{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:26:29Z","timestamp":1791116789741,"version":"4.1.0"},"reference-count":78,"publisher":"American Society of Hematology","issue":"11","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,6,1]]},"abstract":"<jats:p>Identification of cytogenetic abnormalities is an important clue for the elucidation of carcinogenesis. However, the cytogenetic and clinical significance of adult T-cell leukemia\/lymphoma (ATLL) is still unclear. To address this point, cytogenetic findings in 50 cases of ATLL were correlated with clinical characteristics. Karyotypes showed a high degree of diversity and complexity. Aneuploidy and multiple breaks (at least 6) were observed frequently in acute and lymphoma subtypes of ATLL. Breakpoints tended to cluster at specific chromosomal regions, although characteristic cytogenetic subgroups of abnormalities were not found. Of these, aberrations of chromosomes 1p, 1q, 1q10-21, 10p, 10p13, 12q, 14q, and 14q32 correlated with one or more of the following clinical features: hepatosplenomegaly, elevated lactate dehydrogenase, hypercalcemia, and unusual immunophenotype, all indicators of clinical severity of ATLL. Multiple breaks (at least 6); abnormalities of chromosomes 1p, 1p22, 1q, 1q10-21, 2q, 3q, 3q10-12, 3q21, 14q, 14q32, and 17q; and partial loss of chromosomes 2q, 9p, 14p, 14q, and 17q regions correlated with shorter survival. These cytogenetic findings are relevant in predicting clinical outcome and provide useful information to identify chromosomal regions responsible for leukemogenesis. This study also indicates that one model of an oncogenic mechanism, activation of a proto-oncogene by translocation of a T-cell\u2013receptor gene, may not be applicable to the main pathway of development of ATLL and that a multistep process of leukemogenesis is required for the development of ATLL.<\/jats:p>","DOI":"10.1182\/blood.v97.11.3612","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:47Z","timestamp":1027774007000},"page":"3612-3620","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":86,"title":["Cytogenetic analysis and clinical significance in adult T-cell leukemia\/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki"],"prefix":"10.1182","volume":"97","author":[{"given":"Takahiro","family":"Itoyama","sequence":"first","affiliation":[{"name":"From the Laboratory of Cancer Genetics, Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY; the Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan; the Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan; the First Department of Pathology, Fukuoka University School of Medicine, Japan; and the Department of Nursing, Siebold University of Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S. K.","family":"Chaganti","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cancer Genetics, Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY; the Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan; the Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan; the First Department of Pathology, Fukuoka University School of Medicine, Japan; and the Department of Nursing, Siebold University of Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Yamada","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cancer Genetics, Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY; the Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan; the Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan; the First Department of Pathology, Fukuoka University School of Medicine, Japan; and the Department of Nursing, Siebold University of Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Tsukasaki","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cancer Genetics, Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY; the Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan; the Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan; the First Department of Pathology, Fukuoka University School of Medicine, Japan; and the Department of Nursing, Siebold University of Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunao","family":"Atogami","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cancer Genetics, Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY; the Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan; the Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan; the First Department of Pathology, Fukuoka University School of Medicine, Japan; and the Department of Nursing, Siebold University of Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cancer Genetics, Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY; the Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan; the Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan; the First Department of Pathology, Fukuoka University School of Medicine, Japan; and the Department of Nursing, Siebold University of Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Tomonaga","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cancer Genetics, Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY; the Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan; the Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan; the First Department of Pathology, Fukuoka University School of Medicine, Japan; and the Department of Nursing, Siebold University of Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cancer Genetics, Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY; the Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan; the Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan; the First Department of Pathology, Fukuoka University School of Medicine, Japan; and the Department of Nursing, Siebold University of Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cancer Genetics, Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY; the Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan; the Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan; the First Department of Pathology, Fukuoka University School of Medicine, Japan; and the Department of Nursing, Siebold University of Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Sadamori","sequence":"additional","affiliation":[{"name":"From the Laboratory of Cancer Genetics, Cell Biology Program, 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