{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:06:12Z","timestamp":1765976772428,"version":"3.37.3"},"reference-count":59,"publisher":"American Society of Hematology","issue":"26","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6,27]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>Thrombotic thrombocytopenic purpura (TTP), a rare but fatal disease if untreated, is due to alteration in von Willebrand factor cleavage resulting in capillary microthrombus formation and ischemic organ damage. Interleukin-1 (IL-1) has been shown to drive sterile inflammation after ischemia and could play an essential contribution to postischemic organ damage in TTP. Our objectives were to evaluate IL-1 involvement during TTP and to test the efficacy of the recombinant IL-1 receptor antagonist, anakinra, in a murine TTP model. We retrospectively measured plasma IL-1 concentrations in patients with TTP and\u00a0controls. Patients with TTP exhibited elevated plasma IL-1\u03b1 and -1\u03b2 concentrations, which correlated with disease course and survival. In a mouse model of TTP, we administered anakinra (IL-1 inhibitor) or placebo for 5 days and evaluated the efficacy of this\u00a0treatment. Anakinra significantly reduced mortality of mice (P\u00a0&amp;lt; .001). Anakinra significantly decreased TTP-induced cardiac damage as assessed by blood troponin concentrations, evaluation of left ventricular function by echocardiography, [18F]fluorodeoxyglucose positron emission tomography of myocardial glucose metabolism, and cardiac histology. Anakinra also significantly reduced brain TTP-induced damage evaluated through blood PS100b concentrations, nuclear imaging, and histology. We finally showed that IL-1\u03b1 and -1\u03b2 trigger endothelial degranulation in\u00a0vitro, leading to the release of von Willebrand factor. In conclusion, anakinra significantly reduced TTP mortality in a preclinical model of the disease by inhibiting both endothelial degranulation and postischemic inflammation, supporting further evaluations in humans.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1182\/blood.2023021974","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T20:56:28Z","timestamp":1712782588000},"page":"2791-2803","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":3,"title":["Reduction of mortality, cardiac damage, and cerebral damage by IL-1 inhibition in a murine model of TTP"],"prefix":"10.1182","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9857-9089","authenticated-orcid":false,"given":"Romain","family":"Muller","sequence":"first","affiliation":[{"name":"1INSERM, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement, Centre de Recherche en CardioVasculaire et Nutrition, Aix Marseille University, Marseille, France"},{"name":"2Assistance Publique des H\u00f4pitaux de Marseille, Department of Clinical Immunology and Internal Medicine, CHU Conception, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9316-5231","authenticated-orcid":false,"given":"Rapha\u00ebl","family":"Cauchois","sequence":"additional","affiliation":[{"name":"1INSERM, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement, Centre de Recherche en CardioVasculaire et Nutrition, Aix Marseille University, Marseille, France"},{"name":"2Assistance Publique des H\u00f4pitaux de Marseille, Department of Clinical Immunology and Internal Medicine, CHU Conception, Marseille, France"},{"name":"3French Reference Center for Thrombotic Microangiopathies, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4339-7159","authenticated-orcid":false,"given":"Marie","family":"Lagarde","sequence":"additional","affiliation":[{"name":"1INSERM, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement, Centre de Recherche en CardioVasculaire et Nutrition, Aix Marseille University, Marseille, France"},{"name":"3French Reference Center for Thrombotic Microangiopathies, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-4168","authenticated-orcid":false,"given":"Sandrine","family":"Roffino","sequence":"additional","affiliation":[{"name":"4Centre National de la Recherche Scientifique, Institut des Sciences du Mouvement, Aix-Marseille University, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Genovesio","sequence":"additional","affiliation":[{"name":"5Facult\u00e9 de Pharmacie, Aix-Marseille University, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Fernandez","sequence":"additional","affiliation":[{"name":"6Assistance Publique des H\u00f4pitaux de Marseille, INSERM, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement, Centre de Recherche en CardioVasculaire et Nutrition, Centre Europ\u00e9en de Recherche en Imagerie M\u00e9dicale, CHU Timone, Aix-Marseille University, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6474-8101","authenticated-orcid":false,"given":"Guillaume","family":"Hache","sequence":"additional","affiliation":[{"name":"1INSERM, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement, Centre de Recherche en CardioVasculaire et Nutrition, Aix Marseille University, Marseille, France"},{"name":"7Biology Department, Assistance Publique des H\u00f4pitaux de Marseille, INSERM, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement, Centre de Recherche en CardioVasculaire et Nutrition, Centre Europ\u00e9en de Recherche en Imagerie M\u00e9dicale, CHU Timone, Aix-Marseille University, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7578-6824","authenticated-orcid":false,"given":"Benjamin","family":"Guillet","sequence":"additional","affiliation":[{"name":"7Biology Department, Assistance Publique des H\u00f4pitaux de Marseille, INSERM, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement, Centre de Recherche en CardioVasculaire et Nutrition, Centre Europ\u00e9en de Recherche en Imagerie M\u00e9dicale, CHU Timone, Aix-Marseille University, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y\u00e9ter","family":"Kara","sequence":"additional","affiliation":[{"name":"1INSERM, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement, Centre de Recherche en CardioVasculaire et Nutrition, Aix Marseille University, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-8760","authenticated-orcid":false,"given":"Marion","family":"Marlinge","sequence":"additional","affiliation":[{"name":"7Biology Department, Assistance Publique des H\u00f4pitaux de Marseille, INSERM, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement, Centre de Recherche en CardioVasculaire et Nutrition, Centre Europ\u00e9en de Recherche en Imagerie M\u00e9dicale, CHU Timone, Aix-Marseille University, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7937-3429","authenticated-orcid":false,"given":"Peter","family":"Lenting","sequence":"additional","affiliation":[{"name":"8INSERM, H\u00e9mostase Inflammation Thrombose HITh U1176, Universit\u00e9 Paris-Saclay, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2748-4354","authenticated-orcid":false,"given":"Pascale","family":"Poullin","sequence":"additional","affiliation":[{"name":"3French Reference Center for Thrombotic Microangiopathies, Paris, France"},{"name":"9Assistance Publique des H\u00f4pitaux de Marseille, Service d\u2019H\u00e9maph\u00e9r\u00e9se, CHU Conception, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7006-4462","authenticated-orcid":false,"given":"Fran\u00e7oise","family":"Dignat-George","sequence":"additional","affiliation":[{"name":"1INSERM, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement, Centre de Recherche en CardioVasculaire et Nutrition, Aix Marseille University, Marseille, France"},{"name":"10Department of Hematology and Vascular Biology, Assistance Publique des H\u00f4pitaux de Marseille, INSERM, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement, Centre de Recherche en CardioVasculaire et Nutrition, CHU Conception, Aix-Marseille University, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3044-5388","authenticated-orcid":false,"given":"Edwige","family":"Tellier","sequence":"additional","affiliation":[{"name":"1INSERM, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement, Centre de Recherche en CardioVasculaire et Nutrition, Aix Marseille University, Marseille, France"},{"name":"3French Reference Center for Thrombotic Microangiopathies, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0892-9207","authenticated-orcid":false,"given":"Gilles","family":"Kaplanski","sequence":"additional","affiliation":[{"name":"1INSERM, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement, Centre de Recherche en CardioVasculaire et Nutrition, Aix Marseille University, Marseille, France"},{"name":"2Assistance Publique des H\u00f4pitaux de Marseille, Department of Clinical Immunology and Internal Medicine, CHU Conception, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"234","reference":[{"issue":"10","key":"2024062715205763300_bib1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1182\/blood-2017-04-636431","article-title":"Pathophysiology of thrombotic thrombocytopenic purpura","volume":"130","author":"Sadler","year":"2017","journal-title":"Blood"},{"issue":"3","key":"2024062715205763300_bib2","first-page":"536","article-title":"Thrombotic thrombocytopenic purpura: pathophysiology, diagnosis, and management","volume":"10","author":"Sukumar","year":"2021","journal-title":"J\u00a0Clin Med"},{"issue":"13","key":"2024062715205763300_bib3","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1182\/blood.2020007599","article-title":"Real-world experience with caplacizumab in the management of acute TTP","volume":"137","author":"Dutt","year":"2021","journal-title":"Blood"},{"issue":"1","key":"2024062715205763300_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/1744-9987.12191","article-title":"Cardiac injury is a common postmortem finding in thrombotic thrombocytopenic purpura patients: is empiric cardiac monitoring and protection needed?","volume":"19","author":"Nichols","year":"2015","journal-title":"Ther Apher Dial"},{"issue":"10","key":"2024062715205763300_bib5","doi-asserted-by":"crossref","first-page":"E208","DOI":"10.1002\/ajh.24138","article-title":"Increased morbidity during long term follow up of survivors of thrombotic thrombocytopenic purpura","volume":"90","author":"Chaturvedi","year":"2015","journal-title":"Am J Hematol"},{"issue":"2","key":"2024062715205763300_bib6","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1016\/j.amjmed.2020.06.020","article-title":"Cardiovascular complications and their association with mortality in patients with thrombotic thrombocytopenic purpura","volume":"134","author":"Balasubramaniyam","year":"2021","journal-title":"Am J Med"},{"issue":"2","key":"2024062715205763300_bib7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1001\/jamaneurol.2013.5026","article-title":"The innate immune system after ischemic injury \u2014 lessons to be learned from the heart and brain","volume":"71","author":"Courties","year":"2014","journal-title":"JAMA Neurol"},{"issue":"1","key":"2024062715205763300_bib8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12621","article-title":"Overview of the IL-1 family in innate inflammation and acquired immunity","volume":"281","author":"Dinarello","year":"2018","journal-title":"Immunol Rev"},{"key":"2024062715205763300_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fncel.2015.00018","article-title":"Interleukin-1 and acute brain injury","volume":"9","author":"Murray","year":"2015","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"2024062715205763300_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/FJC.0000000000000106","article-title":"Interleukin-1\u03b2 blockade improves left ventricular systolic\/diastolic function and restores contractility reserve in severe ischemic cardiomyopathy in the mouse","volume":"64","author":"Toldo","year":"2014","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"issue":"2","key":"2024062715205763300_bib11","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.yjmcc.2011.05.003","article-title":"Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury","volume":"51","author":"Toldo","year":"2011","journal-title":"J\u00a0Mol Cell Cardiol"},{"issue":"4","key":"2024062715205763300_bib12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/eurjhf\/hfq017","article-title":"Interleukin-1beta modulation using a genetically engineered antibody prevents adverse cardiac remodelling following acute myocardial infarction in the mouse","volume":"12","author":"Abbate","year":"2010","journal-title":"Eur J Heart Fail"},{"issue":"15","key":"2024062715205763300_bib13","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.1523\/JNEUROSCI.21-15-05528.2001","article-title":"Role of IL-1\u03b1 and IL-1\u03b2 in ischemic brain damage","volume":"21","author":"Boutin","year":"2001","journal-title":"J\u00a0Neurosci"},{"issue":"1","key":"2024062715205763300_bib14","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1038\/s41598-023-30662-4","article-title":"The systemic deletion of interleukin-1\u03b1 reduces myocardial inflammation and attenuates ventricular remodeling in murine myocardial infarction","volume":"13","author":"Lugrin","year":"2023","journal-title":"Sci Rep"},{"issue":"11","key":"2024062715205763300_bib15","doi-asserted-by":"crossref","first-page":"e27923","DOI":"10.1371\/journal.pone.0027923","article-title":"Alterations in the interleukin-1\/interleukin-1 receptor antagonist balance modulate cardiac remodeling following myocardial infarction in the mouse","volume":"6","author":"Abbate","year":"2011","journal-title":"PLoS One"},{"issue":"20","key":"2024062715205763300_bib16","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1161\/CIRCULATIONAHA.107.740233","article-title":"Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction","volume":"117","author":"Abbate","year":"2008","journal-title":"Circulation"},{"issue":"3","key":"2024062715205763300_bib17","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10557-012-6389-x","article-title":"Recombinant human interleukin-1 receptor antagonist provides cardioprotection during myocardial ischemia reperfusion in the mouse","volume":"26","author":"Toldo","year":"2012","journal-title":"Cardiovasc Drugs Ther"},{"issue":"1","key":"2024062715205763300_bib18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/cei.13314","article-title":"IL-1 receptor antagonist, anakinra, prevents myocardial dysfunction in a mouse model of Kawasaki disease vasculitis and myocarditis","volume":"198","author":"Gorelik","year":"2019","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"2024062715205763300_bib19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/eurheartj\/ehu272","article-title":"The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study","volume":"36","author":"Morton","year":"2015","journal-title":"Eur Heart J"},{"issue":"10","key":"2024062715205763300_bib20","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.amjcard.2009.12.059","article-title":"Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study)","volume":"105","author":"Abbate","year":"2010","journal-title":"Am J Cardiol"},{"issue":"10","key":"2024062715205763300_bib21","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.amjcard.2013.01.287","article-title":"Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) pilot study]","volume":"111","author":"Abbate","year":"2013","journal-title":"Am J Cardiol"},{"issue":"5","key":"2024062715205763300_bib22","doi-asserted-by":"crossref","first-page":"e014941","DOI":"10.1161\/JAHA.119.014941","article-title":"Interleukin-1 blockade inhibits the acute inflammatory response in patients with ST-segment-elevation myocardial infarction","volume":"9","author":"Abbate","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"3","key":"2024062715205763300_bib23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ajh.2830400303","article-title":"Plasma cytokine levels in thrombotic thrombocytopenic purpura","volume":"40","author":"Wada","year":"1992","journal-title":"Am J Hematol"},{"issue":"5","key":"2024062715205763300_bib24","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/ehjcvp\/pvab075","article-title":"Interleukin-1 blockade with anakinra and heart failure following ST-segment elevation myocardial infarction: results from a pooled analysis of the VCUART clinical trials","volume":"8","author":"Abbate","year":"2022","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"issue":"1","key":"2024062715205763300_bib25","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/s41598-022-05374-w","article-title":"Effect of interleukin-1 blockade with anakinra on leukocyte count in patients with ST-segment elevation acute myocardial infarction","volume":"12","author":"Del Buono","year":"2022","journal-title":"Sci Rep"},{"issue":"10","key":"2024062715205763300_bib26","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1172\/JCI26007","article-title":"Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice","volume":"115","author":"Motto","year":"2005","journal-title":"J\u00a0Clin Invest"},{"issue":"13","key":"2024062715205763300_bib27","doi-asserted-by":"crossref","first-page":"12102","DOI":"10.1074\/jbc.M310436200","article-title":"An experimental model to study the in\u00a0vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation","volume":"279","author":"Lenting","year":"2004","journal-title":"J\u00a0Biol Chem"},{"issue":"3","key":"2024062715205763300_bib28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0049-3848(90)90181-B","article-title":"Multimeric analysis of von Willebrand factor by molecular sieving electrophoresis in sodium dodecyl sulphate agarose gel","volume":"60","author":"Raines","year":"1990","journal-title":"Thromb Res"},{"issue":"4","key":"2024062715205763300_bib29","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.3324\/haematol.2022.280651","article-title":"Immune-mediated thrombotic thrombocytopenic purpura plasma induces calcium- and IgG-dependent endothelial activation: correlations with disease severity","volume":"108","author":"Tellier","year":"2023","journal-title":"Haematologica"},{"issue":"2","key":"2024062715205763300_bib30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/jth.12790","article-title":"Cardiac troponin-I on diagnosis predicts early death and refractoriness in acquired thrombotic thrombocytopenic purpura. Experience of the French Thrombotic Microangiopathies Reference Center","volume":"13","author":"Benhamou","year":"2015","journal-title":"J\u00a0Thromb Haemost"},{"issue":"20","key":"2024062715205763300_bib31","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1182\/bloodadvances.2021005317","article-title":"Blood-brain barrier permeability in survivors of immune-mediated thrombotic thrombocytopenic purpura: a pilot study","volume":"5","author":"Huang","year":"2021","journal-title":"Blood Adv"},{"issue":"5","key":"2024062715205763300_bib32","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/bjh.17126","article-title":"Cerebral MRI findings predict the risk of cognitive impairment in thrombotic thrombocytopenic purpura","volume":"191","author":"Alwan","year":"2020","journal-title":"Br J Haematol"},{"issue":"5","key":"2024062715205763300_bib33","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/trf.14060","article-title":"Depression and cognitive deficits as long-term consequences of thrombotic thrombocytopenic purpura","volume":"57","author":"Falter","year":"2017","journal-title":"Transfusion"},{"issue":"9","key":"2024062715205763300_bib34","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1161\/CIRCRESAHA.120.315937","article-title":"Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease","volume":"126","author":"Abbate","year":"2020","journal-title":"Circ Res"},{"key":"2024062715205763300_bib35","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3389\/fphys.2014.00496","article-title":"Ischemia\/reperfusion activates myocardial innate immune response: the key role of the toll-like receptor","volume":"5","author":"Vilahur","year":"2014","journal-title":"Front Physiol"},{"key":"2024062715205763300_bib36","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.biopha.2017.05.033","article-title":"The protective effect of Luteolin on myocardial ischemia\/reperfusion (I\/R) injury through TLR4\/NF-\u03baB\/NLRP3 inflammasome pathway","volume":"91","author":"Zhang","year":"2017","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"2024062715205763300_bib37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00395-010-0127-y","article-title":"Left ventricular dilation in toll-like receptor 2 deficient mice after myocardial ischemia\/reperfusion through defective scar formation","volume":"106","author":"Mersmann","year":"2011","journal-title":"Basic Res Cardiol"},{"issue":"1-2","key":"2024062715205763300_bib38","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0022-510X(00)00442-1","article-title":"Comparison of serum S-100 protein levels following stroke and traumatic brain injury","volume":"181","author":"Elting","year":"2000","journal-title":"J\u00a0Neurol Sci"},{"issue":"2","key":"2024062715205763300_bib39","first-page":"126","article-title":"Predictive value of selected biochemical markers of brain damage for functional outcome in ischaemic stroke patients","volume":"43","author":"Sienkiewicz-Jarosz","year":"2009","journal-title":"Neurol Neurochir Pol"},{"issue":"3","key":"2024062715205763300_bib40","doi-asserted-by":"crossref","first-page":"102763","DOI":"10.1016\/j.autrev.2021.102763","article-title":"Interleukin 1\u03b1: a comprehensive review on the role of IL-1\u03b1 in the pathogenesis and treatment of autoimmune and inflammatory diseases","volume":"20","author":"Cavalli","year":"2021","journal-title":"Autoimmun Rev"},{"issue":"6","key":"2024062715205763300_bib41","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.smim.2013.10.008","article-title":"Treating inflammation by blocking interleukin-1 in humans","volume":"25","author":"Dinarello","year":"2013","journal-title":"Semin Immunol"},{"issue":"3","key":"2024062715205763300_bib42","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1034\/j.1399-6576.2003.00004.x","article-title":"Anti-inflammatory cytokine response and the development of multiple organ failure in severe sepsis","volume":"47","author":"Loisa","year":"2003","journal-title":"Acta Anaesthesiol Scand"},{"issue":"1","key":"2024062715205763300_bib43","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s40478-020-00957-y","article-title":"Characterization of the TNF and IL-1 systems in human brain and blood after ischemic stroke","volume":"8","author":"Clausen","year":"2020","journal-title":"Acta Neuropathol Commun"},{"issue":"4","key":"2024062715205763300_bib44","first-page":"509","article-title":"IL-1\u03b2, TNF-\u03b1, and IL-6 levels in gingival fluid and serum of patients with ischemic stroke","volume":"58","author":"Wytrykowska","year":"2016","journal-title":"J\u00a0Oral Sci"},{"issue":"4","key":"2024062715205763300_bib45","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1160\/TH11-08-0552","article-title":"Erythropoietin-induced progenitor cell mobilisation in patients with acute ST-segment-elevation myocardial infarction and restenosis","volume":"107","author":"Stein","year":"2012","journal-title":"Thromb Haemost"},{"issue":"9","key":"2024062715205763300_bib46","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.clinbiochem.2015.02.002","article-title":"Relationship between serum cytokine and growth factor concentrations and coronary artery disease","volume":"48","author":"Mirhafez","year":"2015","journal-title":"Clin Biochem"},{"issue":"10","key":"2024062715205763300_bib47","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1111\/jth.13439","article-title":"Assessment of endothelial damage and cardiac injury in a mouse model mimicking thrombotic thrombocytopenic purpura","volume":"14","author":"Le Besnerais","year":"2016","journal-title":"J\u00a0Thromb Haemost"},{"issue":"2","key":"2024062715205763300_bib48","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10557-008-6154-3","article-title":"Anakinra in experimental acute myocardial infarction--does dosage or duration of treatment matter?","volume":"23","author":"Salloum","year":"2009","journal-title":"Cardiovasc Drugs Ther"},{"issue":"11","key":"2024062715205763300_bib49","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1111\/jog.13095","article-title":"Effect of Kineret\u00ae on ovarian ischemia reperfusion injury in a rat model","volume":"42","author":"Nayki","year":"2016","journal-title":"J\u00a0Obstet Gynaecol Res"},{"issue":"3","key":"2024062715205763300_bib50","first-page":"87","article-title":"Effect of anakinra, an interleukin one beta antagonist, on oxidative testicular damage induced in rats with ischemia reperfusion","volume":"16","author":"Hirik","year":"2018","journal-title":"Rev Int Androl"},{"issue":"12","key":"2024062715205763300_bib51","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1002\/1529-0131(200012)43:12<2648::AID-ANR4>3.0.CO;2-M","article-title":"Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models of rheumatoid arthritis","volume":"43","author":"Bendele","year":"2000","journal-title":"Arthritis Rheum"},{"issue":"1","key":"2024062715205763300_bib52","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/1743-422X-9-232","article-title":"Increased expressions of IL-22 and Th22 cells in the coxsackievirus B3-induced mice acute viral myocarditis","volume":"9","author":"Kong","year":"2012","journal-title":"Virol J"},{"key":"2024062715205763300_bib53","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.thromres.2019.07.012","article-title":"Loss of von Willebrand factor high-molecular-weight multimers at acute phase is associated with detectable anti-ADAMTS13 IgG and neurological symptoms in acquired thrombotic thrombocytopenic purpura","volume":"181","author":"B\u00e9ranger","year":"2019","journal-title":"Thromb Res"},{"key":"2024062715205763300_bib54","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3389\/fimmu.2019.00337","article-title":"Complement in thrombotic microangiopathies: unraveling Ariadne\u2019s thread into the labyrinth of complement therapeutics","volume":"10","author":"Gavriilaki","year":"2019","journal-title":"Front Immunol"},{"key":"2024062715205763300_bib55","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.3389\/fimmu.2018.03008","article-title":"Heme\u00a0drives susceptibility of glomerular endothelium to complement overactivation due to inefficient upregulation of heme oxygenase-1","volume":"9","author":"May","year":"2018","journal-title":"Front Immunol"},{"issue":"6","key":"2024062715205763300_bib56","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1055\/s-0035-1556587","article-title":"Thrombosis, microangiopathies, and inflammation","volume":"41","author":"Matevosyan","year":"2015","journal-title":"Semin Thromb Hemost"},{"issue":"4","key":"2024062715205763300_bib57","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/jth.13956","article-title":"Pathophysiology of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome","volume":"16","author":"Kremer Hovinga","year":"2018","journal-title":"J\u00a0Thromb Haemost"},{"issue":"3","key":"2024062715205763300_bib58","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.revmed.2020.12.011","article-title":"Dysfonction endoth\u00e9liale au cours du Purpura Thrombotique Thrombocytop\u00e9nique : un nouvel axe de prise en charge [in French]","volume":"42","author":"Prevel","year":"2021","journal-title":"Rev Med Interne"},{"issue":"3","key":"2024062715205763300_bib59","first-page":"758","article-title":"Is endothelial activation a critical event in thrombotic thrombocytopenic purpura?","volume":"12","author":"Cauchois","year":"2023","journal-title":"J\u00a0Clin Med"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/143\/26\/2791\/2232886\/blood_bld-2023-021974-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/143\/26\/2791\/2232886\/blood_bld-2023-021974-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T16:48:56Z","timestamp":1719506936000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/143\/26\/2791\/515691\/Reduction-of-mortality-cardiac-damage-and-cerebral"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,27]]},"references-count":59,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2024,6,27]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2023021974","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"type":"print","value":"0006-4971"},{"type":"electronic","value":"1528-0020"}],"subject":[],"published":{"date-parts":[[2024,6,27]]}}}