{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T18:08:46Z","timestamp":1793988526100,"version":"4.8.0"},"reference-count":62,"publisher":"American Society of Hematology","issue":"12","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,21]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>Antiphospholipid antibodies (aPL) in primary or secondary antiphospholipid syndrome (APS) are a major cause for acquired thrombophilia, but specific interventions preventing autoimmune aPL development are an unmet clinical need. Although autoimmune aPL cross react with various coagulation regulatory proteins, lipid-reactive aPL, including those derived from patients with COVID-19, recognize the endolysosomal phospholipid lysobisphosphatidic acid presented by the cell surface\u2013expressed endothelial protein C receptor. This specific recognition leads to complement-mediated activation of tissue factor (TF)\u2013dependent proinflammatory signaling and thrombosis. Here, we show that specific inhibition of the TF coagulation initiation complex with nematode anticoagulant protein c2 (NAPc2) prevents the prothrombotic effects of aPL derived from patients with COVID-19 in mice and the aPL\u2013induced proinflammatory and prothrombotic activation of monocytes. The induction of experimental APS is dependent on the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex, and NAPc2 suppresses monocyte endosomal reactive oxygen species production requiring the TF cytoplasmic domain and interferon-\u03b1 secretion from dendritic cells. Latent infection with murine cytomegalovirus causes TF cytoplasmic domain\u2013dependent development of persistent aPL and circulating phospholipid-reactive B1 cells, which is prevented by short-term intervention with NAPc2 during acute viral infection. In addition, treatment of lupus prone MRL-lpr mice with NAPc2, but not with heparin, suppresses dendritic-cell activation in the spleen, aPL production and circulating phospholipid-reactive B1 cells, and attenuates lupus pathology. These data demonstrate a convergent TF-dependent mechanism of aPL development in latent viral infection and autoimmune disease and provide initial evidence that specific targeting of the TF initiation complex has therapeutic benefits beyond currently used clinical anticoagulant strategies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1182\/blood.2023022276","type":"journal-article","created":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T12:57:30Z","timestamp":1703422650000},"page":"1167-1180","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":13,"title":["Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development"],"prefix":"10.1182","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0409-7474","authenticated-orcid":false,"given":"Nadine","family":"M\u00fcller-Calleja","sequence":"first","affiliation":[{"name":"1Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany"},{"name":"2Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Medical Center, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Grunz","sequence":"additional","affiliation":[{"name":"1Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Son","family":"Nguyen","sequence":"additional","affiliation":[{"name":"1Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Posma","sequence":"additional","affiliation":[{"name":"1Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3324-7088","authenticated-orcid":false,"given":"Denise","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"1Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3243-2540","authenticated-orcid":false,"given":"Myriam","family":"Meineck","sequence":"additional","affiliation":[{"name":"3Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Hollerbach","sequence":"additional","affiliation":[{"name":"2Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Medical Center, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Braun","sequence":"additional","affiliation":[{"name":"1Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Muth","sequence":"additional","affiliation":[{"name":"4Institute for Immunology, Johannes Gutenberg University Medical Center, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansj\u00f6rg","family":"Schild","sequence":"additional","affiliation":[{"name":"4Institute for Immunology, Johannes Gutenberg University Medical Center, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4483-1557","authenticated-orcid":false,"given":"Kathrin","family":"Saar","sequence":"additional","affiliation":[{"name":"5Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"},{"name":"6Charite-Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"7German Center for Cardiovascular Research (DZHK), Partner site Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"H\u00fcbner","sequence":"additional","affiliation":[{"name":"5Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"},{"name":"6Charite-Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"7German Center for Cardiovascular Research (DZHK), Partner site Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6381-4325","authenticated-orcid":false,"given":"Sriram","family":"Krishnaswamy","sequence":"additional","affiliation":[{"name":"8Department of Pediatrics, Children\u2019s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Royce","sequence":"additional","affiliation":[{"name":"9Department of Immunology and Microbiology, Scripps Research, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Teyton","sequence":"additional","affiliation":[{"name":"9Department of Immunology and Microbiology, Scripps Research, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9190-6497","authenticated-orcid":false,"given":"Niels","family":"Lemmermann","sequence":"additional","affiliation":[{"name":"10Institute for Virology, Johannes Gutenberg University Medical Center, Mainz, Germany"},{"name":"11Institute of Virology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7344-8381","authenticated-orcid":false,"given":"Julia","family":"Weinmann-Menke","sequence":"additional","affiliation":[{"name":"3Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-7931","authenticated-orcid":false,"given":"Karl J.","family":"Lackner","sequence":"additional","affiliation":[{"name":"2Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Medical Center, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6064-2166","authenticated-orcid":false,"given":"Wolfram","family":"Ruf","sequence":"additional","affiliation":[{"name":"1Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany"},{"name":"9Department of Immunology and Microbiology, Scripps Research, La Jolla, CA"},{"name":"12German Center for Cardiovascular Research (DZHK), Partner site Rhein-Main, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"21","key":"2024032115211835300_bib1","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1056\/NEJMra1705454","article-title":"Diagnosis and management of the antiphospholipid syndrome","volume":"378","author":"Garcia","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"2024032115211835300_bib2","doi-asserted-by":"crossref","first-page":"17103","DOI":"10.1038\/nrdp.2017.103","article-title":"Antiphospholipid syndrome","volume":"4","author":"Schreiber","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"2024032115211835300_bib3","doi-asserted-by":"crossref","first-page":"e069717","DOI":"10.1136\/bmj-2021-069717","article-title":"Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management","volume":"380","author":"Knight","year":"2023","journal-title":"BMJ"},{"issue":"11","key":"2024032115211835300_bib4","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1073\/pnas.0400281101","article-title":"Beta 2-glycoprotein I binds factor XI and inhibits its activation by thrombin and factor XIIa: loss of inhibition by clipped beta 2-glycoprotein I","volume":"101","author":"Shi","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024032115211835300_bib5","doi-asserted-by":"crossref","first-page":"102747","DOI":"10.1016\/j.jaut.2021.102747","article-title":"Betaeta-2-glycoprotein I exerts antithrombotic function through its domain V in mice","volume":"126","author":"Passam","year":"2022","journal-title":"J\u00a0Autoimmun"},{"issue":"10","key":"2024032115211835300_bib6","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1182\/blood.V81.10.2618.2618","article-title":"Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S: an explanation for their pathogenic mechanism?","volume":"81","author":"Oosting","year":"1993","journal-title":"Blood"},{"issue":"4","key":"2024032115211835300_bib7","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/jth.15241","article-title":"Anti-beta2-glycoprotein I and anti-prothrombin antibodies cause lupus anticoagulant through different mechanisms of action","volume":"19","author":"Noordermeer","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"issue":"7","key":"2024032115211835300_bib8","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1136\/ard-2022-223808","article-title":"Machine learning identifies clusters of longitudinal autoantibody profiles predictive of systemic lupus erythematosus disease outcomes","volume":"82","author":"Choi","year":"2023","journal-title":"Ann Rheum Dis"},{"issue":"6672","key":"2024032115211835300_bib9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/32440","article-title":"A\u00a0lipid associated with the antiphospholipid syndrome regulates endosome structure and\u00a0function","volume":"392","author":"Kobayashi","year":"1998","journal-title":"Nature"},{"issue":"6534","key":"2024032115211835300_bib10","doi-asserted-by":"crossref","first-page":"eabc0956","DOI":"10.1126\/science.abc0956","article-title":"Lipid presentation by the protein C receptor links coagulation with autoimmunity","volume":"371","author":"Muller-Calleja","year":"2021","journal-title":"Science"},{"issue":"12","key":"2024032115211835300_bib11","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1182\/blood.V97.12.3820","article-title":"The clonal analysis of anticardiolipin antibodies in a single patient with primary antiphospholipid syndrome reveals an extreme antibody heterogeneity","volume":"97","author":"Lieby","year":"2001","journal-title":"Blood"},{"issue":"1-2","key":"2024032115211835300_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.imbio.2010.05.001","article-title":"Structural and functional characterization of a human IgG monoclonal antiphospholipid antibody","volume":"216","author":"Prinz","year":"2011","journal-title":"Immunobiology"},{"issue":"8","key":"2024032115211835300_bib13","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1182\/blood-2009-01-199117","article-title":"Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies","volume":"114","author":"Seshan","year":"2009","journal-title":"Blood"},{"key":"2024032115211835300_bib14","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1196\/annals.1361.083","article-title":"Complement activation: a novel pathogenic mechanism in the antiphospholipid syndrome","volume":"1051","author":"Pierangeli","year":"2005","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"2024032115211835300_bib15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1182\/blood.2019003863","article-title":"Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS","volume":"135","author":"Chaturvedi","year":"2020","journal-title":"Blood"},{"issue":"4","key":"2024032115211835300_bib16","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1160\/TH13-09-0802","article-title":"Synergies of phosphatidylserine and protein disulfide isomerase in tissue factor activation","volume":"111","author":"Langer","year":"2014","journal-title":"Thromb Haemost"},{"issue":"11","key":"2024032115211835300_bib17","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1182\/blood-2010-02-271494","article-title":"Beta 2 glycoprotein I is a substrate of thiol oxidoreductases","volume":"116","author":"Passam","year":"2010","journal-title":"Blood"},{"issue":"9","key":"2024032115211835300_bib18","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1182\/bloodadvances.2018017095","article-title":"Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies","volume":"2","author":"Muller-Calleja","year":"2018","journal-title":"Blood Adv"},{"issue":"14","key":"2024032115211835300_bib19","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1182\/blood.2019001530","article-title":"Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis","volume":"134","author":"Muller-Calleja","year":"2019","journal-title":"Blood"},{"issue":"9","key":"2024032115211835300_bib20","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1111\/jth.15455","article-title":"Pathogenic lipid-binding antiphospholipid antibodies are associated with severity of COVID-19","volume":"19","author":"Hollerbach","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"issue":"7","key":"2024032115211835300_bib21","doi-asserted-by":"crossref","first-page":"5756","DOI":"10.1074\/jbc.M110.201228","article-title":"The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors","volume":"286","author":"Disse","year":"2011","journal-title":"J\u00a0Biol Chem"},{"issue":"18","key":"2024032115211835300_bib22","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1182\/blood-2014-11-610717","article-title":"EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice","volume":"125","author":"Liang","year":"2015","journal-title":"Blood"},{"issue":"6","key":"2024032115211835300_bib23","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1182\/blood-2004-09-3422","article-title":"Regulation of tissue factor-induced signaling by endogenous and recombinant tissue factor pathway inhibitor 1","volume":"105","author":"Ahamed","year":"2005","journal-title":"Blood"},{"issue":"8","key":"2024032115211835300_bib24","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1182\/blood-2011-01-330639","article-title":"Antiphospholipid antibodies induce translocation of TLR7 and TLR8 to the endosome in human monocytes and plasmacytoid dendritic cells","volume":"118","author":"Prinz","year":"2011","journal-title":"Blood"},{"issue":"3","key":"2024032115211835300_bib25","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1160\/TH12-06-0421","article-title":"Endosomal NADPH-oxidase is critical for induction of the tissue factor gene in monocytes and endothelial cells. Lessons from the antiphospholipid syndrome","volume":"109","author":"Prinz","year":"2013","journal-title":"Thromb Haemost"},{"issue":"17","key":"2024032115211835300_bib26","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1182\/blood-2013-09-526277","article-title":"Multiple roles of the coagulation protease cascade during virus infection","volume":"123","author":"Antoniak","year":"2014","journal-title":"Blood"},{"issue":"11","key":"2024032115211835300_bib27","doi-asserted-by":"crossref","first-page":"6151","DOI":"10.1172\/JCI141374","article-title":"Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis","volume":"130","author":"Skendros","year":"2020","journal-title":"J\u00a0Clin Invest"},{"issue":"2","key":"2024032115211835300_bib28","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1161\/ATVBAHA.120.315547","article-title":"Patients with COVID-19 have elevated levels of circulating extracellular vesicle tissue factor activity that is associated with severity and mortality-brief report","volume":"41","author":"Rosell","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"2024032115211835300_bib29","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1182\/bloodadvances.2020003308","article-title":"Dissemination of extreme levels of extracellular vesicles: tissue factor activity in patients with severe COVID-19","volume":"5","author":"Guervilly","year":"2021","journal-title":"Blood Adv"},{"issue":"4","key":"2024032115211835300_bib30","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.autrev.2007.10.001","article-title":"Antiphospholipid antibodies, antiphospholipid syndrome and infections","volume":"7","author":"Sene","year":"2008","journal-title":"Autoimmun Rev"},{"issue":"570","key":"2024032115211835300_bib31","doi-asserted-by":"crossref","first-page":"eabd3876","DOI":"10.1126\/scitranslmed.abd3876","article-title":"Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19","volume":"12","author":"Zuo","year":"2020","journal-title":"Sci Transl Med"},{"issue":"2","key":"2024032115211835300_bib32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1365-2249.1993.tb07978.x","article-title":"Induction of phospholipid-binding antibodies in mice and rabbits by immunization with human beta 2 glycoprotein 1 or anticardiolipin antibodies alone","volume":"93","author":"Pierangeli","year":"1993","journal-title":"Clin Exp Immunol"},{"key":"2024032115211835300_bib33","doi-asserted-by":"crossref","first-page":"668885","DOI":"10.3389\/fimmu.2021.668885","article-title":"Stochastic episodes of latent cytomegalovirus transcription drive CD8 T-cell \u201cMemory Inflation\u201d and Avoid Immune Evasion","volume":"12","author":"Griessl","year":"2021","journal-title":"Front Immunol"},{"issue":"11","key":"2024032115211835300_bib34","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.4049\/jimmunol.179.11.7466","article-title":"Programmed death 1 ligand (PD-L) 1 and PD-L2 limit autoimmune kidney disease: distinct roles","volume":"179","author":"Menke","year":"2007","journal-title":"J\u00a0Immunol"},{"issue":"5","key":"2024032115211835300_bib35","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1073\/pnas.93.5.2149","article-title":"Anticoagulant repertoire of the hookworm Ancylostoma caninum","volume":"93","author":"Stassens","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"2024032115211835300_bib36","doi-asserted-by":"crossref","first-page":"10063","DOI":"10.1074\/jbc.M009116200","article-title":"Role of zymogen and activated factor X as scaffolds for the inhibition of the blood coagulation factor VIIa-tissue factor complex by recombinant nematode anticoagulant protein c2","volume":"276","author":"Bergum","year":"2001","journal-title":"J\u00a0Biol Chem"},{"issue":"12","key":"2024032115211835300_bib37","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1086\/421031","article-title":"Inhibition of the tissue factor\/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice","volume":"189","author":"Weijer","year":"2004","journal-title":"J\u00a0Infect Dis"},{"issue":"9400","key":"2024032115211835300_bib38","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/S0140-6736(03)15012-X","article-title":"Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa\/tissue factor: a study in rhesus monkeys","volume":"362","author":"Geisbert","year":"2003","journal-title":"Lancet"},{"issue":"11","key":"2024032115211835300_bib39","first-page":"2997","article-title":"Tissue factor\/factor VIIa inhibitors block angiogenesis and tumor growth through a nonhemostatic mechanism","volume":"63","author":"Hembrough","year":"2003","journal-title":"Cancer Res"},{"issue":"4","key":"2024032115211835300_bib40","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1055\/s-0037-1613266","article-title":"Recombinant nematode anticoagulant protein c2, a novel inhibitor of tissue factor-factor VIIa activity, abrogates endotoxin-induced coagulation in chimpanzees","volume":"88","author":"Moons","year":"2002","journal-title":"Thromb Haemost"},{"issue":"6","key":"2024032115211835300_bib41","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1161\/ATVBAHA.107.142539","article-title":"Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis","volume":"27","author":"Uusitalo-Jarvinen","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"2024032115211835300_bib42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1538-7836.2004.00526.x","article-title":"Recombinant nematode anticoagulant protein c2, an inhibitor of tissue factor\/factor VIIa, attenuates coagulation and the interleukin-10 response in human endotoxemia","volume":"2","author":"de Pont","year":"2004","journal-title":"J\u00a0Thromb Haemost"},{"issue":"1","key":"2024032115211835300_bib43","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1161\/hc2601.091386","article-title":"Dose-response study of recombinant factor VIIa\/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement","volume":"104","author":"Lee","year":"2001","journal-title":"Circulation"},{"issue":"8","key":"2024032115211835300_bib44","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1161\/ATVBAHA.122.318748","article-title":"Novel tissue factor inhibition for thromboprophylaxis in COVID-19: primary results of the ASPEN-COVID-19 Trial","volume":"43","author":"Hess","year":"2023","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"2024032115211835300_bib45","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/jth.13263","article-title":"Cofactor-independent human antiphospholipid antibodies induce venous thrombosis in mice","volume":"14","author":"Manukyan","year":"2016","journal-title":"J\u00a0Thromb Haemost"},{"issue":"12","key":"2024032115211835300_bib46","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1111\/jth.13865","article-title":"Antiphospholipid antibody-induced cellular responses depend on epitope specificity: implications for treatment of antiphospholipid syndrome","volume":"15","author":"Muller-Calleja","year":"2017","journal-title":"J\u00a0Thromb Haemost"},{"issue":"29","key":"2024032115211835300_bib47","doi-asserted-by":"crossref","first-page":"26689","DOI":"10.1074\/jbc.M202507200","article-title":"Nematode anticoagulant protein c2 reveals a site on factor Xa that is important for macromolecular substrate binding to human prothrombinase","volume":"277","author":"Buddai","year":"2002","journal-title":"J\u00a0Biol Chem"},{"issue":"2","key":"2024032115211835300_bib48","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s11239-019-01970-2","article-title":"Induction of tissue factor expression by anti-beta2-glycoprotein I is mediated by tumor necrosis factor alpha","volume":"49","author":"Hollerbach","year":"2020","journal-title":"J\u00a0Thromb Thrombolysis"},{"issue":"14","key":"2024032115211835300_bib49","doi-asserted-by":"crossref","first-page":"7742","DOI":"10.1073\/pnas.141126698","article-title":"Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor","volume":"98","author":"Riewald","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"14","key":"2024032115211835300_bib50","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1182\/blood-2017-02-767079","article-title":"Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex","volume":"130","author":"Kamikubo","year":"2017","journal-title":"Blood"},{"issue":"10","key":"2024032115211835300_bib51","first-page":"3453","article-title":"Activation of neutrophils by the tissue factor-factor VIIa-PAR2 axis mediates fetal death in antiphospholipid syndrome","volume":"118","author":"Redecha","year":"2008","journal-title":"J\u00a0Clin Invest"},{"issue":"7","key":"2024032115211835300_bib52","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1161\/01.CIR.94.7.1746","article-title":"Thrombogenic properties of murine anti-cardiolipin antibodies induced by beta 2 glycoprotein 1 and human immunoglobulin G antiphospholipid antibodies","volume":"94","author":"Pierangeli","year":"1996","journal-title":"Circulation"},{"issue":"6","key":"2024032115211835300_bib53","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1182\/blood-2017-02-768218","article-title":"Identification of the integrin-binding site on coagulation factor VIIa required for proangiogenic PAR2 signaling","volume":"131","author":"Rothmeier","year":"2018","journal-title":"Blood"},{"issue":"4","key":"2024032115211835300_bib54","doi-asserted-by":"crossref","first-page":"e156436","DOI":"10.1172\/JCI156436","article-title":"Targeting myeloid cell coagulation signaling blocks MAP kinase\/TGF-beta1-driven fibrotic remodeling in ischemic heart failure","volume":"133","author":"Garlapati","year":"2023","journal-title":"J\u00a0Clin Invest"},{"issue":"6","key":"2024032115211835300_bib55","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/eji.200940050","article-title":"Class switching and consecutive loss of dsDNA-reactive B1a B cells from the peritoneal cavity during murine lupus development","volume":"40","author":"Enghard","year":"2010","journal-title":"Eur J Immunol"},{"issue":"6644","key":"2024032115211835300_bib56","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1126\/science.adg6427","article-title":"Innate virus-sensing pathways in B cell systemic autoimmunity","volume":"380","author":"Vinuesa","year":"2023","journal-title":"Science"},{"issue":"3","key":"2024032115211835300_bib57","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.immuni.2006.07.013","article-title":"Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus","volume":"25","author":"Christensen","year":"2006","journal-title":"Immunity"},{"key":"2024032115211835300_bib58","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3389\/fimmu.2012.00372","article-title":"Multiple regulatory mechanisms control B-1 B cell activation","volume":"3","author":"Sindhava","year":"2012","journal-title":"Front Immunol"},{"issue":"39","key":"2024032115211835300_bib59","doi-asserted-by":"crossref","first-page":"eaaw8405","DOI":"10.1126\/sciimmunol.aaw8405","article-title":"Myeloid cell-synthesized coagulation factor X dampens antitumor immunity","volume":"4","author":"Graf","year":"2019","journal-title":"Sci Immunol"},{"issue":"6","key":"2024032115211835300_bib60","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/art.42459","article-title":"Fluctuation of anti-domain 1 and anti-beta(2) -glycoprotein I antibody titers over time in patients with persistently positive antiphospholipid antibodies","volume":"75","author":"Chighizola","year":"2023","journal-title":"Arthritis Rheumatol"},{"issue":"5","key":"2024032115211835300_bib61","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/annrheumdis-2016-210012","article-title":"Hydroxychloroquine inhibits proinflammatory signalling pathways by targeting endosomal NADPH oxidase","volume":"76","author":"Muller-Calleja","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"13","key":"2024032115211835300_bib62","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1182\/blood-2018-04-848333","article-title":"Rivaroxaban vs warfarin in high-risk patients with antiphospholipid syndrome","volume":"132","author":"Pengo","year":"2018","journal-title":"Blood"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/143\/12\/1167\/2218496\/blood_bld-2023-022276-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/143\/12\/1167\/2218496\/blood_bld-2023-022276-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T15:23:16Z","timestamp":1711034596000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/143\/12\/1167\/506715\/Targeting-the-tissue-factor-coagulation-initiation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,21]]},"references-count":62,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,3,21]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2023022276","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,21]]}}}