{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:13:54Z","timestamp":1791252834494,"version":"4.1.0"},"reference-count":60,"publisher":"American Society of Hematology","issue":"7","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Platelet-derived growth factor (PDGF)-B and PDGF \u03b2-receptor (PDGFR\u03b2) deficiency in mice is embryonic lethal and results in cardiovascular, renal, placental, and hematologic disorders. The hematologic disorders are described, and a correlation with hepatic hypocellularity is demonstrated. To explore possible causes, the colony-forming activity of fetal liver cells in vitro was assessed, and hematopoietic chimeras were demonstrated by the transplantation of mutant fetal liver cells into lethally irradiated recipients. It was found that mutant colony formation is equivalent to that of wild-type controls. Hematopoietic chimeras reconstituted with PDGF-B\u2212\/\u2212, PDGFR\u03b2\u2212\/\u2212, or wild-type fetal liver cells show complete engraftment (greater than 98%) with donor granulocytes, monocytes, B cells, and T cells and display none of the cardiovascular or hematologic abnormalities seen in mutants. In mouse embryos, PDGF-B is expressed by vascular endothelial cells and megakaryocytes. After birth, expression is seen in macrophages and neurons. This study demonstrates that hematopoietic PDGF-B or PDGFR\u03b2 expression is not required for hematopoiesis or integrity of the cardiovascular system. It is argued that metabolic stress arising from mutant defects in the placenta, heart, or blood vessels may lead to impaired liver growth and decreased production of blood cells. The chimera models in this study will serve as valuable tools to test the role of PDGF in inflammatory and immune responses.<\/jats:p>","DOI":"10.1182\/blood.v97.7.1990","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:47Z","timestamp":1027774007000},"page":"1990-1998","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":67,"title":["Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF \u03b2-receptor null mice"],"prefix":"10.1182","volume":"97","author":[{"given":"Wolfgang E.","family":"Kaminski","sequence":"first","affiliation":[{"name":"From the Departments of Pathology and Medicine, University of Washington School of Medicine; the Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA; the Department of Medical Biochemistry, University of Go\u0308teborg; and the Department of Clinical Chemistry, Sahlgrenska Hospital, Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Lindahl","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Medicine, University of Washington School of Medicine; the Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA; the Department of Medical Biochemistry, University of Go\u0308teborg; and the Department of Clinical Chemistry, Sahlgrenska Hospital, Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Lin","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Medicine, University of Washington School of Medicine; the Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA; the Department of Medical Biochemistry, University of Go\u0308teborg; and the Department of Clinical Chemistry, Sahlgrenska Hospital, Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia C.","family":"Broudy","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Medicine, University of Washington School of Medicine; the Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA; the Department of Medical Biochemistry, University of Go\u0308teborg; and the Department of Clinical Chemistry, Sahlgrenska Hospital, Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Crosby","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Medicine, University of Washington School of Medicine; the Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA; the Department of Medical Biochemistry, University of Go\u0308teborg; and the Department of Clinical Chemistry, Sahlgrenska Hospital, Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Hellstro\u0308m","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Medicine, University of Washington School of Medicine; the Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA; the Department of Medical Biochemistry, University of Go\u0308teborg; and the Department of Clinical Chemistry, Sahlgrenska Hospital, Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Swolin","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Medicine, University of Washington School of Medicine; the Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA; the Department of Medical Biochemistry, University of Go\u0308teborg; and the Department of Clinical Chemistry, Sahlgrenska Hospital, Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Bowen-Pope","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Medicine, University of Washington School of Medicine; the Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA; the Department of Medical Biochemistry, University of Go\u0308teborg; and the Department of Clinical Chemistry, Sahlgrenska Hospital, Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Martin","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Medicine, University of Washington School of Medicine; the Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA; the Department of Medical Biochemistry, University of Go\u0308teborg; and the Department of Clinical Chemistry, Sahlgrenska Hospital, Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Ross","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Medicine, University of Washington School of Medicine; the Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA; the Department of Medical Biochemistry, University of Go\u0308teborg; and the Department of Clinical Chemistry, Sahlgrenska Hospital, Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Betsholtz","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology and Medicine, University of Washington School of Medicine; the Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA; the Department of Medical Biochemistry, University of Go\u0308teborg; and the Department of Clinical Chemistry, Sahlgrenska Hospital, Go\u0308teborg, 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