{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:35:49Z","timestamp":1792121749793,"version":"4.4.0"},"reference-count":47,"publisher":"American Society of Hematology","issue":"16","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Granulopoiesis is a tightly regulated process encompassing the production, maturation, and release of neutrophils in the bone marrow, ensuring their optimal physiological contribution to host defense. The mechanisms that maintain balanced regulation of neutrophil effector functions during this process remain incompletely understood. In this study, we identified bone marrow\u2013resident erythroblasts as a key source of specialized proresolving mediators (SPMs) and also showed that they imprint neutrophil development and function. Maturing erythroblasts highly express the key SPM biosynthetic enzyme 12\/15-lipoxygenase (Alox15) and accordingly generate several SPMs, including n-3 docosapentaenoic acid\u2013derived resolvin D5 (RvD5n-3DPA). Conditional erythroblast-specific depletion of Alox15 decreased bone marrow SPM levels and caused altered neutrophil phenotypes, including augmented release of reactive oxygen species and neutrophil extracellular traps, as well as increased migration toward chemotactic stimuli. This was accompanied by increased neutrophil sequestration in peripheral organs and concomitant neutropenia. Mice with erythroblast-specific Alox15 depletion displayed impaired bacterial clearance in experimental peritonitis and increased severity in dextran sodium sulfate\u2013induced colitis. Aberrant neutrophil phenotypes were rectified by reconstitution with RvD5n-3DPA and were largely recapitulated by the specific depletion of the SPM receptor Gpr101 in bone marrow macrophages, but not in neutrophil precursors, suggesting that the involvement of the macrophage niche mediates the SPM effects on granulopoiesis. Thus, our findings establish a central role for erythroblasts and their SPM production in instructing granulopoiesis for balanced functional neutrophil responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2026033170","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T18:57:50Z","timestamp":1785265070000},"page":"2043-2058","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":1,"title":["Erythroblast-derived lipid mediators program neutrophil development and function"],"prefix":"10.1182","volume":"148","author":[{"given":"Duco S.","family":"Koenis","sequence":"first","affiliation":[{"name":"1William Harvey Research Institute, Barts and The London, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, United 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