{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:46:23Z","timestamp":1761540383355},"reference-count":19,"publisher":"American Society of Hematology","issue":"12","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,6,15]]},"abstract":"<jats:p>The glycoprotein (GP)\u2013Ib-IX-V receptor complex has recently been reported to signal through a pathway similar to that used by the collagen receptor GPVI, with a critical role described for the Fc receptor \u03b3-chain. The evidence for this was based in part on studies with the GPIb\u03b1-selective snake venom toxin, alboaggregin-A. In the present study, it is reported that alboaggregin-A has activity at the collagen receptor GPVI in addition to GPIb\u03b1, and evidence is provided that this contributes to protein tyrosine phosphorylation, shape change, and GPIIb-IIIa\u2013dependent aggregation. This may explain why responses to alboaggregin-A are distinct from those to von Willebrand factor\u2013 ristocetin.<\/jats:p>","DOI":"10.1182\/blood.v97.12.3989","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:47Z","timestamp":1027774007000},"page":"3989-3991","update-policy":"http:\/\/dx.doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":22,"title":["The snake venom toxin alboaggregin-A activates glycoprotein VI"],"prefix":"10.1182","volume":"97","author":[{"given":"Naoki","family":"Asazuma","sequence":"first","affiliation":[{"name":"From the Department of Pharmacology, University of Oxford, and the Department of Pharmacology, University of Bristol, School of Medical Sciences, United Kingdom; and the Baker Medical Research Institute, Melbourne, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart J.","family":"Marshall","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, University of Oxford, and the Department of Pharmacology, University of Bristol, School of Medical Sciences, United Kingdom; and the Baker Medical Research Institute, Melbourne, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Berlanga","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, University of Oxford, and the Department of Pharmacology, University of Bristol, School of Medical Sciences, United Kingdom; and the Baker Medical Research Institute, Melbourne, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Snell","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, University of Oxford, and the Department of Pharmacology, University of Bristol, School of Medical Sciences, United Kingdom; and the Baker Medical Research Institute, Melbourne, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alastair W.","family":"Poole","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, University of Oxford, and the Department of Pharmacology, University of Bristol, School of Medical Sciences, United Kingdom; and the Baker Medical Research Institute, Melbourne, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Berndt","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, University of Oxford, and the Department of Pharmacology, University of Bristol, School of Medical Sciences, United Kingdom; and the Baker Medical Research Institute, Melbourne, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert K.","family":"Andrews","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, University of Oxford, and the Department of Pharmacology, University of 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