{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T02:14:46Z","timestamp":1794449686523,"version":"4.9.1"},"reference-count":35,"publisher":"American Society of Hematology","issue":"12","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Many malignancies of mature B cells are characterized by chromosomal translocations involving the immunoglobulin heavy chain(IGH) locus on chromosome 14q32.3 and result in deregulated expression of the translocated oncogene. t(2;14)(p13;q32.3) is a rare event in B-cell malignancies. In contrast, gains and amplifications of the same region of chromosome 2p13 have been reported in 20% of extranodal B-cell non-Hodgkin lymphomas (B-NHL), in follicular and mediastinal B-NHL, and in Hodgkin disease (HD). It has been suggested that REL, an NF-\u03baB gene family member, mapping within the amplified region, is the pathologic target. However, by molecular cloning of t(2;14)(p13;q32.3) from 3 cases of aggressive B-cell chronic lymphocytic leukemia (CLL)\/immunocytoma, this study has shown clustered breakpoints on chromosome 2p13 immediately upstream of a CpG island located about 300 kb telomeric of REL. This CpG island was associated with a Kru\u0308ppel zinc finger gene (BCL11A), which is normally expressed at high levels only in fetal brain and in germinal center B-cells. There were 3 major RNA isoforms ofBCL11A, differing in the number of carboxy-terminal zinc fingers. All 3 RNA isoforms were deregulated as a consequence of t(2;14)(p13;q32.3). BCL11A was highly conserved, being 95% identical to mouse, chicken, and Xenopus homologues.BCL11A was also highly homologous to another gene(BCL11B) on chromosome 14q32.1. BCL11Acoamplified with REL in B-NHL cases and HD lymphoma cell lines with gains and amplifications of 2p13, suggesting thatBCL11A may be involved in lymphoid malignancies through either chromosomal translocation or amplification.<\/jats:p>","DOI":"10.1182\/blood.v98.12.3413","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T08:46:40Z","timestamp":1027759600000},"page":"3413-3420","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":275,"title":["The BCL11 gene family: involvement of BCL11A in lymphoid malignancies"],"prefix":"10.1182","volume":"98","author":[{"given":"Ed","family":"Satterwhite","sequence":"first","affiliation":[{"name":"From the Academic Department of Haematology and Cytogenetics, Haddow Laboratories, Institute of Cancer Research, Sutton, United Kingdom; University of Texas at Austin, Institute for Cellular and Molecular Biology, Molecular Genetics and Microbiology, Austin, TX; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sonoki","sequence":"additional","affiliation":[{"name":"From the Academic Department of Haematology and Cytogenetics, Haddow Laboratories, Institute of Cancer Research, Sutton, United Kingdom; University of Texas at Austin, Institute for Cellular and Molecular Biology, Molecular Genetics and Microbiology, Austin, TX; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony G.","family":"Willis","sequence":"additional","affiliation":[{"name":"From the Academic Department of Haematology and Cytogenetics, Haddow Laboratories, Institute of Cancer Research, Sutton, United Kingdom; University of Texas at Austin, Institute for Cellular and Molecular Biology, Molecular Genetics and Microbiology, Austin, TX; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Harder","sequence":"additional","affiliation":[{"name":"From the Academic Department of Haematology and Cytogenetics, Haddow Laboratories, Institute of Cancer Research, Sutton, United Kingdom; University of Texas at Austin, Institute for Cellular and Molecular Biology, Molecular Genetics and Microbiology, Austin, TX; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Nowak","sequence":"additional","affiliation":[{"name":"From the Academic Department of Haematology and Cytogenetics, Haddow Laboratories, Institute of Cancer Research, Sutton, United Kingdom; University of Texas at Austin, Institute for Cellular and Molecular Biology, Molecular Genetics and Microbiology, Austin, TX; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"Arriola","sequence":"additional","affiliation":[{"name":"From the Academic Department of Haematology and Cytogenetics, Haddow Laboratories, Institute of Cancer Research, Sutton, United Kingdom; University of Texas at Austin, Institute for Cellular and Molecular Biology, Molecular Genetics and Microbiology, Austin, TX; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Academic Department of Haematology and Cytogenetics, Haddow Laboratories, Institute of Cancer Research, Sutton, United Kingdom; University of Texas at Austin, Institute for Cellular and Molecular Biology, Molecular Genetics and Microbiology, Austin, TX; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen P.","family":"Price","sequence":"additional","affiliation":[{"name":"From the Academic Department of Haematology and Cytogenetics, Haddow Laboratories, Institute of Cancer Research, Sutton, United Kingdom; University of Texas at Austin, Institute for Cellular and Molecular Biology, Molecular Genetics and Microbiology, Austin, TX; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gesk","sequence":"additional","affiliation":[{"name":"From the Academic Department of Haematology and Cytogenetics, Haddow Laboratories, Institute of Cancer Research, Sutton, United Kingdom; University of Texas at Austin, Institute for Cellular and Molecular Biology, Molecular Genetics and Microbiology, Austin, TX; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Steinemann","sequence":"additional","affiliation":[{"name":"From the Academic Department of Haematology and Cytogenetics, Haddow Laboratories, Institute of Cancer Research, Sutton, United Kingdom; University of Texas at Austin, Institute for Cellular and Molecular Biology, Molecular Genetics and Microbiology, Austin, TX; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Schlegelberger","sequence":"additional","affiliation":[{"name":"From the Academic Department of Haematology and Cytogenetics, Haddow Laboratories, Institute of Cancer Research, Sutton, United Kingdom; University of Texas at Austin, Institute for Cellular and Molecular Biology, Molecular Genetics and Microbiology, Austin, TX; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Oscier","sequence":"additional","affiliation":[{"name":"From the Academic Department of Haematology and Cytogenetics, Haddow Laboratories, Institute of Cancer Research, Sutton, United Kingdom; University of Texas at Austin, Institute for Cellular and Molecular Biology, Molecular Genetics and Microbiology, Austin, TX; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Siebert","sequence":"additional","affiliation":[{"name":"From the Academic Department of Haematology and Cytogenetics, Haddow Laboratories, Institute of Cancer Research, Sutton, United Kingdom; University of Texas at Austin, Institute for Cellular and Molecular Biology, Molecular Genetics and Microbiology, Austin, TX; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip W.","family":"Tucker","sequence":"additional","affiliation":[{"name":"From the Academic Department of Haematology and Cytogenetics, Haddow Laboratories, Institute of Cancer Research, Sutton, United Kingdom; University of Texas at Austin, Institute for Cellular and Molecular Biology, Molecular Genetics and Microbiology, Austin, TX; Institute of Human Genetics, University Hospital Kiel, Kiel, Germany; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J. 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