{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:58:17Z","timestamp":1782763097513,"version":"3.54.5"},"reference-count":123,"publisher":"American Society of Hematology","issue":"24","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,11]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Long-term maintenance of somatic stem cells relies on precise regulation of self-renewal and differentiation. Understanding the molecular framework for these homeostatic processes is essential for improved cellular therapies and treatment of myeloid neoplasms. CUX1 is a widely expressed, dosage-sensitive transcription factor crucial for development and frequently deleted in myeloid neoplasia in the context of \u20137\/(del7q). Here, using novel mouse models and single-cell approaches, we report that dynamic and distinct CUX1 levels are integral to hematopoietic stem cell (HSC) activity. Knockdown of CUX1 reverses HSC differentiation and strikingly reendows progenitors with stem cell function, accompanied by restoration of the HSC transcriptome and DNA accessibility landscape. CUX1 mediates these activities, in part, via suppressing endogenous retroelements (EREs) and the ensuing interferon-stimulated gene expression program. Both EREs and the interferon response are upregulated in CUX1-deficient acute myeloid leukemia, suggesting a conserved role of CUX1 in regulating these elements. These data establish an unexpected entwinement between stem cell\u2013intrinsic innate immune activation and the transcriptional programs of stem cell identity. Furthermore, we reveal the profound effects of transcription factor levels in cell fate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2024026815","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T18:07:31Z","timestamp":1757354851000},"page":"2914-2930","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":2,"title":["CUX1 restrains latent hematopoietic stem cell plasticity by suppressing stem cell\u2013intrinsic inflammatory pathways"],"prefix":"10.1182","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7074-9610","authenticated-orcid":false,"given":"Tanner C.","family":"Martinez","sequence":"first","affiliation":[{"name":"1Medical Scientist Training Program, The University of Chicago, Chicago, IL"},{"name":"2Department of Pathology, The University of Chicago, Chicago, IL"},{"name":"3Committee on Immunology, The University of Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-8625","authenticated-orcid":false,"given":"Matthew R. M.","family":"Jotte","sequence":"additional","affiliation":[{"name":"1Medical Scientist Training Program, The University of Chicago, Chicago, IL"},{"name":"2Department of Pathology, The University of Chicago, Chicago, IL"},{"name":"4Committee on Cancer Biology, The University of Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saira","family":"Khan","sequence":"additional","affiliation":[{"name":"2Department of Pathology, The University of Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Stoddart","sequence":"additional","affiliation":[{"name":"2Department of Pathology, The University of Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunter","family":"Blaylock","sequence":"additional","affiliation":[{"name":"2Department of Pathology, The University of Chicago, Chicago, IL"},{"name":"4Committee on Cancer Biology, The University of Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Malik","sequence":"additional","affiliation":[{"name":"5Department of Microbiology and Immunology, The University of North Carolina, Chapel Hill, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-3598","authenticated-orcid":false,"given":"Megan E.","family":"McNerney","sequence":"additional","affiliation":[{"name":"2Department of Pathology, The University of Chicago, Chicago, IL"},{"name":"6Department of Pediatrics, The University of Chicago, Chicago, IL"},{"name":"7The University of Chicago Medicine Comprehensive Cancer Center, The University of Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"9","key":"2025121111215606300_bib1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41576-020-0241-0","article-title":"Haematopoietic stem cell self-renewal in vivo and ex 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