{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:16:26Z","timestamp":1788452186531,"version":"build-2803163510"},"reference-count":47,"publisher":"American Society of Hematology","issue":"10","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>The distinctive milieu of the bone marrow (BM), known as the BM niche, supports hematopoietic stem cells (HSCs) and serves as a foundation for hematopoietic regeneration. Myeloablative stress disrupts not only hematopoietic stem and progenitor cells but also essential BM niche components, including endothelial cells (ECs) and mesenchymal stromal cells (MSCs); disruption of the latter impairs efficient hematopoietic recovery. However, therapeutic strategies targeting niche restoration remain largely underdeveloped. Here, we demonstrate that the Hippo pathway effectors YAP and TAZ are critical for enabling ECs and MSCs to respond to BM injury, and that YAP\/TAZ activation accelerates BM niche recovery, thereby promoting hematopoietic regeneration. We found that YAP and TAZ are rapidly activated in both MSCs and ECs after myeloablative stress, maintaining MSC multipotency and orchestrating vascular remodeling. Mechanistically, YAP and TAZ function as transcriptional hubs in MSCs, regulating key transcription factors such as Ebf1 and Ebf3. This regulation preserves MSC identity by preventing osteogenic and fibrogenic differentiation while promoting the expression of hematopoietic factors such as Cxcl12 and angiogenic factors. In addition, YAP\/TAZ signaling in MSCs and ECs appeared to coordinately remodel sinusoidal vessels after BM injury. These YAP\/TAZ-mediated niche responses are essential for HSC retention and hematopoietic regeneration after diverse myelosuppressive therapies. Notably, pharmacological activation of YAP\/TAZ enhances BM niche reorganization and augments hematopoietic regeneration after myeloablative therapies. These findings establish YAP\/TAZ as central regulators of BM niche resilience, providing a rationale for niche-targeted therapeutic strategies to enhance hematopoietic regeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2025030831","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:56:46Z","timestamp":1782147406000},"page":"1263-1276","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":0,"title":["Niche-targeted therapy via YAP\/TAZ activation enhances hematopoietic regeneration"],"prefix":"10.1182","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1520-6808","authenticated-orcid":false,"given":"Shun","family":"Uemura","sequence":"first","affiliation":[{"name":"1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9459-4329","authenticated-orcid":false,"given":"Masayuki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"},{"name":"2Division of Experimental Hematology, Department of Hematology, St. Jude Children\u2019s Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3879-7046","authenticated-orcid":false,"given":"Takako","family":"Yokomizo-Nakano","sequence":"additional","affiliation":[{"name":"1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Aihara","sequence":"additional","affiliation":[{"name":"3Biological Research Laboratories, Nissan Chemical Corporation, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-7675","authenticated-orcid":false,"given":"Takumi","family":"Iwawaki","sequence":"additional","affiliation":[{"name":"3Biological Research Laboratories, Nissan Chemical Corporation, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Koide","sequence":"additional","affiliation":[{"name":"1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaeko","family":"Nakajima-Takagi","sequence":"additional","affiliation":[{"name":"1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiko","family":"Oshima","sequence":"additional","affiliation":[{"name":"1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6212-0441","authenticated-orcid":false,"given":"Yoshiki","family":"Omatsu","sequence":"additional","affiliation":[{"name":"4Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan"},{"name":"5Graduate School of Medicine, Osaka University, Osaka, Japan"},{"name":"6World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4938-5728","authenticated-orcid":false,"given":"Yuki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"7Department of Anatomy, Keio University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6672-4122","authenticated-orcid":false,"given":"Yoshiaki","family":"Kubota","sequence":"additional","affiliation":[{"name":"7Department of Anatomy, Keio University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4014-2789","authenticated-orcid":false,"given":"Bahityar","family":"Rahmutulla","sequence":"additional","affiliation":[{"name":"8Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kaneda","sequence":"additional","affiliation":[{"name":"8Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan"},{"name":"9Health and Disease Omics Center, Chiba University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Nishio","sequence":"additional","affiliation":[{"name":"10Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-8808","authenticated-orcid":false,"given":"Akira","family":"Suzuki","sequence":"additional","affiliation":[{"name":"10Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nagasawa","sequence":"additional","affiliation":[{"name":"4Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan"},{"name":"5Graduate School of Medicine, Osaka University, Osaka, Japan"},{"name":"6World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Kagaya","sequence":"additional","affiliation":[{"name":"3Biological Research Laboratories, Nissan Chemical Corporation, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5298-4353","authenticated-orcid":false,"given":"Taito","family":"Nishino","sequence":"additional","affiliation":[{"name":"11Nissan Chemical Corporation Head Office, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9410-8992","authenticated-orcid":false,"given":"Atsushi","family":"Iwama","sequence":"additional","affiliation":[{"name":"1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"},{"name":"12Laboratory of Cellular and Molecular Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan"},{"name":"13The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"4","key":"2026090311215124900_bib1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2008.01.025","article-title":"Hematopoiesis: an evolving paradigm for stem cell biology","volume":"132","author":"Orkin","year":"2008","journal-title":"Cell"},{"issue":"7483","key":"2026090311215124900_bib2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12984","article-title":"The bone marrow niche for haematopoietic stem cells","volume":"505","author":"Morrison","year":"2014","journal-title":"Nature"},{"key":"2026090311215124900_bib3","doi-asserted-by":"crossref","first-page":"104817","DOI":"10.1016\/j.exphem.2025.104817","article-title":"Intra-bone marrow diversity of endothelial cells and its impact on hematopoietic stem cell development and maintenance","volume":"149","author":"Shimizu","year":"2025","journal-title":"Exp Hematol"},{"key":"2026090311215124900_bib4","doi-asserted-by":"crossref","first-page":"104749","DOI":"10.1016\/j.exphem.2025.104749","article-title":"Bone marrow niches for hematopoietic stem cells in homeostasis and aging","volume":"144","author":"Nakatani","year":"2025","journal-title":"Exp Hematol"},{"key":"2026090311215124900_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.exphem.2018.04.006","article-title":"Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells","volume":"63","author":"Si","year":"2018","journal-title":"Exp Hematol"},{"issue":"3","key":"2026090311215124900_bib6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.stem.2009.01.006","article-title":"Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells","volume":"4","author":"Hooper","year":"2009","journal-title":"Cell Stem Cell"},{"issue":"6","key":"2026090311215124900_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2019.10.006","article-title":"Apelin+ endothelial niche cells control hematopoiesis and mediate vascular regeneration after myeloablative injury","volume":"25","author":"Chen","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"1","key":"2026090311215124900_bib8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41556-019-0444-9","article-title":"Dynamic responses of the haematopoietic stem cell niche to diverse stresses","volume":"22","author":"Batsivari","year":"2020","journal-title":"Nat Cell Biol"},{"issue":"2","key":"2026090311215124900_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2017.07.004","article-title":"Long-term engraftment of primary bone marrow stromal cells repairs niche damage and improves hematopoietic stem cell transplantation","volume":"21","author":"Abbuehl","year":"2017","journal-title":"Cell Stem Cell"},{"issue":"4","key":"2026090311215124900_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2019.06.003","article-title":"Stress-induced changes in bone marrow stromal cell populations revealed through single-cell protein expression mapping","volume":"25","author":"Severe","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"4","key":"2026090311215124900_bib11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41580-018-0086-y","article-title":"Hippo\u2013YAP\/TAZ signalling in organ regeneration and regenerative medicine","volume":"20","author":"Moya","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"8","key":"2026090311215124900_bib12","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","article-title":"YAP\/TAZ upstream signals and downstream responses","volume":"20","author":"Totaro","year":"2018","journal-title":"Nat Cell Biol"},{"issue":"4","key":"2026090311215124900_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2020.01.006","article-title":"YAP regulates hematopoietic stem cell formation in response to the biomechanical forces of blood flow","volume":"52","author":"Lundin","year":"2020","journal-title":"Dev Cell"},{"issue":"2","key":"2026090311215124900_bib14","doi-asserted-by":"crossref","first-page":"e32013","DOI":"10.1371\/journal.pone.0032013","article-title":"Normal hematopoietic stem cell function in mice with enforced expression of the hippo signaling effector YAP1","volume":"7","author":"Jansson","year":"2012","journal-title":"PLoS ONE"},{"issue":"9","key":"2026090311215124900_bib15","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1038\/s41375-018-0111-3","article-title":"YAP and TAZ are dispensable for physiological and malignant haematopoiesis","volume":"32","author":"Donato","year":"2018","journal-title":"Leukemia"},{"key":"2026090311215124900_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.exphem.2019.11.002","article-title":"Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration","volume":"80","author":"Hao","year":"2019","journal-title":"Exp Hematol"},{"issue":"20","key":"2026090311215124900_bib17","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1182\/blood.2023023601","article-title":"YAP1 regulates thrombopoiesis by binding to MYH9 in immune thrombocytopenia","volume":"144","author":"Hu","year":"2024","journal-title":"Blood"},{"issue":"16","key":"2026090311215124900_bib18","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1182\/blood.2019004113","article-title":"Yap1-Scribble polarization is required for hematopoietic stem cell division and fate","volume":"136","author":"Althoff","year":"2020","journal-title":"Blood"},{"issue":"1","key":"2026090311215124900_bib19","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1038\/s41467-022-32970-1","article-title":"Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity","volume":"13","author":"Kim","year":"2022","journal-title":"Nat Commun"},{"issue":"5","key":"2026090311215124900_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2017.08.002","article-title":"YAP\/TAZ orchestrate VEGF signaling during developmental angiogenesis","volume":"42","author":"Wang","year":"2017","journal-title":"Dev Cell"},{"issue":"9","key":"2026090311215124900_bib21","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1172\/JCI93825","article-title":"YAP\/TAZ regulates sprouting angiogenesis and vascular barrier maturation","volume":"127","author":"Kim","year":"2017","journal-title":"J Clin Invest"},{"key":"2026090311215124900_bib22","doi-asserted-by":"crossref","first-page":"e50770","DOI":"10.7554\/eLife.50770","article-title":"YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells","volume":"9","author":"Sivaraj","year":"2020","journal-title":"eLife"},{"issue":"8","key":"2026090311215124900_bib23","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/s44161-024-00508-x","article-title":"Endothelial LATS2 is a suppressor of bone marrow fibrosis","volume":"3","author":"Sivaraj","year":"2024","journal-title":"Nat Cardiovasc Res"},{"issue":"4","key":"2026090311215124900_bib24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.stem.2023.03.005","article-title":"Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation","volume":"30","author":"Zhang","year":"2023","journal-title":"Cell Stem Cell"},{"issue":"7920","key":"2026090311215124900_bib25","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/s41586-022-04924-6","article-title":"YAP\/TAZ activity in stromal cells prevents ageing by controlling cGAS\u2013STING","volume":"607","author":"Sladitschek-Martens","year":"2022","journal-title":"Nature"},{"issue":"7599","key":"2026090311215124900_bib26","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature17624","article-title":"Distinct bone marrow blood vessels differentially regulate haematopoiesis","volume":"532","author":"Itkin","year":"2016","journal-title":"Nature"},{"issue":"1","key":"2026090311215124900_bib27","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1038\/s41467-021-27263-y","article-title":"Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution","volume":"12","author":"Termini","year":"2021","journal-title":"Nat Commun"},{"issue":"7382","key":"2026090311215124900_bib28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10783","article-title":"Endothelial and perivascular cells maintain haematopoietic stem cells","volume":"481","author":"Ding","year":"2012","journal-title":"Nature"},{"issue":"4","key":"2026090311215124900_bib29","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cell.2011.09.048","article-title":"The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells","volume":"147","author":"Cordenonsi","year":"2011","journal-title":"Cell"},{"issue":"7","key":"2026090311215124900_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.04.040","article-title":"A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia","volume":"177","author":"Baryawno","year":"2019","journal-title":"Cell"},{"issue":"5-6","key":"2026090311215124900_bib31","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1101\/gad.311068.117","article-title":"Stem cell niche-specific Ebf3 maintains the bone marrow cavity","volume":"32","author":"Seike","year":"2018","journal-title":"Genes Dev"},{"issue":"7440","key":"2026090311215124900_bib32","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nature11926","article-title":"CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance","volume":"495","author":"Greenbaum","year":"2013","journal-title":"Nature"},{"issue":"7440","key":"2026090311215124900_bib33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature11885","article-title":"Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches","volume":"495","author":"Ding","year":"2013","journal-title":"Nature"},{"key":"2026090311215124900_bib34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bbrc.2022.06.050","article-title":"YAP1\/TAZ activity maintains vascular integrity and organismal survival","volume":"619","author":"Uemura","year":"2022","journal-title":"Biochem Bioph Res Co"},{"issue":"23","key":"2026090311215124900_bib35","doi-asserted-by":"crossref","first-page":"dev195453","DOI":"10.1242\/dev.195453","article-title":"YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling","volume":"147","author":"Cha","year":"2020","journal-title":"Development"},{"issue":"3","key":"2026090311215124900_bib36","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41590-020-0595-7","article-title":"EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential","volume":"21","author":"Derecka","year":"2020","journal-title":"Nat Immunol"},{"issue":"1","key":"2026090311215124900_bib37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1101\/gad.948702","article-title":"C\/EBP\u03b1 induces adipogenesis through PPAR\u03b3: a unified pathway","volume":"16","author":"Rosen","year":"2002-01-01 2002","journal-title":"Genes Dev"},{"issue":"7497","key":"2026090311215124900_bib38","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/nature13071","article-title":"Foxc1 is a critical regulator of haematopoietic stem\/progenitor cell niche formation","volume":"508","author":"Omatsu","year":"2014","journal-title":"Nature"},{"issue":"4","key":"2026090311215124900_bib39","doi-asserted-by":"crossref","first-page":"101779","DOI":"10.1016\/j.jbc.2022.101779","article-title":"Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions","volume":"298","author":"Aihara","year":"2022","journal-title":"J Biol Chem"},{"issue":"1","key":"2026090311215124900_bib40","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.1038\/s41467-023-42047-2","article-title":"Ebf3+ niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells","volume":"14","author":"Nakatani","year":"2023","journal-title":"Nat Commun"},{"key":"2026090311215124900_bib41","first-page":"33","article-title":"Bone marrow niche, microenvironments critical for immune cell development","volume":"434","author":"Omatsu","year":"2022","journal-title":"Curr Top Microbiol Immunol"},{"key":"2026090311215124900_bib42","doi-asserted-by":"crossref","first-page":"e05521","DOI":"10.7554\/eLife.05521","article-title":"Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1","volume":"4","author":"Zhou","year":"2015","journal-title":"eLife"},{"issue":"16","key":"2026090311215124900_bib43","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1182\/blood.2020005699","article-title":"VEGF-C protects the integrity of bone marrow perivascular niche","volume":"136","author":"Fang","year":"2020","journal-title":"Blood"},{"key":"2026090311215124900_bib44","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1038\/s41556-023-01284-9","article-title":"Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor","volume":"25","author":"Gao","year":"2023","journal-title":"Nat Cell Biol"},{"issue":"4","key":"2026090311215124900_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2024.03.003","article-title":"NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo","volume":"31","author":"Namoto","year":"2024","journal-title":"Cell Stem Cell"},{"issue":"1","key":"2026090311215124900_bib46","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1038\/s41467-024-46531-1","article-title":"Expected and unexpected effects after systemic inhibition of Hippo transcriptional output in cancer","volume":"15","author":"Baroja","year":"2024","journal-title":"Nat Commun"},{"issue":"1","key":"2026090311215124900_bib47","first-page":"9","article-title":"YAP\/TAZ as master regulators in cancer: modulation, function and therapeutic approaches","volume":"4","author":"Piccolo","year":"2023","journal-title":"Nat Cancer"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/148\/10\/1263\/2541932\/blood_bld-2025-030831-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/148\/10\/1263\/2541932\/blood_bld-2025-030831-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:22:02Z","timestamp":1788448922000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/148\/10\/1263\/569276\/Niche-targeted-therapy-via-YAP-TAZ-activation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,9,3]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2025030831","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9,3]]},"published":{"date-parts":[[2026,9,3]]}}}