{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:27:17Z","timestamp":1792459637472,"version":"4.5.0"},"reference-count":40,"publisher":"American Society of Hematology","issue":"12","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,6,15]]},"abstract":"<jats:p>In this study, cord blood CD34+ cells expressed CD81, a member of the transmembrane 4 superfamily, and were classified into 3 subpopulations on the basis of their expression levels: CD34+CD81+, CD34lowCD81+, and CD34+CD81high. The lymphohematopoietic activity of each subpopulation was then examined by using suspension and clonogenic cultures for hematopoietic potential, coculture with MS-5 cells for B-cell potential, organ cultures of thymus lobes from nonobese diabetic\/severe combined immunodeficiency disease (NOD\/SCID) fetal mice, coculture with stromal cells derived from NOD\/SCID fetal-mouse liver tissue for natural killer (NK) cell and mast cell potentials, and xenotransplantation into NOD\/SCID mice for long-term repopulating (LTR) ability. CD34+CD81+ cells represented a heterogeneous population that had all the lymphohematopoietic activities, including NOD\/SCID mouse-repopulating ability. CD34lowCD81+ cells were enriched in erythroid, megakaryocytic, and NK lineage potentials but had lost T-cell and B-cell potentials and LTR ability. The CD34+CD81high fraction was depleted of most lymphohematopoietic potentials except NK cell and mast cell potentials. Thus, along the differentiation cascade from CD34+CD81+ lymphohematopoietic stem cells, an up-regulation of CD81 or a down-regulation of CD34 results in a change in lymphohematopoietic properties. CD81 may serve as a marker for defining developmental stages of lymphohematopoietic stem cells.<\/jats:p>","DOI":"10.1182\/blood.v97.12.3755","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:47Z","timestamp":1027774007000},"page":"3755-3762","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":22,"title":["Development of human lymphohematopoietic stem and progenitor cells defined by expression of CD34 and CD81"],"prefix":"10.1182","volume":"97","author":[{"given":"Feng","family":"Ma","sequence":"first","affiliation":[{"name":"From the Divisions of Cellular Therapy and Molecular Therapy, Advanced Clinical Research Center, and the Department of Transfusion Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan; the Central Institute for Experimental Animals, Kawasaki, Japan; the Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan; and the Department of Pediatrics, Kyoto University, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Wada","sequence":"additional","affiliation":[{"name":"From the Divisions of Cellular Therapy and Molecular Therapy, Advanced Clinical Research Center, and the Department of Transfusion Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan; the Central Institute for Experimental Animals, Kawasaki, Japan; the Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan; and the Department of Pediatrics, Kyoto University, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yoshino","sequence":"additional","affiliation":[{"name":"From the Divisions of Cellular Therapy and Molecular Therapy, Advanced Clinical Research Center, and the Department of Transfusion Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan; the Central Institute for Experimental 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the Divisions of Cellular Therapy and Molecular Therapy, Advanced Clinical Research Center, and the Department of Transfusion Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan; the Central Institute for Experimental Animals, Kawasaki, Japan; the Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan; and the Department of Pediatrics, Kyoto University, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taira","family":"Maekawa","sequence":"additional","affiliation":[{"name":"From the Divisions of Cellular Therapy and Molecular Therapy, Advanced Clinical Research Center, and the Department of Transfusion Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan; the Central Institute for Experimental Animals, Kawasaki, Japan; the Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan; and the Department of Pediatrics, Kyoto University, Kyoto, 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