{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:12:25Z","timestamp":1788811945664,"version":"build-2803163510"},"reference-count":56,"publisher":"American Society of Hematology","issue":"14","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4,4]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>Acquired aplastic anemia is a bone marrow failure syndrome characterized by hypocellular bone marrow and peripheral blood pancytopenia. Frequent clinical responses to calcineurin inhibition and antithymocyte globulin strongly suggest critical roles for hematopoietic stem\/progenitor cell\u2013reactive T-cell clones in disease pathophysiology; however, their exact contribution and antigen specificities remain unclear. We determined differentiation states and targets of dominant T-cell clones along with their potential to eliminate hematopoietic progenitor cells in the bone marrow of 15 patients with acquired aplastic anemia. Single-cell sequencing and immunophenotyping revealed oligoclonal expansion and effector differentiation of CD8+ T-cell compartments. We reexpressed 28 dominant T-cell receptors (TCRs) of 9 patients in reporter cell lines to determine reactivity with (1) in vitro\u2013expanded CD34+ bone marrow, (2) CD34\u2212 bone marrow, or (3) peptide pools covering immunodominant epitopes of highly prevalent viruses. Besides 5 cytomegalovirus-reactive TCRs, we identified 3 TCRs that recognized antigen presented on hematopoietic progenitor cells. T cells transduced with these TCRs eliminated hematopoietic progenitor cells of the respective patients in\u00a0vitro. One progenitor cell\u2013reactive TCR (11A5) also recognized an epitope of the Epstein-Barr virus\u2013derived latent membrane protein 1 (LMP1) presented on HLA-A\u221702:01. We identified 2 LMP1-related mimotopes within the human proteome as activating targets of TCR 11A5, providing proof of concept that molecular mimicry of viral and self-epitopes can drive T cell\u2013mediated elimination of hematopoietic progenitor cells in aplastic anemia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1182\/blood.2023023142","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T21:11:38Z","timestamp":1706303498000},"page":"1365-1378","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":27,"title":["Virus-reactive T cells expanded in aplastic anemia eliminate hematopoietic progenitor cells by molecular mimicry"],"prefix":"10.1182","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3021-7406","authenticated-orcid":false,"given":"Amin","family":"Ben Hamza","sequence":"first","affiliation":[{"name":"1Department of Hematology, Oncology and Tumor Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3098-9003","authenticated-orcid":false,"given":"Carlotta","family":"Welters","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Oncology and Tumor Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3834-8769","authenticated-orcid":false,"given":"Serena","family":"Stadler","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Oncology and Tumor Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"2German Cancer Consortium, Partner Site Berlin, and German Cancer Research Center, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"3Department of Medicine II, Hematology and Oncology, University Hospital Schleswig Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Dietze","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Oncology and Tumor Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Brauns","sequence":"additional","affiliation":[{"name":"4Miltenyi Biotec B.V. & Co. 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