{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:46:26Z","timestamp":1792899986041,"version":"4.5.0"},"reference-count":68,"publisher":"American Society of Hematology","issue":"11","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,11]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>In inflammation, circulating neutrophils indirectly damage the skeleton by inducing formation of bone-resorbing osteoclasts. However, neutrophil progenitors in marrow have no known physiological function. A bone-protective role for the neutrophil lineage was recently suggested when a profound defect in bone structure was observed in mice with neutropenia due to granulocyte colony-stimulating factor deletion coupled with STAT3 hyperactivation in bone cells. Here, we tested the existence of this protective effect by manipulating neutrophil progenitors in bone marrow using anti-Ly6G (\u03b1Ly6G) treatment. Two protocols revealed an inverse relationship between marrow neutrophil progenitors and osteoclasts. Two weeks of \u03b1Ly6G treatment increased marrow immature neutrophils by 25%, and halved osteoclast markers in cortical bone. In contrast, 6 weeks of \u03b1Ly6G, combined with anti-rat immunoglobulin G2a to maintain antigenicity, reduced marrow preneutrophils by 50%. This latter treatment doubled trabecular osteoclast surface, halved trabecular bone mass, and significantly reduced high-density bone mass, both in control mice and in mice with bone-specific STAT3 hyperactivation. In culture, isolated preneutrophils dose-dependently inhibited osteoclastogenesis, independent of direct contact. We conclude that neutrophil progenitors directly inhibit osteoclast formation by releasing soluble factors. This identifies a novel action of hematopoietic cells in marrow to protect bone structure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1182\/blood.2025028310","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T17:29:32Z","timestamp":1750440572000},"page":"1331-1345","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":19,"title":["Bone marrow neutrophil progenitors suppress osteoclast formation in murine cortical and trabecular bone"],"prefix":"10.1182","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0011-0325","authenticated-orcid":false,"given":"Tsuyoshi","family":"Isojima","sequence":"first","affiliation":[{"name":"1Bone Cell Biology and Disease Unit, St. Vincent\u2019s Institute of Medical Research, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blessing","family":"Crimeen-Irwin","sequence":"additional","affiliation":[{"name":"1Bone Cell Biology and Disease Unit, St. Vincent\u2019s Institute of Medical Research, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narelle E.","family":"McGregor","sequence":"additional","affiliation":[{"name":"1Bone Cell Biology and Disease Unit, St. Vincent\u2019s Institute of Medical Research, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7628-4175","authenticated-orcid":false,"given":"Ryan C.","family":"Chai","sequence":"additional","affiliation":[{"name":"2Bone Biology Lab, Garvan Institute of Medical Research, Darlinghurst, Australia"},{"name":"3School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid J.","family":"Poulton","sequence":"additional","affiliation":[{"name":"1Bone Cell Biology and Disease Unit, St. Vincent\u2019s Institute of Medical Research, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma C.","family":"Walker","sequence":"additional","affiliation":[{"name":"1Bone Cell Biology and Disease Unit, St. Vincent\u2019s Institute of Medical Research, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4240-1219","authenticated-orcid":false,"given":"Mriga","family":"Dutt","sequence":"additional","affiliation":[{"name":"4Department of Anatomy and Physiology, The University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1818-2183","authenticated-orcid":false,"given":"Benjamin L.","family":"Parker","sequence":"additional","affiliation":[{"name":"4Department of Anatomy and Physiology, The University of Melbourne, Melbourne, 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