{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:53:14Z","timestamp":1791391994714,"version":"4.3.3"},"reference-count":0,"publisher":"American Society of Hematology","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Single-cell-resolution PIGA sequencing showed that rare glycosylphosphatidylinositol-deficient cells in healthy individuals are polyclonal, comprising long-lived hematopoietic stem\/progenitor-derived clones and nonpersistent populations. Those in acquired aplastic anemia reflect the selective expansion of multipotent PIGA-mutant stem\/progenitor cells across myeloid and lymphoid lineages.<\/jats:p>","DOI":"10.1182\/blood.2026033685","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:08:26Z","timestamp":1791389306000},"update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":0,"title":["The origins of rare glycosylphosphatidylinositol-deficient cells in normal and immune-mediated hematopoiesis"],"prefix":"10.1182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4108-5245","authenticated-orcid":false,"given":"Yoshitaka","family":"Zaimoku","sequence":"first","affiliation":[{"name":"Kanazawa University Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4272-6862","authenticated-orcid":false,"given":"Dung Cao","family":"Tran","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Sciences, Kanazawa University, KANAZAWA, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Hosomichi","sequence":"additional","affiliation":[{"name":"Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Mizumaki","sequence":"additional","affiliation":[{"name":"Kanazawa University Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Kano","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miku","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9116-3363","authenticated-orcid":false,"given":"Eriko","family":"Morishita","sequence":"additional","affiliation":[{"name":"Kanazawa University, Kanazawa, Is, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7674-7368","authenticated-orcid":false,"given":"Tatsuya","family":"Imi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa-shi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3423-1523","authenticated-orcid":false,"given":"Kohei","family":"Hosokawa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa,Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Nannya","sequence":"additional","affiliation":[{"name":"The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7778-5374","authenticated-orcid":false,"given":"Seishi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3018-2098","authenticated-orcid":false,"given":"Hirohito","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Kanazawa University Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Kanazawa University Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9674-624X","authenticated-orcid":false,"given":"Shinji","family":"Nakao","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2026,10,7]]},"container-title":["Blood Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/doi\/10.1182\/blood.2026033685\/2594106\/blood.2026033685.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/doi\/10.1182\/blood.2026033685\/2594106\/blood.2026033685.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:08:26Z","timestamp":1791389306000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/doi\/10.1182\/blood.2026033685\/571413\/The-origins-of-rare-glycosylphosphatidylinositol"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1182\/blood.2026033685","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"article-number":"blood.2026033685"}}