{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:50:41Z","timestamp":1789588241384,"version":"build-2803163510"},"reference-count":13,"publisher":"American Society of Hematology","issue":"5","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,3,1]]},"abstract":"<jats:p>Various studies have demonstrated the aberrant expression of normal testicular proteins in neoplastic cells. These proteins collectively form the new class of tumor antigens called cancer-testis (CT) antigens. Their selective normal tissue expression makes them ideal antigens for immune targeting of the malignant disease. In this study, the expression of a spermatozoa protein, Sp17, in multiple myeloma was investigated. It was found that Sp17 is detectable in tumor cells from 12 of 47 (26%) myeloma patients. Reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis detected Sp17 transcripts and proteins, respectively. Northern blot analysis and RT-PCR demonstrated that Sp17 transcripts were detected only in normal testis, supporting its tissue specificity. Since a high proportion of normal individuals develop antibodies against Sp17 following vasectomy, Sp17 is likely to be a highly immunogenic protein in vivo. Sp17 is therefore a novel member of the CT antigen family and should be an ideal target for immunotherapy of multiple myeloma.<\/jats:p>","DOI":"10.1182\/blood.v97.5.1508","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:47Z","timestamp":1027774007000},"page":"1508-1510","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":110,"title":["Sperm protein 17 is a novel cancer-testis antigen in multiple myeloma"],"prefix":"10.1182","volume":"97","author":[{"given":"Seah H.","family":"Lim","sequence":"first","affiliation":[{"name":"From the Center for Immunology and Microbial Disease and the Department of Medicine, Albany Medical College, Albany, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqing","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Center for Immunology and Microbial Disease and the Department of Medicine, Albany Medical College, Albany, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Chiriva-Internati","sequence":"additional","affiliation":[{"name":"From the Center for Immunology and Microbial Disease and the Department of Medicine, Albany Medical College, Albany, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Xue","sequence":"additional","affiliation":[{"name":"From the Center for Immunology and Microbial Disease and the Department of Medicine, Albany Medical College, Albany, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021220584958200_B1","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1182\/blood.V95.12.4008","article-title":"Results of high-dose therapy for 1000 patients with multiple myeloma: durable complete remissions and superior survival in the absence of chromosome 13 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