{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:05:47Z","timestamp":1791176747650,"version":"4.1.0"},"reference-count":56,"publisher":"American Society of Hematology","issue":"10","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Stem cell homing into the bone microenvironment is the first step in the initiation of marrow-derived blood cells. It is reported that human severe combined immunodeficient (SCID) repopulating cells home and accumulate rapidly, within a few hours, in the bone marrow and spleen of immunodeficient mice previously conditioned with total body irradiation. Primitive CD34+CD38\u2212\/lowCXCR4+ cells capable of engrafting primary and secondary recipient mice selectively homed to the bone marrow and spleen, whereas CD34\u2212CD38\u2212\/lowLin\u2212 cells were not detected. Moreover, whereas freshly isolated CD34+CD38+\/high cells did not home, in vivo stimulation with granulocyte colony-stimulating factor as part of the mobilization process, or in vitro stem cell factor stimulation for 2 to 4 days, potentiated the homing capabilities of cytokine-stimulated CD34+CD38+ cells. Homing of enriched human CD34+ cells was inhibited by pretreatment with anti-CXCR4 antibodies. Moreover, primitive CD34+CD38\u2212\/lowCXCR4+cells also homed in response to a gradient of human stromal cell-derived factor 1 (SDF-1), directly injected into the bone marrow or spleen of nonirradiated NOD\/SCID mice. Homing was also inhibited by pretreatment of CD34+ cells with antibodies for the major integrins VLA-4, VLA-5, and LFA-1. Pertussis toxin, an inhibitor of signals mediated by G\u03b1iproteins, inhibited SDF-1\u2013mediated in vitro transwell migration but not adhesion or in vivo homing of CD34+ cells. Homing of human CD34+ cells was also blocked by chelerythrine chloride, a broad-range protein kinase C inhibitor. This study reveals rapid and efficient homing to the murine bone marrow by primitive human CD34+CD38\u2212\/lowCXCR4+cells that is integrin mediated and depends on activation of the protein kinase C signal transduction pathway by SDF-1.<\/jats:p>","DOI":"10.1182\/blood.v97.10.3283","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:40Z","timestamp":1027774000000},"page":"3283-3291","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":259,"title":["Rapid and efficient homing of human CD34+CD38\u2212\/lowCXCR4+stem and progenitor cells to the bone marrow and spleen of NOD\/SCID and NOD\/SCID\/B2mnull mice"],"prefix":"10.1182","volume":"97","author":[{"given":"Orit","family":"Kollet","sequence":"first","affiliation":[{"name":"From the Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; Department of Internal Medicine, Meir Hospital, Kfar Saba, Israel; Department of Obstetrics and Gynecology and Danek Gertner Institute of Human Genetics, Sheba Medical Center Tel-Hashomer, and Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel; and Hadassah University Hospital, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asaf","family":"Spiegel","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; Department of Internal Medicine, Meir Hospital, Kfar Saba, Israel; Department of Obstetrics and Gynecology and Danek Gertner Institute of Human Genetics, Sheba Medical Center Tel-Hashomer, and Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel; and Hadassah University Hospital, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amnon","family":"Peled","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; Department of Internal Medicine, Meir Hospital, Kfar Saba, Israel; Department of Obstetrics and Gynecology and Danek Gertner Institute of Human Genetics, Sheba Medical Center Tel-Hashomer, and Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel; and Hadassah University Hospital, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Petit","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; Department of Internal Medicine, Meir Hospital, Kfar Saba, Israel; Department of Obstetrics and Gynecology and Danek Gertner Institute of Human Genetics, Sheba Medical Center Tel-Hashomer, and Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel; and Hadassah University Hospital, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Byk","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; Department of Internal Medicine, Meir Hospital, Kfar Saba, Israel; Department of Obstetrics and Gynecology and Danek Gertner Institute of Human Genetics, Sheba Medical Center Tel-Hashomer, and Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel; and Hadassah University Hospital, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Hershkoviz","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; Department of Internal Medicine, Meir Hospital, Kfar Saba, Israel; Department of Obstetrics and Gynecology and Danek Gertner Institute of Human Genetics, Sheba Medical Center Tel-Hashomer, and Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel; and Hadassah University Hospital, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Guetta","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; Department of Internal Medicine, Meir Hospital, Kfar Saba, Israel; Department of Obstetrics and Gynecology and Danek Gertner Institute of Human Genetics, Sheba Medical Center Tel-Hashomer, and Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel; and Hadassah University Hospital, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gad","family":"Barkai","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; Department of Internal Medicine, Meir Hospital, Kfar Saba, Israel; Department of Obstetrics and Gynecology and Danek Gertner Institute of Human Genetics, Sheba Medical Center Tel-Hashomer, and Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel; and Hadassah University Hospital, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon","family":"Nagler","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; Department of Internal Medicine, Meir Hospital, Kfar Saba, Israel; Department of Obstetrics and Gynecology and Danek Gertner Institute of Human Genetics, Sheba Medical Center Tel-Hashomer, and Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel; and Hadassah University Hospital, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsvee","family":"Lapidot","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; Department of Internal Medicine, Meir Hospital, Kfar Saba, Israel; Department of Obstetrics and Gynecology and Danek Gertner Institute of Human Genetics, Sheba Medical Center Tel-Hashomer, and Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel; and Hadassah University Hospital, Jerusalem, 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