{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:46:45Z","timestamp":1793713605998,"version":"4.6.1"},"reference-count":37,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myasthenia gravis (MG) is the leading paraneoplastic manifestation of thymomas and is probably related to the capacity of thymomas to mature and export potentially autoreactive T cells. Why some thymomas are MG associated (MG+) and others are not (MG\u2212) has been unclear. We addressed this question by comparing the percentages of intratumorous naive mature CD45RA+ thymocytes in 9 MG(+) and in 13 MG(\u2212) thymomas by fluorescence-activated cell sorting analysis. Our results show that intratumorous naive CD4 T cells were present in all MG(+) thymomas and in one MG(\u2212) thymoma with the development of MG only 2 months after surgery. By contrast, the percentage of naive CD4+ T cells was significantly reduced in all 13 MG(\u2212) thymomas (P\u2009&amp;lt;\u2009.0001). Alterations in intratumorous thymopoiesis were reflected by corresponding alterations of naive T-cell subset composition in the blood, in that only MG(\u2212) patients had significantly decreased levels (P\u2009=\u2009.02) of naive CD4+ T cells compared with age- and sex-matched control persons. We conclude that paraneoplastic MG is highly associated with the efficiency of thymomas to produce and export naive CD4+T cells. The acquisition of the CD45RA+ phenotype on CD4+ T cells during terminal intratumorous thymopoiesis is associated with the presence of MG in most thymoma patients.<\/jats:p>","DOI":"10.1182\/blood.v100.1.159","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T21:48:18Z","timestamp":1033508898000},"page":"159-166","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":107,"title":["Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4+ T cells in thymomas"],"prefix":"10.1182","volume":"100","author":[{"given":"Philipp","family":"Stro\u0308bel","sequence":"first","affiliation":[{"name":"From the Institute of Pathology, University of Wuerzburg; Department of Neurology, Universities of Wuerzburg, Mainz, and Regensburg; Department of Thoracic and Cardiac Surgery, Universities of Wuerzburg and Muenster, Germany; and Department of Microbiology and Immunology, University of Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Helmreich","sequence":"additional","affiliation":[{"name":"From the Institute of Pathology, University of Wuerzburg; Department of Neurology, Universities of Wuerzburg, Mainz, and Regensburg; Department of Thoracic and Cardiac Surgery, Universities of Wuerzburg and Muenster, Germany; and Department of Microbiology and Immunology, University of Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Menioudakis","sequence":"additional","affiliation":[{"name":"From the Institute of Pathology, University of Wuerzburg; Department of Neurology, Universities of Wuerzburg, Mainz, and Regensburg; Department of Thoracic and Cardiac Surgery, Universities of Wuerzburg and Muenster, Germany; and Department of Microbiology and Immunology, University of Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon R.","family":"Lewin","sequence":"additional","affiliation":[{"name":"From the Institute of Pathology, University of Wuerzburg; Department of Neurology, Universities of Wuerzburg, Mainz, and Regensburg; Department of Thoracic and Cardiac Surgery, Universities of Wuerzburg and Muenster, Germany; and Department of Microbiology and Immunology, University of Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ru\u0308diger","sequence":"additional","affiliation":[{"name":"From the Institute of Pathology, University of Wuerzburg; Department of Neurology, Universities of Wuerzburg, Mainz, and Regensburg; Department of Thoracic and Cardiac Surgery, Universities of Wuerzburg and Muenster, Germany; and Department of Microbiology and Immunology, University of Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bauer","sequence":"additional","affiliation":[{"name":"From the Institute of Pathology, University of Wuerzburg; Department of Neurology, Universities of Wuerzburg, Mainz, and Regensburg; Department of Thoracic and Cardiac Surgery, Universities of Wuerzburg and Muenster, Germany; and Department of Microbiology and Immunology, University of Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Hoffacker","sequence":"additional","affiliation":[{"name":"From the Institute of Pathology, University of Wuerzburg; Department of Neurology, Universities of Wuerzburg, Mainz, and Regensburg; Department of Thoracic and Cardiac Surgery, Universities of Wuerzburg and Muenster, Germany; and Department of Microbiology and Immunology, University of Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Gold","sequence":"additional","affiliation":[{"name":"From the Institute of Pathology, University of Wuerzburg; Department of Neurology, Universities of Wuerzburg, Mainz, and Regensburg; Department of Thoracic and Cardiac Surgery, Universities of Wuerzburg and Muenster, Germany; and Department of Microbiology and Immunology, University of Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfred","family":"Nix","sequence":"additional","affiliation":[{"name":"From the Institute of Pathology, University of Wuerzburg; Department of Neurology, Universities of Wuerzburg, Mainz, and Regensburg; Department of Thoracic and Cardiac Surgery, Universities of Wuerzburg and Muenster, Germany; and Department of Microbiology and Immunology, University of Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Schalke","sequence":"additional","affiliation":[{"name":"From the Institute of Pathology, University of Wuerzburg; Department of Neurology, Universities of Wuerzburg, Mainz, and Regensburg; Department of Thoracic and Cardiac Surgery, Universities of Wuerzburg and Muenster, Germany; and Department of Microbiology and Immunology, University of Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Elert","sequence":"additional","affiliation":[{"name":"From the Institute of Pathology, University of Wuerzburg; Department of Neurology, Universities of Wuerzburg, Mainz, and Regensburg; Department of Thoracic and Cardiac Surgery, Universities of Wuerzburg and Muenster, Germany; and Department of Microbiology and Immunology, University of Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Semik","sequence":"additional","affiliation":[{"name":"From the Institute of Pathology, University of Wuerzburg; Department of Neurology, Universities of Wuerzburg, Mainz, and Regensburg; Department of Thoracic and Cardiac Surgery, Universities of Wuerzburg and Muenster, Germany; and Department of Microbiology and Immunology, University of Melbourne, 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