{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:00:09Z","timestamp":1786978809581,"version":"build-2736575974"},"reference-count":60,"publisher":"American Society of Hematology","issue":"18","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Plasmodium knowlesi, a zoonotic malaria species, has become a significant public health concern in Southeast Asia. In regions such as Malaysia and southern Thailand, P knowlesi incidence has risen, even as other human malaria parasites are nearing elimination. Similar to its close relative Plasmodium vivax, P knowlesi relies on the Duffy antigen receptor for chemokine (DARC) as a key receptor for erythrocyte invasion. Only Duffy-positive individuals are thought to be susceptible to clinical infection. Here, we demonstrate that P knowlesi possesses greater invasion plasticity than previously recognized. This parasite can bypass the need for DARC, as shown by its in vitro adaptation to invade and replicate within Duffy-negative (Fy\u2212) erythrocytes. This adaptation is stable and independent of DARC binding, enabling the adapted parasite line to be maintained in Fy\u2212 erythrocytes and to resist inhibition by \u03b1-DARC antibodies. Genomic analysis identified a genomic recombination event between the parasite's dbp\u03b1 and dbp\u03b3 genes, resulting in a new chimeric gene dbp\u03b1\u03b3. Using CRISPR-Cas9 targeted reversion, we could demonstrate that dbp\u03b1\u03b3 is essential for invasion of Fy\u2212 erythrocytes. These findings shed new light on the invasion plasticity of P knowlesi, with implications for the parasite\u2019s potential spread beyond Southeast Asia and for understanding the complex host-cell specificity and atypical invasion pathways seen in P vivax.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2025029557","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T22:04:03Z","timestamp":1771365843000},"page":"2132-2142","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":1,"title":["<i>Plasmodium knowlesi<\/i>\n                    can adapt to infect Duffy-negative erythrocytes"],"prefix":"10.1182","volume":"147","author":[{"given":"Maria","family":"Zinga","sequence":"first","affiliation":[{"name":"1Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"2Department of Medical Parasitology, Catholic 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Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-4731","authenticated-orcid":false,"given":"Thorey K.","family":"Jonsdottir","sequence":"additional","affiliation":[{"name":"3Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sutharinee","family":"Ngernna","sequence":"additional","affiliation":[{"name":"1Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Amabilino-Perez","sequence":"additional","affiliation":[{"name":"5Department of Biochemistry, University of Oxford, Oxford, United 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G.","family":"Clark","sequence":"additional","affiliation":[{"name":"3Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom"},{"name":"6Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9374-6749","authenticated-orcid":false,"given":"Jun","family":"Miao","sequence":"additional","affiliation":[{"name":"7Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-1974","authenticated-orcid":false,"given":"Liwang","family":"Cui","sequence":"additional","affiliation":[{"name":"7Department of Internal Medicine, Morsani College of Medicine, University of 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