{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:59:22Z","timestamp":1785232762294,"version":"3.55.0"},"reference-count":18,"publisher":"American Society of Hematology","issue":"24","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,11]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Hepcidin is the key hyposideremic hormone produced primarily by the liver. However, recent reports reveal extrahepatic functional sources of hepcidin, including the intestine, the site of dietary iron absorption. To determine whether intestinal hepcidin may play a role in plasma iron lowering, we generated transgenic mice overexpressing the peptide specifically in this tissue. At 1 month of age, transgenic mice exhibited severe iron deficiency along with decreased hematologic indices and a drastic suppression of liver hepcidin in response to hyposideremia. Mechanistically, we showed that intestinal hepcidin was produced in the intestine lumen, inducing a striking downregulation of divalent metal transporter 1 (DMT1) protein at the enterocyte. To confirm the capacity of hepcidin to decrease DMT1, we developed food-grade recombinant lactic acid bacteria (recLAB) genetically modified to deliver hepcidin directly into the intestinal lumen. These recLAB induced a rapid decrease of duodenal DMT1 and, most importantly, when daily orally administrated, protected against iron overload in a mouse model of hemochromatosis. Taken together, our data reveal a previously unrecognized role of intestinal hepcidin as a regulator of systemic iron homeostasis, acting on DMT1 on the apical side of enterocytes, with potential therapeutic relevance for hematologic or iron disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2025028370","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:57:42Z","timestamp":1757455062000},"page":"2863-2869","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":5,"title":["Intestinal hepcidin overexpression promotes iron deficiency anemia and counteracts iron overload via DMT1 downregulation"],"prefix":"10.1182","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7747-7294","authenticated-orcid":false,"given":"Marion","family":"Falabr\u00e8gue","sequence":"first","affiliation":[{"name":"1Universit\u00e9 Paris Cit\u00e9, Centre National de la Recherche 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Boussetta","sequence":"additional","affiliation":[{"name":"1Universit\u00e9 Paris Cit\u00e9, Centre National de la Recherche Scientifique, INSERM, Institut Cochin, Paris, France"},{"name":"2Initiatives IdEx Globule Rouge d\u2019Excellence, Universit\u00e9 Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6980-0629","authenticated-orcid":false,"given":"Sara","family":"Zumerle","sequence":"additional","affiliation":[{"name":"1Universit\u00e9 Paris Cit\u00e9, Centre National de la Recherche Scientifique, INSERM, Institut Cochin, Paris, France"},{"name":"2Initiatives IdEx Globule Rouge d\u2019Excellence, Universit\u00e9 Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouzha","family":"Djebrani-Oussedik","sequence":"additional","affiliation":[{"name":"3Laboratoire de Toxicologie 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-5592","authenticated-orcid":false,"given":"Zoubida","family":"Karim","sequence":"additional","affiliation":[{"name":"5Universit\u00e9 de Toulouse, INSERM, Centre National de la Recherche Scientifique, Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Universit\u00e9 Paul Sabatier, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6288-0872","authenticated-orcid":false,"given":"Emeric","family":"Dupe","sequence":"additional","affiliation":[{"name":"6Universit\u00e9 Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, AgroParisTech, Micalis Insitute, Domaine de Vilvert, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Aucouturier","sequence":"additional","affiliation":[{"name":"6Universit\u00e9 Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, AgroParisTech, Micalis Insitute, Domaine de Vilvert, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7882-3464","authenticated-orcid":false,"given":"Philippe","family":"Langella","sequence":"additional","affiliation":[{"name":"6Universit\u00e9 Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, AgroParisTech, Micalis Insitute, Domaine de Vilvert, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis G.","family":"Bermudez-Humar\u00e1n","sequence":"additional","affiliation":[{"name":"6Universit\u00e9 Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, AgroParisTech, Micalis Insitute, Domaine de Vilvert, Jouy-en-Josas, 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