{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:10:28Z","timestamp":1790302228416,"version":"4.1.0"},"reference-count":18,"publisher":"American Society of Hematology","issue":"5","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7,30]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Lymphodepleting preconditioning (LD) is essential for the efficacy of chimeric antigen receptor (CAR) T-cell therapy in hematologic malignancies. However, in the setting of autoimmune diseases (ADs), the contribution of LD for efficacy is unclear. Here, we report on the early safety, efficacy, and correlative data of the first 4 patients with pemphigus vulgaris (PV) who received resecabtagene autoleucel (rese-cel), a fully human CD19 CAR T-cell therapy, without LD in the RESET-PV trial, a substudy of the DesCAARTes trial. Following infusion, pemphigus disease area index scores improved significantly in all patients. A favorable safety profile was observed, with a single episode of grade 1 cytokine release syndrome. Immune effector cell\u2013associated neurotoxicity was not observed. Rese-cel expansion was similar in patients with PV compared with other rese-cel\u2013treated patients with AD who received LD. B-cell depletion was observed in all patients with PV, with 3 of 4 patients achieving B-cell aplasia. Elevations in serum B-cell activating factor (BAFF) level were observed, with 3 of 4 patients achieving levels within the lowest end of the range exhibited in rese-cel\u2013treated patients with AD who received LD. PV autoantibodies decreased in 2 of 4 patients. These preliminary data suggest that LD may be dispensable for humanized CAR T-cell efficacy in patients with AD. This trial was registered at www.clinicaltrials.gov as NCT04422912.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2025032093","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:01:52Z","timestamp":1779897712000},"page":"574-580","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":5,"title":["CD19 CAR T-cell therapy is feasible for patients with pemphigus vulgaris treated without lymphodepletion in the RESET-PV trial"],"prefix":"10.1182","volume":"148","author":[{"given":"Daniel","family":"Nunez","sequence":"first","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Stadanlick","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Furmanak","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav S.","family":"Choudhary","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallorie","family":"Werner","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Vorndran","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Hadi-Nezhad","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Thompson","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4606-6254","authenticated-orcid":false,"given":"Domenick","family":"Braccia","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8093-7500","authenticated-orcid":false,"given":"Alexandra","family":"Ellis","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Cicarelli","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Flanagan","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jazmean","family":"Williams","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Kobulsky","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Toreki","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Schreiber","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8119-7198","authenticated-orcid":false,"given":"Naomi","family":"Bass","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Impagliazzo","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quynh","family":"Lam","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8488-3194","authenticated-orcid":false,"given":"Arturo","family":"Dominguez","sequence":"additional","affiliation":[{"name":"2Department of Dermatology, University of Texas Southwestern, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1813-9812","authenticated-orcid":false,"given":"Farrukh","family":"Awan","sequence":"additional","affiliation":[{"name":"3Department of Hematology\/Oncology, University of Texas Southwestern, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6177-2472","authenticated-orcid":false,"given":"Xiaolong","family":"Zhou","sequence":"additional","affiliation":[{"name":"4Department of Dermatology, Northwestern University, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Brieva","sequence":"additional","affiliation":[{"name":"4Department of Dermatology, Northwestern University, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4640-0977","authenticated-orcid":false,"given":"Mehrdad","family":"Abedi","sequence":"additional","affiliation":[{"name":"5Division of Malignant Hematology\/Cellular Therapy and Transplantation, University of California, Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanual","family":"Maverakis","sequence":"additional","affiliation":[{"name":"6Department of Dermatology, University of California, Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-1520","authenticated-orcid":false,"given":"Kiren","family":"Kresa-Reahl","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Tummala","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chang","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolyn K.","family":"Binder","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenell","family":"Volkov","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0109-7997","authenticated-orcid":false,"given":"Samik","family":"Basu","sequence":"additional","affiliation":[{"name":"1Cabaletta Bio, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"10083","key":"2026073011322508700_bib1","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/S0140-6736(17)30070-3","article-title":"First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial","volume":"389","author":"Joly","year":"2017","journal-title":"Lancet"},{"issue":"2","key":"2026073011322508700_bib2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/bjd\/ljae107","article-title":"Beyond the skin: B cells in pemphigus vulgaris, tolerance and treatment","volume":"191","author":"Strandmoe","year":"2024","journal-title":"Br J Dermatol"},{"issue":"1","key":"2026073011322508700_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1136\/ard-2024-226142","article-title":"CD19-CAR T-cell therapy induces deep tissue depletion of B cells","volume":"84","author":"Tur","year":"2025","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"2026073011322508700_bib4","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1056\/NEJMoa2308917","article-title":"CD19 CAR T-cell therapy in autoimmune disease\u2013a case series with follow-up","volume":"390","author":"M\u00fcller","year":"2024","journal-title":"N Engl J Med"},{"issue":"6","key":"2026073011322508700_bib5","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.medj.2024.03.002","article-title":"CD19-targeted chimeric antigen receptor T cell therapy in two patients with multiple sclerosis","volume":"5","author":"Fischbach","year":"2024","journal-title":"Med"},{"key":"2026073011322508700_bib6","first-page":"5181","article-title":"6 months-follow up data of systemic sclerosis patients treated with CD 19 targeting CAR-T cells [abstract]","volume":"75","author":"Bergmann","year":"2023","journal-title":"Arthritis Rheumatol"},{"issue":"suppl 1","key":"2026073011322508700_bib7","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/annrheumdis-2023-eular.3842","article-title":"First evidence for efficacy of CAR T cell treatment in refractory antisynthetase syndrome [abstract]","volume":"82","author":"Taubmann","year":"2023","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"2026073011322508700_bib8","doi-asserted-by":"crossref","first-page":"201663","DOI":"10.1016\/j.omta.2025.201663","article-title":"Case study of resecabtagene autoleucel in a subject with diffuse cutaneous systemic sclerosis treated in the RESET-SSc trial","volume":"34","author":"Daniel","year":"2026","journal-title":"Mol Ther Adv"},{"issue":"11","key":"2026073011322508700_bib9","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1016\/j.ymthe.2024.09.009","article-title":"Case study of CD19 CAR T therapy in a subject with immune-mediate necrotizing myopathy treated in the RESET-Myositis phase I\/II trial","volume":"32","author":"Volkov","year":"2024","journal-title":"Mol Ther"},{"issue":"6","key":"2026073011322508700_bib10","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1172\/JCI126397","article-title":"B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma","volume":"129","author":"Cohen","year":"2019","journal-title":"J Clin Invest"},{"issue":"18","key":"2026073011322508700_bib11","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1182\/blood-2011-04-348540","article-title":"Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias","volume":"118","author":"Brentjens","year":"2011","journal-title":"Blood"},{"key":"2026073011322508700_bib12","doi-asserted-by":"crossref","first-page":"1303935","DOI":"10.3389\/fimmu.2023.1303935","article-title":"Lymphodepletion - an essential but undervalued part of the chimeric antigen receptor T-cell therapy cycle","volume":"14","author":"Lickefett","year":"2023","journal-title":"Front Immunol"},{"issue":"95","key":"2026073011322508700_bib13","doi-asserted-by":"crossref","first-page":"95ra73","DOI":"10.1126\/scitranslmed.3002842","article-title":"T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia","volume":"3","author":"Kalos","year":"2011","journal-title":"Sci Transl Med"},{"issue":"5","key":"2026073011322508700_bib14","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/bjd.19718","article-title":"Establishing cut-off values for mild, moderate and severe disease in patients with pemphigus using the Pemphigus Disease Area Index","volume":"184","author":"Krain","year":"2021","journal-title":"Br J Dermatol"},{"issue":"5","key":"2026073011322508700_bib15","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/bjd\/ljae283","article-title":"Establishing minimal clinically important differences for the Pemphigus Disease Area Index","volume":"191","author":"Tseng","year":"2024","journal-title":"Br J Dermatol"},{"key":"2026073011322508700_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.exphem.2020.07.003","article-title":"Analysis of IL-6 serum levels and CAR T cell-specific digital PCR in the context of cytokine release syndrome","volume":"88","author":"Pabst","year":"2020","journal-title":"Exp Hematol"},{"key":"2026073011322508700_bib17","doi-asserted-by":"crossref","first-page":"666022","DOI":"10.3389\/fimmu.2021.666022","article-title":"Modifications of the BAFF\/BAFF-receptor axis in patients with pemphigus treated with rituximab versus standard corticosteroid regimen","volume":"12","author":"Hebert","year":"2021","journal-title":"Front Immunol"},{"key":"2026073011322508700_bib18","doi-asserted-by":"crossref","first-page":"101104","DOI":"10.1016\/j.omtm.2023.08.023","article-title":"Cytokine and reactivity profiles in SLE patients following anti-CD19 CART therapy","volume":"31","author":"Nunez","year":"2023","journal-title":"Mol Ther Methods Clin Dev"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/148\/5\/574\/2535835\/blood_bld-2025-032093-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/148\/5\/574\/2535835\/blood_bld-2025-032093-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:32:37Z","timestamp":1785425557000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/148\/5\/574\/568726\/CD19-CAR-T-cell-therapy-is-feasible-for-patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,7,30]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2025032093","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7,30]]},"published":{"date-parts":[[2026,7,30]]}}}