{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T10:28:28Z","timestamp":1794565708592,"version":"4.9.1"},"reference-count":64,"publisher":"American Society of Hematology","issue":"17","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4,23]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Acute myeloid leukemia (AML) is a complex hematologic malignancy with multiple disease subgroups defined by somatic mutations and heterogeneous outcomes. Although genome-wide association studies (GWAS) have identified a small number of common genetic variants influencing AML risk, the heritable component of this disease outside of familial susceptibility remains largely undefined. Here, we perform a meta-analysis of 4 published GWAS plus 2 new GWAS, totaling 4710 AML cases and 12\u2009938 controls. We identify a new genome-wide significant risk locus for pan-AML at 2p23.3 (rs4665765; P = 1.35 \u00d7 10\u22128; EFR3B, POMC, DNMT3A, and DNAJC27), which also significantly associates with patient survival (P = 6.09 \u00d7 10\u22123). Our analysis also identifies 3 new genome-wide significant risk loci for disease subgroups, including AML with deletions of chromosome 5 and\/or 7 at 1q23.3 (rs12078864; P = 7.0 \u00d7 10\u221210; DUSP23) and cytogenetically complex AML at 2q33.3 (rs12988876; P = 3.28 \u00d7 10\u22128; PARD3B) and 2p21 (rs79918355; P = 1.60 \u00d7 10\u22129; EPCAM). We also investigated loci previously associated with the risk of clonal hematopoiesis (CH) or CH of indeterminate potential and identified several variants associated with the risk of AML. Our results further inform on AML etiology and demonstrate the existence of disease subgroup specific risk loci.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2025031266","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T21:43:29Z","timestamp":1769723009000},"page":"1958-1969","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":3,"title":["Common variation at 1q23.3, 2p23.3, 2q33.3, and 2p21 influences the risk of acute myeloid leukemia"],"prefix":"10.1182","volume":"147","author":[{"given":"Diyanath","family":"Ranasinghe","sequence":"first","affiliation":[{"name":"1Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9267-7988","authenticated-orcid":false,"given":"Wei-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"1Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3778-8634","authenticated-orcid":false,"given":"Sarah E.","family":"Fordham","sequence":"additional","affiliation":[{"name":"1Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6466-653X","authenticated-orcid":false,"given":"Abrar","family":"Alharbi","sequence":"additional","affiliation":[{"name":"1Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom"},{"name":"2Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Taibah University, Medina, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola J.","family":"Sunter","sequence":"additional","affiliation":[{"name":"1Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4252-493X","authenticated-orcid":false,"given":"Claire","family":"Elstob","sequence":"additional","affiliation":[{"name":"1Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed H.","family":"Nahari","sequence":"additional","affiliation":[{"name":"1Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom"},{"name":"3Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaobo","family":"Xu","sequence":"additional","affiliation":[{"name":"1Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Park","sequence":"additional","affiliation":[{"name":"1Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hungate","sequence":"additional","affiliation":[{"name":"4University of Chicago Comprehensive Cancer Center, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4973-3024","authenticated-orcid":false,"given":"Anne","family":"Quante","sequence":"additional","affiliation":[{"name":"5Institute of Human Genetics, Technical University of Munich, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Strauch","sequence":"additional","affiliation":[{"name":"6Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"},{"name":"7Chair of Genetic Epidemiology, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"8Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes Gutenberg University, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6986-9554","authenticated-orcid":false,"given":"Christian","family":"Gieger","sequence":"additional","affiliation":[{"name":"7Chair of Genetic Epidemiology, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Skol","sequence":"additional","affiliation":[{"name":"4University of Chicago Comprehensive Cancer Center, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thahira","family":"Rahman","sequence":"additional","affiliation":[{"name":"1Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Sucheston-Campbell","sequence":"additional","affiliation":[{"name":"9Karmanos Cancer Institute and Department of Oncology, Wayne State University School of Medicine, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3835-8855","authenticated-orcid":false,"given":"Theresa","family":"Hahn","sequence":"additional","affiliation":[{"name":"10Department of Cancer Prevention, Roswell Park Cancer Institute, Buffalo, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa I.","family":"Clay-Gilmour","sequence":"additional","affiliation":[{"name":"11Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail L.","family":"Jones","sequence":"additional","affiliation":[{"name":"12Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen J.","family":"Marr","sequence":"additional","affiliation":[{"name":"12Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham H.","family":"Jackson","sequence":"additional","affiliation":[{"name":"12Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Menne","sequence":"additional","affiliation":[{"name":"12Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6585-9586","authenticated-orcid":false,"given":"Matthew","family":"Collin","sequence":"additional","affiliation":[{"name":"12Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Ivey","sequence":"additional","affiliation":[{"name":"13Department of Pathology, Alfred Hospital, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Hills","sequence":"additional","affiliation":[{"name":"14Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan K.","family":"Burnett","sequence":"additional","affiliation":[{"name":"15Paul O\u2019Gorman Leukaemia Research 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Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Palm","sequence":"additional","affiliation":[{"name":"24West Midlands Regional Genetics Laboratory, Birmingham Women\u2019s Hospital, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Piechocki","sequence":"additional","affiliation":[{"name":"24West Midlands Regional Genetics Laboratory, Birmingham Women\u2019s Hospital, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Jeffries","sequence":"additional","affiliation":[{"name":"24West Midlands Regional Genetics Laboratory, Birmingham Women\u2019s Hospital, Birmingham, United 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Ser\u00e0gnoli,\u201d University of Bologna, Bologna, Italy"},{"name":"31Hematology Unit, Ospedale S. Maria delle Croci, University of Bologna, Ravenna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1025-4210","authenticated-orcid":false,"given":"Giovanni","family":"Martinelli","sequence":"additional","affiliation":[{"name":"30Institute of Hematology \u201cL. and A. Ser\u00e0gnoli,\u201d University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6309-0515","authenticated-orcid":false,"given":"Giovanni","family":"Marconi","sequence":"additional","affiliation":[{"name":"31Hematology Unit, Ospedale S. 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-4371","authenticated-orcid":false,"given":"Heinz","family":"Sill","sequence":"additional","affiliation":[{"name":"34Division of Hematology, Medical University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-4761","authenticated-orcid":false,"given":"Maria Teresa","family":"Voso","sequence":"additional","affiliation":[{"name":"35Dipartimento di Biomedicina e Prevenzione, Universit\u00e0 di Roma Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Dombret","sequence":"additional","affiliation":[{"name":"36H\u00f4pital Saint-Louis, Institut Universitaire d'H\u00e9matologie, Universit\u00e9 Paris Diderot, Paris, 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