{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T16:25:59Z","timestamp":1786638359991,"version":"build-2736575974"},"reference-count":60,"publisher":"American Society of Hematology","issue":"7","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8,13]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Polycomb repressive complex 1 (PRC1) and PRC2 regulate diverse developmental processes, including the fetal-to-adult switch in hemoglobin (Hb) production, a process whose reversal is a goal for the treatment of sickle cell disease and \u03b2-thalassemia. PRC inhibitors show promise for various disorders, but use is limited because of pleiotropic PRC activities. We explored whether fetal Hb (HbF) can be reactivated in adult erythroid cells by selective perturbations of PRC1 or PRC2 components without complete loss of PRC function. A high-density CRISPR\u2013CRISPR-associated protein 9 (Cas9) mutagenesis screen identified a region in EZH2 in which Cas9 induced exon 14 skipping (EZH2\u039414). EZH2\u039414, which lacks a portion of the CXC domain, relieves HbF repression while largely maintaining cellular fitness. EZH2\u039414 retains H3K27 methylation and repression of a PRC target gene subset. Experiments in cells derived from mice bearing human \u03b2-globin genes confirm that pathways mediating EZH2 control of HbF expression can function in a mouse model of HBG switching. These findings demonstrate that partial disruption of PRC can yield selective phenotypes, highlighting the therapeutic potential of targeting nonenzymatic domains within chromatin-modifying complexes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2026033804","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:20:18Z","timestamp":1780075218000},"page":"882-895","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":1,"title":["Dissecting polycomb complexes for enhanced fetal hemoglobin production"],"prefix":"10.1182","volume":"148","author":[{"given":"Paul J.","family":"Kaminski","sequence":"first","affiliation":[{"name":"1Division of Hematology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Min","sequence":"additional","affiliation":[{"name":"1Division of Hematology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Traxler","sequence":"additional","affiliation":[{"name":"2Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-9710","authenticated-orcid":false,"given":"Eugene","family":"Khandros","sequence":"additional","affiliation":[{"name":"1Division of Hematology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-4291","authenticated-orcid":false,"given":"Osheiza","family":"Abdulmalik","sequence":"additional","affiliation":[{"name":"1Division of Hematology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailey","family":"Godfrey","sequence":"additional","affiliation":[{"name":"1Division of Hematology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6594-0245","authenticated-orcid":false,"given":"Cheryl A.","family":"Keller","sequence":"additional","affiliation":[{"name":"3Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, State College, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-1074","authenticated-orcid":false,"given":"Belinda M.","family":"Giardine","sequence":"additional","affiliation":[{"name":"3Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, State College, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4084-7516","authenticated-orcid":false,"given":"Ross C.","family":"Hardison","sequence":"additional","affiliation":[{"name":"3Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, State College, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8427-6316","authenticated-orcid":false,"given":"Junwei","family":"Shi","sequence":"additional","affiliation":[{"name":"4Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd A.","family":"Blobel","sequence":"additional","affiliation":[{"name":"1Division of Hematology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"23","key":"2026081311214918700_bib1","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJM199406093302303","article-title":"Mortality in sickle cell disease -- life expectancy and risk factors for early death","volume":"330","author":"Platt","year":"1994","journal-title":"N Engl J Med Overseas Ed"},{"issue":"5","key":"2026081311214918700_bib2","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1073\/pnas.0711566105","article-title":"Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of-thalassemia","volume":"105","author":"Uda","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"2026081311214918700_bib3","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/ng2108","article-title":"A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15","volume":"39","author":"Menzel","year":"2007","journal-title":"Nat Genet"},{"issue":"18","key":"2026081311214918700_bib4","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1056\/NEJMoa2309676","article-title":"Exagamglogene autotemcel for severe sickle cell disease","volume":"390","author":"Frangoul","year":"2024","journal-title":"N Engl J Med"},{"issue":"4","key":"2026081311214918700_bib5","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/s41588-018-0085-0","article-title":"Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding","volume":"50","author":"Martyn","year":"2018","journal-title":"Nat Genet"},{"issue":"5909","key":"2026081311214918700_bib6","first-page":"1839","article-title":"Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A","volume":"322","author":"Sankaran","year":"2008","journal-title":"Science (1979)"},{"issue":"6270","key":"2026081311214918700_bib7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1126\/science.aad3312","article-title":"Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin","volume":"351","author":"Masuda","year":"2016","journal-title":"Science"},{"issue":"5","key":"2026081311214918700_bib8","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41588-021-00843-w","article-title":"ZNF410 represses fetal globin by singular control of CHD4","volume":"53","author":"Vinjamur","year":"2021","journal-title":"Nat Genet"},{"issue":"2","key":"2026081311214918700_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.molcel.2020.11.006","article-title":"ZNF410 uniquely activates the NuRD component CHD4 to silence fetal hemoglobin expression","volume":"81","author":"Lan","year":"2021","journal-title":"Mol Cell"},{"issue":"1","key":"2026081311214918700_bib10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0092-8674(83)90150-2","article-title":"DNA methylation and the regulation of globin gene expression","volume":"34","author":"Busslinger","year":"1983","journal-title":"Cell"},{"issue":"1","key":"2026081311214918700_bib11","doi-asserted-by":"crossref","first-page":"6919","DOI":"10.1038\/s41467-025-62177-z","article-title":"Removal of promoter CpG methylation by epigenome editing reverses HBG silencing","volume":"16","author":"Bell","year":"2025","journal-title":"Nat Commun"},{"issue":"13","key":"2026081311214918700_bib12","doi-asserted-by":"crossref","first-page":"gkaf637","DOI":"10.1093\/nar\/gkaf637","article-title":"Dissecting the epigenetic regulation of the fetal hemoglobin genes to unravel a novel therapeutic approach for \u03b2-hemoglobinopathies","volume":"53","author":"Amistadi","year":"2025","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"2026081311214918700_bib13","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.3324\/haematol.2018.210963","article-title":"Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human adult erythroid cells","volume":"104","author":"Yu","year":"2019","journal-title":"Haematologica"},{"issue":"16","key":"2026081311214918700_bib14","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.1073\/pnas.1303976110","article-title":"Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A","volume":"110","author":"Xu","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"22","key":"2026081311214918700_bib15","first-page":"2756","article-title":"Molecular basis of polycomb group protein-mediated fetal hemoglobin repression","volume":"141","author":"Qin","year":"2023","journal-title":"Blood"},{"issue":"7330","key":"2026081311214918700_bib16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nature09784","article-title":"The Polycomb complex PRC2 and its mark in life","volume":"469","author":"Margueron","year":"2011","journal-title":"Nature"},{"issue":"11","key":"2026081311214918700_bib17","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/s41576-022-00499-0","article-title":"Context-specific Polycomb mechanisms in development","volume":"23","author":"Kim","year":"2022","journal-title":"Nat Rev Genet"},{"issue":"6","key":"2026081311214918700_bib18","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.immuni.2004.11.004","article-title":"Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1","volume":"21","author":"Iwama","year":"2004","journal-title":"Immunity"},{"issue":"6","key":"2026081311214918700_bib19","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.stemcr.2015.05.003","article-title":"Bmi-1 regulates extensive erythroid self-renewal","volume":"4","author":"Kim","year":"2015","journal-title":"Stem Cell Rep"},{"issue":"1","key":"2026081311214918700_bib20","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1038\/s41467-025-62993-3","article-title":"BMI1 regulates human erythroid self-renewal through both gene repression and gene activation","volume":"16","author":"McGrath","year":"2025","journal-title":"Nat Commun"},{"issue":"6937","key":"2026081311214918700_bib21","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nature01587","article-title":"Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells","volume":"423","author":"Park","year":"2003","journal-title":"Nature"},{"issue":"1","key":"2026081311214918700_bib22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.stem.2013.10.001","article-title":"Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner","volume":"14","author":"Xie","year":"2014","journal-title":"Cell Stem Cell"},{"issue":"2","key":"2026081311214918700_bib23","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.molcel.2014.12.009","article-title":"Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions","volume":"57","author":"Xu","year":"2015","journal-title":"Mol Cell"},{"issue":"4","key":"2026081311214918700_bib24","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.devcel.2012.09.003","article-title":"Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis","volume":"23","author":"Xu","year":"2012","journal-title":"Dev Cell"},{"issue":"15","key":"2026081311214918700_bib25","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1101\/gad.16985411","article-title":"Polycomb eviction as a new distant enhancer function","volume":"25","author":"Vernimmen","year":"2011","journal-title":"Genes Dev"},{"issue":"9","key":"2026081311214918700_bib26","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1182\/blood-2008-06-161901","article-title":"The role of the polycomb complex in silencing \u03ac-globin gene expression in nonerythroid cells","volume":"112","author":"Garrick","year":"2008","journal-title":"Blood"},{"issue":"28","key":"2026081311214918700_bib27","doi-asserted-by":"crossref","first-page":"E5664","DOI":"10.1073\/pnas.1609552114","article-title":"IGF2BP1 overexpression causes fetal-like hemoglobin expression patterns in cultured human adult erythroblasts","volume":"114","author":"de Vasconcellos","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"2026081311214918700_bib28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41588-019-0568-7","article-title":"Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation","volume":"52","author":"Basak","year":"2020","journal-title":"Nat Genet"},{"issue":"6","key":"2026081311214918700_bib29","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1182\/blood-2012-12-472308","article-title":"LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo","volume":"122","author":"Lee","year":"2013","journal-title":"Blood"},{"issue":"suppl 1","key":"2026081311214918700_bib30","article-title":"Pociredir, a novel oral once-daily fetal hemoglobin inducer: results from the phase 1b pioneer study in adult participants with severe sickle cell disease and hydroxyurea intolerance or unresponsiveness [abstract]","volume":"146","author":"Alan","year":"2025","journal-title":"Blood"},{"issue":"24","key":"2026081311214918700_bib31","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1182\/blood.2020005301","article-title":"The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression","volume":"135","author":"Huang","year":"2020","journal-title":"Blood"},{"issue":"23","key":"2026081311214918700_bib32","doi-asserted-by":"crossref","first-page":"5956","DOI":"10.1182\/bloodadvances.2022007904","article-title":"Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression","volume":"6","author":"Wakabayashi","year":"2022","journal-title":"Blood Adv"},{"issue":"6","key":"2026081311214918700_bib33","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41588-022-01076-1","article-title":"Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells","volume":"54","author":"Qin","year":"2022","journal-title":"Nat Genet"},{"issue":"9","key":"2026081311214918700_bib34","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/s41588-022-01152-6","article-title":"HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription","volume":"54","author":"Huang","year":"2022","journal-title":"Nat Genet"},{"issue":"6399","key":"2026081311214918700_bib35","first-page":"285","article-title":"Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells","volume":"361","author":"Grevet","year":"2018","journal-title":"Science (1979)"},{"issue":"3","key":"2026081311214918700_bib36","doi-asserted-by":"crossref","first-page":"e59890","DOI":"10.1371\/journal.pone.0059890","article-title":"Establishment of immortalized human erythroid progenitor cell lines able to produce enucleated red blood cells","volume":"8","author":"Kurita","year":"2013","journal-title":"PLoS One"},{"key":"2026081311214918700_bib37","doi-asserted-by":"crossref","first-page":"e21856","DOI":"10.7554\/eLife.21856","article-title":"An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites","volume":"6","author":"Skene","year":"2017","journal-title":"Elife"},{"issue":"12","key":"2026081311214918700_bib38","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1186\/s13059-014-0554-4","article-title":"MAGeCK enables robust identification of essential genes from genome-scale CRISPR\/Cas9 knockout screens","volume":"15","author":"Li","year":"2014","journal-title":"Genome Biol"},{"issue":"1","key":"2026081311214918700_bib39","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s13059-018-1563-5","article-title":"CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis Jin-Soo Kim","volume":"19","author":"Schoonenberg","year":"2018","journal-title":"Genome Biol"},{"issue":"11","key":"2026081311214918700_bib40","doi-asserted-by":"crossref","first-page":"e0166438","DOI":"10.1371\/journal.pone.0166438","article-title":"An alternative approach to ChIP-Seq normalization enables detection of genome-wide changes in histone H3 lysine 27 trimethylation upon EZH2 inhibition","volume":"11","author":"Egan","year":"2016","journal-title":"PLoS One"},{"issue":"7381","key":"2026081311214918700_bib41","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature10730","article-title":"Differential oestrogen receptor binding is associated with clinical outcome in breast cancer","volume":"481","author":"Ross-Innes","year":"2012","journal-title":"Nature"},{"issue":"9","key":"2026081311214918700_bib42","first-page":"2487","article-title":"Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation","volume":"108","author":"Li","year":"2023","journal-title":"Haematologica"},{"issue":"2","key":"2026081311214918700_bib43","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cell.2014.09.014","article-title":"CRISPR-Cas9 knockin mice for genome editing and cancer modeling","volume":"159","author":"Platt","year":"2014","journal-title":"Cell"},{"issue":"4","key":"2026081311214918700_bib44","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1182\/blood-2006-02-004812","article-title":"Correction of sickle cell disease by homologous recombination in embryonic stem cells","volume":"108","author":"Wu","year":"2006","journal-title":"Blood"},{"issue":"1","key":"2026081311214918700_bib45","doi-asserted-by":"crossref","first-page":"101070","DOI":"10.1016\/j.xpro.2021.101070","article-title":"FACS and immunomagnetic isolation of early erythroid progenitor cells from mouse fetal liver","volume":"3","author":"Braun","year":"2022","journal-title":"STAR Protoc"},{"key":"2026081311214918700_bib46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-1-4939-7428-3_4","article-title":"Dissecting regulatory mechanisms using mouse fetal liver-derived erythroid cells","volume":"1698","author":"McIver","year":"2018","journal-title":"Methods Mol Biol"},{"issue":"17","key":"2026081311214918700_bib47","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1182\/blood.2025030137","article-title":"Optimized CRISPR-Cas12a genome-wide screen reveals PTPA phosphatase pathway in fetal hemoglobin silencing","volume":"147","author":"Traxler","year":"2026","journal-title":"Blood J"},{"issue":"6","key":"2026081311214918700_bib48","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1182\/blood.2025029429","article-title":"Highly discriminative globin gene activation by the noncanonical BAF chromatin remodeling complex","volume":"147","author":"Bagchi","year":"2026","journal-title":"Blood"},{"issue":"7","key":"2026081311214918700_bib49","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/s41588-019-0453-4","article-title":"Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis","volume":"51","author":"Sher","year":"2019","journal-title":"Nat Genet"},{"issue":"1","key":"2026081311214918700_bib50","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13072-018-0242-9","article-title":"EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation","volume":"11","author":"Mu","year":"2018","journal-title":"Epigenetics Chromatin"},{"issue":"1","key":"2026081311214918700_bib51","doi-asserted-by":"crossref","first-page":"69","DOI":"10.7150\/ijbs.28129","article-title":"Identification and functional characterization of a new splicing variant of EZH2 in the central nervous system","volume":"15","author":"Li","year":"2019","journal-title":"Int J Biol Sci"},{"issue":"4","key":"2026081311214918700_bib52","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nm.4293","article-title":"EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas","volume":"23","author":"Mohammad","year":"2017","journal-title":"Nat Med"},{"issue":"1","key":"2026081311214918700_bib53","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/s41467-019-09140-x","article-title":"H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2\/me3 and is essential for glioma tumorigenesis","volume":"10","author":"Harutyunyan","year":"2019","journal-title":"Nat Commun"},{"issue":"19-20","key":"2026081311214918700_bib54","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1101\/gad.328773.119","article-title":"Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma","volume":"33","author":"Lee","year":"2019","journal-title":"Genes Dev"},{"issue":"4","key":"2026081311214918700_bib55","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.molcel.2020.09.028","article-title":"H3 K27M and EZHIP impede H3K27-methylation spreading by inhibiting allosterically stimulated PRC2","volume":"80","author":"Jain","year":"2020","journal-title":"Mol Cell"},{"issue":"3","key":"2026081311214918700_bib56","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41594-018-0036-6","article-title":"Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2","volume":"25","author":"H\u00f8jfeldt","year":"2018","journal-title":"Nat Struct Mol Biol"},{"issue":"6","key":"2026081311214918700_bib57","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.molcel.2018.05.023","article-title":"Capturing the onset of PRC2-mediated repressive domain formation","volume":"70","author":"Oksuz","year":"2018","journal-title":"Mol Cell"},{"key":"2026081311214918700_bib58","article-title":"Mapping early PRC2 nucleation sites upon Suz12 reintroduction reveals features of de novo Polycomb recruitment","author":"Hern\u00e1ndez-Romero","year":"2  2025","journal-title":"bioRXiv"},{"issue":"11","key":"2026081311214918700_bib59","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1182\/bloodadvances.2021006802","article-title":"Identification of novel \u03b3-globin inducers among all potential erythroid druggable targets","volume":"6","author":"Yu","year":"2022","journal-title":"Blood Adv"},{"issue":"4","key":"2026081311214918700_bib60","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.ymthe.2025.02.032","article-title":"Antisense-mediated exon skipping targeting EZH2 suppresses tumor growth in a xenograft mouse model of hepatocellular carcinoma","volume":"33","author":"Bai","year":"2025","journal-title":"Mol Ther"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/148\/7\/882\/2537568\/blood_bld-2026-033804-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/148\/7\/882\/2537568\/blood_bld-2026-033804-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:21:56Z","timestamp":1786634516000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/148\/7\/882\/568802\/Dissecting-polycomb-complexes-for-enhanced-fetal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":60,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,8,13]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2026033804","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8,13]]},"published":{"date-parts":[[2026,8,13]]}}}