{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T07:23:10Z","timestamp":1781940190866,"version":"3.54.5"},"reference-count":36,"publisher":"American Society of Hematology","issue":"9","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Optimal numbers of CD34+ cells to be reinfused in patients undergoing peripheral blood progenitor cell (PBPC) transplantation after high-dose chemotherapy are still unknown. Hematologic reconstitution of 168 transplantations performed in patients with lymphoproliferative diseases was analyzed according to the number of CD34+ cells reinfused. The number of days from PBPC reinfusion until neutrophil recovery (&gt;1.0 \u00d7 109\/L) and unsustained platelet recovery (&gt;50 \u00d7 109\/L) were analyzed in three groups defined by the number of CD34+ cells reinfused: a low group with less than or equal to 2.5 \u00d7 106 CD34+ cells\/kg, a high group with greater than 15 \u00d7 106 CD34+cells\/kg, and an intermediate group to which the former two groups were compared. The 22 low-group patients had a significantly delayed neutrophil (P &lt; .0001) and platelet recovery (P &lt; .0001). The 41 high-group patients experienced significantly shorter engraftment compared with the intermediate group with a median of 11 (range, 8 to 16) versus 12 (range, 7 to 17) days for neutrophil recovery (P = .003), and a median of 11 (range, 7 to 24) versus 14 (range, 8 to 180+) days for platelet recovery (P&lt; .0001). These patients required significantly less platelet transfusions (P = .002). In a multivariate analysis, the amount of CD34+ cells reinfused was the only variable showing significance for neutrophil and platelet recovery. High-group patients had a shorter hospital stay (P = .01) and tended to need fewer days of antibotic administration (P = .12). In conclusion, these results suggest that reinfusion of greater than 15 \u00d7 106 CD34+ cells\/kg after high-dose chemotherapy for lymphoproliferative diseases further shortens hematopoietic reconstitution, reduces platelet requirements, and may improve patients' quality of life.<\/jats:p>","DOI":"10.1182\/blood.v91.9.3148","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T04:36:40Z","timestamp":1571027800000},"page":"3148-3155","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":161,"title":["High CD34+ Cell Counts Decrease Hematologic Toxicity of Autologous Peripheral Blood Progenitor Cell Transplantation"],"prefix":"10.1182","volume":"91","author":[{"given":"Nicolas","family":"Ketterer","sequence":"first","affiliation":[{"name":"From the Service d'He\u0301matologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon and UPRES-JE 1879 \u201cHe\u0301mopathies Lympho\u0131\u0308des malignes\u201d, Universite\u0301 Claude Bernard, Pierre-Be\u0301nite; and Etablissement de Transfusion Sanguine de Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Salles","sequence":"additional","affiliation":[{"name":"From the Service d'He\u0301matologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon and UPRES-JE 1879 \u201cHe\u0301mopathies Lympho\u0131\u0308des malignes\u201d, Universite\u0301 Claude Bernard, Pierre-Be\u0301nite; and Etablissement de Transfusion Sanguine de Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Raba","sequence":"additional","affiliation":[{"name":"From the Service d'He\u0301matologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon and UPRES-JE 1879 \u201cHe\u0301mopathies Lympho\u0131\u0308des malignes\u201d, Universite\u0301 Claude Bernard, Pierre-Be\u0301nite; and Etablissement de Transfusion Sanguine de Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Espinouse","sequence":"additional","affiliation":[{"name":"From the Service d'He\u0301matologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon and UPRES-JE 1879 \u201cHe\u0301mopathies Lympho\u0131\u0308des malignes\u201d, Universite\u0301 Claude Bernard, Pierre-Be\u0301nite; and Etablissement de Transfusion Sanguine de Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Sonet","sequence":"additional","affiliation":[{"name":"From the Service d'He\u0301matologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon and UPRES-JE 1879 \u201cHe\u0301mopathies Lympho\u0131\u0308des malignes\u201d, Universite\u0301 Claude Bernard, Pierre-Be\u0301nite; and Etablissement de Transfusion Sanguine de Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Tremisi","sequence":"additional","affiliation":[{"name":"From the Service d'He\u0301matologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon and UPRES-JE 1879 \u201cHe\u0301mopathies Lympho\u0131\u0308des malignes\u201d, Universite\u0301 Claude Bernard, Pierre-Be\u0301nite; and Etablissement de Transfusion Sanguine de Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Dumontet","sequence":"additional","affiliation":[{"name":"From the Service d'He\u0301matologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon and UPRES-JE 1879 \u201cHe\u0301mopathies Lympho\u0131\u0308des malignes\u201d, Universite\u0301 Claude Bernard, Pierre-Be\u0301nite; and Etablissement de Transfusion Sanguine de Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Moullet","sequence":"additional","affiliation":[{"name":"From the Service d'He\u0301matologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon and UPRES-JE 1879 \u201cHe\u0301mopathies Lympho\u0131\u0308des malignes\u201d, Universite\u0301 Claude Bernard, Pierre-Be\u0301nite; and Etablissement de Transfusion Sanguine de Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assia","family":"Eljaafari-Corbin","sequence":"additional","affiliation":[{"name":"From the Service d'He\u0301matologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon and UPRES-JE 1879 \u201cHe\u0301mopathies Lympho\u0131\u0308des malignes\u201d, Universite\u0301 Claude Bernard, Pierre-Be\u0301nite; and Etablissement de Transfusion Sanguine de Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve-Marie","family":"Neidhardt-Berard","sequence":"additional","affiliation":[{"name":"From the Service d'He\u0301matologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon and UPRES-JE 1879 \u201cHe\u0301mopathies Lympho\u0131\u0308des malignes\u201d, Universite\u0301 Claude Bernard, Pierre-Be\u0301nite; and Etablissement de Transfusion Sanguine de Lyon, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadhela","family":"Bouafia","sequence":"additional","affiliation":[{"name":"From the Service d'He\u0301matologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon and UPRES-JE 1879 \u201cHe\u0301mopathies Lympho\u0131\u0308des malignes\u201d, Universite\u0301 Claude Bernard, Pierre-Be\u0301nite; and Etablissement de Transfusion Sanguine de Lyon, Lyon, 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