{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T07:47:26Z","timestamp":1772956046296,"version":"3.50.1"},"reference-count":23,"publisher":"American Society of Hematology","issue":"3","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Bone marrow transplantation (BMT) for severe combined immunodeficiency (SCID) with human leukocyte antigen (HLA)-identical sibling donors but no pretransplantation cytoreduction results in T-lymphocyte engraftment and correction of immune dysfunction but not in full hematopoietic engraftment. A case of a 17-month-old girl with adenosine deaminase (ADA) deficiency SCID in whom full hematopoietic engraftment developed after BMT from her HLA-identical sister is reported. No myeloablative or immunosuppressive therapy or graft-versus-host disease (GVHD) prophylaxis was given. Mild acute and chronic GVHD developed, her B- and T-cell functions became reconstituted, and she is well almost 11 years after BMT. After BMT, repeated studies demonstrated: (1) Loss of a recipient-specific chromosomal marker in peripheral blood leukocytes (PBLs) and bone marrow, (2) conversion of recipient red blood cell antigens to donor type, (3) conversion of recipient T-cell, B-cell, and granulocyte lineages to donor origin by DNA analysis, and (4) increased ADA activity and metabolic correction in red blood cells and PBLs.<\/jats:p>","DOI":"10.1182\/blood.v97.3.809","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T08:46:40Z","timestamp":1027759600000},"page":"809-811","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":15,"title":["Full hematopoietic engraftment after allogeneic bone marrow transplantation without cytoreduction in a child with severe combined immunodeficiency"],"prefix":"10.1182","volume":"97","author":[{"given":"Ronald J.","family":"Rubocki","sequence":"first","affiliation":[{"name":"From the Departments of Pediatric-Hematology\/Oncology and Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; and the Department of Rheumatology and Immunology, Duke University Medical Center, Durham, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer R.","family":"Parsa","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric-Hematology\/Oncology and Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; and the Department of Rheumatology and Immunology, Duke University Medical Center, Durham, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Hershfield","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric-Hematology\/Oncology and Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; and the Department of Rheumatology and Immunology, Duke University Medical Center, Durham, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren G.","family":"Sanger","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric-Hematology\/Oncology and Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; and the Department of Rheumatology and Immunology, Duke University Medical Center, Durham, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel J.","family":"Pirruccello","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric-Hematology\/Oncology and Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; and the Department of Rheumatology and Immunology, Duke University Medical Center, Durham, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Santisteban","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric-Hematology\/Oncology and Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; and the Department of Rheumatology and Immunology, Duke University Medical Center, Durham, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce G.","family":"Gordon","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric-Hematology\/Oncology and Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; and the Department of Rheumatology and Immunology, Duke University Medical Center, Durham, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Strandjord","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric-Hematology\/Oncology and Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; and the Department of Rheumatology and Immunology, Duke University Medical Center, Durham, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyllis I.","family":"Warkentin","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric-Hematology\/Oncology and Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; and the Department of Rheumatology and Immunology, Duke University Medical Center, Durham, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter F.","family":"Coccia","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric-Hematology\/Oncology and Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; and the Department of Rheumatology and Immunology, Duke University Medical Center, Durham, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"234","reference":[{"key":"2020021220244180000_B1","first-page":"346","article-title":"Hematopoietic stem cell transplantation for primary lymphoid immunodeficiencies.","volume":"35","author":"Kapoor","year":"1998","journal-title":"Semin 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