{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:25:28Z","timestamp":1789442728864,"version":"build-2803163510"},"reference-count":51,"publisher":"American Society of Hematology","issue":"3","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7,16]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Despite great progress in understanding the genomic basis of immature T-cell acute lymphoblastic leukemia\/lymphoblastic lymphoma (T-ALL) and acute leukemias of ambiguous lineage, there are still cases that lack defining genetic markers, complicating risk stratification, and limiting targeted therapeutic options. Recent studies have shown that enhancer hijacking drives oncogene activation in approximately half of T-ALL cases, with the BCL11B (BCL11 transcription factor B) enhancer frequently involved. Here, we describe a subtype of leukemia with a distinct gene-expression signature, and immunophenotype characterized by positivity for immature (CD38), myeloid (CD13), T-lymphoid (cytoplasmic [c]CD3, CD7), and B-lymphoid markers (CD19, CD79a, CD10). This subtype is defined by the t(14;16)(q32;q24) translocation, which places the FOXF1 gene and its antisense long noncoding RNA gene FENDRR under the regulatory control of the BCL11B enhancer, leading to their ectopic transcriptional activation. Common concomitant genetic lesions are loss-of-function alterations of GATA3, CDKN2A\/CDKN2B deletion and activating JAK\/STAT and NOTCH1 pathway mutations. Patients were predominantly children and adolescents\/young adults and experienced poor treatment outcome. High-throughput drug screening of 176 compounds demonstrated efficacy of combined BCL2 apoptosis regulator family proteins and JAK\/STAT signaling inhibitors. Additionally, the clinical use of tyrosine kinase inhibitors in some of these patients showed therapeutic efficacy. Collectively, these findings identify BCL11B-enhancer\u2013mediated deregulation of FOXF1\/FENDRR as a hallmark of a subtype of high-risk lineage ambiguous leukemia that is potentially amenable to targeted therapeutic intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2025031402","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T01:54:06Z","timestamp":1772848446000},"page":"317-334","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":5,"title":["Deregulation of\n                    <i>FOXF1<\/i>\n                    \/\n                    <i>FENDRR<\/i>\n                    from t(14;16)(q32;q24) defines a subtype of high-risk lineage ambiguous leukemia"],"prefix":"10.1182","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5558-7967","authenticated-orcid":false,"given":"Danika","family":"Di Giacomo","sequence":"first","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"},{"name":"2Laboratory of Molecular Medicine, Centro di Ricerca Emato-Oncologico, Santa Maria della Misericordia Hospital and Department of Medicine and Surgery, University of Perugia, Perugia, Italy"},{"name":"3Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6128-9985","authenticated-orcid":false,"given":"Petri","family":"P\u00f6l\u00f6nen","sequence":"additional","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Bardelli","sequence":"additional","affiliation":[{"name":"2Laboratory of Molecular Medicine, Centro di Ricerca Emato-Oncologico, Santa Maria della Misericordia Hospital and Department of Medicine and Surgery, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2158-467X","authenticated-orcid":false,"given":"Shunsuke","family":"Kimura","sequence":"additional","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Pierini","sequence":"additional","affiliation":[{"name":"2Laboratory of Molecular Medicine, Centro di Ricerca Emato-Oncologico, Santa Maria della Misericordia Hospital and Department of Medicine and Surgery, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-3522","authenticated-orcid":false,"given":"Luca","family":"Pagliaro","sequence":"additional","affiliation":[{"name":"4Department of Medicine and Surgery, Translational Hematology and Chemogenomics, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Arniani","sequence":"additional","affiliation":[{"name":"2Laboratory of Molecular Medicine, Centro di Ricerca Emato-Oncologico, Santa Maria della Misericordia Hospital and Department of Medicine and Surgery, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchao","family":"Chang","sequence":"additional","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9930-8499","authenticated-orcid":false,"given":"Qingsong","family":"Gao","sequence":"additional","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2342-6349","authenticated-orcid":false,"given":"Lindsey E.","family":"Montefiori","sequence":"additional","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5083-8950","authenticated-orcid":false,"given":"Yiming","family":"Wu","sequence":"additional","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-3953","authenticated-orcid":false,"given":"Chun Shik","family":"Park","sequence":"additional","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2274-9966","authenticated-orcid":false,"given":"William C.","family":"Wright","sequence":"additional","affiliation":[{"name":"5Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4753-5063","authenticated-orcid":false,"given":"Federica","family":"Vento","sequence":"additional","affiliation":[{"name":"4Department of Medicine and Surgery, Translational Hematology and Chemogenomics, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimei","family":"Wei","sequence":"additional","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9553-4819","authenticated-orcid":false,"given":"Caterina","family":"Matteucci","sequence":"additional","affiliation":[{"name":"2Laboratory of Molecular Medicine, Centro di Ricerca Emato-Oncologico, Santa Maria della Misericordia Hospital and Department of Medicine and Surgery, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Lei","sequence":"additional","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7031-3430","authenticated-orcid":false,"given":"Wojciech","family":"Rosikiewicz","sequence":"additional","affiliation":[{"name":"6Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3167-4177","authenticated-orcid":false,"given":"Carlotta","family":"Nardelli","sequence":"additional","affiliation":[{"name":"2Laboratory of Molecular Medicine, Centro di Ricerca Emato-Oncologico, Santa Maria della Misericordia Hospital and Department of Medicine and Surgery, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5653-8307","authenticated-orcid":false,"given":"Anair Graciela","family":"Lema Fernandez","sequence":"additional","affiliation":[{"name":"2Laboratory of Molecular Medicine, Centro di Ricerca Emato-Oncologico, Santa Maria della Misericordia Hospital and Department of Medicine and Surgery, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Backhaus Wagner","sequence":"additional","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradyuamna","family":"Baviskar","sequence":"additional","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cerrano","sequence":"additional","affiliation":[{"name":"7S.C. Ematologia, Azienda Ospedaliera-Universitaria Citt\u00e0 della Salute e della Scienza-Presidio Molinette, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Leocin","sequence":"additional","affiliation":[{"name":"8Hematology Unit, Ospedale dell'Angelo, Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Manabe","sequence":"additional","affiliation":[{"name":"9Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Hirabayashi","sequence":"additional","affiliation":[{"name":"9Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Takita","sequence":"additional","affiliation":[{"name":"10Department of Pediatrics, Graduate School of Medicine Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-9568","authenticated-orcid":false,"given":"Daisuke","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"11Department of Pediatrics, St. Luke's International Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"11Department of Pediatrics, St. Luke's International Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9535-4183","authenticated-orcid":false,"given":"Antonio","family":"Macchiarulo","sequence":"additional","affiliation":[{"name":"12Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Xu","sequence":"additional","affiliation":[{"name":"13Graduate Group in Genomics and Computational Biology, Department of Internal Medicine, Stanford University, Stanford, CA"},{"name":"14Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7373-8987","authenticated-orcid":false,"given":"David T.","family":"Teachey","sequence":"additional","affiliation":[{"name":"15Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Roti","sequence":"additional","affiliation":[{"name":"4Department of Medicine and Surgery, Translational Hematology and Chemogenomics, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2008-1365","authenticated-orcid":false,"given":"Ilaria","family":"Iacobucci","sequence":"additional","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5854-9846","authenticated-orcid":false,"given":"Roberta","family":"La Starza","sequence":"additional","affiliation":[{"name":"2Laboratory of Molecular Medicine, Centro di Ricerca Emato-Oncologico, Santa Maria della Misericordia Hospital and Department of Medicine and Surgery, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1623-0148","authenticated-orcid":false,"given":"Cristina","family":"Mecucci","sequence":"additional","affiliation":[{"name":"2Laboratory of Molecular Medicine, Centro di Ricerca Emato-Oncologico, Santa Maria della Misericordia Hospital and Department of Medicine and Surgery, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1871-1850","authenticated-orcid":false,"given":"Charles G.","family":"Mullighan","sequence":"additional","affiliation":[{"name":"1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"},{"name":"16Center of Excellence for Leukemia Studies, St. Jude Children's Research Hospital, Memphis TN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2026071611215885900_bib1","volume-title":"Haematolymphoid Tumours","author":"Elder","year":"2024","edition":"5th ed"},{"issue":"2","key":"2026071611215885900_bib2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1470-2045(08)70314-0","article-title":"Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia","volume":"10","author":"Coustan-Smith","year":"2009","journal-title":"Lancet Oncol"},{"issue":"7380","key":"2026071611215885900_bib3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature10725","article-title":"The genetic basis of early T-cell precursor acute lymphoblastic leukaemia","volume":"481","author":"Zhang","year":"2012","journal-title":"Nature"},{"issue":"8027","key":"2026071611215885900_bib4","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/s41586-024-07807-0","article-title":"The genomic basis of childhood T-lineage acute lymphoblastic leukaemia","volume":"632","author":"Polonen","year":"2024","journal-title":"Nature"},{"issue":"7727","key":"2026071611215885900_bib5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41586-018-0436-0","article-title":"The genetic basis and cell of origin of mixed phenotype acute leukaemia","volume":"562","author":"Alexander","year":"2018","journal-title":"Nature"},{"issue":"3","key":"2026071611215885900_bib6","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1158\/2643-3230.BCD-21-0163","article-title":"ZNF384 fusion oncoproteins drive lineage aberrancy in acute leukemia","volume":"3","author":"Dickerson","year":"2022","journal-title":"Blood Cancer Discov"},{"issue":"9","key":"2026071611215885900_bib7","first-page":"773","article-title":"14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia","volume":"138","author":"Di Giacomo","year":"2021","journal-title":"Blood"},{"issue":"11","key":"2026071611215885900_bib8","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1158\/2159-8290.CD-21-0145","article-title":"Enhancer hijacking drives oncogenic BCL11B expression in lineage-ambiguous stem cell leukemia","volume":"11","author":"Montefiori","year":"2021","journal-title":"Cancer Discov"},{"issue":"8","key":"2026071611215885900_bib9","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/ng.3909","article-title":"The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia","volume":"49","author":"Liu","year":"2017","journal-title":"Nat Genet"},{"issue":"17","key":"2026071611215885900_bib10","first-page":"5329","article-title":"The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2)","volume":"63","author":"Nagel","year":"2003","journal-title":"Cancer Res"},{"issue":"4","key":"2026071611215885900_bib11","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1158\/0008-5472.CAN-06-2615","article-title":"Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1","volume":"67","author":"Nagel","year":"2007","journal-title":"Cancer Res"},{"issue":"9","key":"2026071611215885900_bib12","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/gcc.20348","article-title":"Transforming potential of the T-cell acute lymphoblastic leukemia-associated homeobox genes HOXA13, TLX1, and TLX3","volume":"45","author":"Su","year":"2006","journal-title":"Genes Chromosomes Cancer"},{"issue":"11","key":"2026071611215885900_bib13","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1038\/s41375-022-01671-5","article-title":"Chromothripsis is a frequent event and underlies typical genetic changes in early T-cell precursor lymphoblastic leukemia in adults","volume":"36","author":"Arniani","year":"2022","journal-title":"Leukemia"},{"issue":"1","key":"2026071611215885900_bib14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cell.2017.09.001","article-title":"Non-coding transcription instructs chromatin folding and compartmentalization to dictate enhancer-promoter communication and T cell fate","volume":"171","author":"Isoda","year":"2017","journal-title":"Cell"},{"issue":"6","key":"2026071611215885900_bib15","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1182\/blood-2012-08-447839","article-title":"A far downstream enhancer for murine Bcl11b controls its T-cell specific expression","volume":"122","author":"Li","year":"2013","journal-title":"Blood"},{"issue":"10","key":"2026071611215885900_bib16","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/s41590-020-0747-9","article-title":"Distinct and temporary-restricted epigenetic mechanisms regulate human alphabeta and gammadelta T cell development","volume":"21","author":"Roels","year":"2020","journal-title":"Nat Immunol"},{"issue":"1","key":"2026071611215885900_bib17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1600-065X.2010.00954.x","article-title":"From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation","volume":"238","author":"Hosoya","year":"2010","journal-title":"Immunol Rev"},{"key":"2026071611215885900_bib18","doi-asserted-by":"crossref","first-page":"11171","DOI":"10.1038\/ncomms11171","article-title":"GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate","volume":"7","author":"Van de Walle","year":"2016","journal-title":"Nat Commun"},{"issue":"1","key":"2026071611215885900_bib19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s43018-024-00863-5","article-title":"A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia","volume":"6","author":"Xu","year":"2025","journal-title":"Nat Cancer"},{"issue":"2","key":"2026071611215885900_bib20","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1158\/2159-8290.CD-17-0468","article-title":"FOXF1 defines the core-regulatory circuitry in gastrointestinal stromal tumor","volume":"8","author":"Ran","year":"2018","journal-title":"Cancer Discov"},{"issue":"6","key":"2026071611215885900_bib21","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/humu.24198","article-title":"Lung-specific distant enhancer cis regulates expression of FOXF1 and lncRNA FENDRR","volume":"42","author":"Szafranski","year":"2021","journal-title":"Hum Mutat"},{"key":"2026071611215885900_bib22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jbior.2018.09.012","article-title":"IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: an update","volume":"71","author":"Oliveira","year":"2019","journal-title":"Adv Biol Regul"},{"issue":"7","key":"2026071611215885900_bib23","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1182\/blood-2009-07-234963","article-title":"STAT5 requires the N-domain for suppression of miR15\/16, induction of bcl-2, and survival signaling in myeloproliferative disease","volume":"115","author":"Li","year":"2010","journal-title":"Blood"},{"key":"2026071611215885900_bib24","doi-asserted-by":"crossref","first-page":"750789","DOI":"10.3389\/fonc.2021.750789","article-title":"Early T-cell precursor acute lymphoblastic leukemia: diagnosis, updates in molecular pathogenesis, management, and novel therapies","volume":"11","author":"Sin","year":"2021","journal-title":"Front Oncol"},{"issue":"1","key":"2026071611215885900_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrc2986","article-title":"For better or for worse: the role of Pim oncogenes in tumorigenesis","volume":"11","author":"Nawijn","year":"2011","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"2026071611215885900_bib26","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1158\/2159-8290.CD-20-1465","article-title":"Venetoclax and navitoclax in combination with chemotherapy in patients with relapsed or refractory acute lymphoblastic leukemia and lymphoblastic lymphoma","volume":"11","author":"Pullarkat","year":"2021","journal-title":"Cancer Discov"},{"issue":"18","key":"2026071611215885900_bib27","doi-asserted-by":"crossref","first-page":"10957","DOI":"10.3390\/ijms231810957","article-title":"The emerging role of venetoclax-based treatments in acute lymphoblastic leukemia","volume":"23","author":"Aumann","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"11","key":"2026071611215885900_bib28","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1182\/blood-2014-06-580480","article-title":"Efficacy of JAK\/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia","volume":"125","author":"Maude","year":"2015","journal-title":"Blood"},{"issue":"23","key":"2026071611215885900_bib29","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1182\/blood.2025028566","article-title":"STAT1-mediated interferon signatures are associated with preclinical JAK inhibitor sensitivity in T-ALL","volume":"145","author":"Xu","year":"2025","journal-title":"Blood"},{"issue":"2","key":"2026071611215885900_bib30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2174\/1389202916666150122223252","article-title":"Genomic and epigenetic complexity of the FOXF1 locus in 16q24.1: implications for development and disease","volume":"16","author":"Dharmadhikari","year":"2015","journal-title":"Curr Genomics"},{"issue":"6","key":"2026071611215885900_bib31","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.gendis.2022.05.002","article-title":"Ultra-conserved non-coding sequences within the FOXF1 enhancer are critical for human lung development","volume":"9","author":"Szafranski","year":"2022","journal-title":"Genes Dis"},{"key":"2026071611215885900_bib32","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12881-015-0241-7","article-title":"A 16q deletion involving FOXF1 enhancer is associated to pulmonary capillary hemangiomatosis","volume":"16","author":"Dello Russo","year":"2015","journal-title":"BMC Med Genet"},{"issue":"2","key":"2026071611215885900_bib33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3390\/genes12020177","article-title":"Long non-coding RNA FENDRR: gene structure, expression, and biological relevance","volume":"12","author":"Szafranski","year":"2021","journal-title":"Genes (Basel)"},{"issue":"6","key":"2026071611215885900_bib34","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/humu.24198","article-title":"Lung-specific distant enhancer cis regulates expression of FOXF1 and lncRNA FENDRR","volume":"42","author":"Szafranski","year":"2021","journal-title":"Hum Mutat"},{"issue":"7","key":"2026071611215885900_bib35","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.4049\/jimmunol.1301663","article-title":"GATA-3 dose-dependent checkpoints in early T cell commitment","volume":"193","author":"Scripture-Adams","year":"2014","journal-title":"J Immunol"},{"issue":"17-18","key":"2026071611215885900_bib36","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1101\/gad.327163.119","article-title":"Programming for T-lymphocyte fates: modularity and mechanisms","volume":"33","author":"Rothenberg","year":"2019","journal-title":"Genes Dev"},{"issue":"1","key":"2026071611215885900_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4049\/jimmunol.2100366","article-title":"Realization of the T lineage program involves GATA-3 induction of Bcl11b and repression of Cdkn2b expression","volume":"209","author":"Thompson","year":"2022","journal-title":"J Immunol"},{"issue":"10","key":"2026071611215885900_bib38","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1182\/blood-2012-06-440065","article-title":"GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice","volume":"121","author":"Garcia-Ojeda","year":"2013","journal-title":"Blood"},{"issue":"25","key":"2026071611215885900_bib39","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1182\/blood-2014-05-574566","article-title":"ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia","volume":"124","author":"Peirs","year":"2014","journal-title":"Blood"},{"issue":"9","key":"2026071611215885900_bib40","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1158\/2159-8290.CD-14-0353","article-title":"Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199","volume":"4","author":"Chonghaile","year":"2014","journal-title":"Cancer Discov"},{"issue":"6","key":"2026071611215885900_bib41","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1182\/blood-2011-04-347849","article-title":"Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets","volume":"118","author":"Schoenwaelder","year":"2011","journal-title":"Blood"},{"issue":"9","key":"2026071611215885900_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10428194.2017.1283032","article-title":"Pathways and mechanisms of venetoclax resistance","volume":"58","author":"Bose","year":"2017","journal-title":"Leuk Lymphoma"},{"issue":"2","key":"2026071611215885900_bib43","doi-asserted-by":"crossref","first-page":"380","DOI":"10.20517\/cdr.2021.125","article-title":"Venetoclax resistance: mechanistic insights and future strategies","volume":"5","author":"Ong","year":"2022","journal-title":"Cancer Drug Resist"},{"issue":"3","key":"2026071611215885900_bib44","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1182\/blood.2024027117","article-title":"Efficacy of a novel BCL-xL degrader, DT2216, in preclinical models of JAK2-mutated post-MPN AML","volume":"146","author":"Wang","year":"2025","journal-title":"Blood"},{"issue":"1","key":"2026071611215885900_bib45","doi-asserted-by":"crossref","first-page":"100056","DOI":"10.1016\/j.bneo.2024.100056","article-title":"Addition of navitoclax to ruxolitinib for patients with myelofibrosis with progression or suboptimal response","volume":"2","author":"Pemmaraju","year":"2025","journal-title":"Blood Neoplasia"},{"issue":"16","key":"2026071611215885900_bib46","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1182\/bloodadvances.2022009596","article-title":"Pegaspargase-modified risk-oriented program for adult acute lymphoblastic leukemia: results of the GIMEMA LAL1913 trial","volume":"7","author":"Bassan","year":"2023","journal-title":"Blood Adv"},{"issue":"4","key":"2026071611215885900_bib47","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3324\/haematol.2009.014274","article-title":"Outcome after relapse of acute lymphoblastic leukemia in adult patients included in four consecutive risk-adapted trials by the PETHEMA Study Group","volume":"95","author":"Oriol","year":"2010","journal-title":"Haematologica"},{"issue":"6","key":"2026071611215885900_bib48","doi-asserted-by":"crossref","first-page":"e419","DOI":"10.1016\/S2352-3026(23)00072-8","article-title":"Nelarabine, intensive L-asparaginase, and protracted intrathecal therapy for newly diagnosed T-cell acute lymphoblastic leukaemia in children and young adults (ALL-T11): a nationwide, multicenter, phase 2 trial including randomisation in the very high-risk group","volume":"10","author":"Sato","year":"2023","journal-title":"Lancet Haematol"},{"issue":"suppl 1","key":"2026071611215885900_bib49","first-page":"S124","article-title":"Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia","volume":"83","author":"Pui","year":"2004","journal-title":"Ann Hematol"},{"issue":"4","key":"2026071611215885900_bib50","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/leu.2014.29","article-title":"Philadelphia chromosome-negative very high-risk acute lymphoblastic leukemia in children and adolescents: results from Children's Oncology Group Study AALL0031","volume":"28","author":"Schultz","year":"2014","journal-title":"Leukemia"},{"issue":"29","key":"2026071611215885900_bib51","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1200\/JCO.2018.77.7250","article-title":"Improved survival for children and young adults with T-lineage acute lymphoblastic leukemia: results from the Children's Oncology Group AALL0434 Methotrexate Randomization","volume":"36","author":"Winter","year":"2018","journal-title":"J Clin Oncol"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/doi\/10.1182\/blood.2025031402\/2533990\/blood_bld-2025-031402-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/doi\/10.1182\/blood.2025031402\/2533990\/blood_bld-2025-031402-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:22:10Z","timestamp":1784215330000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/148\/3\/317\/567001\/Deregulation-of-FOXF1-FENDRR-from-t-14-16-q32-q24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7,16]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2025031402","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7,16]]},"published":{"date-parts":[[2026,7,16]]}}}