{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:22:43Z","timestamp":1791116563824,"version":"4.1.0"},"reference-count":9,"publisher":"American Society of Hematology","issue":"3","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recent reports have suggested an association betweenHelicobacter pylori infection and idiopathic thrombocytopenic purpura (ITP). The prevalence of H pyloriinfection and the effect of its eradication in a series of 30 ITP patients were investigated. H pylori infection has been documented in 13 patients (43.33%) by 13C urea breath test and confirmed by histologic examination. Bacterium eradication with antibiotics, obtained in 12 of 13 infected patients (92.3%), led to a complete response in 4 (33.33%) and to a partial response (platelets 90\u2009\u00d7\u2009109\/L-120\u2009\u00d7\u2009109\/L) in 2 (16.66%). The response was maintained for a median of 8.33 months, but 1 patient relapsed 7 months after eradication. Search for H pyloriinfection seems appropriate in ITP patients at diagnosis. Bacterium eradication provides a new good option for a nonimmunosuppressive treatment in some ITP patients.<\/jats:p>","DOI":"10.1182\/blood.v97.3.812","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:47Z","timestamp":1027774007000},"page":"812-814","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":181,"title":["Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura"],"prefix":"10.1182","volume":"97","author":[{"given":"Giovanni","family":"Emilia","sequence":"first","affiliation":[{"name":"From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Longo","sequence":"additional","affiliation":[{"name":"From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Luppi","sequence":"additional","affiliation":[{"name":"From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Gandini","sequence":"additional","affiliation":[{"name":"From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Morselli","sequence":"additional","affiliation":[{"name":"From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Ferrara","sequence":"additional","affiliation":[{"name":"From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Amarri","sequence":"additional","affiliation":[{"name":"From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Cagossi","sequence":"additional","affiliation":[{"name":"From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Torelli","sequence":"additional","affiliation":[{"name":"From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021223432460700_B1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.5694\/j.1326-5377.1985.tb113443.x","article-title":"Attempt to fulfil Koch's postulates for pyloric Campylobacter.","volume":"142","author":"Marshall","year":"1985","journal-title":"Med J Aust."},{"key":"2020021223432460700_B2","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1136\/bmj.302.6788.1302","article-title":"Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.","volume":"302","author":"Forman","year":"1991","journal-title":"BMJ."},{"key":"2020021223432460700_B3","first-page":"25","article-title":"Host response.","volume":"13(suppl 1)","author":"Bamford","year":"1997","journal-title":"Curr Opin Gastroenterol."},{"key":"2020021223432460700_B4","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0016-5085(98)70200-8","article-title":"The gastricH+\/K+-ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body mucosa atrophy.","volume":"115","author":"Claeys","year":"1998","journal-title":"Gastroenterology."},{"key":"2020021223432460700_B5","first-page":"S2","article-title":"Bacterial factor and immune pathogenesis in Helicobacter pylori infection.","volume":"43(suppl 1)","author":"Shimoyama","year":"1998","journal-title":"Gut."},{"key":"2020021223432460700_B6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0016-5085(99)70161-7","article-title":"Is Helicobacter pylori infection a risk factor for disease severity in rheumatoid arthritis?","volume":"116","author":"Zentilin","year":"1999","journal-title":"Gastroenterology."},{"key":"2020021223432460700_B7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00004836-199806000-00008","article-title":"Helicobacter pylori infection is markedly increased in patients with autoimmune atrophic thyroiditis.","volume":"26","author":"De Luis","year":"1998","journal-title":"J Clin Gastroenterol."},{"key":"2020021223432460700_B8","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0140-6736(05)60004-9","article-title":"Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori.","volume":"352","author":"Gasbarrini","year":"1998","journal-title":"Lancet."},{"key":"2020021223432460700_B9","first-page":"283","article-title":"Resolution of thrombocytopenia after treatment for Helicobacter pylori: a case report.","volume":"84","author":"Grimaz","year":"1999","journal-title":"Haematologica."}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/97\/3\/812\/1671227\/812.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/97\/3\/812\/1671227\/812.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T04:44:16Z","timestamp":1581569056000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/97\/3\/812\/52816\/Helicobacter-pylori-eradication-can-induce"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2,1]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,2,1]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.v97.3.812","relation":{},"ISSN":["1528-0020","0006-4971"],"issn-type":[{"value":"1528-0020","type":"electronic"},{"value":"0006-4971","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2,1]]}}}