{"name":"2Clinical Research Unit \u201cCATCH ALL\u201d (KFO 5010\/1), Kiel, Germany"},{"name":"15Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Harder","sequence":"additional","affiliation":[{"name":"16Institut f\u00fcr Tumorgenetik Nord, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6333-5049","authenticated-orcid":false,"given":"Claudia","family":"Haferlach","sequence":"additional","affiliation":[{"name":"3MLL Munich Leukemia Laboratory, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Pfeifer","sequence":"additional","affiliation":[{"name":"10Department of Medicine II, Hematology\/Oncology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2291-8245","authenticated-orcid":false,"given":"Nicola","family":"G\u00f6kbuget","sequence":"additional","affiliation":[{"name":"10Department of Medicine II, Hematology\/Oncology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5514-5010","authenticated-orcid":false,"given":"Monika","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"},{"name":"2Clinical Research Unit \u201cCATCH ALL\u201d (KFO 5010\/1), Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia D.","family":"Baldus","sequence":"additional","affiliation":[{"name":"1Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany"},{"name":"2Clinical Research Unit \u201cCATCH ALL\u201d (KFO 5010\/1), Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"6","key":"2024040415204755200_bib1","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/leu.2012.352","article-title":"Randomized comparison of prophylactic and minimal residual disease-triggered imatinib after allogeneic stem cell transplantation for BCR\u2013ABL1-positive acute lymphoblastic leukemia","volume":"27","author":"Pfeifer","year":"2013","journal-title":"Leukemia"},{"issue":"2","key":"2024040415204755200_bib2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1182\/blood-2018-08-832105","article-title":"How I treat Philadelphia chromosome\u2013positive acute lymphoblastic\u00a0leukemia","volume":"133","author":"Ravandi","year":"2019","journal-title":"Blood"},{"issue":"S3","key":"2024040415204755200_bib3","doi-asserted-by":"crossref","first-page":"e33834d6","DOI":"10.1097\/01.HS9.0000968332.33834.d6","article-title":"P355: favorable outcome of Philadelphia-positive acute lymphoblastic leukemia with imatinib, dose-reduced induction followed by allogeneic stem cell transplantation \u2013results from the GMALL trial 08\/13","volume":"7","author":"Pfeifer","year":"2023","journal-title":"Hemasphere"},{"issue":"16","key":"2024040415204755200_bib4","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1200\/JCO.2016.69.3531","article-title":"Complete hematologic and molecular response in adult patients with relapsed\/refractory Philadelphia chromosome\u2013positive B-precursor acute lymphoblastic leukemia following treatment with blinatumomab: results from a phase II, single-arm, multicenter study","volume":"35","author":"Martinelli","year":"2017","journal-title":"J\u00a0Clin Oncol"},{"issue":"17","key":"2024040415204755200_bib5","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1056\/NEJMoa2016272","article-title":"Dasatinib-blinatumomab for Ph-positive acute lymphoblastic leukemia in adults","volume":"383","author":"Fo\u00e0","year":"2020","journal-title":"N\u00a0Engl J Med"},{"issue":"18","key":"2024040415204755200_bib6","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1182\/blood-2017-05-782888","article-title":"Hematopoietic stem cell involvement in BCR-ABL1\u2013positive ALL as a potential mechanism of resistance to blinatumomab therapy","volume":"130","author":"Nagel","year":"2017","journal-title":"Blood"},{"issue":"20","key":"2024040415204755200_bib7","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1182\/blood-2016-11-749978","article-title":"Monitoring of childhood ALL using BCR-ABL1 genomic breakpoints identifies a subgroup with CML-like biology","volume":"129","author":"Hovorkova","year":"2017","journal-title":"Blood"},{"key":"2024040415204755200_bib8","doi-asserted-by":"crossref","first-page":"586567","DOI":"10.3389\/fonc.2020.586567","article-title":"Multi-lineage BCR-ABL expression in Philadelphia chromosome-positive acute lymphoblastic leukemia is associated with improved prognosis but no specific molecular features","volume":"10","author":"Nishiwaki","year":"2020","journal-title":"Front Oncol"},{"issue":"suppl 1","key":"2024040415204755200_bib9","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1182\/blood-2021-150126","article-title":"Frequency and outcome of Philadelphia chromosome-positive acute lymphoblastic leukemia with BCR-ABL1 clonal hematopoiesis after blast clearance: results from the Graaph-2014 trial [abstract]","volume":"138","author":"Kim","year":"2021","journal-title":"Blood"},{"issue":"11","key":"2024040415204755200_bib10","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.2022015850","article-title":"International consensus classification of myeloid neoplasms and acute leukemia: integrating morphological, clinical, and genomic data","volume":"140","author":"Arber","year":"2022","journal-title":"Blood"},{"issue":"6","key":"2024040415204755200_bib11","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1038\/s41375-022-01557-6","article-title":"UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment","volume":"36","author":"Bastian","year":"2022","journal-title":"Leukemia"},{"issue":"1","key":"2024040415204755200_bib12","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1186\/s12885-021-08635-5","article-title":"Clinical application of whole transcriptome sequencing for the classification of patients with acute lymphoblastic leukemia","volume":"21","author":"Walter","year":"2021","journal-title":"BMC Cancer"},{"issue":"2","key":"2024040415204755200_bib13","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41588-018-0315-5","article-title":"PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia","volume":"51","author":"Gu","year":"2019","journal-title":"Nat Genet"},{"issue":"7","key":"2024040415204755200_bib14","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/s41588-023-01429-4","article-title":"Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia","volume":"55","author":"Kim","year":"2023","journal-title":"Nat Genet"},{"issue":"9","key":"2024040415204755200_bib15","doi-asserted-by":"crossref","first-page":"e939","DOI":"10.1097\/HS9.0000000000000939","article-title":"The gene expression classifier ALLCatchR identifies B-cell precursor ALL subtypes and underlying developmental trajectories across age","volume":"7","author":"Beder","year":"2023","journal-title":"Hemasphere"},{"issue":"8","key":"2024040415204755200_bib16","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1038\/s41375-019-0430-z","article-title":"PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia","volume":"33","author":"Bastian","year":"2019","journal-title":"Leukemia"},{"key":"2024040415204755200_bib17","doi-asserted-by":"crossref","first-page":"e83077","DOI":"10.7554\/eLife.83077","article-title":"T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation","volume":"12","author":"Landshammer","year":"2023  31","journal-title":"ELife"},{"issue":"9","key":"2024040415204755200_bib18","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1038\/s41375-019-0496-7","article-title":"Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study","volume":"33","author":"Br\u00fcggemann","year":"2019","journal-title":"Leukemia"},{"issue":"2","key":"2024040415204755200_bib19","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3324\/haematol.2023.283814","article-title":"Frequent, high density expression of surface CD38 as a potential therapeutic target in adult T-lineage acute lymphoblastic leukemia","volume":"109","author":"Koslowski","year":"2024","journal-title":"Haematologica"},{"issue":"1","key":"2024040415204755200_bib20","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1186\/s12859-018-2435-4","article-title":"Single sample scoring of molecular phenotypes","volume":"19","author":"Foroutan","year":"2018","journal-title":"BMC Bioinformatics"},{"issue":"12","key":"2024040415204755200_bib21","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1038\/s41375-022-01668-0","article-title":"Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease","volume":"36","author":"Zuna","year":"2022","journal-title":"Leukemia"},{"issue":"4","key":"2024040415204755200_bib22","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/sj.leu.2403324","article-title":"Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with\u00a0outcome","volume":"18","author":"Heerema","year":"2004","journal-title":"Leukemia"},{"issue":"4","key":"2024040415204755200_bib23","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1046\/j.1365-2141.1996.d01-1968.x","article-title":"Prognostic significance of additional chromosome abnormalities in adult patients with Philadelphia chromosome positive acute lymphoblastic leukaemia","volume":"95","author":"Rieder","year":"1996","journal-title":"Br J Haematol"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/143\/14\/1391\/2219824\/blood_bld-2023-021752-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/143\/14\/1391\/2219824\/blood_bld-2023-021752-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T15:21:09Z","timestamp":1712244069000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/143\/14\/1391\/506890\/Developmental-trajectories-and-cooperating-genomic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,4]]},"references-count":23,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2024,4,4]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2023021752","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,4]]}}}