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We demonstrate the CYB5R3 T117S variant associates with reduced sGC stimulator riociguat efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/blood.2026034193","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:59:13Z","timestamp":1783537153000},"page":"1750-1753","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":0,"title":["The CYB5R3 T117S missense variant is associated with attenuated riociguat efficacy in sickle cell disease"],"prefix":"10.1182","volume":"148","author":[{"given":"Katherine C.","family":"Wood","sequence":"first","affiliation":[{"name":"1Department of Medicine, Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA"},{"name":"2Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, 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