{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:17:28Z","timestamp":1771485448823,"version":"3.50.1"},"reference-count":66,"publisher":"American Society of Hematology","issue":"17","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,23]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>The US Food and Drug Administration recently licensed 14-day cold-stored platelets for bleeding patients. This policy change represents a reversal from the 1970s when cold-stored platelets were discontinued because of their short circulation time in healthy humans. This change will increase their availability in US hospitals with large trauma populations and in remote and rural settings in the United States. In some of these hospitals, cold-stored platelets will be the only platelets available. It is currently unclear whether patients with hypoproliferative thrombocytopenia who need platelet transfusion for prophylaxis benefit from cold-stored platelets. However, it is noteworthy that in recent clinical trials using room temperature\u2013stored platelets, the transfusion interval in patients with hematologic and oncologic conditions can be as short as 1 transfusion per day, very similar to what one would expect to achieve with cold-stored platelets. Furthermore, the emphasis on the posttransfusion count increment and the platelet count as a transfusion trigger per se is questionable. In the PLADO trial, there was only a poor correlation between the morning platelet count and bleeding events, implicating other factors, such as red blood cells, coagulation factors, and vascular health, as possible culprits. In this perspective article, we review the history of cold platelets and the reason for their discontinuation, focus on recent clinical trial data using room temperature\u2013stored platelets, and review the platelet count as a transfusion trigger. Overall, using cold platelets for prophylaxis may seem counterintuitive, but a closer look at the available data suggests that the indication expansion may hold more promise.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2025029252","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T19:03:47Z","timestamp":1754939027000},"page":"2023-2028","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":2,"title":["Chilling controversy: cold-stored platelets for prophylactic transfusions"],"prefix":"10.1182","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2866-1674","authenticated-orcid":false,"given":"Moritz","family":"Stolla","sequence":"first","affiliation":[{"name":"1Bloodworks Northwest Research Institute, Bloodworks Northwest, Seattle, WA"},{"name":"2Division of Hematology and Oncology, Department of Medicine, University of Washington Medical Center, Seattle, WA"},{"name":"3Department of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, WA"},{"name":"4Clinical Research Division, Fred Hutchinson Cancer Institute, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P.","family":"Cap","sequence":"additional","affiliation":[{"name":"5Department of Medicine, Uniformed Services University, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip C.","family":"Spinella","sequence":"additional","affiliation":[{"name":"6Department Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"234","reference":[{"issue":"suppl 4","key":"2025102311220697900_bib1","first-page":"S8","article-title":"Continued stabilization of blood collections and transfusions in the United States: findings from the 2021 national blood collection and utilization survey","volume":"63","author":"Free","year":"2023","journal-title":"Transfusion"},{"issue":"5","key":"2025102311220697900_bib2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/tme.12155","article-title":"Why has demand for platelet components increased? A review","volume":"24","author":"Estcourt","year":"2014","journal-title":"Transfus Med"},{"issue":"4","key":"2025102311220697900_bib3","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1423-0410.2012.01627.x","article-title":"Platelet transfusions in haematology patients: are we using them appropriately?","volume":"103","author":"Estcourt","year":"2012","journal-title":"Vox Sang"},{"issue":"1","key":"2025102311220697900_bib4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/trf.15637","article-title":"The epidemiology of platelet transfusions: an analysis of platelet use at 12 US hospitals","volume":"60","author":"Gottschall","year":"2020","journal-title":"Transfusion"},{"issue":"4","key":"2025102311220697900_bib5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/tme.12126","article-title":"Where did platelets go in 2012? A survey of platelet transfusion practice in the North of England","volume":"24","author":"Charlton","year":"2014","journal-title":"Transfus Med"},{"key":"2025102311220697900_bib6","unstructured":"Department of Health and Human Services\n          . The 2011 National Blood Collection and Utilization Survey Report. 2011. Accessed 12 May 2025. https:\/\/www.hhs.gov\/sites\/default\/files\/ash\/bloodsafety\/2011-nbcus.pdf."},{"key":"2025102311220697900_bib7","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18187","article-title":"Have we reached a new baseline for blood collection and transfusion in the United States? National Blood Collection and Utilization Survey, 2023","author":"McDavid","year":"11  2025","journal-title":"Transfusion"},{"issue":"4","key":"2025102311220697900_bib8","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1182\/blood-2015-07-655944","article-title":"Detection of septic transfusion reactions to platelet transfusions by active and passive surveillance","volume":"127","author":"Hong","year":"2016","journal-title":"Blood"},{"issue":"0","key":"2025102311220697900_bib9","article-title":"FDA guidance on bacterial contamination risk control strategies to enhance the safety and availability of platelets: advantages and limitations","volume":"6","author":"Jacobs","year":"2021","journal-title":"Ann Blood"},{"key":"2025102311220697900_bib10","unstructured":"Association for the Advancement of Blood & Biotherapies\n          . Impact of the FDA Guidance \u201cBacterial Risk Control Strategies for Blood Collection Establishments and Transfusion Services to Enhance the Safety and Availability of Platelets for Transfusion.\u201d. 2021. Accessed 12 May 2025. https:\/\/www.aabb.org\/docs\/default-source\/default-document-library\/resources\/association-bulletins\/ab21-02.pdf?sfvrsn=6c304e60."},{"issue":"2","key":"2025102311220697900_bib11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tmrv.2019.01.001","article-title":"Transfusion-transmitted infections reported to the national healthcare safety network hemovigilance module","volume":"33","author":"Haass","year":"2019","journal-title":"Transfus Med Rev"},{"issue":"S2","key":"2025102311220697900_bib12","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/trf.15255","article-title":"Platelet enhancement of bacterial growth during room temperature storage: mitigation through refrigeration","volume":"59","author":"Ketter","year":"2019","journal-title":"Transfusion"},{"issue":"2","key":"2025102311220697900_bib13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/trf.16785","article-title":"Time from apheresis platelet donation to cold storage: evaluation of platelet quality and bacterial growth","volume":"62","author":"Brown","year":"2022","journal-title":"Transfusion"},{"issue":"1","key":"2025102311220697900_bib14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tmrv.2019.08.006","article-title":"Is platelet expiring out of date? A systematic review","volume":"34","author":"Flint","year":"2020","journal-title":"Transfus Med Rev"},{"issue":"4","key":"2025102311220697900_bib15","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.tmrv.2020.09.008","article-title":"Frozen platelets \u2013 development and future directions","volume":"34","author":"Kelly","year":"2020","journal-title":"Transfus Med Rev"},{"issue":"9","key":"2025102311220697900_bib16","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1111\/trf.14780","article-title":"Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia","volume":"58","author":"Slichter","year":"2018","journal-title":"Transfusion"},{"issue":"6","key":"2025102311220697900_bib17","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1097\/ALN.0000000000003550","article-title":"A pilot trial of platelets stored cold versus at room temperature for complex cardiothoracic surgery","volume":"133","author":"Strandenes","year":"2020","journal-title":"Anesthesiology"},{"issue":"19","key":"2025102311220697900_bib18","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1182\/bloodadvances.2021004692","article-title":"Storage temperature determines platelet GPVI levels and function in mice and humans","volume":"5","author":"Miles","year":"2021","journal-title":"Blood Adv"},{"issue":"20","key":"2025102311220697900_bib19","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1182\/blood.2023022593","article-title":"Platelet dysfunction reversal with cold-stored vs. room temperature-stored platelet transfusions","volume":"143","author":"Kogler","year":"2024","journal-title":"Blood"},{"issue":"3","key":"2025102311220697900_bib20","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000040940","article-title":"Influence of aspirin on platelet count and volume in humans","volume":"101","author":"Erhart","year":"1999","journal-title":"Acta Haematol"},{"issue":"2","key":"2025102311220697900_bib21","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1182\/blood.V34.2.204.204","article-title":"The standardized normal Ivy bleeding time and its prolongation by aspirin","volume":"34","author":"Mielke","year":"1969","journal-title":"Blood"},{"issue":"20","key":"2025102311220697900_bib22","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1056\/NEJM196905152802004","article-title":"Platelet preservation \u2014 effect of storage temperature on maintenance of platelet viability \u2014deleterious effect of refrigerated storage","volume":"280","author":"Murphy","year":"1969","journal-title":"N Engl J Med"},{"issue":"5","key":"2025102311220697900_bib23","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1182\/blood.V66.5.1105.1105","article-title":"Platelet kinetics in patients with bone marrow hypoplasia: evidence for a fixed platelet requirement","volume":"66","author":"Hanson","year":"1985","journal-title":"Blood"},{"issue":"7","key":"2025102311220697900_bib24","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1056\/NEJMoa0904084","article-title":"Dose of prophylactic platelet transfusions and prevention of hemorrhage","volume":"362","author":"Slichter","year":"2010","journal-title":"N Engl J Med"},{"issue":"6","key":"2025102311220697900_bib25","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1182\/blood-2002-03-0932","article-title":"Transfusion of pooled buffy coat platelet components prepared with photochemical pathogen inactivation treatment: the euroSPRITE trial","volume":"101","author":"van Rhenen","year":"2003","journal-title":"Blood"},{"issue":"9","key":"2025102311220697900_bib26","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1182\/blood-2006-04-020131","article-title":"A multicenter randomized study of the efficacy of transfusions with platelets stored in platelet additive solution II versus plasma","volume":"108","author":"Kerkhoffs","year":"2006","journal-title":"Blood"},{"issue":"2","key":"2025102311220697900_bib27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2141.2010.08227.x","article-title":"Clinical effectiveness of leucoreduced, pooled donor platelet concentrates, stored in plasma or additive solution with and without pathogen reduction","volume":"150","author":"Kerkhoffs","year":"2010","journal-title":"Br J Haematol"},{"issue":"4","key":"2025102311220697900_bib28","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1001\/jamaoncol.2017.5123","article-title":"Comparison of the hemostatic efficacy of pathogen-reduced platelets vs untreated platelets in patients with thrombocytopenia and malignant hematologic diseases: a randomized clinical trial","volume":"4","author":"Garban","year":"2018","journal-title":"Jama Oncol"},{"issue":"5","key":"2025102311220697900_bib29","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1182\/blood-2003-12-4443","article-title":"Therapeutic efficacy and safety of platelets treated with a photochemical process for pathogen inactivation: the SPRINT trial","volume":"104","author":"McCullough","year":"2004","journal-title":"Blood"},{"issue":"9","key":"2025102311220697900_bib30","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1111\/j.1537-2995.2005.00550.x","article-title":"Therapeutic efficacy and safety of photochemically treated apheresis platelets processed with an optimized integrated set","volume":"45","author":"Janetzko","year":"2005","journal-title":"Transfusion"},{"issue":"3","key":"2025102311220697900_bib31","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2141.2011.08635.x","article-title":"A multi-centre study of therapeutic efficacy and safety of platelet components treated with amotosalen and ultraviolet A pathogen inactivation stored for 6 or 7 d prior to transfusion","volume":"153","author":"Lozano","year":"2011","journal-title":"Br J Haematol"},{"issue":"11","key":"2025102311220697900_bib32","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1111\/j.1537-2995.2010.02694.x","article-title":"A randomized controlled clinical trial evaluating the performance and safety of platelets treated with MIRASOL pathogen reduction technology","volume":"50","author":"Mirasol Clinical Evaluation Study Group","year":"2010","journal-title":"Transfusion"},{"issue":"5","key":"2025102311220697900_bib33","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/trf.14042","article-title":"Clinical effectiveness of platelets in additive solution treated with two commercial pathogen-reduction technologies","volume":"57","author":"Rebulla","year":"2017","journal-title":"Transfusion"},{"issue":"2","key":"2025102311220697900_bib34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1182\/blood-2018-02-831289","article-title":"Hemostatic efficacy of pathogen-inactivated vs untreated platelets: a randomized controlled trial","volume":"132","author":"van der Meer","year":"2018","journal-title":"Blood"},{"issue":"3","key":"2025102311220697900_bib35","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/trf.17720","article-title":"Results of clinical effectiveness of conventional versus Mirasol-treated Apheresis Platelets in Patients with Hypoproliferative Thrombocytopenia (MiPLATE) trial","volume":"64","author":"Koepsell","year":"2024","journal-title":"Transfusion"},{"issue":"4","key":"2025102311220697900_bib36","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1182\/blood-2011-11-389569","article-title":"Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia","volume":"120","author":"Josephson","year":"2012","journal-title":"Blood"},{"issue":"26","key":"2025102311220697900_bib37","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1182\/blood-2017-04-780825","article-title":"Platelet interaction with activated endothelium: mechanistic insights from microfluidics","volume":"130","author":"Coenen","year":"2017","journal-title":"Blood"},{"issue":"3","key":"2025102311220697900_bib38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1182\/blood-2017-06-742676","article-title":"Platelets and vascular integrity: how platelets prevent bleeding in inflammation","volume":"131","author":"Ho-Tin-No\u00e9","year":"2018","journal-title":"Blood"},{"issue":"12","key":"2025102311220697900_bib39","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1056\/NEJMra0800887","article-title":"Platelets, petechiae, and preservation of the vascular wall","volume":"359","author":"Nachman","year":"2008","journal-title":"N Engl J Med"},{"issue":"5188","key":"2025102311220697900_bib40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/222033a0","article-title":"Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium","volume":"222","author":"Gimbrone","year":"1969","journal-title":"Nature"},{"issue":"24","key":"2025102311220697900_bib41","doi-asserted-by":"crossref","first-page":"1901725","DOI":"10.1002\/advs.201901725","article-title":"Transforming endothelium with platelet-rich plasma in engineered microvessels","volume":"6","author":"Nagao","year":"2019","journal-title":"Adv Sci"},{"issue":"39","key":"2025102311220697900_bib42","doi-asserted-by":"crossref","first-page":"24316","DOI":"10.1073\/pnas.2007642117","article-title":"Hemostasis vs. homeostasis: platelets are essential for preserving vascular barrier function in the absence of injury or inflammation","volume":"117","author":"Gupta","year":"2020","journal-title":"Proc Natl Acad Sci"},{"issue":"26","key":"2025102311220697900_bib43","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1056\/NEJM199712253372602","article-title":"The threshold for prophylactic platelet transfusions in adults with acute myeloid leukemia. Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto","volume":"337","author":"Rebulla","year":"1997","journal-title":"N Engl J Med"},{"issue":"8058","key":"2025102311220697900_bib44","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0140-6736(78)90505-6","article-title":"Platelet prophylaxis in acute non-lymphoblastic leukemia","volume":"311","author":"Solomon","year":"1978","journal-title":"Lancet"},{"issue":"4","key":"2025102311220697900_bib45","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/ajh.2830120406","article-title":"Indications for platelet transfusion in children with acute leukemia","volume":"12","author":"Murphy","year":"1982","journal-title":"Am J Hematol"},{"issue":"3","key":"2025102311220697900_bib46","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1200\/JCO.1997.15.3.1143","article-title":"Randomized study of prophylactic platelet transfusion threshold during induction therapy for adult acute leukemia: 10,000\/microL versus 20,000\/microL","volume":"15","author":"Heckman","year":"1997","journal-title":"J Clin Oncol"},{"issue":"10","key":"2025102311220697900_bib47","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1053\/bbmt.2002.v8.pm12434952","article-title":"A prospective randomized trial of prophylactic platelet transfusion and bleeding incidence in hematopoietic stem cell transplant recipients: 10,000\/L versus 20,000\/microL trigger","volume":"8","author":"Zumberg","year":"2002","journal-title":"Biol Blood Marrow Transplant"},{"issue":"7","key":"2025102311220697900_bib48","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/j.1537-2995.2005.04157.x","article-title":"A prospective randomized trial of a prophylactic platelet transfusion trigger of 10 \u00d7 109 per L versus 30 \u00d7 109 per L in allogeneic hematopoietic progenitor cell transplant recipients","volume":"45","author":"Diedrich","year":"2005","journal-title":"Transfusion"},{"issue":"19","key":"2025102311220697900_bib49","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1056\/NEJMoa1212772","article-title":"A no-prophylaxis platelet-transfusion strategy for hematologic cancers","volume":"368","author":"Stanworth","year":"2013","journal-title":"N Engl J Med"},{"issue":"48","key":"2025102311220697900_bib50","first-page":"809","article-title":"Platelet transfusion in hematology, oncology and surgery","volume":"111","author":"Wandt","year":"2014","journal-title":"Deutsches Aerzteblatt Online"},{"issue":"3","key":"2025102311220697900_bib51","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/trf.15669","article-title":"Effects of storage time prolongation on in vivo and in vitro characteristics of 4\u00b0C\u2013stored platelets","volume":"60","author":"Stolla","year":"2020","journal-title":"Transfusion"},{"issue":"7","key":"2025102311220697900_bib52","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1001\/jama.2025.7529","article-title":"Platelet transfusion: 2025 AABB and ICTMG international clinical practice guidelines","volume":"334","author":"Metcalf","year":"2025","journal-title":"JAMA"},{"issue":"3","key":"2025102311220697900_bib53","doi-asserted-by":"crossref","first-page":"e0289395","DOI":"10.1371\/journal.pone.0289395","article-title":"Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets","volume":"19","author":"Stratiievska","year":"2024","journal-title":"PLoS ONE"},{"issue":"10","key":"2025102311220697900_bib54","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1111\/trf.14833","article-title":"In vivo viability of extended 4\u00b0C-stored autologous apheresis platelets","volume":"58","author":"Stolla","year":"2018","journal-title":"Transfusion"},{"issue":"1","key":"2025102311220697900_bib55","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/trf.16741","article-title":"Effect of bedside filtration on aggregates from cold-stored whole blood\u2013derived platelet-rich plasma and apheresis platelet concentrates","volume":"62","author":"Li","year":"2022","journal-title":"Transfusion"},{"issue":"26","key":"2025102311220697900_bib56","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1182\/blood.2021014889","article-title":"There and back again: the once and current developments in donor-derived platelet products for hemostatic therapy","volume":"139","author":"Kogler","year":"2022","journal-title":"Blood"},{"issue":"4","key":"2025102311220697900_bib57","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.tmrv.2020.08.003","article-title":"Cold-stored platelets: review of studies in humans","volume":"34","author":"Mack","year":"2020","journal-title":"Transfus Med Rev"},{"issue":"4","key":"2025102311220697900_bib58","doi-asserted-by":"crossref","first-page":"988","DOI":"10.3324\/haematol.2021.279865","article-title":"In vitro and in vivo effects of short-term cold storage of platelets in PAS-C","volume":"107","author":"Bailey","year":"2021","journal-title":"Haematologica"},{"issue":"01","key":"2025102311220697900_bib59","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/SHK.0000000000000082","article-title":"Hemostatic function of apheresis platelets stored at 4\u00b0C and 22\u00b0C","volume":"41","author":"Reddoch","year":"2014","journal-title":"Shock"},{"issue":"1","key":"2025102311220697900_bib60","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/bjh.14751","article-title":"Platelets stored at 4\u00b0C contribute to superior clot properties compared to current standard-of-care through fibrin-crosslinking","volume":"178","author":"Nair","year":"2017","journal-title":"Br J Haematol"},{"issue":"2","key":"2025102311220697900_bib61","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/SHK.0000000000000493","article-title":"Endothelium-derived inhibitors efficiently attenuate the aggregation and adhesion responses of refrigerated platelets","volume":"45","author":"Reddoch","year":"2016","journal-title":"Shock"},{"issue":"13","key":"2025102311220697900_bib62","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1182\/blood-2017-03-743211","article-title":"Cancer-associated pathways and biomarkers of venous thrombosis","volume":"130","author":"Hisada","year":"2017","journal-title":"Blood"},{"issue":"suppl 1","key":"2025102311220697900_bib63","first-page":"S52","article-title":"The effects of 22\u00b0C and 4\u00b0C storage of platelets on vascular endothelial integrity and function","volume":"56","author":"Baimukanova","year":"2016","journal-title":"Transfusion"},{"issue":"11","key":"2025102311220697900_bib64","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1111\/j.1537-2995.2012.03634.x","article-title":"A new tool to assess bleeding severity in patients with chemotherapy-induced thrombocytopenia (CME)","volume":"52","author":"Webert","year":"2012","journal-title":"Transfusion"},{"issue":"7","key":"2025102311220697900_bib65","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1182\/blood-2008-09-178236","article-title":"A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (SToP) to patients with thrombocytopenia","volume":"113","author":"Heddle","year":"2009","journal-title":"Blood"},{"issue":"12","key":"2025102311220697900_bib66","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/j.0041-1132.2004.04118.x","article-title":"Low-dose prophylactic platelet transfusions in recipients of an autologous peripheral blood progenitor cell transplant and patients with acute leukemia: a randomized controlled trial with a sequential Bayesian design","volume":"44","author":"Tinmouth","year":"2004","journal-title":"Transfusion"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/146\/17\/2023\/2417526\/blood_bld-2025-029252-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/146\/17\/2023\/2417526\/blood_bld-2025-029252-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T15:22:21Z","timestamp":1761232941000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/146\/17\/2023\/546600\/Chilling-controversy-cold-stored-platelets-for"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,23]]},"references-count":66,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,10,23]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2025029252","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10,23]]},"published":{"date-parts":[[2025,10,23]]}}}