{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T04:57:33Z","timestamp":1794200253076,"version":"4.8.0"},"reference-count":167,"publisher":"American Society of Hematology","issue":"10","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Pediatric hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome, characterized by heightened T-cell activation and overwhelming interferon gamma production. Rather than a binary \u201cprimary\u201d vs \u201csecondary\u201d framework, it is best conceptualized as a threshold phenomenon that occurs when combined genetic and environmental factors exceed a critical tipping point, leading to a recognizable clinical pattern of abnormal immunopathology. In addition to classic genetic cytotoxic defects, an increasing number of genetic lesions continue to be recognized as related to HLH. Environmental triggers frequently include malignancy, infection, and rheumatologic disorders, and identifying underlying factors driving HLH is a crucial component of evaluation. The revised HLH-2004 criteria are an important tool in promptly recognizing HLH, but clinical criteria may be fulfilled by other inflammatory disorders. Genetic and functional immune testing are complementary tools for diagnosis and establishing recurrence risk. Dexamethasone and etoposide remain cornerstones of initial therapy but are best used in an individualized, response-based manner with close monitoring of inflammatory markers. Newer, more targeted agents continue to emerge and are often critical additions for achieving disease control. Most patients with inherited cytotoxic defects and other select causes require hematopoietic cell transplant for cure, which should occur as soon as feasible once adequate, not perfect, HLH control is established to minimize risk of reactivation, infection, and toxicity. This review aims to highlight key advancements in defining, diagnosing, and treating HLH based on a growing understanding of HLH pathophysiology. We also provide perspectives on practical clinical approaches that may be useful for diagnosing and treating pediatric HLH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2025028762","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:16:58Z","timestamp":1767374218000},"page":"1019-1036","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":14,"title":["Pediatric hemophagocytic lymphohistiocytosis: current conceptualization, diagnosis, and treatment"],"prefix":"10.1182","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9316-5207","authenticated-orcid":false,"given":"Bethany","family":"Verkamp","sequence":"first","affiliation":[{"name":"1Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH"},{"name":"2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH"},{"name":"3Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4207-3542","authenticated-orcid":false,"given":"Michael B.","family":"Jordan","sequence":"additional","affiliation":[{"name":"1Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH"},{"name":"2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH"},{"name":"3Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6625-739X","authenticated-orcid":false,"given":"Carl E.","family":"Allen","sequence":"additional","affiliation":[{"name":"4Division of Pediatric Hematology and Oncology, Baylor College of Medicine, Houston, TX"},{"name":"5Texas Children\u2019s Cancer 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