{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:28:24Z","timestamp":1791332904289,"version":"4.3.1"},"reference-count":40,"publisher":"American Society of Hematology","issue":"10","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Opportunistic infections frequently occur in patients with adult T-cell leukemia (ATL) and human T-cell leukemia virus type I (HTLV-I) carriers. However, the underlying mechanisms of such infections remain unknown. To clarify the mechanism of immunodeficiency in those infected with HTLV-I, this study analyzed the T-cell subsets in HTLV-I carriers and patients with HTLV-I\u2013associated myelopathy\/tropical spastic paraparesis and ATL using 3-color fluorescence with CD62L and CD45RA coexpression either with CD4+ or CD8+ T cells. The number of naive T lymphocytes was markedly suppressed in patients with ATL, particularly in those with acute form, compared with uninfected control individuals. The number of naive T cells was low in HTLV-I\u2013infected individuals under 50 years old compared with uninfected individuals, whereas the number of memory T lymphocytes was greater in HTLV-I\u2013infected individuals. Although the increase of memory T lymphocytes correlated with HTLV-I provirus loads, no relationship was found between naive T-cell counts and provirus loads. T-cell receptor rearrangement excision circles (TRECs), which are generated by DNA recombination during early T lymphopoiesis, were quantified to evaluate thymic function in HTLV-I\u2013infected individuals. TREC levels were lower in HTLV-I\u2013infected individuals than in uninfected individuals. In HTLV-I carriers less than 70 years old, an increase of Epstein-Barr virus DNA in peripheral blood mononuclear cells was observed in 6 of 16 (38%) examined, whereas it was detectable in only 1 of 11 uninfected controls. These results suggested that the low number of naive T lymphocytes was due to suppressed production of T lymphocytes in the thymus, which might account for immunodeficiency observed in HTLV-I\u2013infected individuals.<\/jats:p>","DOI":"10.1182\/blood.v97.10.3177","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:40Z","timestamp":1027774000000},"page":"3177-3183","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":135,"title":["Impaired production of naive T lymphocytes in human T-cell leukemia virus type I\u2013infected individuals: its implications in the immunodeficient state"],"prefix":"10.1182","volume":"97","author":[{"given":"Jun-ichirou","family":"Yasunaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsunori","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kisato","family":"Nosaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichiro","family":"Etoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadahiro","family":"Tamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Koga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Mita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Uchino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Mitsuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021221060294100_B1","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1073\/pnas.77.12.7415","article-title":"Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.","volume":"77","author":"Poiesz","year":"1980","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021221060294100_B2","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1073\/pnas.78.10.6476","article-title":"Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.","volume":"78","author":"Hinuma","year":"1981","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021221060294100_B3","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1073\/pnas.79.6.2031","article-title":"Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.","volume":"79","author":"Yoshida","year":"1982","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021221060294100_B4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/317395a0","article-title":"Human T-lymphotropic retroviruses.","volume":"317","author":"Wong-Staal","year":"1985","journal-title":"Nature."},{"key":"2020021221060294100_B5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(85)92734-5","article-title":"Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis.","volume":"ii","author":"Gessain","year":"1985","journal-title":"Lancet."},{"key":"2020021221060294100_B6","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0140-6736(86)91298-5","article-title":"HTLV-I associated myelopathy, a new clinical entity.","volume":"i","author":"Osame","year":"1986","journal-title":"Lancet."},{"key":"2020021221060294100_B7","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/0140-6736(90)92896-P","article-title":"Infective dermatitis of Jamaican children: a marker for HTLV-I infection.","volume":"336","author":"LaGrenade","year":"1990","journal-title":"Lancet."},{"key":"2020021221060294100_B8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1349-7006.1992.tb00092.x","article-title":"HTLV-I uveitis: a distinct clinical entity caused by HTLV-I.","volume":"83","author":"Mochizuki","year":"1992","journal-title":"Jpn J Cancer Res."},{"key":"2020021221060294100_B9","first-page":"73","article-title":"Adult T cell leukemia in Japan.","volume-title":"Topics in Hematology. 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