{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:13:20Z","timestamp":1793146400605,"version":"4.5.0"},"reference-count":59,"publisher":"American Society of Hematology","issue":"6","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2,6]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>The transcription factor GATA-binding protein 3 (GATA-3) and the transcriptional program it regulates have emerged as oncogenic drivers across diverse T-cell lymphomas (TCLs), many of which are resistant to conventional chemotherapeutic agents and characterized by recurrent losses of key tumor suppressor genes, including TP53 and PTEN, both of which are clients of the nuclear export protein XPO1. Here, we demonstrated that XPO1 is highly expressed by malignant T cells expressing GATA-3 and by lymphoma-associated macrophages (LAMs) within their tumor microenvironment (TME). Using complementary genetically engineered mouse models, we demonstrated that TP53- and\/or phosphate and tensin homolog (PTEN)-deficient TCLs, and LAMs within their TME, are sensitive to the selective exportin-1 (XPO1) antagonist selinexor. In an effort to identify TP53- and PTEN-independent mechanisms, we used complementary and orthogonal approaches to investigate the role of eIF4E and XPO1-dependent messenger RNA nuclear export in these TCLs. We identified a novel role for eIF4E\/XPO1 in exporting GATA-3 and GATA-3\u2013dependent transcripts from the nucleus in TCLs, and in the export of therapeutically relevant transcripts, including colony-stimulating factor-1 receptor, from LAMs. Therefore, XPO1 antagonism, by impairing oncogenic transcriptional programs in TCLs and depleting LAMs from their TME, is a novel approach to target 2 independent dependencies in a group of therapeutically challenging TCLs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1182\/blood.2024025484","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T20:23:36Z","timestamp":1733775816000},"page":"597-611","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":12,"title":["The GATA-3\u2013dependent transcriptome and tumor microenvironment are regulated by eIF4E and XPO1 in T-cell lymphomas"],"prefix":"10.1182","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8670-8752","authenticated-orcid":false,"given":"Nermin","family":"Kady","sequence":"first","affiliation":[{"name":"1Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI"},{"name":"2Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhaib","family":"Abdelrahman","sequence":"additional","affiliation":[{"name":"1Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5639-2208","authenticated-orcid":false,"given":"Ahmar M.","family":"Rauf","sequence":"additional","affiliation":[{"name":"1Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8736-6125","authenticated-orcid":false,"given":"Alyssa","family":"Burgess","sequence":"additional","affiliation":[{"name":"3Department of Chemistry, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Weiss","sequence":"additional","affiliation":[{"name":"1Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3750-2309","authenticated-orcid":false,"given":"Hirushi","family":"Gunasekara","sequence":"additional","affiliation":[{"name":"3Department of Chemistry, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8813-596X","authenticated-orcid":false,"given":"Neal","family":"Ramseier","sequence":"additional","affiliation":[{"name":"3Department of Chemistry, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira P.","family":"Maine","sequence":"additional","affiliation":[{"name":"1Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Zevallos-Morales","sequence":"additional","affiliation":[{"name":"4Department of Pathology, University of Illinois Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9129-3221","authenticated-orcid":false,"given":"Vanessa","family":"Perez-Silos","sequence":"additional","affiliation":[{"name":"4Department of Pathology, University of Illinois Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0340-2788","authenticated-orcid":false,"given":"Ashley","family":"Wolfe","sequence":"additional","affiliation":[{"name":"1Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra C.","family":"Hristov","sequence":"additional","affiliation":[{"name":"5Department of Pathology, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah A.","family":"Brown","sequence":"additional","affiliation":[{"name":"5Department of Pathology, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedar","family":"Inamdar","sequence":"additional","affiliation":[{"name":"6Department of Pathology, Henry Ford Hospital, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Sverdlov","sequence":"additional","affiliation":[{"name":"7Research Resources Center and Department of Pathology, University of Illinois Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3912-7063","authenticated-orcid":false,"given":"Ying S.","family":"Hu","sequence":"additional","affiliation":[{"name":"3Department of Chemistry, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2238-5066","authenticated-orcid":false,"given":"Carlos","family":"Murga-Zamalloa","sequence":"additional","affiliation":[{"name":"4Department of Pathology, University of Illinois Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9082-2117","authenticated-orcid":false,"given":"Chenguang","family":"Wang","sequence":"additional","affiliation":[{"name":"1Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-0760","authenticated-orcid":false,"given":"Ryan A.","family":"Wilcox","sequence":"additional","affiliation":[{"name":"1Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"16","key":"2025032119475121900_bib1","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1200\/JCO.2012.44.7524","article-title":"Survival of patients with peripheral T-cell lymphoma after first relapse or progression: spectrum of disease and rare long-term survivors","volume":"31","author":"Mak","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"issue":"3","key":"2025032119475121900_bib2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/ajh.24992","article-title":"Survival following salvage therapy for primary refractory peripheral T-cell lymphomas (PTCL)","volume":"93","author":"Zhang","year":"2018","journal-title":"Am J Hematol"},{"issue":"19","key":"2025032119475121900_bib3","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1182\/blood-2013-11-536359","article-title":"Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma","volume":"123","author":"Iqbal","year":"2014","journal-title":"Blood"},{"issue":"19","key":"2025032119475121900_bib4","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood-2013-12-544809","article-title":"GATA-3 expression identifies a high-risk subset of PTCL, NOS with distinct molecular and clinical features","volume":"123","author":"Wang","year":"2014","journal-title":"Blood"},{"issue":"10","key":"2025032119475121900_bib5","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1158\/1078-0432.CCR-16-1996","article-title":"T-cell receptor signaling activates an ITK\/NF-kappaB\/GATA-3 axis in T-cell lymphomas facilitating resistance to chemotherapy","volume":"23","author":"Wang","year":"2017","journal-title":"Clin Cancer Res"},{"issue":"15","key":"2025032119475121900_bib6","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1182\/blood-2018-09-872549","article-title":"Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma","volume":"133","author":"Heavican","year":"2019","journal-title":"Blood"},{"issue":"11","key":"2025032119475121900_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41408-022-00745-y","article-title":"GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms","volume":"12","author":"Geng","year":"2022","journal-title":"Blood Cancer J"},{"issue":"1","key":"2025032119475121900_bib8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1600-065X.2010.00954.x","article-title":"From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation","volume":"238","author":"Hosoya","year":"2010","journal-title":"Immunol Rev"},{"issue":"2","key":"2025032119475121900_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.immuni.2014.06.006","article-title":"GATA-3 function in innate and adaptive immunity","volume":"41","author":"Tindemans","year":"2014","journal-title":"Immunity"},{"issue":"2","key":"2025032119475121900_bib10","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1158\/0008-5472.CAN-14-2789","article-title":"Targeting the eIF4F translation initiation complex: a critical nexus for cancer development","volume":"75","author":"Pelletier","year":"2015","journal-title":"Cancer Res"},{"issue":"1","key":"2025032119475121900_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jgg.2018.01.003","article-title":"Structure and functions of the translation initiation factor eIF4E and its role in cancer development and treatment","volume":"45","author":"Pisera","year":"2018","journal-title":"J\u00a0Genet Genomics"},{"issue":"5","key":"2025032119475121900_bib12","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1042\/BST20150126","article-title":"Signalling to eIF4E in cancer","volume":"43","author":"Siddiqui","year":"2015","journal-title":"Biochem Soc Trans"},{"issue":"3","key":"2025032119475121900_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1182\/blood-2015-02-629543","article-title":"The mTORC1 inhibitor everolimus has antitumor activity in\u00a0vitro and produces tumor responses in patients with relapsed T-cell lymphoma","volume":"126","author":"Witzig","year":"2015","journal-title":"Blood"},{"issue":"2","key":"2025032119475121900_bib14","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.clml.2011.12.002","article-title":"Phosphorylated AKT protein is overexpressed in human peripheral T-cell lymphomas and predicts decreased patient survival","volume":"12","author":"Cai","year":"2012","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"2","key":"2025032119475121900_bib15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.celrep.2012.07.007","article-title":"The oncogene eIF4E reprograms the nuclear pore complex to promote mRNA export and oncogenic transformation","volume":"2","author":"Culjkovic-Kraljacic","year":"2012","journal-title":"Cell Rep"},{"issue":"6","key":"2025032119475121900_bib16","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1261\/rna.060137.116","article-title":"A\u00a0biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery","volume":"23","author":"Volpon","year":"2017","journal-title":"RNA"},{"issue":"3","key":"2025032119475121900_bib17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41571-020-00442-4","article-title":"The nuclear export protein XPO1\u2013from biology to targeted therapy","volume":"18","author":"Azmi","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"issue":"7","key":"2025032119475121900_bib18","doi-asserted-by":"crossref","first-page":"960","DOI":"10.4161\/cc.8.7.8093","article-title":"The eukaryotic translation initiation factor 4E (eIF4E) and HuR RNA operons collaboratively regulate the expression of survival and proliferative genes","volume":"8","author":"Topisirovic","year":"2009","journal-title":"Cell Cycle"},{"issue":"8","key":"2025032119475121900_bib19","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/emboj.2009.53","article-title":"Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP","volume":"28","author":"Topisirovic","year":"2009","journal-title":"EMBO J"},{"issue":"2","key":"2025032119475121900_bib20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1083\/jcb.200501019","article-title":"eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR","volume":"169","author":"Culjkovic","year":"2005","journal-title":"J\u00a0Cell Biol"},{"issue":"3","key":"2025032119475121900_bib21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1083\/jcb.200607020","article-title":"eIF4E is a central node of an RNA regulon that governs cellular proliferation","volume":"175","author":"Culjkovic","year":"2006","journal-title":"J\u00a0Cell Biol"},{"issue":"1","key":"2025032119475121900_bib22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1083\/jcb.200707018","article-title":"The eIF4E RNA regulon promotes the Akt signaling pathway","volume":"181","author":"Culjkovic","year":"2008","journal-title":"J\u00a0Cell Biol"},{"issue":"12","key":"2025032119475121900_bib23","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1158\/2767-9764.CRC-22-0336","article-title":"Targeting lymphoma-associated macrophage expansion via CSF1R\/JAK inhibition is a therapeutic vulnerability in peripheral T-cell lymphomas","volume":"2","author":"Gao","year":"2022","journal-title":"Cancer Res Commun"},{"issue":"12","key":"2025032119475121900_bib24","doi-asserted-by":"crossref","first-page":"e28546","DOI":"10.1371\/journal.pone.0028546","article-title":"Characterization of a new mouse model for peripheral T cell lymphoma in humans","volume":"6","author":"Beyersdorf","year":"2011","journal-title":"PLoS One"},{"issue":"7","key":"2025032119475121900_bib25","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.yexcr.2006.01.027","article-title":"Involvement of the transcriptional factor E2F1 in the regulation of the rRNA promoter","volume":"312","author":"Ayrault","year":"2006","journal-title":"Exp Cell Res"},{"issue":"29","key":"2025032119475121900_bib26","doi-asserted-by":"crossref","first-page":"21173","DOI":"10.1074\/jbc.M113.483719","article-title":"Cyclin-dependent kinase 9 links RNA polymerase II transcription to processing of ribosomal RNA","volume":"288","author":"Burger","year":"2013","journal-title":"J\u00a0Biol Chem"},{"issue":"12","key":"2025032119475121900_bib27","doi-asserted-by":"crossref","first-page":"140532","DOI":"10.1016\/j.bbapap.2020.140532","article-title":"Nucleophosmin, a multifunctional nucleolar organizer with a role in DNA repair","volume":"1868","author":"Lopez","year":"2020","journal-title":"Biochim Biophys Acta Proteins Proteom"},{"issue":"1","key":"2025032119475121900_bib28","doi-asserted-by":"crossref","first-page":"118879","DOI":"10.1016\/j.bbamcr.2020.118879","article-title":"The interaction between nucleophosmin\/NPM1 and the large ribosomal subunit precursors contribute to maintaining the nucleolar structure","volume":"1868","author":"Okuwaki","year":"2021","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"1","key":"2025032119475121900_bib29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrc.2017.104","article-title":"Ribosome biogenesis in cancer: new players and therapeutic avenues","volume":"18","author":"Pelletier","year":"2018","journal-title":"Nat Rev Cancer"},{"issue":"7224","key":"2025032119475121900_bib30","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nature07449","article-title":"Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency","volume":"456","author":"Barna","year":"2008","journal-title":"Nature"},{"issue":"5","key":"2025032119475121900_bib31","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1158\/2159-8290.CD-21-1207","article-title":"Genomic and single-cell landscape reveals novel drivers and therapeutic vulnerabilities of transformed cutaneous T-cell lymphoma","volume":"12","author":"Song","year":"2022","journal-title":"Cancer Discov"},{"issue":"1","key":"2025032119475121900_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/ajh.24203","article-title":"A\u00a0three-signal model of T-cell lymphoma pathogenesis","volume":"91","author":"Wilcox","year":"2016","journal-title":"Am J Hematol"},{"issue":"14","key":"2025032119475121900_bib33","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1182\/blood-2009-05-220111","article-title":"Monocytes promote tumor cell survival in T-cell lymphoproliferative disorders and are impaired in their ability to differentiate into mature dendritic cells","volume":"114","author":"Wilcox","year":"2009","journal-title":"Blood"},{"issue":"4","key":"2025032119475121900_bib34","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.immuni.2016.09.016","article-title":"Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation","volume":"45","author":"Huang","year":"2016","journal-title":"Immunity"},{"issue":"3","key":"2025032119475121900_bib35","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1158\/1078-0432.CCR-19-1486","article-title":"Colony-stimulating factor 1 receptor (CSF1R) activates AKT\/mTOR signaling and promotes T-cell lymphoma viability","volume":"26","author":"Murga-Zamalloa","year":"2020","journal-title":"Clin Cancer Res"},{"issue":"1","key":"2025032119475121900_bib36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1182\/blood.V99.1.111","article-title":"Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects","volume":"99","author":"Dai","year":"2002","journal-title":"Blood"},{"issue":"12","key":"2025032119475121900_bib37","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1073\/pnas.87.12.4828","article-title":"Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op\/op) mouse","volume":"87","author":"Wiktor-Jedrzejczak","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2025032119475121900_bib38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1084\/jem.184.1.61","article-title":"The transcription factor PU.1 is involved in macrophage proliferation","volume":"184","author":"Celada","year":"1996","journal-title":"J\u00a0Exp Med"},{"issue":"3","key":"2025032119475121900_bib39","first-page":"1597","article-title":"Pillars article: the macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell, 1990. 61: 113-124","volume":"181","author":"Klemsz","year":"2008","journal-title":"J\u00a0Immunol"},{"issue":"4","key":"2025032119475121900_bib40","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0167-5699(99)01442-5","article-title":"The key role of PU.1\/SPI-1 in B cells, myeloid cells and macrophages","volume":"20","author":"Lloberas","year":"1999","journal-title":"Immunol Today"},{"issue":"6","key":"2025032119475121900_bib41","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.cell.2019.08.009","article-title":"Fate mapping via Ms4a3-expression history traces monocyte-derived cells","volume":"178","author":"Liu","year":"2019","journal-title":"Cell"},{"issue":"7","key":"2025032119475121900_bib42","doi-asserted-by":"crossref","first-page":"e511","DOI":"10.1016\/S2352-3026(20)30120-4","article-title":"Selinexor in patients with relapsed or refractory diffuse large B-cell lymphoma (SADAL): a single-arm, multinational, multicentre, open-label, phase 2 trial","volume":"7","author":"Kalakonda","year":"2020","journal-title":"Lancet Haematol"},{"issue":"24","key":"2025032119475121900_bib43","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1182\/blood-2016-11-750174","article-title":"Selective inhibition of nuclear export with selinexor in patients with non-Hodgkin lymphoma","volume":"129","author":"Kuruvilla","year":"2017","journal-title":"Blood"},{"issue":"9","key":"2025032119475121900_bib44","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/ng.3356","article-title":"Genomic landscape of cutaneous T cell lymphoma","volume":"47","author":"Choi","year":"2015","journal-title":"Nat Genet"},{"issue":"12","key":"2025032119475121900_bib45","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/ng.3442","article-title":"The mutational landscape of cutaneous T cell lymphoma and Sezary syndrome","volume":"47","author":"da Silva Almeida","year":"2015","journal-title":"Nat Genet"},{"issue":"2","key":"2025032119475121900_bib46","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1365-2133.2012.10918.x","article-title":"The tumour suppressor p53 is frequently nonfunctional in Sezary syndrome","volume":"167","author":"Lamprecht","year":"2012","journal-title":"Br J Dermatol"},{"issue":"2","key":"2025032119475121900_bib47","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.molcel.2011.11.022","article-title":"Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis","volume":"45","author":"Golomb","year":"2012","journal-title":"Mol Cell"},{"issue":"16","key":"2025032119475121900_bib48","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1101\/gad.13.16.2118","article-title":"Nuclear export of the small ribosomal subunit requires the ran-GTPase cycle and certain nucleoporins","volume":"13","author":"Moy","year":"1999","journal-title":"Genes Dev"},{"issue":"16","key":"2025032119475121900_bib49","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1038\/sj.emboj.7600752","article-title":"Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells","volume":"24","author":"Rouquette","year":"2005","journal-title":"EMBO J"},{"issue":"15","key":"2025032119475121900_bib50","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/j.febslet.2007.05.013","article-title":"Nuclear export and cytoplasmic maturation of ribosomal subunits","volume":"581","author":"Zemp","year":"2007","journal-title":"FEBS Lett"},{"issue":"7","key":"2025032119475121900_bib51","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrg2111","article-title":"RNA regulons: coordination of post-transcriptional events","volume":"8","author":"Keene","year":"2007","journal-title":"Nat Rev Genet"},{"issue":"7","key":"2025032119475121900_bib52","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1182\/blood-2015-05-645069","article-title":"Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas","volume":"127","author":"Culjkovic-Kraljacic","year":"2016","journal-title":"Blood"},{"issue":"1","key":"2025032119475121900_bib53","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1158\/0008-5472.CAN-23-1992","article-title":"XPO1 enables adaptive regulation of mRNA export required for genotoxic stress tolerance in cancer cells","volume":"84","author":"Marullo","year":"2024","journal-title":"Cancer Res"},{"issue":"1","key":"2025032119475121900_bib54","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1038\/s41467-021-22548-8","article-title":"Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease","volume":"12","author":"Watt","year":"2021","journal-title":"Nat Commun"},{"issue":"12","key":"2025032119475121900_bib55","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1158\/1078-0432.CCR-20-4929","article-title":"Selinexor in combination with R-CHOP for frontline treatment of non-Hodgkin lymphoma: results of a phase I study","volume":"27","author":"Seymour","year":"2021","journal-title":"Clin Cancer Res"},{"issue":"12","key":"2025032119475121900_bib56","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.3324\/haematol.2020.251454","article-title":"Phase I study of selinexor in combination with dexamethasone, ifosfamide, carboplatin, etoposide chemotherapy in patients with relapsed or refractory peripheral T-cell or natural-killer\/T-cell lymphoma","volume":"106","author":"Tang","year":"2020","journal-title":"Haematologica"},{"issue":"6","key":"2025032119475121900_bib57","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/1878-0261.13191","article-title":"Ex\u00a0vivo drug sensitivity screening in multiple myeloma identifies drug combinations that act synergistically","volume":"16","author":"Giliberto","year":"2022","journal-title":"Mol Oncol"},{"issue":"5","key":"2025032119475121900_bib58","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1158\/1078-0432.CCR-23-1699","article-title":"GATA-3 dependent gene transcription is impaired upon HDAC inhibition","volume":"30","author":"Geng","year":"2024","journal-title":"Clin Cancer Res"},{"issue":"12","key":"2025032119475121900_bib59","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1038\/leu.2016.136","article-title":"Next-generation XPO1 inhibitor shows improved efficacy and in\u00a0vivo tolerability in hematological malignancies","volume":"30","author":"Hing","year":"2016","journal-title":"Leukemia"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/145\/6\/597\/2354427\/blood_bld-2024-025484-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/145\/6\/597\/2354427\/blood_bld-2024-025484-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T21:03:26Z","timestamp":1742591006000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/145\/6\/597\/534405\/The-GATA-3-dependent-transcriptome-and-tumor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,2,6]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2024025484","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]}}}