{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:20:47Z","timestamp":1745554847724,"version":"3.40.4"},"reference-count":64,"publisher":"American Society of Hematology","issue":"17","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4,24]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>Apolipoprotein E (APOE) has multiple functions in metabolism and immunoregulation. Its common germ line variants APOE2, APOE3, and APOE4 give rise to 3 functionally distinct gene products. Previous studies reported yin-yang roles of APOE2 and APOE4 in immunological processes, but their effects in hematopoietic stem cell transplantation (HSCT) have never been studied. We performed APOE genotyping in 2 contemporary cohorts of 348 and 447 patients with acute myeloid leukemia who had received allogeneic HSCT and evaluated the associations of recipient and donor APOE genetic variations with posttransplant outcomes. Patients who carried at least 1 APOE2 allele had a higher risk of posttransplant death than APOE4 carriers in the discovery (hazard ratio [HR], 2.09; P\u00a0=\u00a0.024) and validation cohorts (HR, 1.96; P\u00a0=\u00a0.040). Detrimental APOE2 effects were driven by an increased risk of severe chronic graft-versus-host disease (GVHD; adjusted HR [HRadj], 1.85; P\u00a0=\u00a0.034) and nonrelapse death (HRadj, 1.72; P\u00a0=\u00a0.044). In non-APOE2 recipients, transplantation of an APOE2-positive allograft was associated with an increased incidence of grade 3 to 4 acute GVHD (HRadj, 2.82; P\u00a0=\u00a0.012) and severe chronic GVHD (HRadj, 2.54; P\u00a0=\u00a0.022) compared with APOE2-negative grafts. In summary, the APOE2 allele, typically considered a longevity gene in the general population, was associated with a higher risk of acute GVHD (HRadj, 2.75; P\u00a0=\u00a0.002), chronic GVHD (HRadj, 2.57; P\u00a0=\u00a0.001), and posttransplant mortality (HRadj, 1.79; P\u00a0=\u00a0.004), when present in either the host or transplanted from the donor.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1182\/blood.2024026886","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T21:56:18Z","timestamp":1736978178000},"page":"1943-1956","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":1,"title":["Common hereditary variants of the <i>APOE<\/i> gene and posttransplant outcome in acute myeloid leukemia"],"prefix":"10.1182","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1955-0709","authenticated-orcid":false,"given":"Julian","family":"Ronnacker","sequence":"first","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1909-0133","authenticated-orcid":false,"given":"Michael","family":"Grau","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1424-2165","authenticated-orcid":false,"given":"Maximilian","family":"Klasmeier","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Klesse","sequence":"additional","affiliation":[{"name":"2Collaborative Biobank, DKMS Group gGmbH, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Baldauf","sequence":"additional","affiliation":[{"name":"2Collaborative Biobank, DKMS Group gGmbH, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Abert","sequence":"additional","affiliation":[{"name":"2Collaborative Biobank, DKMS Group gGmbH, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7120-2780","authenticated-orcid":false,"given":"Andrew F.","family":"Berdel","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friederike T.","family":"F\u00fcsser","sequence":"additional","affiliation":[{"name":"3Institute for Pharmaceutical and Medical Chemistry, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5011-0641","authenticated-orcid":false,"given":"Sarah","family":"Sandmann","sequence":"additional","affiliation":[{"name":"4Institute of Medical Informatics, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rn","family":"Albring","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Reicherts","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Call","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Marx","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0916-070X","authenticated-orcid":false,"given":"Matthias","family":"Floeth","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"E\u00dfeling","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4850-7359","authenticated-orcid":false,"given":"Lina","family":"Kolloch","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4152-0366","authenticated-orcid":false,"given":"Philipp","family":"Berning","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Scheller","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1899-3261","authenticated-orcid":false,"given":"Klaus","family":"Wethmar","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Schmidt","sequence":"additional","affiliation":[{"name":"5Center for Laboratory Medicine, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Schl\u00fcter","sequence":"additional","affiliation":[{"name":"5Center for Laboratory Medicine, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3030-6567","authenticated-orcid":false,"given":"Wolfgang E.","family":"Berdel","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4492-9252","authenticated-orcid":false,"given":"Benjamin N.","family":"Ostendorf","sequence":"additional","affiliation":[{"name":"6Department of Hematology, Oncology, and Tumor Immunology, Berlin Institute of Health, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"7Berlin Institute for Medical Systems Biology, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohail F.","family":"Tavazoie","sequence":"additional","affiliation":[{"name":"8Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Henrik","family":"Mikesch","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Lenz","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5827-8000","authenticated-orcid":false,"given":"Katharina","family":"Fleischhauer","sequence":"additional","affiliation":[{"name":"9Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2780-2981","authenticated-orcid":false,"given":"Johannes","family":"Schetelig","sequence":"additional","affiliation":[{"name":"2Collaborative Biobank, DKMS Group gGmbH, T\u00fcbingen, Germany"},{"name":"10Department of Medicine I, University Hospital Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Stelljes","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1755-9583","authenticated-orcid":false,"given":"Christoph","family":"Schliemann","sequence":"additional","affiliation":[{"name":"1Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"234","reference":[{"issue":"5123","key":"2025042411221735800_bib1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"issue":"12","key":"2025042411221735800_bib2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/s41577-018-0051-1","article-title":"Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight","volume":"18","author":"Shi","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"2025042411221735800_bib3","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.omtn.2023.07.031","article-title":"Apolipoprotein E and viral infection: risks and mechanisms","volume":"33","author":"Chen","year":"2023","journal-title":"Mol Ther Nucleic Acids"},{"issue":"4","key":"2025042411221735800_bib4","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.cell.2017.12.026","article-title":"LXR\/ApoE activation restricts innate immune suppression in cancer","volume":"172","author":"Tavazoie","year":"2018","journal-title":"Cell"},{"issue":"7","key":"2025042411221735800_bib5","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/s41591-020-0879-3","article-title":"Common germline variants of the human APOE gene modulate melanoma progression and survival","volume":"26","author":"Ostendorf","year":"2020","journal-title":"Nat Med"},{"issue":"7935","key":"2025042411221735800_bib6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41586-022-05344-2","article-title":"Common human genetic variants of APOE impact murine COVID-19 mortality","volume":"611","author":"Ostendorf","year":"2022","journal-title":"Nature"},{"issue":"2","key":"2025042411221735800_bib7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1212\/01.WNL.0000149643.91367.8A","article-title":"APOE genotype and cognitive decline in a middle-aged cohort","volume":"64","author":"Blair","year":"2005","journal-title":"Neurology"},{"issue":"5","key":"2025042411221735800_bib8","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/clinchem\/30.5.641","article-title":"Apolipoprotein E polymorphism and hyperlipidemia","volume":"30","author":"Assmann","year":"1984","journal-title":"Clin Chem"},{"issue":"33","key":"2025042411221735800_bib9","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1093\/eurheartj\/ehz402","article-title":"Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105 949 individuals from a White general population cohort","volume":"40","author":"Rasmussen","year":"2019","journal-title":"Eur Heart J"},{"issue":"Pt 4","key":"2025042411221735800_bib10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1469-1809.1999.6340301.x","article-title":"Apolipoprotein E (APOE) allele distribution in the world. Is APOE\u22174 a \u2018thrifty\u2019 allele?","volume":"63","author":"Corbo","year":"1999","journal-title":"Ann Hum Genet"},{"issue":"1","key":"2025042411221735800_bib11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/ajpa.21298","article-title":"Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history","volume":"143","author":"Eisenberg","year":"2010","journal-title":"Am J Phys Anthropol"},{"issue":"3","key":"2025042411221735800_bib12","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/03014460600594513","article-title":"APOE distribution in world populations with new data from India and the UK","volume":"33","author":"Singh","year":"2006","journal-title":"Ann Hum Biol"},{"issue":"9","key":"2025042411221735800_bib13","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1096\/fj.11-180935","article-title":"APOE \u03b54 is associated with higher vitamin D levels in targeted replacement mice and humans","volume":"25","author":"Huebbe","year":"2011","journal-title":"FASEB J"},{"issue":"11","key":"2025042411221735800_bib14","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1111\/jgs.15059","article-title":"Racial differences in the association between apolipoprotein E risk alleles and overall and total cardiovascular mortality over 18 years","volume":"65","author":"Rajan","year":"2017","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"2025042411221735800_bib15","doi-asserted-by":"crossref","first-page":"e40048","DOI":"10.7554\/eLife.40048","article-title":"Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer\u2019s disease","volume":"7","author":"Xian","year":"2018","journal-title":"Elife"},{"issue":"5","key":"2025042411221735800_bib16","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1016\/S0021-9258(18)34954-8","article-title":"Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site","volume":"257","author":"Weisgraber","year":"1982","journal-title":"J\u00a0Biol Chem"},{"issue":"8987","key":"2025042411221735800_bib17","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/S0140-6736(95)92405-1","article-title":"Apolipoprotein E allele epsilon 4, dementia, and cognitive decline in a population sample","volume":"346","author":"Henderson","year":"1995","journal-title":"Lancet"},{"issue":"7","key":"2025042411221735800_bib18","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1212\/01.WNL.0000118302.66674.E1","article-title":"The impact of APOE on myocardial infarction, stroke, and dementia","volume":"62","author":"Slooter","year":"2004","journal-title":"Neurology"},{"issue":"5","key":"2025042411221735800_bib19","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/s41591-024-02931-w","article-title":"APOE4 homozygosity represents a distinct genetic form of Alzheimer\u2019s disease [published correction appears in Nat Med. 2024;30(7):2093]","volume":"30","author":"Fortea","year":"2024","journal-title":"Nat Med"},{"issue":"2","key":"2025042411221735800_bib20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng0694-180","article-title":"Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease","volume":"7","author":"Corder","year":"1994","journal-title":"Nat Genet"},{"issue":"1","key":"2025042411221735800_bib21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ng0194-29","article-title":"Genetic associations with human longevity at the APOE and ACE loci","volume":"6","author":"Sch\u00e4chter","year":"1994","journal-title":"Nat Genet"},{"issue":"6","key":"2025042411221735800_bib22","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nrg1871","article-title":"The quest for genetic determinants of human longevity: challenges and insights","volume":"7","author":"Christensen","year":"2006","journal-title":"Nat Rev Genet"},{"issue":"11","key":"2025042411221735800_bib64","doi-asserted-by":"crossref","first-page":"e4792","DOI":"10.1002\/pro.4792","article-title":"UCSF ChimeraX: tools for structure building\u00a0and analysis","volume":"32","author":"Meng","year":"2023","journal-title":"Protein Sci"},{"issue":"5","key":"2025042411221735800_bib23","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.cell.2012.10.028","article-title":"Convergent multi-miRNA targeting of ApoE drives LRP1\/LRP8-dependent melanoma metastasis and angiogenesis","volume":"151","author":"Pencheva","year":"2012","journal-title":"Cell"},{"issue":"23","key":"2025042411221735800_bib24","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.3390\/cancers15235565","article-title":"The role of apolipoproteins in the commonest cancers: a review","volume":"15","author":"Darwish","year":"2023","journal-title":"Cancers"},{"issue":"1","key":"2025042411221735800_bib25","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1038\/s41467-018-05322-1","article-title":"Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation","volume":"9","author":"Bonacina","year":"2018","journal-title":"Nat Commun"},{"issue":"3","key":"2025042411221735800_bib26","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1046\/j.1365-2567.2003.01665.x","article-title":"Apolipoprotein E modulates immune activation by acting on the antigen-presenting cell","volume":"109","author":"Tenger","year":"2003","journal-title":"Immunology"},{"issue":"1","key":"2025042411221735800_bib27","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13045-017-0453-8","article-title":"Immunotherapy in hematologic malignancies: past, present, and\u00a0future","volume":"10","author":"Im","year":"2017","journal-title":"J Hematol Oncol"},{"issue":"1","key":"2025042411221735800_bib28","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1172\/JCI115288","article-title":"Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation","volume":"88","author":"Linton","year":"1991","journal-title":"J\u00a0Clin Invest"},{"issue":"2","key":"2025042411221735800_bib29","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1172\/JCI118098","article-title":"Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation","volume":"96","author":"Boisvert","year":"1995","journal-title":"J\u00a0Clin Invest"},{"issue":"5200","key":"2025042411221735800_bib30","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1126\/science.7863332","article-title":"Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation","volume":"267","author":"Linton","year":"1995","journal-title":"Science"},{"issue":"3","key":"2025042411221735800_bib31","doi-asserted-by":"crossref","first-page":"e141513","DOI":"10.1172\/JCI141513","article-title":"Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223-enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis","volume":"131","author":"He","year":"2021","journal-title":"J\u00a0Clin Invest"},{"issue":"3","key":"2025042411221735800_bib32","doi-asserted-by":"crossref","first-page":"101106","DOI":"10.1016\/j.jbc.2021.101106","article-title":"Distinct pro-inflammatory properties of myeloid cell-derived apolipoprotein E2 and E4 in atherosclerosis promotion","volume":"297","author":"Igel","year":"2021","journal-title":"J\u00a0Biol Chem"},{"issue":"7728","key":"2025042411221735800_bib33","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41586-018-0623-z","article-title":"Functional genomic landscape of acute myeloid leukaemia","volume":"562","author":"Tyner","year":"2018","journal-title":"Nature"},{"issue":"7726","key":"2025042411221735800_bib34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"issue":"1","key":"2025042411221735800_bib35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41398-024-02848-5","article-title":"A\u00a0comprehensive analysis of APOE genotype effects on human brain structure in the UK Biobank","volume":"14","author":"Heise","year":"2024","journal-title":"Transl Psychiatry"},{"issue":"1","key":"2025042411221735800_bib36","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbmt.2015.09.001","article-title":"International, multicenter standardization of acute graft-versus-host disease clinical data collection: a report from the Mount Sinai Acute GVHD International Consortium","volume":"22","author":"Harris","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"2025042411221735800_bib37","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","article-title":"National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 Diagnosis and Staging Working Group report","volume":"21","author":"Jagasia","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"issue":"12","key":"2025042411221735800_bib38","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.bbmt.2007.08.047","article-title":"A\u00a0scheme for defining cause of death and its application in the T cell depletion trial","volume":"13","author":"Copelan","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"issue":"446","key":"2025042411221735800_bib39","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A\u00a0proportional hazards model for the subdistribution of a competing\u00a0risk","volume":"94","author":"Fine","year":"1999","journal-title":"J\u00a0Am Stat Assoc"},{"issue":"9","key":"2025042411221735800_bib40","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.4049\/jimmunol.1700893","article-title":"NetMHCpan-4.0: improved peptide-MHC class I interaction predictions integrating eluted ligand and peptide binding affinity data","volume":"199","author":"Jurtz","year":"2017","journal-title":"J\u00a0Immunol"},{"issue":"W1","key":"2025042411221735800_bib41","doi-asserted-by":"crossref","first-page":"W449","DOI":"10.1093\/nar\/gkaa379","article-title":"NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data","volume":"48","author":"Reynisson","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"2025042411221735800_bib42","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/tan.13378","article-title":"Common and well-documented HLA alleles of German stem cell donors by haplotype frequency estimation","volume":"92","author":"Eberhard","year":"2018","journal-title":"HLA"},{"issue":"5","key":"2025042411221735800_bib43","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/ana.24628","article-title":"APOE2 eases cognitive decline during aging: clinical and preclinical evaluations","volume":"79","author":"Shinohara","year":"2016","journal-title":"Ann Neurol"},{"issue":"11","key":"2025042411221735800_bib44","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1172\/JCI6172","article-title":"Apo E structure determines VLDL clearance and atherosclerosis risk in mice","volume":"103","author":"Knouff","year":"1999","journal-title":"J\u00a0Clin Invest"},{"issue":"18","key":"2025042411221735800_bib45","doi-asserted-by":"crossref","first-page":"10771","DOI":"10.1016\/S0021-9258(18)87014-4","article-title":"Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein","volume":"265","author":"Kowal","year":"1990","journal-title":"J\u00a0Biol Chem"},{"issue":"8","key":"2025042411221735800_bib46","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/S0022-2275(20)38060-3","article-title":"Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2\/2","volume":"23","author":"Breslow","year":"1982","journal-title":"J\u00a0Lipid Res"},{"key":"2025042411221735800_bib47","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.atherosclerosis.2021.05.007","article-title":"APOE gene variants in primary dyslipidemia","volume":"328","author":"Khalil","year":"2021","journal-title":"Atherosclerosis"},{"key":"2025042411221735800_bib48","doi-asserted-by":"crossref","first-page":"107435","DOI":"10.1016\/j.leukres.2024.107435","article-title":"Altered lipid metabolism in patients with acute graft-versus-host disease after allogeneic hematopoietic cell transplantation","volume":"137","author":"Tyszka","year":"2024","journal-title":"Leuk Res"},{"issue":"10","key":"2025042411221735800_bib49","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.bbmt.2020.06.014","article-title":"Global metabolomics in allogeneic hematopoietic cell transplantation recipients discordant for chronic graft-versus-host disease","volume":"26","author":"Lynch Kelly","year":"2020","journal-title":"Biol Blood Marrow Transplant"},{"issue":"16","key":"2025042411221735800_bib50","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1182\/blood.2019002887","article-title":"External validation of models for KIR2DS1\/KIR3DL1-informed selection of hematopoietic cell donors fails","volume":"135","author":"Schetelig","year":"2020","journal-title":"Blood"},{"key":"2025042411221735800_bib51","doi-asserted-by":"crossref","first-page":"1350470","DOI":"10.3389\/fimmu.2024.1350470","article-title":"Donor KIR genotype based outcome prediction after allogeneic stem cell transplantation: no land in sight","volume":"15","author":"Schetelig","year":"2024","journal-title":"Front Immunol"},{"issue":"3","key":"2025042411221735800_bib52","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1182\/bloodadvances.2023011622","article-title":"Systematic evaluation of donor-KIR\/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML","volume":"8","author":"Fein","year":"2024","journal-title":"Blood Adv"},{"issue":"21","key":"2025042411221735800_bib53","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1056\/NEJMc1411443","article-title":"Donor activating KIR2DS1 in leukemia","volume":"371","author":"Venstrom","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"6628","key":"2025042411221735800_bib54","doi-asserted-by":"crossref","first-page":"eadd1236","DOI":"10.1126\/science.add1236","article-title":"ApoE isoform\u2013 and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy","volume":"379","author":"Seo","year":"2023","journal-title":"Science"},{"issue":"8","key":"2025042411221735800_bib55","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1182\/blood-2016-09-691394","article-title":"The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease","volume":"129","author":"Staffas","year":"2017","journal-title":"Blood"},{"issue":"22","key":"2025042411221735800_bib56","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1182\/blood.2021015352","article-title":"Preservation of the fecal microbiome is associated with reduced severity of graft-versus-host disease. [published correction appears in Blood. 2023;141(10):1234]","volume":"140","author":"Burgos da Silva","year":"2022","journal-title":"Blood"},{"issue":"11","key":"2025042411221735800_bib57","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1182\/blood.2020007158","article-title":"Microbiome markers are early predictors of acute GVHD in allogeneic hematopoietic stem cell transplant recipients","volume":"137","author":"Greco","year":"2021","journal-title":"Blood"},{"issue":"18","key":"2025042411221735800_bib58","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1182\/blood.2023022343","article-title":"Expanding the repertoire reveals recurrent, cryptic, and hematopoietic HLA class I minor histocompatibility antigens","volume":"143","author":"Fuchs","year":"2024","journal-title":"Blood"},{"issue":"18","key":"2025042411221735800_bib59","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1182\/blood.2024024345","article-title":"Hidden treasures of histocompatibility","volume":"143","author":"Fleischhauer","year":"2024","journal-title":"Blood"},{"issue":"7060","key":"2025042411221735800_bib60","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/nature04001","article-title":"Apolipoprotein-mediated pathways of lipid antigen presentation","volume":"437","author":"van den Elzen","year":"2005","journal-title":"Nature"},{"issue":"11","key":"2025042411221735800_bib61","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1038\/s41591-019-0611-3","article-title":"Resistance to autosomal dominant Alzheimer\u2019s disease in an APOE3 Christchurch homozygote: a case report","volume":"25","author":"Arboleda-Velasquez","year":"2019","journal-title":"Nat Med"},{"issue":"613","key":"2025042411221735800_bib62","first-page":"eabc9375","article-title":"APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia","volume":"13","author":"Liu","year":"2021","journal-title":"Sci\u00a0Transl Med"},{"issue":"3","key":"2025042411221735800_bib63","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1056\/NEJMoa0809578","article-title":"Disclosure of APOE genotype for risk of Alzheimer\u2019s disease","volume":"361","author":"Green","year":"2009","journal-title":"N\u00a0Engl J Med"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/145\/17\/1943\/2370366\/blood_bld-2024-026886-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/145\/17\/1943\/2370366\/blood_bld-2024-026886-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T15:22:33Z","timestamp":1745508153000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/145\/17\/1943\/535113\/Common-hereditary-variants-of-the-APOE-gene-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,24]]},"references-count":64,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,4,24]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2024026886","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"type":"print","value":"0006-4971"},{"type":"electronic","value":"1528-0020"}],"subject":[],"published":{"date-parts":[[2025,4,24]]}}}