{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T18:41:53Z","timestamp":1793990513449,"version":"4.8.0"},"reference-count":60,"publisher":"American Society of Hematology","issue":"6","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8,6]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>The transcription factor GATA1 has pleiotropic hematopoietic functions, particularly in erythroid and megakaryocytic ontogeny. Although mechanistic investigations have uncovered many facets of GATA1 biology, how GATA1 coregulates divergent cell fates remains incompletely characterized. We previously described that loss of Stag2, a member of the cohesin complex and a recurrent mutational target in myelodysplastic syndrome (MDS) and myeloid leukemia of Down syndrome, results in altered chromatin accessibility, transcription factor function, and cell differentiation. Therefore, we hypothesized that chromatin accessibility determines GATA1 cistrome specificity and lineage fate decisions. To understand the connection between chromatin accessibility and GATA1, we comprehensively studied erythropoiesis in Stag2\u0394 mice. Defects in Stag2-deficient hematopoiesis included reduced numbers of erythroid progenitors (EryPs), impaired terminal erythroid differentiation, increased number of megakaryocyte progenitors, and increased megakaryocytes. RNA- and assay for transposase-accessible chromatin\u2013sequencing of EryPs revealed altered patterns of Gata1 target gene expression with altered accessibility in conjunction with loss of expression of erythroid targets and gain of megakaryocyte targets. Despite unchanged Gata1 expression, Gata1 occupancy was reprogrammed from erythroid to megakaryocyte targets with Fli1 motifs enriched at Stag2\u0394 Gata1 binding sites. Functionally, we observed that Stag2-deficient EryPs have a diminished erythroid output and augmented megakaryocyte output in orthogonal differentiation assays, which was partially reversed with Fli1 knockdown. Human models and patients with primary MDS recapitulated the essential phenotypic and molecular features of our in vivo murine MDS model. Collectively, this study establishes chromatin accessibility as a determinant of transcription factor binding specificity, revealing an accessibility-driven Gata1 retargeting mechanism underlying MDS dyserythropoiesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2025030554","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:01:22Z","timestamp":1779105682000},"page":"767-782","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":3,"title":["Stag2-dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome"],"prefix":"10.1182","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8639-8907","authenticated-orcid":false,"given":"Varun S.","family":"Sudunagunta","sequence":"first","affiliation":[{"name":"1Columbia University Vagelos College of Physicians and Surgeons, New York, NY"},{"name":"2Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5949-7301","authenticated-orcid":false,"given":"Edna M.","family":"Stewart","sequence":"additional","affiliation":[{"name":"2Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY"},{"name":"3Department of Biomedical Engineering, Columbia University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4891-8289","authenticated-orcid":false,"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"2Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY"},{"name":"4Division of Hematology\/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY"},{"name":"5Columbia Stem Cell Initiative, Department of Genetics and Development, Columbia University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8187-2788","authenticated-orcid":false,"given":"Hongxia","family":"Yan","sequence":"additional","affiliation":[{"name":"6Red Cell Physiology Laboratory, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7571-8904","authenticated-orcid":false,"given":"Sebastian","family":"Fernando","sequence":"additional","affiliation":[{"name":"4Division of Hematology\/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY"},{"name":"5Columbia Stem Cell Initiative, Department of Genetics and Development, Columbia University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3791-7499","authenticated-orcid":false,"given":"Viviana","family":"Scoca","sequence":"additional","affiliation":[{"name":"2Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY"},{"name":"4Division of Hematology\/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY"},{"name":"5Columbia Stem Cell Initiative, Department of Genetics and Development, Columbia University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Pantazi","sequence":"additional","affiliation":[{"name":"4Division of Hematology\/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY"},{"name":"5Columbia Stem Cell Initiative, Department of Genetics and Development, Columbia University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5170-3361","authenticated-orcid":false,"given":"Rong","family":"Deng","sequence":"additional","affiliation":[{"name":"2Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY"},{"name":"4Division of Hematology\/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY"},{"name":"5Columbia Stem Cell Initiative, Department of Genetics and Development, Columbia University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5065-4860","authenticated-orcid":false,"given":"Jane J.","family":"Xu","sequence":"additional","affiliation":[{"name":"2Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY"},{"name":"4Division of Hematology\/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY"},{"name":"5Columbia Stem Cell Initiative, Department of Genetics and Development, Columbia University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2271-5296","authenticated-orcid":false,"given":"Narla","family":"Mohandas","sequence":"additional","affiliation":[{"name":"6Red Cell Physiology Laboratory, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-0110","authenticated-orcid":false,"given":"Aaron D.","family":"Viny","sequence":"additional","affiliation":[{"name":"1Columbia University Vagelos College of Physicians and Surgeons, New York, NY"},{"name":"2Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY"},{"name":"4Division of Hematology\/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY"},{"name":"5Columbia Stem Cell Initiative, Department of Genetics and Development, Columbia University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"24","key":"2026080611222208600_bib1","doi-asserted-by":"crossref","first-page":"6258","DOI":"10.1182\/blood-2011-07-356006","article-title":"From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications","volume":"118","author":"Hattangadi","year":"2011","journal-title":"Blood"},{"key":"2026080611222208600_bib2","doi-asserted-by":"crossref","first-page":"100740","DOI":"10.1016\/j.blre.2020.100740","article-title":"Understanding terminal erythropoiesis: an update on chromatin condensation, enucleation, and reticulocyte maturation","volume":"46","author":"Mei","year":"2021","journal-title":"Blood Rev"},{"issue":"11","key":"2026080611222208600_bib3","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1016\/j.celrep.2019.05.046","article-title":"Transcriptional states and chromatin accessibility underlying human erythropoiesis","volume":"27","author":"Ludwig","year":"2019","journal-title":"Cell Rep"},{"issue":"4","key":"2026080611222208600_bib4","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41588-019-0362-6","article-title":"Interrogation of human hematopoiesis at single-cell and single-variant resolution","volume":"51","author":"Ulirsch","year":"2019","journal-title":"Nat Genet"},{"issue":"11","key":"2026080611222208600_bib5","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1016\/j.celrep.2019.08.020","article-title":"A unique epigenomic landscape defines human erythropoiesis","volume":"28","author":"Schulz","year":"2019","journal-title":"Cell Rep"},{"issue":"12","key":"2026080611222208600_bib6","doi-asserted-by":"crossref","first-page":"105554","DOI":"10.1016\/j.isci.2022.105554","article-title":"Chromatin reconstruction during mouse terminal erythropoiesis","volume":"25","author":"Bi","year":"2022","journal-title":"iScience"},{"issue":"3","key":"2026080611222208600_bib7","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/ncb1693","article-title":"Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2","volume":"10","author":"Ji","year":"2008","journal-title":"Nat Cell Biol"},{"issue":"9","key":"2026080611222208600_bib8","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1182\/blood-2017-05-787051","article-title":"Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome","volume":"130","author":"Nowak","year":"2017","journal-title":"Blood"},{"issue":"11","key":"2026080611222208600_bib9","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.1182\/blood-2003-09-3362","article-title":"Caspase-3 has a nonapoptotic function in erythroid maturation","volume":"103","author":"Carlile","year":"2004","journal-title":"Blood"},{"issue":"12","key":"2026080611222208600_bib10","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.3324\/haematol.2010.029827","article-title":"Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts","volume":"95","author":"Ji","year":"2010","journal-title":"Haematologica"},{"issue":"10","key":"2026080611222208600_bib11","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.3324\/haematol.2011.061093","article-title":"A novel role for survivin in erythroblast enucleation","volume":"97","author":"Keerthivasan","year":"2012","journal-title":"Haematologica"},{"key":"2026080611222208600_bib12","first-page":"669","article-title":"Interaction of the macrophage and primitive erythroid lineages in the mammalian embryo","volume":"7","author":"Palis","year":"2016","journal-title":"Front Immunol"},{"issue":"26","key":"2026080611222208600_bib13","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1182\/blood.2023020078","article-title":"Diagnosis and classification of myelodysplastic syndromes","volume":"142","author":"Hasserjian","year":"2023","journal-title":"Blood"},{"key":"2026080611222208600_bib14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.med.051308.132852","article-title":"Myelodysplastic syndromes","volume":"61","author":"Scott","year":"2010","journal-title":"Annu Rev Med"},{"issue":"10","key":"2026080611222208600_bib15","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1182\/blood-2018-10-844621","article-title":"Genetics of MDS","volume":"133","author":"Ogawa","year":"2019","journal-title":"Blood"},{"issue":"11","key":"2026080611222208600_bib16","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1182\/blood-2014-04-567057","article-title":"Genetic alterations of the cohesin complex genes in myeloid malignancies","volume":"124","author":"Thota","year":"2014","journal-title":"Blood"},{"issue":"1","key":"2026080611222208600_bib17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1080\/10428194.2024.2400210","article-title":"Untangling the loops of STAG2 mutations in myelodysplastic syndrome","volume":"66","author":"Sudunagunta","year":"2025","journal-title":"Leuk Lymphoma"},{"issue":"14","key":"2026080611222208600_bib18","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1182\/blood.2024027540","article-title":"IPSS-M risk and specific sex-associated somatic mutations predict response to ESA therapy in LR-MDS: building a new score","volume":"146","author":"Raddi","year":"2025","journal-title":"Blood"},{"issue":"5","key":"2026080611222208600_bib19","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.stem.2019.08.003","article-title":"Cohesin members Stag1 and Stag2 display distinct roles in chromatin accessibility and topological control of HSC self-renewal and differentiation","volume":"25","author":"Viny","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"2","key":"2026080611222208600_bib20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/leu.2013.336","article-title":"Landscape of genetic lesions in 944 patients with myelodysplastic syndromes","volume":"28","author":"Haferlach","year":"2014","journal-title":"Leukemia"},{"issue":"10","key":"2026080611222208600_bib21","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1101\/gad.8.10.1184","article-title":"Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells","volume":"8","author":"Weiss","year":"1994","journal-title":"Genes Dev"},{"issue":"21","key":"2026080611222208600_bib22","doi-asserted-by":"crossref","first-page":"9623","DOI":"10.1073\/pnas.92.21.9623","article-title":"Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis","volume":"92","author":"Weiss","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"2026080611222208600_bib23","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1093\/emboj\/16.13.3965","article-title":"A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development","volume":"16","author":"Shivdasani","year":"1997","journal-title":"EMBO J"},{"issue":"11","key":"2026080611222208600_bib24","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1084\/jem.20020656","article-title":"Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo","volume":"195","author":"Yu","year":"2002","journal-title":"J Exp Med"},{"issue":"3","key":"2026080611222208600_bib25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1084\/jem.20021149","article-title":"GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant","volume":"197","author":"Migliaccio","year":"3 2003","journal-title":"J Exp Med"},{"issue":"2","key":"2026080611222208600_bib26","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/emboj.2009.336","article-title":"NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development","volume":"29","author":"Miccio","year":"2010","journal-title":"EMBO J"},{"issue":"3","key":"2026080611222208600_bib27","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1084\/jem.20070544","article-title":"Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage","volume":"205","author":"Cantor","year":"2008","journal-title":"J Exp Med"},{"issue":"11","key":"2026080611222208600_bib28","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1182\/blood-2009-10-251280","article-title":"FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment","volume":"115","author":"Gregory","year":"2010","journal-title":"Blood"},{"issue":"16","key":"2026080611222208600_bib29","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1182\/blood-2011-09-380634","article-title":"Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis","volume":"119","author":"Dore","year":"2012","journal-title":"Blood"},{"issue":"4","key":"2026080611222208600_bib30","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.molcel.2012.05.051","article-title":"Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression","volume":"47","author":"Chlon","year":"2012","journal-title":"Mol Cell"},{"issue":"2","key":"2026080611222208600_bib31","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/emboj.2011.390","article-title":"FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors","volume":"31","author":"Mancini","year":"2012","journal-title":"EMBO J"},{"issue":"5","key":"2026080611222208600_bib32","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.devcel.2011.04.008","article-title":"Genome-wide analysis of simultaneous GATA1\/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators","volume":"20","author":"Tijssen","year":"2011","journal-title":"Dev Cell"},{"issue":"4","key":"2026080611222208600_bib33","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41594-023-00939-3","article-title":"Heterochromatin rewiring and domain disruption-mediated chromatin compaction during erythropoiesis","volume":"30","author":"Li","year":"2023","journal-title":"Nat Struct Mol Biol"},{"issue":"13","key":"2026080611222208600_bib34","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.1093\/nar\/gkad468","article-title":"Multidimensional profiling reveals GATA1-modulated stage-specific chromatin states and functional associations during human erythropoiesis","volume":"51","author":"Li","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"2026080611222208600_bib35","doi-asserted-by":"crossref","first-page":"e20200164","DOI":"10.1084\/jem.20200164","article-title":"IL-33 promotes anemia during chronic inflammation by inhibiting differentiation of erythroid progenitors","volume":"217","author":"Swann","year":"2020","journal-title":"J Exp Med"},{"issue":"5","key":"2026080611222208600_bib36","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.celrep.2016.06.085","article-title":"Comprehensive proteomic analysis of human erythropoiesis","volume":"16","author":"Gautier","year":"2016","journal-title":"Cell Rep"},{"issue":"14","key":"2026080611222208600_bib37","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1182\/blood-2016-08-736587","article-title":"Distinct roles for TET family proteins in regulating human erythropoiesis","volume":"129","author":"Yan","year":"2017","journal-title":"Blood"},{"issue":"16","key":"2026080611222208600_bib38","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1182\/blood-2013-01-476390","article-title":"Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo","volume":"121","author":"Hu","year":"2013","journal-title":"Blood"},{"issue":"24","key":"2026080611222208600_bib39","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1182\/blood-2014-07-588806","article-title":"Isolation and transcriptome analyses of human erythroid progenitors: BFU-E and CFU-E","volume":"124","author":"Li","year":"2014","journal-title":"Blood"},{"issue":"7","key":"2026080611222208600_bib40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2105-7-123","article-title":"Detecting outliers when fitting data with nonlinear regression\u2013a new method based on robust nonlinear regression and the false discovery rate","volume":"7","author":"Motulsky","year":"2006","journal-title":"BMC Bioinformatics"},{"issue":"4","key":"2026080611222208600_bib41","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.stem.2007.07.005","article-title":"Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy","volume":"1","author":"Pronk","year":"2007","journal-title":"Cell Stem Cell"},{"issue":"7694","key":"2026080611222208600_bib42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nature25741","article-title":"Population snapshots predict early haematopoietic and erythroid hierarchies","volume":"555","author":"Tusi","year":"2018","journal-title":"Nature"},{"issue":"22","key":"2026080611222208600_bib43","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1182\/blood-2014-01-548305","article-title":"Global transcriptome analyses of human and murine terminal erythroid differentiation","volume":"123","author":"An","year":"2014","journal-title":"Blood"},{"issue":"4","key":"2026080611222208600_bib44","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/rth2.12129","article-title":"Genomics and transcriptomics of megakaryocytes and platelets: implications for health and disease","volume":"2","author":"Fisher","year":"2018","journal-title":"Res Pract Thromb Haemost"},{"issue":"14","key":"2026080611222208600_bib45","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1182\/blood.2021010697","article-title":"Single-cell analysis of ploidy and the transcriptome reveals functional and spatial divergency in murine megakaryopoiesis","volume":"138","author":"Sun","year":"2021","journal-title":"Blood"},{"key":"2026080611222208600_bib46","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exphem.2021.01.001","article-title":"Erythroid enucleation: a gateway into a \"bloody\" world","volume":"95","author":"Menon","year":"2021","journal-title":"Exp Hematol"},{"issue":"3","key":"2026080611222208600_bib47","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1182\/blood-2007-07-098996","article-title":"EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiation","volume":"112","author":"Bouilloux","year":"2008","journal-title":"Blood"},{"issue":"23","key":"2026080611222208600_bib48","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1182\/blood-2014-11-610519","article-title":"RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation","volume":"125","author":"Kuvardina","year":"2015","journal-title":"Blood"},{"issue":"24","key":"2026080611222208600_bib49","doi-asserted-by":"crossref","first-page":"8547","DOI":"10.1128\/MCB.00589-07","article-title":"Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis","volume":"27","author":"Siatecka","year":"2007","journal-title":"Mol Cell Biol"},{"issue":"W1","key":"2026080611222208600_bib50","doi-asserted-by":"crossref","first-page":"W212","DOI":"10.1093\/nar\/gkz446","article-title":"ChEA3: transcription factor enrichment analysis by orthogonal omics integration","volume":"47","author":"Keenan","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"7818","key":"2026080611222208600_bib51","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/s41586-020-2493-4","article-title":"Expanded encyclopaedias of DNA elements in the human and mouse genomes","volume":"583","author":"Moore","year":"2020","journal-title":"Nature"},{"issue":"24","key":"2026080611222208600_bib52","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1182\/blood.2019001553","article-title":"Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies","volume":"134","author":"Sasca","year":"2019","journal-title":"Blood"},{"issue":"6795","key":"2026080611222208600_bib53","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/35020086","article-title":"An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells","volume":"406","author":"Whyatt","year":"2000","journal-title":"Nature"},{"issue":"9","key":"2026080611222208600_bib54","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1002\/ajh.26247","article-title":"Comprehensive phenotyping of erythropoiesis in human bone marrow: evaluation of normal and ineffective erythropoiesis","volume":"96","author":"Yan","year":"2021","journal-title":"Am J Hematol"},{"issue":"8","key":"2026080611222208600_bib55","doi-asserted-by":"crossref","first-page":"114498","DOI":"10.1016\/j.celrep.2024.114498","article-title":"STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia","volume":"43","author":"Fischer","year":"2024","journal-title":"Cell Rep"},{"key":"2026080611222208600_bib56","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1038\/ncomms6901","article-title":"Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes","volume":"6","author":"Gerstung","year":"2015","journal-title":"Nat Commun"},{"issue":"19","key":"2026080611222208600_bib57","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1182\/blood.2019001234","article-title":"Chromatin occupancy and epigenetic analysis reveal new insights into the function of the GATA1 N terminus in erythropoiesis","volume":"134","author":"Ling","year":"2019","journal-title":"Blood"},{"issue":"13","key":"2026080611222208600_bib58","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1182\/bloodadvances.2022008124","article-title":"Gata1s mutant mice display persistent defects in the erythroid lineage","volume":"7","author":"Ling","year":"2023","journal-title":"Blood Adv"},{"issue":"11","key":"2026080611222208600_bib59","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/ng.2759","article-title":"The landscape of somatic mutations in Down syndrome-related myeloid disorders","volume":"45","author":"Yoshida","year":"2013","journal-title":"Nat Genet"},{"issue":"12","key":"2026080611222208600_bib60","doi-asserted-by":"crossref","first-page":"111830","DOI":"10.1016\/j.celrep.2022.111830","article-title":"EKLF\/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release","volume":"41","author":"Mukherjee","year":"2022","journal-title":"Cell Rep"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/148\/6\/767\/2536630\/blood_bld-2025-030554-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/148\/6\/767\/2536630\/blood_bld-2025-030554-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T15:22:54Z","timestamp":1786029774000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/148\/6\/767\/568191\/Stag2-dependent-chromatin-remodeling-enforces-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8,6]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2025030554","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8,6]]},"published":{"date-parts":[[2026,8,6]]}}}