{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:28:34Z","timestamp":1792603714772,"version":"4.5.0"},"reference-count":79,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7,4]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Platelet \u03b1-granules are rich in transforming growth factor \u03b21 (TGF-\u03b21), which is associated with myeloid-derived suppressor cell (MDSC) biology. Responders to thrombopoietin receptor agonists (TPO-RAs) revealed a parallel increase in the number of both platelets and MDSCs. Here, anti-CD61 immune-sensitized splenocytes were transferred into severe combined immunodeficient mice to establish an active murine model of immune thrombocytopenia (ITP). Subsequently, we demonstrated that TPO-RAs augmented the inhibitory activities of MDSCs by arresting plasma cells differentiation, reducing Fas ligand expression on cytotoxic T cells, and rebalancing T-cell subsets. Mechanistically, transcriptome analysis confirmed the participation of TGF-\u03b2\/Smad pathways in TPO-RA\u2013corrected\u00a0MDSCs, which was offset by Smad2\/3 knockdown. In platelet TGF-\u03b21\u2013deficient mice, TPO-RA-induced amplification and enhanced suppressive capacity of MDSCs was waived. Furthermore, our retrospective data revealed that patients with ITP achieving complete platelet response showed superior long-term outcomes compared with those who only reach partial response. In conclusion, we demonstrate that platelet TGF-\u03b21 induces the expansion and functional reprogramming of MDSCs via the TGF-\u03b2\/Smad pathway. These data indicate that platelet recovery not only serves as an end point of treatment response but also paves the way for immune homeostasis in immune-mediated thrombocytopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2023022738","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T16:01:56Z","timestamp":1712246516000},"page":"99-112","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":48,"title":["Platelet-derived TGF-\u03b21 induces functional reprogramming of myeloid-derived suppressor cells in\u00a0immune thrombocytopenia"],"prefix":"10.1182","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2465-5944","authenticated-orcid":false,"given":"Lingjun","family":"Wang","sequence":"first","affiliation":[{"name":"1Department of Hematology, Qilu Hospital of Shandong University, Shandong University, Jinan, 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