{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:14:51Z","timestamp":1791422091403,"version":"4.3.3"},"reference-count":40,"publisher":"American Society of Hematology","issue":"6","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,3,15]]},"abstract":"<jats:p>Interleukin-6 (IL-6), although often regarded as a B-cell differentiation factor, was recently described as the essential survival factor for human plasmablasts in vivo in reactive plasmacytosis. The present study reinvestigated the roles of IL-6 and IL-2 in the generation of plasma cells from human memory B cells in vitro. The cells involved in this differentiation process were identified as preplasmablasts (CD20\u00b1CD38\u00b1CD138\u2212), plasmablasts (CD20\u2212CD38++CD138\u2212), and early plasma cells (CD20\u2212CD38+++CD138+++). IL-2 or IL-10 induced a strong generation of plasmablasts and early plasma cells (PCs). Compared to IL-2 or IL-10, IL-6 alone was inefficient at PC generation. However, when combined with IL-2 or IL-10, IL-6 enhanced generation of early PCs. Moreover, anti\u2013IL-6 monoclonal antibody markedly reduced IL-2\u2013induced generation of early plasma cells, but not of plasmablasts. These roles of IL-2 and IL-6 were consistent with the difference in the expression of their respective receptors (R). CD25 (IL-2R\u03b1) was increased 72\u2009\u00b1\u200910-fold on activated B cells, but decreased and then disappeared on plasmablasts. Conversely, CD126 (IL-6R\u03b1) was barely expressed on activated B cells, but increased 18\u2009\u00b1\u20092-fold on preplasmablasts. Finally, IL-6 enhanced the proliferation (2-fold increase) of IL-2\u2013generated plasmablasts. In conclusion, the data indicate that IL-6 is a growth factor for nonmalignant human plasmablasts.<\/jats:p>","DOI":"10.1182\/blood.v97.6.1817","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:47Z","timestamp":1027774007000},"page":"1817-1822","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":169,"title":["Interleukin-6 is a growth factor for nonmalignant human plasmablasts"],"prefix":"10.1182","volume":"97","author":[{"given":"Gae\u0308tan","family":"Jego","sequence":"first","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U463 and Laboratoire d'He\u0301matologie, Institut de Biologie, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Re\u0301gis","family":"Bataille","sequence":"additional","affiliation":[{"name":"From the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale 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