{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T04:46:29Z","timestamp":1770525989441,"version":"3.49.0"},"reference-count":54,"publisher":"American Society of Hematology","issue":"12","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Monocyte differentiation induced by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is interrupted during the course of acute promyelocytic leukemia (APL). One form of APL is associated with the translocation t(11;17), which joins the promyelocytic leukemia zinc finger (PLZF) and retinoic acid receptor \u03b1 (RAR\u03b1) genes. Because PLZF is coexpressed in the myeloid lineage with the vitamin D3 receptor (VDR), the interplay between PLZF and VDR was examined. It was found that PLZF interacts directly with VDR. This occurred at least partly through contacts in the DNA-binding domain of VDR and the broad complex, tram-trak, bric-a-brac\/pox virus zinc finger (BTB\/POZ) domain of PLZF. Moreover, PLZF altered the mobility of VDR derived from nuclear extracts when bound to its cognate binding site, forming a slowly migrating DNA-protein complex. Overexpression of PLZF in a monocytic cell line abrogated 1,25(OH)2D3 activation from both a minimal VDR responsive reporter and the promoter of p21WAF1\/CIP1, a target gene of VDR. Deletion of the BTB\/POZ domain significantly relieved PLZF-mediated repression of 1,25(OH)2D3-dependent activation. In addition, stable, inducible expression of PLZF in U937 cells inhibited the ability of 1,25(OH)2D3 to induce surface expression of the monocytic marker CD14 and morphologic changes associated with differentiation. These results suggest that PLZF may play an important role in regulating the process by which 1,25(OH)2D3 induces monocytic differentiation in hematopoietic cells.<\/jats:p>","DOI":"10.1182\/blood.v98.12.3290","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:40Z","timestamp":1027774000000},"page":"3290-3300","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":47,"title":["The acute promyelocytic leukemia\u2013associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D3\u2013induced monocytic differentiation of U937 cells through a physical interaction with vitamin D3receptor"],"prefix":"10.1182","volume":"98","author":[{"given":"Jeremy O.","family":"Ward","sequence":"first","affiliation":[{"name":"From the Programs of Cell Biology and Human Genetics, Memorial Sloan-Kettering Cancer Center and Sloan-Kettering Division, Joan and Sanford I. Weill Graduate School of Medical Sciences of Cornell University; and the Department of Medicine Biochemistry and Molecular Biology, Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie J.","family":"McConnell","sequence":"additional","affiliation":[{"name":"From the Programs of Cell Biology and Human Genetics, Memorial Sloan-Kettering Cancer Center and Sloan-Kettering Division, Joan and Sanford I. Weill Graduate School of Medical Sciences of Cornell University; and the Department of Medicine Biochemistry and Molecular Biology, Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme W.","family":"Carlile","sequence":"additional","affiliation":[{"name":"From the Programs of Cell Biology and Human Genetics, Memorial Sloan-Kettering Cancer Center and Sloan-Kettering Division, Joan and Sanford I. Weill Graduate School of Medical Sciences of Cornell University; and the Department of Medicine Biochemistry and Molecular Biology, Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Paolo","family":"Pandolfi","sequence":"additional","affiliation":[{"name":"From the Programs of Cell Biology and Human Genetics, Memorial Sloan-Kettering Cancer Center and Sloan-Kettering Division, Joan and Sanford I. Weill Graduate School of Medical Sciences of Cornell University; and the Department of Medicine Biochemistry and Molecular Biology, Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Licht","sequence":"additional","affiliation":[{"name":"From the Programs of Cell Biology and Human Genetics, Memorial Sloan-Kettering Cancer Center and Sloan-Kettering Division, Joan and Sanford I. Weill Graduate School of Medical Sciences of Cornell University; and the Department of Medicine Biochemistry and Molecular Biology, Derald H. 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