{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:16:57Z","timestamp":1788452217825,"version":"build-2803163510"},"reference-count":57,"publisher":"American Society of Hematology","issue":"10","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) is required for cancer cell proliferation, but whether PRMTs mediate resistance to therapy remains unclear. Here, we performed loss-of-function screens in venetoclax-resistant (VEN-R) acute myeloid leukemia (AML) patient-derived xenograft cells and found that PRMT9 plays a critical role in promoting VEN resistance. Specifically, VEN-R AML samples exhibited high levels of PRMT9, and PRMT9 inhibition resensitized AML cells to VEN treatment. In preclinical resistant models, genetic ablation of PRMT9 synergized with VEN to eradicate AML cells. Consistently, pharmacologic inhibition of PRMT9 combined with VEN produced similar effects in VEN-R AML mouse models. Mechanistically, PRMT9 ablation disrupted RNA splicing by inducing exon skipping in mRNA encoding ALG13, an uridine diphosphate (UDP)-N-acetylglucosaminyltransferase subunit, thereby downregulating expression of the VEN efflux transporter encoded by the adenosine triphosphate\u2013binding cassette subfamily C member 1 gene. PRMT9 inhibition also suppressed protein synthesis, leading to downregulation of short-lived oncoproteins such as MCL1. These findings establish a connection between PRMT9-mediated arginine methylation and poor VEN responsiveness and demonstrate that targeting PRMT9 may represent a viable strategy to overcome VEN resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2026034144","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:02:34Z","timestamp":1778605354000},"page":"1328-1343","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":2,"title":["Targeting PRMT9 overcomes venetoclax resistance in AML by modulating splicing and inhibiting translation"],"prefix":"10.1182","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9097-6089","authenticated-orcid":false,"given":"Yang","family":"Li","sequence":"first","affiliation":[{"name":"1Department of Hematology, Fujian Medical University Union Hospital, Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fuzhou, China"},{"name":"2Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope Medical Center, Duarte, CA"},{"name":"3Union Clinical Medical Colleges, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"He","sequence":"additional","affiliation":[{"name":"2Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"2Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Dong","sequence":"additional","affiliation":[{"name":"2Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-0234","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"4RNA Institute, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9595-1567","authenticated-orcid":false,"given":"Yuan","family":"Che","sequence":"additional","affiliation":[{"name":"5Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh Prasad","family":"Yadav","sequence":"additional","affiliation":[{"name":"2Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5040-4156","authenticated-orcid":false,"given":"Meng","family":"Liu","sequence":"additional","affiliation":[{"name":"2Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-0088","authenticated-orcid":false,"given":"Lianjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"2Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8271-6080","authenticated-orcid":false,"given":"Shuaishuai","family":"Ge","sequence":"additional","affiliation":[{"name":"2Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Wu","sequence":"additional","affiliation":[{"name":"2Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5917-2961","authenticated-orcid":false,"given":"Yu-Hsuan","family":"Fu","sequence":"additional","affiliation":[{"name":"2Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1929-3769","authenticated-orcid":false,"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"6Integrative Genomics Core, Beckman Research Institute, City of Hope Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2595-0419","authenticated-orcid":false,"given":"Ya-Huei","family":"Kuo","sequence":"additional","affiliation":[{"name":"2Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"4RNA Institute, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Marcucci","sequence":"additional","affiliation":[{"name":"2Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7428-8682","authenticated-orcid":false,"given":"Shaoyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Fujian Medical University Union Hospital, Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fuzhou, China"},{"name":"3Union Clinical Medical Colleges, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"2Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope Medical Center, Duarte, CA"},{"name":"7Department of Pediatrics, City of Hope Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"2","key":"2026090311220781800_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41408-021-00425-3","article-title":"Acute myeloid leukemia: current progress and future directions","volume":"11","author":"Kantarjian","year":"2021","journal-title":"Blood Cancer J"},{"issue":"9","key":"2026090311220781800_bib2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3390\/cancers10090340","article-title":"Autologous transplantation for older adults with AML","volume":"10","author":"Mueller","year":"2018","journal-title":"Cancers (Basel)"},{"issue":"8","key":"2026090311220781800_bib3","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/s43018-020-0103-x","article-title":"Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia","volume":"1","author":"Zhang","year":"2020","journal-title":"Nat Cancer"},{"issue":"7","key":"2026090311220781800_bib4","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1158\/2159-8290.CD-19-0125","article-title":"The TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition in AML cells","volume":"9","author":"Nechiporuk","year":"2019","journal-title":"Cancer Discov"},{"issue":"8","key":"2026090311220781800_bib5","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1182\/blood.2021012775","article-title":"Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL","volume":"139","author":"Blombery","year":"2022","journal-title":"Blood"},{"issue":"1","key":"2026090311220781800_bib6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1517\/14728222.2013.733001","article-title":"Targeting the Bcl-2 family for cancer therapy","volume":"17","author":"Thomas","year":"2013","journal-title":"Expert Opin Ther Targets"},{"issue":"1","key":"2026090311220781800_bib7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41392-021-00578-4","article-title":"FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3\/ITD acute leukemia cells through BIM activation","volume":"6","author":"Zhu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"2026090311220781800_bib8","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1182\/blood.2022016090","article-title":"Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia","volume":"141","author":"Moujalled","year":"2023","journal-title":"Blood"},{"issue":"1","key":"2026090311220781800_bib9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41408-024-01186-5","article-title":"What have we learned about TP53-mutated acute myeloid leukemia?","volume":"14","author":"Shahzad","year":"2024","journal-title":"Blood Cancer J"},{"issue":"2","key":"2026090311220781800_bib10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/ajh.27138","article-title":"Venetoclax and hypomethylating agent combination therapy in newly diagnosed acute myeloid leukemia: genotype signatures for response and survival among 301 consecutive patients","volume":"99","author":"Gangat","year":"2024","journal-title":"Am J Hematol"},{"key":"2026090311220781800_bib11","doi-asserted-by":"crossref","first-page":"894","DOI":"10.3389\/fonc.2020.00894","article-title":"Resistance-associated mutations in chronic lymphocytic leukemia patients treated with novel agents","volume":"10","author":"Sedlarikova","year":"2020","journal-title":"Front Oncol"},{"issue":"1","key":"2026090311220781800_bib12","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41467-018-03170-7","article-title":"Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia","volume":"9","author":"Herling","year":"2018","journal-title":"Nat Commun"},{"issue":"14","key":"2026090311220781800_bib13","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1080\/10428194.2024.2400228","article-title":"Homoharringtonine sensitized resistant acute myeloid leukemia cells to venetoclax-induced apoptosis","volume":"65","author":"Yin","year":"2024","journal-title":"Leuk Lymphoma"},{"issue":"19","key":"2026090311220781800_bib14","doi-asserted-by":"crossref","first-page":"e121438","DOI":"10.1172\/jci.insight.121438","article-title":"Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies","volume":"3","author":"Ten Hacken","year":"2018","journal-title":"JCI Insight"},{"issue":"1","key":"2026090311220781800_bib15","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ccell.2022.12.002","article-title":"Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia","volume":"41","author":"Wang","year":"2023","journal-title":"Cancer Cell"},{"issue":"13","key":"2026090311220781800_bib16","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.scib.2021.01.004","article-title":"A systematic survey of PRMT interactomes reveals the key roles of arginine methylation in the global control of RNA splicing and translation","volume":"66","author":"Wei","year":"2021","journal-title":"Sci Bull"},{"issue":"1","key":"2026090311220781800_bib17","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/s41467-017-01009-1","article-title":"Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation","volume":"8","author":"Infantino","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"2026090311220781800_bib18","first-page":"17","article-title":"PRMT2 interacts with splicing factors and regulates the alternative splicing of BCL-X","volume":"162","author":"Vhuiyan","year":"2017","journal-title":"J Biochem"},{"issue":"20","key":"2026090311220781800_bib19","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1182\/bloodadvances.2023009906","article-title":"PRMT5 inhibition drives therapeutic vulnerability to combination treatment with BCL-2 inhibition in mantle cell lymphoma","volume":"7","author":"Brown-Burke","year":"2023","journal-title":"Blood Adv"},{"issue":"7","key":"2026090311220781800_bib20","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1158\/2159-8290.CD-22-0601","article-title":"Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia","volume":"13","author":"Glytsou","year":"2023","journal-title":"Cancer Discov"},{"issue":"7","key":"2026090311220781800_bib21","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1158\/2159-8290.CD-19-0117","article-title":"Targeting mitochondrial structure sensitizes acute myeloid leukemia to venetoclax treatment","volume":"9","author":"Chen","year":"2019","journal-title":"Cancer Discov"},{"issue":"8","key":"2026090311220781800_bib22","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1038\/s41375-023-01951-8","article-title":"The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax\/azacitidine in acute myeloid leukemia","volume":"37","author":"Weidenauer","year":"2023","journal-title":"Leukemia"},{"issue":"4","key":"2026090311220781800_bib23","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1158\/2159-8290.CD-19-0710","article-title":"Monocytic subclones confer resistance to venetoclax-based therapy in patients with acute myeloid leukemia","volume":"10","author":"Pei","year":"2020","journal-title":"Cancer Discov"},{"issue":"674","key":"2026090311220781800_bib24","doi-asserted-by":"crossref","first-page":"eabo6891","DOI":"10.1126\/scitranslmed.abo6891","article-title":"The path to venetoclax resistance is paved with mutations, metabolism, and more","volume":"14","author":"Sullivan","year":"2022","journal-title":"Sci Transl Med"},{"issue":"5","key":"2026090311220781800_bib25","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.cell.2015.01.042","article-title":"Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy","volume":"160","author":"Montero","year":"2015","journal-title":"Cell"},{"issue":"4","key":"2026090311220781800_bib26","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s43018-024-00736-x","article-title":"Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity","volume":"5","author":"Dong","year":"2024","journal-title":"Nat Cancer"},{"issue":"9","key":"2026090311220781800_bib27","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1158\/2159-8290.CD-22-1297","article-title":"A novel type of monocytic leukemia stem cell revealed by the clinical use of venetoclax-based therapy","volume":"13","author":"Pei","year":"2023","journal-title":"Cancer Discov"},{"key":"2026090311220781800_bib28","doi-asserted-by":"crossref","first-page":"27696","DOI":"10.1038\/srep27696","article-title":"Targeting MCL-1\/BCL-XL forestalls the acquisition of resistance to ABT-199 in acute myeloid leukemia","volume":"6","author":"Lin","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"2026090311220781800_bib29","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ccell.2019.07.003","article-title":"Therapeutic targeting of RNA splicing catalysis through inhibition of protein arginine methylation","volume":"36","author":"Fong","year":"2019","journal-title":"Cancer Cell"},{"issue":"11","key":"2026090311220781800_bib30","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1158\/2159-8290.CD-13-0253","article-title":"Misregulation of pre-mRNA alternative splicing in cancer","volume":"3","author":"Zhang","year":"2013","journal-title":"Cancer Discov"},{"issue":"43","key":"2026090311220781800_bib31","doi-asserted-by":"crossref","first-page":"36254","DOI":"10.1074\/jbc.M507569200","article-title":"Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation","volume":"280","author":"Gao","year":"2005","journal-title":"J Biol Chem"},{"issue":"41","key":"2026090311220781800_bib32","doi-asserted-by":"crossref","first-page":"34500","DOI":"10.1074\/jbc.M506358200","article-title":"Biosynthesis of lipid-linked oligosaccharides in Saccharomyces cerevisiae: Alg13p and Alg14p form a complex required for the formation of GlcNAc(2)-PP-dolichol","volume":"280","author":"Bickel","year":"2005","journal-title":"J Biol Chem"},{"issue":"5","key":"2026090311220781800_bib33","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1091\/mbc.e07-10-1077","article-title":"Alg13p, the catalytic subunit of the endoplasmic reticulum UDP-GlcNAc glycosyltransferase, is a target for proteasomal degradation","volume":"19","author":"Averbeck","year":"2008","journal-title":"Mol Biol Cell"},{"issue":"47","key":"2026090311220781800_bib34","doi-asserted-by":"crossref","first-page":"32534","DOI":"10.1074\/jbc.M804060200","article-title":"Interaction between the C termini of Alg13 and Alg14 mediates formation of the active UDP-N-acetylglucosamine transferase complex","volume":"283","author":"Gao","year":"2008","journal-title":"J Biol Chem"},{"issue":"1","key":"2026090311220781800_bib35","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1038\/s41467-023-41229-2","article-title":"ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia","volume":"14","author":"Ebner","year":"2023","journal-title":"Nat Commun"},{"issue":"5","key":"2026090311220781800_bib36","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1158\/1541-7786.MCR-20-0973","article-title":"Selective ERBB2 and BCL2 inhibition is synergistic for mitochondrial-mediated apoptosis in MDS and AML cells","volume":"19","author":"Kam","year":"2021","journal-title":"Mol Cancer Res"},{"issue":"1","key":"2026090311220781800_bib37","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41375-022-01748-1","article-title":"Loss of bisecting GlcNAcylation on MCAM of bone marrow stoma determined pro-tumoral niche in MDS\/AML","volume":"37","author":"Feng","year":"2023","journal-title":"Leukemia"},{"issue":"11","key":"2026090311220781800_bib38","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1158\/2159-8290.CD-20-1378","article-title":"AXL inhibition in macrophages stimulates host-versus-leukemia immunity and eradicates na\u00efve and treatment-resistant leukemia","volume":"11","author":"Tirado-Gonzalez","year":"2021","journal-title":"Cancer Discov"},{"key":"2026090311220781800_bib39","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.freeradbiomed.2023.04.003","article-title":"Targeting ABCB6 with nitidine chloride inhibits PI3K\/AKT signaling pathway to promote ferroptosis in multiple myeloma","volume":"203","author":"Yin","year":"2023","journal-title":"Free Radic Biol Med"},{"issue":"9","key":"2026090311220781800_bib40","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.trecan.2019.07.005","article-title":"Emerging roles of GLI-similar Kr\u00fcppel-like zinc finger transcription factors in leukemia and other cancers","volume":"5","author":"Jetten","year":"2019","journal-title":"Trends Cancer"},{"issue":"6","key":"2026090311220781800_bib41","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.3390\/jcm9061703","article-title":"Unleashing the diagnostic, prognostic and therapeutic potential of the neuronostatin\/GPR107 system in prostate cancer","volume":"9","author":"S\u00e1ez-Mart\u00ednez","year":"2020","journal-title":"J Clin Med"},{"issue":"7","key":"2026090311220781800_bib42","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1016\/j.celrep.2018.04.071","article-title":"Sensory-neuropathy-causing mutations in ATL3 cause aberrant ER membrane tethering","volume":"23","author":"Krols","year":"2018","journal-title":"Cell Rep"},{"issue":"21","key":"2026090311220781800_bib43","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1158\/0008-5472.CAN-20-1357","article-title":"FAM46C and FNDC3A are multiple myeloma tumor suppressors that act in concert to impair clearing of protein aggregates and autophagy","volume":"80","author":"Manfrini","year":"2020","journal-title":"Cancer Res"},{"issue":"12","key":"2026090311220781800_bib44","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.stem.2024.09.008","article-title":"Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance","volume":"31","author":"Han","year":"2024","journal-title":"Cell Stem Cell"},{"issue":"12","key":"2026090311220781800_bib45","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1158\/2159-8290.CD-18-0140","article-title":"A novel MCL1 inhibitor combined with venetoclax rescues venetoclax-resistant acute myelogenous leukemia","volume":"8","author":"Ramsey","year":"2018","journal-title":"Cancer Discov"},{"issue":"7498","key":"2026090311220781800_bib46","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature13035","article-title":"Haematopoietic stem cells require a highly regulated protein synthesis rate","volume":"509","author":"Signer","year":"2014","journal-title":"Nature"},{"issue":"4","key":"2026090311220781800_bib47","doi-asserted-by":"crossref","first-page":"e1700492","DOI":"10.1002\/biot.201700492","article-title":"OPP labeling enables total protein synthesis quantification in CHO production cell lines at the single-cell level","volume":"13","author":"Nagelreiter","year":"2018","journal-title":"Biotechnol J"},{"issue":"10","key":"2026090311220781800_bib48","doi-asserted-by":"crossref","first-page":"e409","DOI":"10.1038\/cddis.2012.149","article-title":"Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor","volume":"3","author":"Lindqvist","year":"2012","journal-title":"Cell Death Dis"},{"issue":"2","key":"2026090311220781800_bib49","doi-asserted-by":"crossref","first-page":"58","DOI":"10.5732\/cjc.011.10329","article-title":"Multidrug resistance associated proteins in multidrug resistance","volume":"31","author":"Sodani","year":"2012","journal-title":"Chin J Cancer"},{"key":"2026090311220781800_bib50","doi-asserted-by":"crossref","first-page":"101016","DOI":"10.1016\/j.drup.2023.101016","article-title":"Promising role of protein arginine methyltransferases in overcoming anti-cancer drug resistance","volume":"72","author":"Zhu","year":"2024","journal-title":"Drug Resist Updat"},{"issue":"9","key":"2026090311220781800_bib51","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41568-021-00380-y","article-title":"The plasticity of mRNA translation during cancer progression and therapy resistance","volume":"21","author":"Fabbri","year":"2021","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"2026090311220781800_bib52","doi-asserted-by":"crossref","first-page":"5534","DOI":"10.1038\/s41598-018-23863-9","article-title":"Distinct metabolic features differentiating FLT3-ITD AML from FLT3-WT childhood acute myeloid leukemia","volume":"8","author":"Stockard","year":"2018","journal-title":"Sci Rep"},{"issue":"22","key":"2026090311220781800_bib53","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1158\/0008-5472.CAN-09-1653","article-title":"TP53 cancerous mutations exhibit selection for translation efficiency","volume":"69","author":"Waldman","year":"2009","journal-title":"Cancer Res"},{"issue":"359","key":"2026090311220781800_bib54","doi-asserted-by":"crossref","first-page":"359ra129","DOI":"10.1126\/scitranslmed.aaf3735","article-title":"Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia","volume":"8","author":"Lam","year":"2016","journal-title":"Sci Transl Med"},{"issue":"8","key":"2026090311220781800_bib55","doi-asserted-by":"crossref","first-page":"490","DOI":"10.21037\/atm-22-1459","article-title":"Synergistic efficacy of homoharringtonine and venetoclax on acute myeloid leukemia cells and the underlying mechanisms","volume":"10","author":"Yuan","year":"2022","journal-title":"Ann Transl Med"},{"issue":"12","key":"2026090311220781800_bib56","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.medj.2024.07.018","article-title":"Homoharringtonine synergizes with venetoclax in early T cell progenitor acute lymphoblastic leukemia: bench and bed","volume":"5","author":"Suo","year":"2024","journal-title":"Med"},{"issue":"7-8","key":"2026090311220781800_bib57","doi-asserted-by":"crossref","first-page":"151186","DOI":"10.1016\/j.ejcb.2021.151186","article-title":"Advances in understanding N-glycosylation structure, function, and regulation in health and disease","volume":"100","author":"Esmail","year":"2021","journal-title":"Eur J Cell Biol"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/148\/10\/1328\/2541995\/blood_bld-2026-034144-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/148\/10\/1328\/2541995\/blood_bld-2026-034144-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:22:17Z","timestamp":1788448937000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/148\/10\/1328\/568354\/Targeting-PRMT9-overcomes-venetoclax-resistance-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,9,3]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2026034144","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9,3]]},"published":{"date-parts":[[2026,9,3]]}}}