{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:21:51Z","timestamp":1793467311254,"version":"4.5.0"},"reference-count":25,"publisher":"American Society of Hematology","issue":"2","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,8]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>High-grade B-cell lymphoma with 11q aberration (HGBCL-11q) is a rare pediatric non-Hodgkin lymphoma. This study assessed outcome in 90 children with HGBCL-11q. With survival rates \u226595%, patients with HGBCL-11q and no predisposition are candidates for deescalated therapy in future prospective trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2025031086","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T20:05:09Z","timestamp":1761768309000},"page":"209-214","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":3,"title":["High-grade\/large B-cell lymphoma-11q has a very good prognosis in children and young people without a predisposition"],"prefix":"10.1182","volume":"147","author":[{"given":"Leila","family":"Ronceray","sequence":"first","affiliation":[{"name":"1Department of Pediatric Hematology and Oncology, St. Anna Children\u2019s Hospital, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minke H. W.","family":"Huibers","sequence":"additional","affiliation":[{"name":"2Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Reutter","sequence":"additional","affiliation":[{"name":"3Department of Pediatric Hematology and Oncology, Non-Hodgkin Lymphoma Berlin-Frankfurt-M\u00fcnster Study Center, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oussama","family":"Abla","sequence":"additional","affiliation":[{"name":"4Division of Hematology and Oncology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Andr\u00e9s","sequence":"additional","affiliation":[{"name":"5Department of Pediatric Hematology and Oncology, University Hospital La Fe of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Balagu\u00e9","sequence":"additional","affiliation":[{"name":"6Hematopathology Section, Department of Pathology, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4202-891X","authenticated-orcid":false,"given":"Monika","family":"Cs\u00f3ka","sequence":"additional","affiliation":[{"name":"7Pediatric Clinic (T\u0171zolt\u00f3 Street Department), Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6120-3527","authenticated-orcid":false,"given":"Gil","family":"Gilad","sequence":"additional","affiliation":[{"name":"8Department of Pediatric Hematology and Oncology, Schneider Children\u2019s Medical Center, Petah Tikva, Israel"},{"name":"9Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie M.","family":"Hagleitner","sequence":"additional","affiliation":[{"name":"2Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0634-6961","authenticated-orcid":false,"given":"Daiki","family":"Hori","sequence":"additional","affiliation":[{"name":"10Department of Hematology and Oncology for Children and Adolescents, Sapporo Hokuyu Hospital, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5186-3365","authenticated-orcid":false,"given":"Lisa L.","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"11Department of Pediatrics and Adolescent Medicine, University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janez","family":"Jazbec","sequence":"additional","affiliation":[{"name":"12Division of Pediatric Hematology and Oncology, University Medical Center Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Klapper","sequence":"additional","affiliation":[{"name":"13Hematopathology Section, Department of Pathology, University Hospital Schleswig-Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"14Department of Clinical Research, Saitama Children\u2019s Medical Center, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Verd\u00fa-Amor\u00f3s","sequence":"additional","affiliation":[{"name":"15Department of Pediatric Hematology and Oncology, Hospital Cl\u00ednico Universitario, Biomedical Research Institute, Instituto de Investigaci\u00f3n Sanitaria, Valencia, Valencia, Spain"},{"name":"16Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"von Mersi","sequence":"additional","affiliation":[{"name":"1Department of Pediatric Hematology and Oncology, St. Anna Children\u2019s Hospital, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"W\u00f6ssmann","sequence":"additional","affiliation":[{"name":"17Department of Pediatric Hematology and Oncology, Non-Hodgkin Lymphoma Berlin-Frankfurt-M\u00fcnster Study Center, Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-3798","authenticated-orcid":false,"given":"Ana C.","family":"Xavier","sequence":"additional","affiliation":[{"name":"18Division of Hematology and Oncology, Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-829X","authenticated-orcid":false,"given":"Birgit","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"3Department of Pediatric Hematology and Oncology, Non-Hodgkin Lymphoma Berlin-Frankfurt-M\u00fcnster Study Center, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2427-9822","authenticated-orcid":false,"given":"Itziar","family":"Salaverria","sequence":"additional","affiliation":[{"name":"19Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-6898","authenticated-orcid":false,"given":"Andishe","family":"Attarbaschi","sequence":"additional","affiliation":[{"name":"1Department of Pediatric Hematology and Oncology, St. Anna Children\u2019s Hospital, Medical University of Vienna, Vienna, Austria"},{"name":"20St. Anna Children\u2019s Cancer Research Institute, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"7","key":"2026010811215402300_bib1","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"issue":"27","key":"2026010811215402300_bib2","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1200\/JCO.24.00070","article-title":"Lymphoma classifications, how to develop a future unified taxonomy","volume":"42","author":"Campo","year":"2024","journal-title":"J Clin Oncol"},{"issue":"23","key":"2026010811215402300_bib3","doi-asserted-by":"crossref","first-page":"13213","DOI":"10.3390\/ijms252313213","article-title":"A diagnostic approach in large B-cell lymphomas according to the fifth World Health Organization and International Consensus Classifications and a practical algorithm in routine practice","volume":"25","author":"Zanelli","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2026010811215402300_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/his.15362","article-title":"Dedicated diagnostic approaches for mature B-cell non-Hodgkin lymphomas occurring in children, adolescents, and young adults","volume":"86","author":"Xavier","year":"2025","journal-title":"Histopathology"},{"issue":"3","key":"2026010811215402300_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00428-023-03590-x","article-title":"Emerging entities: high-grade\/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP\/SH Lymphoma Workshop","volume":"483","author":"Quintanilla-Martinez","year":"2023","journal-title":"Virchows Arch"},{"issue":"8","key":"2026010811215402300_bib6","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1182\/blood-2013-06-507996","article-title":"A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma","volume":"123","author":"Salaverria","year":"2014","journal-title":"Blood"},{"issue":"9","key":"2026010811215402300_bib7","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1182\/blood-2018-07-864025","article-title":"The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma","volume":"133","author":"Wagener","year":"2019","journal-title":"Blood"},{"issue":"1","key":"2026010811215402300_bib8","doi-asserted-by":"crossref","first-page":"e70021","DOI":"10.1002\/gcc.70021","article-title":"MicroRNA expression in high-grade B-cell lymphoma with 11q aberration","volume":"64","author":"Di Stefano","year":"2025","journal-title":"Genes Chromosomes Cancer"},{"issue":"5","key":"2026010811215402300_bib9","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/bjh.16578","article-title":"Experience with provisional WHO-entities large B-cell lymphoma with IRF4 -rearrangement and Burkitt-like lymphoma with 11q aberration in paediatric patients of the NHL-BFM group","volume":"190","author":"Au-Yeung","year":"2020","journal-title":"Br J Haematol"},{"issue":"9","key":"2026010811215402300_bib10","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.3324\/haematol.2018.207928","article-title":"Burkitt-like lymphoma with 11q aberration: a germinal center-derived lymphoma genetically unrelated to Burkitt lymphoma","volume":"104","author":"Gonzalez-Farre","year":"2019","journal-title":"Haematologica"},{"issue":"11","key":"2026010811215402300_bib11","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1182\/blood.2024024283","article-title":"ATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological malignancies","volume":"144","author":"Elitzur","year":"2024","journal-title":"Blood"},{"issue":"7","key":"2026010811215402300_bib12","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.3324\/haematol.2015.124305","article-title":"Post-transplant molecularly defined Burkitt lymphomas are frequently MYC-negative and characterized by the 11q-gain\/loss pattern","volume":"100","author":"Ferreiro","year":"2015","journal-title":"Haematologica"},{"issue":"9","key":"2026010811215402300_bib13","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1182\/blood-2019-01-894329","article-title":"A new Burkitt \u201clook-alike\u201d lymphoma","volume":"133","author":"Cairo","year":"2019","journal-title":"Blood"},{"issue":"6","key":"2026010811215402300_bib14","doi-asserted-by":"crossref","first-page":"810","DOI":"10.3324\/haematol.2014.121434","article-title":"Outcome of and prognostic factors for relapse in children and adolescents with mature B-cell lymphoma and leukemia treated in three consecutive prospective \u201cLymphomes Malins B\u201d protocols. A Soci\u00e9t\u00e9 Fran\u00e7aise des Cancers de l'Enfant study","volume":"100","author":"Jourdain","year":"2015","journal-title":"Haematologica"},{"issue":"23","key":"2026010811215402300_bib15","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1056\/NEJMoa1915315","article-title":"Rituximab for high-risk, mature B-cell non-Hodgkin\u2019s lymphoma in children","volume":"382","author":"Minard-Colin","year":"2020","journal-title":"N Engl J Med"},{"issue":"9","key":"2026010811215402300_bib16","doi-asserted-by":"crossref","first-page":"e27873","DOI":"10.1002\/pbc.27873","article-title":"Outcome of relapse in children and adolescents with B-cell non-Hodgkin lymphoma and mature acute leukemia: a report from the French LMB study","volume":"66","author":"Rigaud","year":"2019","journal-title":"Pediatr Blood Cancer"},{"issue":"18","key":"2026010811215402300_bib17","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1200\/JCO.2014.59.7203","article-title":"Revised international pediatric non-Hodgkin lymphoma staging system","volume":"33","author":"Rosolen","year":"2015","journal-title":"J Clin Oncol"},{"issue":"7","key":"2026010811215402300_bib18","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/pbc.24975","article-title":"Improved treatment results of children with B-cell non-Hodgkin lymphoma: a report from the Japanese Pediatric Leukemia\/Lymphoma Study Group B-NHL03 study","volume":"61","author":"Tsurusawa","year":"2014","journal-title":"Pediatr Blood Cancer"},{"issue":"3","key":"2026010811215402300_bib19","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1182\/blood-2004-03-0973","article-title":"The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95","volume":"105","author":"Woessmann","year":"2005","journal-title":"Blood"},{"issue":"3","key":"2026010811215402300_bib20","first-page":"332","article-title":"Classification, staging and end results of treatment of childhood non-Hodgkin's lymphomas: dissimilarities from lymphomas in adults","volume":"7","author":"Murphy","year":"1980","journal-title":"Semin Oncol"},{"issue":"6","key":"2026010811215402300_bib21","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3343\/alm.2021.41.6.593","article-title":"A case of Burkitt-like lymphoma with 11q aberration with HIV infection in East Asia and literature review","volume":"41","author":"Kim","year":"2021","journal-title":"Ann Lab Med"},{"issue":"12","key":"2026010811215402300_bib22","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.3324\/haematol.2016.147116","article-title":"Non-Hodgkin lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents","volume":"101","author":"Attarbaschi","year":"2016","journal-title":"Haematologica"},{"issue":"2","key":"2026010811215402300_bib23","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41375-020-0841-x","article-title":"Second malignant neoplasms after treatment of non-Hodgkin's lymphoma-a retrospective multinational study of 189 children and adolescents","volume":"35","author":"Attarbaschi","year":"2021","journal-title":"Leukemia"},{"issue":"8","key":"2026010811215402300_bib24","doi-asserted-by":"crossref","first-page":"e28416","DOI":"10.1002\/pbc.28416","article-title":"Rare non-Hodgkin lymphoma of childhood and adolescence: a consensus diagnostic and therapeutic approach to pediatric-type follicular lymphoma, marginal zone lymphoma, and nonanaplastic peripheral T-cell lymphoma","volume":"67","author":"Attarbaschi","year":"2020","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"2026010811215402300_bib25","doi-asserted-by":"crossref","first-page":"101440","DOI":"10.1016\/j.beha.2023.101440","article-title":"Diagnosis and management of rare paediatric non-Hodgkin lymphoma","volume":"36","author":"Xavier","year":"2023","journal-title":"Best Pract Res Clin Haematol"}],"updated-by":[{"DOI":"10.1182\/blood.2026033346","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000}}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/147\/2\/209\/2478720\/blood_bld-2025-031086-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/147\/2\/209\/2478720\/blood_bld-2025-031086-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:22:01Z","timestamp":1767889321000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/147\/2\/209\/547975\/High-grade-large-B-cell-lymphoma-11q-has-a-very"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,8]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2025031086","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1,8]]},"published":{"date-parts":[[2026,1,8]]}}}