{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:38:34Z","timestamp":1792852714047,"version":"4.5.0"},"reference-count":54,"publisher":"American Society of Hematology","issue":"17","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10,24]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Loss of endothelial barrier function contributes to the pathophysiology of many inflammatory diseases. Coagulation factor XI (FXI) plays a regulatory role in inflammation. Although activation of FXI increases vascular permeability in\u00a0vivo, the mechanism by which FXI or its activated form FXIa disrupts endothelial barrier function is unknown. We investigated the role of FXIa in human umbilical vein endothelial cell (HUVEC) or human aortic endothelial cell (HAEC) permeability. The expression patterns of vascular endothelial (VE)-cadherin and other proteins of interest were examined by western blot or immunofluorescence. Endothelial cell permeability was analyzed by Transwell assay. We demonstrate that FXIa increases endothelial cell permeability by inducing cleavage of the VE-cadherin extracellular domain, releasing a soluble fragment. The activation of a disintegrin and metalloproteinase 10 (ADAM10) mediates the FXIa-dependent cleavage of VE-cadherin, because adding an ADAM10 inhibitor prevented the cleavage of VE-cadherin induced by FXIa. The binding of FXIa with plasminogen activator inhibitor 1 and very low\u2013density lipoprotein receptor on HUVEC or HAEC surfaces activates vascular endothelial growth receptor factor 2 (VEGFR2). The activation of VEGFR2 triggers the mitogen-activated protein kinase (MAPK) signaling pathway and promotes the expression of active ADAM10 on the cell surface. In a pilot experiment using an established baboon model of sepsis, the inhibition of FXI activation significantly decreased the levels of soluble VE-cadherin to preserve barrier function. This study reveals a novel pathway by which FXIa regulates vascular permeability. The effect of FXIa on barrier function may be another way by which FXIa contributes to the development of inflammatory diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2023022257","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T07:21:58Z","timestamp":1724052118000},"page":"1821-1833","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":34,"title":["Coagulation factor XI regulates endothelial cell permeability and barrier function in\u00a0vitro and in\u00a0vivo"],"prefix":"10.1182","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5911-8156","authenticated-orcid":false,"given":"Cristina","family":"Puy","sequence":"first","affiliation":[{"name":"1Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-6917","authenticated-orcid":false,"given":"Samantha A.","family":"Moellmer","sequence":"additional","affiliation":[{"name":"1Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4623-3291","authenticated-orcid":false,"given":"Jiaqing","family":"Pang","sequence":"additional","affiliation":[{"name":"1Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen H.","family":"Vu","sequence":"additional","affiliation":[{"name":"1Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4659-5113","authenticated-orcid":false,"given":"Alexander R.","family":"Melrose","sequence":"additional","affiliation":[{"name":"1Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6885-2352","authenticated-orcid":false,"given":"Christina U.","family":"Lorentz","sequence":"additional","affiliation":[{"name":"1Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR"},{"name":"2Aronora, Inc, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-113X","authenticated-orcid":false,"given":"Erik I.","family":"Tucker","sequence":"additional","affiliation":[{"name":"1Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR"},{"name":"2Aronora, Inc, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Shatzel","sequence":"additional","affiliation":[{"name":"1Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR"},{"name":"3Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4177-9095","authenticated-orcid":false,"given":"Ravi S.","family":"Keshari","sequence":"additional","affiliation":[{"name":"4Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1249-9278","authenticated-orcid":false,"given":"Florea","family":"Lupu","sequence":"additional","affiliation":[{"name":"4Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8142-8014","authenticated-orcid":false,"given":"David","family":"Gailani","sequence":"additional","affiliation":[{"name":"5Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9481-0124","authenticated-orcid":false,"given":"Owen J. T.","family":"McCarty","sequence":"additional","affiliation":[{"name":"1Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR"},{"name":"3Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"4","key":"2024102415211255400_bib1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.molmed.2020.11.006","article-title":"Permeability of the endothelial barrier: identifying and reconciling controversies","volume":"27","author":"Claesson-Welsh","year":"2021","journal-title":"Trends Mol Med"},{"issue":"3","key":"2024102415211255400_bib2","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1152\/physrev.00037.2018","article-title":"Passing the vascular barrier: endothelial signaling processes controlling extravasation","volume":"99","author":"Wettschureck","year":"2019","journal-title":"Physiol Rev"},{"issue":"7057","key":"2024102415211255400_bib3","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature03952","article-title":"A\u00a0mechanosensory complex that mediates the endothelial cell response to fluid shear stress","volume":"437","author":"Tzima","year":"2005","journal-title":"Nature"},{"issue":"18","key":"2024102415211255400_bib4","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1093\/emboj\/cdf497","article-title":"VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts","volume":"21","author":"Nawroth","year":"2002","journal-title":"EMBO J"},{"issue":"4","key":"2024102415211255400_bib5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1083\/jcb.200602080","article-title":"Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments","volume":"174","author":"Lampugnani","year":"2006","journal-title":"J\u00a0Cell Biol"},{"issue":"10","key":"2024102415211255400_bib6","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1161\/CIRCRESAHA.107.169805","article-title":"ADAMIO regulates endothelial permeability and T-cell transmigration by proteolysis of vascular endothelial cadherin","volume":"102","author":"Schulz","year":"2008","journal-title":"Circ Res"},{"issue":"11","key":"2024102415211255400_bib7","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1161\/ATVBAHA.110.213124","article-title":"A\u00a0disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis","volume":"30","author":"Donners","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"2024102415211255400_bib8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/cvr\/cvv144","article-title":"Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis","volume":"107","author":"Flemming","year":"2015","journal-title":"Cardiovasc Res"},{"issue":"4","key":"2024102415211255400_bib9","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1111\/jth.15236","article-title":"Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low-density lipoprotein receptor-deficient mice","volume":"19","author":"Ngo","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"issue":"3","key":"2024102415211255400_bib10","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1161\/ATVBAHA.115.306954","article-title":"Factor XI deficiency protects against atherogenesis in apolipoprotein E\/factor XI double knockout mice","volume":"36","author":"Shnerb Ganor","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"2024102415211255400_bib11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s12975-012-0186-5","article-title":"Inhibition of factor XII-mediated activation of factor XI provides protection against experimental acute ischemic stroke in mice","volume":"3","author":"Leung","year":"2012","journal-title":"Transl Stroke Res"},{"issue":"2","key":"2024102415211255400_bib12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1182\/bloodadvances.2017004879","article-title":"Factor XI contributes to myocardial ischemia-reperfusion injury in mice","volume":"2","author":"Lorentz","year":"2018","journal-title":"Blood Adv"},{"issue":"7","key":"2024102415211255400_bib13","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1007\/s11011-023-01251-1","article-title":"Pharmacological targeting of coagulation factor XI attenuates experimental autoimmune encephalomyelitis in mice","volume":"38","author":"Kohs","year":"2023","journal-title":"Metab Brain Dis"},{"issue":"1","key":"2024102415211255400_bib14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/MOH.0000000000000787","article-title":"Factor XI as a therapeutic target in neuroinflammatory disease","volume":"31","author":"Taskin","year":"2024","journal-title":"Curr Opin Hematol"},{"issue":"4","key":"2024102415211255400_bib15","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1182\/bloodadvances.2018029983","article-title":"Inhibition of contact-mediated activation of factor XI protects baboons against S aureus\u2013induced organ damage and death","volume":"3","author":"Silasi","year":"2019","journal-title":"Blood Adv"},{"issue":"4","key":"2024102415211255400_bib16","doi-asserted-by":"crossref","first-page":"e0152968","DOI":"10.1371\/journal.pone.0152968","article-title":"Factor XI deficiency alters the cytokine response and activation of contact proteases during polymicrobial sepsis in mice","volume":"11","author":"Bane","year":"2016","journal-title":"PLoS One"},{"issue":"20","key":"2024102415211255400_bib17","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1182\/blood-2011-10-386185","article-title":"Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis","volume":"119","author":"Tucker","year":"2012","journal-title":"Blood"},{"key":"2024102415211255400_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.thromres.2019.01.009","article-title":"Alteration in endothelial permeability occurs in response to the activation of PAR2 by factor Xa but not directly by the TF-factor VIIa complex","volume":"175","author":"Benelhaj","year":"2019","journal-title":"Thromb Res"},{"issue":"44","key":"2024102415211255400_bib19","doi-asserted-by":"crossref","first-page":"29888","DOI":"10.1074\/jbc.M803880200","article-title":"Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from G\u03b112\/13 and G\u03b111\/q","volume":"283","author":"Gavard","year":"2008","journal-title":"J\u00a0Biol Chem"},{"issue":"20","key":"2024102415211255400_bib20","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1182\/blood.2020005496","article-title":"Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI\/ITAM-mediated platelet activation programs","volume":"136","author":"Babur","year":"2020","journal-title":"Blood"},{"issue":"2","key":"2024102415211255400_bib21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1161\/ATVBAHA.115.306549","article-title":"Rab11a mediates vascular endothelial-cadherin recycling and controls endothelial barrier function","volume":"36","author":"Yan","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024102415211255400_bib22","article-title":"Substrates, cofactors, and cellular targets of coagulation factor XIa","author":"Lira","year":"2023","journal-title":"Semin Thromb Hemost"},{"issue":"33","key":"2024102415211255400_bib23","doi-asserted-by":"crossref","first-page":"23824","DOI":"10.1074\/jbc.M601542200","article-title":"A\u00a0basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration","volume":"281","author":"Wild-Bode","year":"2006","journal-title":"J\u00a0Biol Chem"},{"issue":"pt 2","key":"2024102415211255400_bib24","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.brainresbull.2016.03.020","article-title":"Regulation of the \u03b1-secretase ADAM10 at transcriptional, translational and post-translational levels","volume":"126","author":"Vincent","year":"2016","journal-title":"Brain Res Bull"},{"issue":"1","key":"2024102415211255400_bib25","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/febs.15026","article-title":"SRC fine-tunes ADAM10 shedding activity to promote pituitary adenoma cell progression","volume":"287","author":"Huang","year":"2020","journal-title":"FEBS J"},{"key":"2024102415211255400_bib26","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fnmol.2018.00198","article-title":"Cosmosiin increases ADAM10 expression via mechanisms involving 5\u2019UTR and PI3K signaling","volume":"11","author":"Min","year":"2018","journal-title":"Front Mol Neurosci"},{"issue":"7","key":"2024102415211255400_bib27","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1161\/ATVBAHA.119.312619","article-title":"Endothelial PAI-1 (plasminogen activator inhibitor-1) blocks the intrinsic pathway of coagulation, inducing the clearance and degradation of FXIA (activated factor XI)","volume":"39","author":"Puy","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"26","key":"2024102415211255400_bib28","doi-asserted-by":"crossref","first-page":"23044","DOI":"10.1074\/jbc.M110.210195","article-title":"Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase","volume":"286","author":"Makarova","year":"2011","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"2024102415211255400_bib29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1161\/ATVBAHA.118.311655","article-title":"Roles of coagulation proteases and PARs (protease-activated receptors) in mouse models of inflammatory diseases","volume":"39","author":"Posma","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"2024102415211255400_bib30","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S1043-2760(01)00526-4","article-title":"Diverse roles for the LDL receptor family","volume":"13","author":"Strickland","year":"2002","journal-title":"Trends Endocrinol Metab"},{"issue":"12","key":"2024102415211255400_bib31","doi-asserted-by":"crossref","first-page":"e0145684","DOI":"10.1371\/journal.pone.0145684","article-title":"Plasminogen activator inhibitor-1 controls vascular integrity by regulating VE-cadherin trafficking","volume":"10","author":"Daniel","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"2024102415211255400_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0960-9822(02)01403-3","article-title":"Reelin activates Src family tyrosine kinases in neurons","volume":"13","author":"Bock","year":"2003","journal-title":"Curr Biol"},{"issue":"694","key":"2024102415211255400_bib33","doi-asserted-by":"crossref","first-page":"eabc6612","DOI":"10.1126\/scisignal.abc6612","article-title":"Emerging roles of PLC\u03b31 in endothelial biology","volume":"14","author":"Chen","year":"2021","journal-title":"Sci Signal"},{"issue":"12","key":"2024102415211255400_bib34","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/sj.embor.7401103","article-title":"Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein","volume":"8","author":"Usui","year":"2007","journal-title":"EMBO Rep"},{"issue":"4","key":"2024102415211255400_bib35","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/01.RES.0000089257.94002.96","article-title":"Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase","volume":"93","author":"Jin","year":"2003","journal-title":"Circ Res"},{"issue":"2","key":"2024102415211255400_bib36","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10456-018-9603-z","article-title":"High-density lipoprotein (HDL) promotes angiogenesis via S1P3-dependent VEGFR2 activation","volume":"21","author":"Jin","year":"2018","journal-title":"Angiogenesis"},{"issue":"4","key":"2024102415211255400_bib37","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s10456-019-09676-y","article-title":"VEGFR2 activation mediates the pro-angiogenic activity of BMP4","volume":"22","author":"Rezzola","year":"2019","journal-title":"Angiogenesis"},{"issue":"1","key":"2024102415211255400_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1253\/circj.68.1","article-title":"Elevated concentration of soluble vascular endothelial cadherin is associated with coronary atherosclerosis","volume":"68","author":"Soeki","year":"2004","journal-title":"Circ J"},{"issue":"4","key":"2024102415211255400_bib39","first-page":"1497","article-title":"Increased levels of soluble vascular endothelial cadherin are associated with poor outcome in severe sepsis","volume":"38","author":"Zhang","year":"2010","journal-title":"J\u00a0Int Med Res"},{"issue":"32","key":"2024102415211255400_bib40","doi-asserted-by":"crossref","first-page":"28498","DOI":"10.1074\/jbc.M203427200","article-title":"Activated platelets but not endothelial cells participate in the initiation of the consolidation phase of blood coagulation","volume":"277","author":"Baird","year":"2002","journal-title":"J\u00a0Biol Chem"},{"issue":"41","key":"2024102415211255400_bib41","doi-asserted-by":"crossref","first-page":"38462","DOI":"10.1074\/jbc.M205902200","article-title":"The interaction of factor XIa with activated platelets but not endothelial cells promotes the activation of factor IX in the consolidation phase of blood coagulation","volume":"277","author":"Baird","year":"2002","journal-title":"J\u00a0Biol Chem"},{"issue":"45","key":"2024102415211255400_bib42","doi-asserted-by":"crossref","first-page":"43983","DOI":"10.1074\/jbc.M304239200","article-title":"The relative priority of prekallikrein and factors XI\/XIa assembly on cultured endothelial cells","volume":"278","author":"Mahdi","year":"2003","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"2024102415211255400_bib43","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13054-019-2315-y","article-title":"Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury","volume":"23","author":"Yu","year":"2019","journal-title":"Crit Care"},{"issue":"1","key":"2024102415211255400_bib44","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/art.33336","article-title":"Soluble VE-cadherin in rheumatoid arthritis patients correlates with disease activity: evidence for tumor necrosis factor \u03b1-induced VE-cadherin cleavage","volume":"64","author":"Sidib\u00e9","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"3","key":"2024102415211255400_bib45","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/bjc.2016.427","article-title":"Soluble VE-cadherin in metastatic breast cancer: an independent prognostic factor for\u00a0both progression-free survival and overall\u00a0survival","volume":"116","author":"Rochefort","year":"2017","journal-title":"Br J Cancer"},{"issue":"16","key":"2024102415211255400_bib46","doi-asserted-by":"crossref","first-page":"14002","DOI":"10.1074\/jbc.M300351200","article-title":"Identification of proteases involved in the proteolysis of vascular endothelium cadherin during neutrophil transmigration","volume":"278","author":"Hermant","year":"2003","journal-title":"J\u00a0Biol Chem"},{"issue":"12","key":"2024102415211255400_bib47","doi-asserted-by":"crossref","first-page":"e80056","DOI":"10.1371\/journal.pone.0080056","article-title":"Evidence for post-translational processing of vascular endothelial (VE)-cadherin in brain tumors: Towards a candidate biomarker","volume":"8","author":"Vilgrain","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"2024102415211255400_bib48","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1161\/01.RES.88.4.430","article-title":"Antigraft antibody-mediated expression of metalloproteinases on endothelial cells: differential expression of TIMP-1 and ADAM-10 depends on antibody specificity and isotype","volume":"88","author":"Boulday","year":"2001","journal-title":"Circ Res"},{"key":"2024102415211255400_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2015.10.003","article-title":"The alpha secretase ADAM10: a metalloprotease with multiple functions in the brain","volume":"135","author":"Saftig","year":"2015","journal-title":"Prog Neurobiol"},{"issue":"1","key":"2024102415211255400_bib50","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1161\/ATVBAHA.114.304554","article-title":"Plasminogen activator inhibitor-1 inhibits angiogenic signaling by uncoupling vascular endothelial growth factor receptor-2-\u03b1V\u03b23 integrin cross talk","volume":"35","author":"Wu","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"2024102415211255400_bib51","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/00041433-200106000-00006","article-title":"Living up to a name: the role of the VLDL receptor in lipid metabolism","volume":"12","author":"Tacken","year":"2001","journal-title":"Curr Opin Lipidol"},{"issue":"10","key":"2024102415211255400_bib52","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.3390\/ijms19103090","article-title":"The reelin receptors apolipoprotein e receptor 2 (ApoER2) and VLDL receptor","volume":"19","author":"Dlugosz","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2024102415211255400_bib53","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1182\/blood-2011-09-382580","article-title":"Identification of VLDLR as a novel endothelial cell receptor for fibrin that modulates fibrin-dependent transendothelial migration of leukocytes","volume":"119","author":"Yakovlev","year":"2012","journal-title":"Blood"},{"issue":"14","key":"2024102415211255400_bib54","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1074\/jbc.273.14.8502","article-title":"Binding of urokinase-type plasminogen activator to its receptor in MCF- 7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility","volume":"273","author":"Nguyen","year":"1998","journal-title":"J\u00a0Biol Chem"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/144\/17\/1821\/2246943\/blood_bld-2023-022257-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/144\/17\/1821\/2246943\/blood_bld-2023-022257-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T11:21:34Z","timestamp":1729768894000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/144\/17\/1821\/517401\/Coagulation-factor-XI-regulates-endothelial-cell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":54,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2024,10,24]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2023022257","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,24]]}}}