{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:45:02Z","timestamp":1793292302684,"version":"4.5.0"},"reference-count":40,"publisher":"American Society of Hematology","issue":"2","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,7,15]]},"abstract":"<jats:p>Thirty patients with chronic active Epstein-Barr virus (CAEBV) infection were analyzed. The study group included 18 male and 12 female patients, ranging in age from 5 to 31 years with a mean age of 14.2 years. Not all patients had high titers of EBV-specific antibodies, but all patients had high viral loads in their peripheral blood (more than 102.5 copies\/\u03bcg DNA). Fifty percent of the patients displayed chromosomal aberrations, and 79% had monoclonality of EBV. Patients were divided into 2 clinically distinct groups, based on whether the predominantly infected cells in their peripheral blood were T cells or natural killer (NK) cells. Over a 68-month period of observation, 10 patients died from hepatic failure, malignant lymphoma, or other causes. Patients with T-cell CAEBV had a shorter survival time than those with NK-cell type of disease.<\/jats:p>","DOI":"10.1182\/blood.v98.2.280","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:47Z","timestamp":1027774007000},"page":"280-286","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":362,"title":["Clinical and virologic characteristics of chronic active Epstein-Barr virus infection"],"prefix":"10.1182","volume":"98","author":[{"given":"Hiroshi","family":"Kimura","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics, Nagoya University Graduate School of Medicine, Department of Health Science, Nagoya University School of Medicine, Nagoya, Japan; Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan; Department of Pediatrics, Osaka Medical Center, and Research Institute for Maternal and Child Health, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo","family":"Hoshino","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Nagoya University Graduate School of Medicine, Department of Health Science, Nagoya University School of Medicine, Nagoya, Japan; 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