{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:13:25Z","timestamp":1791252805563,"version":"4.1.0"},"reference-count":0,"publisher":"American Society of Hematology","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Light chain (AL) amyloidosis is a fatal plasma cell dyscrasia characterized by the overproduction of misfolded l or k immunoglobulin light chains (LCs) produced by clonal plasma cells, which aggregate into amyloid fibrils that deposit in tissues and cause progressive organ damage. While current anti-plasma cell therapies reduce the production of new amyloidogenic LCs, pre-existing fibrils persist and continue to drive organ damage. Amyloid-targeting monoclonal antibodies birtamimab and anselamimab were developed and tested for active AL amyloid clearance; however, they failed to meet the primary endpoint in Phase 3 trials, presumably due to insufficient binding affinity for l LC amyloid, which occurs in ~80% of patients. Here, we reported the development of 1F10, a novel high-affinity l subtype-specific amyloid-binding monoclonal antibody that does not cross-react with soluble native l or k LCs. 1F10 exhibits superior binding affinity to l AL amyloid fibrils and significantly enhances antibody-dependent phagocytosis (ADP) of l AL amyloid compared with birtamimab and anselamimab. Specific binding of 1F10 to l amyloid is confirmed by immunohistochemical staining of patient-derived tissue biopsies. Importantly, 1F10 demonstrates robust in vivo activity, significantly accelerating the resolution of l amyloid fibrils in an AL amyloidoma mouse model. Together, these findings establish 1F10 antibody as a promising subtype-specific immunotherapeutic candidate for targeting l LC amyloid, addressing a critical unmet need for the majority of patients with AL amyloidosis.<\/jats:p>","DOI":"10.1182\/blood.2026033437","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:08:58Z","timestamp":1785359338000},"update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":1,"title":["1F10, a \u03bb Light Chain Amyloid-Specific Monoclonal Antibody for Targeted Therapy of AL Amyloidosis"],"prefix":"10.1182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3894-722X","authenticated-orcid":false,"given":"Jing","family":"Fu","sequence":"first","affiliation":[{"name":"Columbia University Irving Medical Center, NEW YORK, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8042-5006","authenticated-orcid":false,"given":"Michael S","family":"Hughes","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavreel F","family":"Kalantarov","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center, NEW YORK, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Ma","sequence":"additional","affiliation":[{"name":"Columbia University, New york, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirong","family":"Li","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifen","family":"Liu","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center, NEW YORK, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Sekulic","sequence":"additional","affiliation":[{"name":"Columbia University medical center, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Markowitz","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center, NEW YORK, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0790-602X","authenticated-orcid":false,"given":"Tatiana","family":"Prokaeva","sequence":"additional","affiliation":[{"name":"Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6307-2445","authenticated-orcid":false,"given":"Vaishali","family":"Sanchorawala","sequence":"additional","affiliation":[{"name":"Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1507-2547","authenticated-orcid":false,"given":"Sorina Nicoleta","family":"Badelita","sequence":"additional","affiliation":[{"name":"Department of Hematology, Carol Davila University of Medicine and Pharmacy,Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7251-6079","authenticated-orcid":false,"given":"Daniel","family":"Coriu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy Carol Davila, Bucharest, Fundeni Clinical Institute, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus Y","family":"Mapara","sequence":"additional","affiliation":[{"name":"Columbia University, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1708-7344","authenticated-orcid":false,"given":"Suzanne","family":"Lentzsch","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2026,7,29]]},"container-title":["Blood Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/doi\/10.1182\/blood.2026033437\/2536297\/blood.2026033437.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/doi\/10.1182\/blood.2026033437\/2536297\/blood.2026033437.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:08:59Z","timestamp":1785359339000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/doi\/10.1182\/blood.2026033437\/569966\/1F10-a-Light-Chain-Amyloid-Specific-Monoclonal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1182\/blood.2026033437","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"article-number":"blood.2026033437"}}