{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:38:37Z","timestamp":1789609117283,"version":"build-2803163510"},"reference-count":25,"publisher":"American Society of Hematology","issue":"11","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,14]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>We show that red cell exchange (RCE) treats hyperleukocytosis in acute leukemia. RCE provided similar leukoreduction to standard therapeutic leukoreduction and could be superior in patients with severe anemia or monocytic leukemias or when requiring rapid treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1182\/blood.2023021895","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T21:44:58Z","timestamp":1701812698000},"page":"1049-1054","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":3,"title":["Red cell exchange for rapid leukoreduction in adults with hyperleukocytosis and leukostasis"],"prefix":"10.1182","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4529-4917","authenticated-orcid":false,"given":"Ethan A.","family":"Mack","sequence":"first","affiliation":[{"name":"1Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaghan C.","family":"Dougher","sequence":"additional","affiliation":[{"name":"1Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M.","family":"Ginda","sequence":"additional","affiliation":[{"name":"1Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Cahill","sequence":"additional","affiliation":[{"name":"1Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Murter","sequence":"additional","affiliation":[{"name":"1Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Schell","sequence":"additional","affiliation":[{"name":"1Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-3119","authenticated-orcid":false,"given":"Yvette C.","family":"Tanhehco","sequence":"additional","affiliation":[{"name":"2Division of Transfusion Medicine and Cellular Therapy, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay G.","family":"Bhoj","sequence":"additional","affiliation":[{"name":"1Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2705-803X","authenticated-orcid":false,"given":"Andrew D.","family":"Fesnak","sequence":"additional","affiliation":[{"name":"1Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2098-2251","authenticated-orcid":false,"given":"Don L.","family":"Siegel","sequence":"additional","affiliation":[{"name":"1Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Kambayashi","sequence":"additional","affiliation":[{"name":"1Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole A.","family":"Aqui","sequence":"additional","affiliation":[{"name":"1Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Una","family":"O\u2019Doherty","sequence":"additional","affiliation":[{"name":"1Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"2","key":"2024031415212766800_bib1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/17474086.2017.1270754","article-title":"Hyperleukocytosis and leukostasis: management of a medical emergency","volume":"10","author":"Giammarco","year":"2017","journal-title":"Expert Rev Hematol"},{"issue":"11","key":"2024031415212766800_bib2","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.3324\/haematol.2012.065490","article-title":"Predictors and short-term outcomes of hyperleukocytosis in children with acute myeloid leukemia: a report from the Children\u2019s Oncology Group","volume":"97","author":"Sung","year":"2012","journal-title":"Haematologica"},{"issue":"1-2","key":"2024031415212766800_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10428190009053534","article-title":"Hyperleukocytic leukemias and leukostasis: a review of pathophysiology, clinical presentation and management","volume":"39","author":"Porcu","year":"2000","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"2024031415212766800_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1526-0968.2002.00402.x","article-title":"Leukocytoreduction for acute leukemia","volume":"6","author":"Porcu","year":"2002","journal-title":"Ther Apher"},{"issue":"1","key":"2024031415212766800_bib5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1182\/asheducation-2014.1.457","article-title":"Leukocytapheresis for the treatment of hyperleukocytosis secondary to acute leukemia","volume":"2014","author":"Aqui","year":"2014","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"11","key":"2024031415212766800_bib6","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1080\/10428194.2018.1452219","article-title":"Beliefs and practice patterns in hyperleukocytosis management in acute myeloid leukemia: a large U.S. web-based survey","volume":"59","author":"Stahl","year":"2018","journal-title":"Leuk Lymphoma"},{"issue":"5","key":"2024031415212766800_bib7","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1182\/blood.V63.5.1230.1230","article-title":"Hyperleukocytosis and leukostasis: common features of childhood chronic myelogenous leukemia","volume":"63","author":"Rowe","year":"1984","journal-title":"Blood"},{"issue":"2","key":"2024031415212766800_bib8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1182\/blood.V60.2.279.279","article-title":"Hyperleukocytic leukemias: rheological, clinical, and therapeutic considerations","volume":"60","author":"Lichtman","year":"1982","journal-title":"Blood"},{"issue":"10","key":"2024031415212766800_bib9","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1164\/rccm.200206-554OC","article-title":"Acute monocytic leukemia presenting as acute respiratory failure","volume":"167","author":"Azoulay","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"2024031415212766800_bib10","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0002-9343(80)90467-2","article-title":"Association of monocytic leukemia in patients with extreme leukocytosis","volume":"69","author":"Cuttner","year":"1980","journal-title":"Am J Med"},{"issue":"1","key":"2024031415212766800_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0002-9343(85)90544-3","article-title":"Pulmonary leukostasis as the single worst prognostic factor in patients with acute myelocytic leukemia and hyperleukocytosis","volume":"79","author":"Lester","year":"1985","journal-title":"Am J Med"},{"issue":"2","key":"2024031415212766800_bib12","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1172\/JCI107191","article-title":"Rheology of leukocytes, leukocyte suspensions, and blood in leukemia. Possible relationship to clinical manifestations","volume":"52","author":"Lichtman","year":"1973","journal-title":"J\u00a0Clin Invest"},{"issue":"1","key":"2024031415212766800_bib13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1182\/blood.V40.1.52.52","article-title":"Peripheral cytoplasmic characteristics of leukocytes in monocytic leukemia: relationship to clinical manifestations","volume":"40","author":"Lichtman","year":"1972","journal-title":"Blood"},{"key":"2024031415212766800_bib14","first-page":"623","article-title":"Leukapheresis does not improve early survival outcome of acute myeloid leukemia with leukostasis patients\u2014a dual-center retrospective cohort study","volume":"12","author":"Rinaldi","year":"2021","journal-title":"J\u00a0Blood Med"},{"issue":"1","key":"2024031415212766800_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/16078454.2021.2024939","article-title":"Comparison of early mortality between leukapheresis and non-leukapheresis in adult acute myeloid leukemia patients with hyperleukocytosis: a systematic review and meta-analysis","volume":"27","author":"Rinaldi","year":"2022","journal-title":"Hematology"},{"issue":"10","key":"2024031415212766800_bib16","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1111\/trf.15994","article-title":"Leukapheresis for the management of hyperleukocytosis in acute myeloid leukemia\u2014a systematic review and meta-analysis","volume":"60","author":"Bewersdorf","year":"2020","journal-title":"Transfusion"},{"issue":"11","key":"2024031415212766800_bib17","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/ajh.20939","article-title":"Leukapheresis and cranial irradiation in patients with hyperleukocytic acute myeloid leukemia: no impact on early mortality and intracranial hemorrhage","volume":"82","author":"Chang","year":"2007","journal-title":"Am J Hematol"},{"issue":"1","key":"2024031415212766800_bib18","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/trf.14329","article-title":"The effect of therapeutic leukapheresis on early complications and outcomes in patients with acute leukemia and hyperleukocytosis: a propensity score-matched study","volume":"58","author":"Choi","year":"2018","journal-title":"Transfusion"},{"issue":"6","key":"2024031415212766800_bib19","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.transci.2017.11.002","article-title":"Leukapheresis do not improve early death rates in acute myeloid leukemia patients with hyperleukocytosis","volume":"56","author":"Malkan","year":"2017","journal-title":"Transfus Apher Sci"},{"issue":"4","key":"2024031415212766800_bib20","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.leukres.2014.01.004","article-title":"Leukapheresis and low-dose chemotherapy do not reduce early mortality in acute myeloid leukemia hyperleukocytosis: a systematic review and meta-analysis","volume":"38","author":"Oberoi","year":"2014","journal-title":"Leuk Res"},{"issue":"2","key":"2024031415212766800_bib21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1046\/j.1365-2141.1997.1943011.x","article-title":"Therapeutic leukapheresis in hyperleucocytic leukaemias: lack of correlation between degree of cytoreduction and early mortality rate","volume":"98","author":"Porcu","year":"1997","journal-title":"Br J Haematol"},{"issue":"5","key":"2024031415212766800_bib22","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/17474086.2020.1751609","article-title":"Leukocytapheresis for patients with acute myeloid leukemia presenting with hyperleukocytosis and leukostasis: a contemporary appraisal of outcomes and benefits","volume":"13","author":"Shallis","year":"2020","journal-title":"Expert Rev Hematol"},{"issue":"12","key":"2024031415212766800_bib23","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1038\/s41375-020-0783-3","article-title":"Management of hyperleukocytosis and impact of leukapheresis among patients with acute myeloid leukemia (AML) on short- and long-term clinical outcomes: a large, retrospective, multicenter, international study","volume":"34","author":"Stahl","year":"2020","journal-title":"Leukemia"},{"issue":"2","key":"2024031415212766800_bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/jca.22043","article-title":"Guidelines on the use of therapeutic apheresis in clinical practice\u2014evidence-based approach from the Writing Committee of the American Society for Apheresis: the ninth special issue","volume":"38","author":"Connelly-Smith","year":"2023","journal-title":"J\u00a0Clin Apher"},{"issue":"8","key":"2024031415212766800_bib25","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.leukres.2008.01.004","article-title":"Outcome of hyperleukocytic adult acute myeloid leukaemia: a single-center retrospective study and review of literature","volume":"32","author":"Marbello","year":"2008","journal-title":"Leuk Res"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/143\/11\/1049\/2218035\/blood_bld-2023-021895-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/143\/11\/1049\/2218035\/blood_bld-2023-021895-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T15:24:05Z","timestamp":1710429845000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/143\/11\/1049\/506504\/Red-cell-exchange-for-rapid-leukoreduction-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,14]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,3,14]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2023021895","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,14]]}}}