{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:20:10Z","timestamp":1791206410844,"version":"4.1.0"},"reference-count":60,"publisher":"American Society of Hematology","issue":"3","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hodgkin disease (HD) represents a malignant lymphoma in which the putative malignant Hodgkin and Reed-Sternberg cells are rare and surrounded by abundant reactive nonmalignant cells. It has been suggested that cytokines such as interleukin-6 (IL-6) are involved in the pathogenesis of the disease. The expression of the IL-6 receptor (IL-6R) complex and its link to the activation of signal transducers and activators of transcription (STAT) molecules in HD cell lines was investigated. Gel retardation and Western blot analyses revealed a high level of constitutively activated STAT3 in 5 of 7 HD cell lines, which could not be detected in Burkitt lymphoma cell lines. Different levels of IL-6R protein were measured in various HD cell lines: L428 and Dev cells were characterized by very low levels of gp80 and gp130, on KMH2 cells only gp130 but no gp80 was detected, whereas L540, L591, HDLM2, and L1236 were positive for both gp80 and gp130, suggesting a possible autocrine stimulation of STAT3. However, a further increase in STAT3 activation on IL-6 or IL-6\/soluble IL-6R stimulation was not observed. Neutralizing monoclonal antibodies against IL-6, gp80, gp130, or both receptor subunits did not affect the proliferation or the constitutive activation of STAT molecules in HD cell lines. However, the tyrosine kinase inhibitor AG490 blocked the constitutive activation of STAT3 and inhibited spontaneous growth of HD tumor cells. The evidence suggests abnormal STAT signaling and growth regulation in Hodgkin cell lines.<\/jats:p>","DOI":"10.1182\/blood.v98.3.762","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:47Z","timestamp":1027774007000},"page":"762-770","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":171,"title":["STAT3 is constitutively activated in Hodgkin cell lines"],"prefix":"10.1182","volume":"98","author":[{"given":"Dieter","family":"Kube","sequence":"first","affiliation":[{"name":"From Klinik fu\u0308r Innere Medizin I, Zentrum fu\u0308r Molekulare Medizin der Universita\u0308t Ko\u0308ln, Germany; Institut fu\u0308r Biochemie RWTH-Klinikum Aachen, Germany; and Eberhard-Karls-Universita\u0308t Tu\u0308bingen, Institut fu\u0308r Tropenmedizin, Sektion fu\u0308r Humanparasitologie, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Holtick","sequence":"additional","affiliation":[{"name":"From Klinik fu\u0308r Innere Medizin I, Zentrum fu\u0308r Molekulare Medizin der Universita\u0308t Ko\u0308ln, Germany; Institut fu\u0308r Biochemie RWTH-Klinikum Aachen, Germany; and Eberhard-Karls-Universita\u0308t Tu\u0308bingen, Institut fu\u0308r Tropenmedizin, Sektion fu\u0308r Humanparasitologie, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Vockerodt","sequence":"additional","affiliation":[{"name":"From Klinik fu\u0308r Innere Medizin I, Zentrum fu\u0308r Molekulare Medizin der Universita\u0308t Ko\u0308ln, Germany; Institut fu\u0308r Biochemie RWTH-Klinikum Aachen, Germany; and Eberhard-Karls-Universita\u0308t Tu\u0308bingen, Institut fu\u0308r Tropenmedizin, Sektion fu\u0308r Humanparasitologie, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahamtan","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"From Klinik fu\u0308r Innere Medizin I, Zentrum fu\u0308r Molekulare Medizin der Universita\u0308t Ko\u0308ln, Germany; Institut fu\u0308r Biochemie RWTH-Klinikum Aachen, Germany; and Eberhard-Karls-Universita\u0308t Tu\u0308bingen, Institut fu\u0308r Tropenmedizin, Sektion fu\u0308r Humanparasitologie, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Haier","sequence":"additional","affiliation":[{"name":"From Klinik fu\u0308r Innere Medizin I, Zentrum fu\u0308r Molekulare Medizin der Universita\u0308t Ko\u0308ln, Germany; Institut fu\u0308r Biochemie RWTH-Klinikum Aachen, Germany; and Eberhard-Karls-Universita\u0308t Tu\u0308bingen, Institut fu\u0308r Tropenmedizin, Sektion fu\u0308r Humanparasitologie, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Behrmann","sequence":"additional","affiliation":[{"name":"From Klinik fu\u0308r Innere Medizin I, Zentrum fu\u0308r Molekulare Medizin der Universita\u0308t Ko\u0308ln, Germany; Institut fu\u0308r Biochemie RWTH-Klinikum Aachen, Germany; and Eberhard-Karls-Universita\u0308t Tu\u0308bingen, Institut fu\u0308r Tropenmedizin, Sektion fu\u0308r Humanparasitologie, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Heinrich","sequence":"additional","affiliation":[{"name":"From Klinik fu\u0308r Innere Medizin I, Zentrum fu\u0308r Molekulare Medizin der Universita\u0308t Ko\u0308ln, Germany; Institut fu\u0308r Biochemie RWTH-Klinikum Aachen, Germany; and Eberhard-Karls-Universita\u0308t Tu\u0308bingen, Institut fu\u0308r Tropenmedizin, Sektion fu\u0308r Humanparasitologie, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Diehl","sequence":"additional","affiliation":[{"name":"From Klinik fu\u0308r Innere Medizin I, Zentrum fu\u0308r Molekulare Medizin der Universita\u0308t Ko\u0308ln, Germany; Institut fu\u0308r Biochemie RWTH-Klinikum Aachen, Germany; and Eberhard-Karls-Universita\u0308t Tu\u0308bingen, Institut fu\u0308r Tropenmedizin, Sektion fu\u0308r Humanparasitologie, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Tesch","sequence":"additional","affiliation":[{"name":"From Klinik fu\u0308r Innere Medizin I, Zentrum fu\u0308r Molekulare Medizin der Universita\u0308t Ko\u0308ln, Germany; Institut fu\u0308r Biochemie RWTH-Klinikum Aachen, Germany; and Eberhard-Karls-Universita\u0308t Tu\u0308bingen, Institut fu\u0308r Tropenmedizin, Sektion fu\u0308r Humanparasitologie, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021223165323700_B1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0950-3536(96)80020-5","article-title":"Immunology of Hodgkin's disease.","volume":"9","author":"Poppema","year":"1996","journal-title":"Baillieres Clin Haematol."},{"key":"2020021223165323700_B2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1146\/annurev.immunol.16.1.471","article-title":"The origin of Hodgkin and Reed\/Sternberg cells in Hodgkin's disease.","volume":"16","author":"Ku\u0308ppers","year":"1998","journal-title":"Annu Rev Immunol."},{"key":"2020021223165323700_B3","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1182\/blood.V77.11.2413.2413","article-title":"Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease.","volume":"77","author":"Ju\u0308cker","year":"1991","journal-title":"Blood."},{"key":"2020021223165323700_B4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/hon.2900100605","article-title":"Production of multiple cytokines by Hodgkin's disease derived cell lines.","volume":"10","author":"Klein","year":"1992","journal-title":"Hematol Oncol."},{"key":"2020021223165323700_B5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/(SICI)1096-9896(199707)182:3<299::AID-PATH856>3.0.CO;2-8","article-title":"Modulation of interleukin-6 expression in Hodgkin and Reed-Sternberg cells by Epstein-Barr virus.","volume":"182","author":"Herbst","year":"1997","journal-title":"J Pathol."},{"key":"2020021223165323700_B6","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1365-2141.1993.tb03138.x","article-title":"Lymphotoxin, tumour necrosis factor and interleukin-6 gene transcripts are present in Hodgkin and Reed-Sternberg cells of most Hodgkin's disease cases.","volume":"84","author":"Foss","year":"1994","journal-title":"Br J Haematol."},{"key":"2020021223165323700_B7","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1146\/annurev.immunol.15.1.797","article-title":"Gp130 and the interleukin-6 family of cytokines.","volume":"15","author":"Taga","year":"1997","journal-title":"Annu Rev Immunol."},{"key":"2020021223165323700_B8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/bj3340297","article-title":"Interleukin-6-type cytokine signalling through the gp130\/Jak\/STAT pathway.","volume":"334","author":"Heinrich","year":"1998","journal-title":"Biochem J."},{"key":"2020021223165323700_B9","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1084\/jem.167.2.332","article-title":"The essential role of B cell stimulatory factor 2 (BSF-2\/IL-6) for the terminal differentiation of B cells.","volume":"167","author":"Muraguchi","year":"1988","journal-title":"J Exp Med."},{"key":"2020021223165323700_B10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/332083a0","article-title":"Autocrine generation and requirement of BSF-2\/IL-6 for human multiple myelomas.","volume":"332","author":"Kawano","year":"1988","journal-title":"Nature."},{"key":"2020021223165323700_B11","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1128\/JVI.64.6.3033-3041.1990","article-title":"Identification of interleukin-6 as an autocrine growth factor for Epstein-Barr virus-immortalized B cells.","volume":"64","author":"Tosato","year":"1990","journal-title":"J Virol."},{"key":"2020021223165323700_B12","first-page":"13","article-title":"Key differentiation steps in normal B cells and in myeloma cells.","volume":"34","author":"Zubler","year":"1997","journal-title":"Semin Hematol."},{"key":"2020021223165323700_B13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1074-7613(00)80011-4","article-title":"Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells.","volume":"10","author":"Catlett-Falcone","year":"1999","journal-title":"Immunity."},{"key":"2020021223165323700_B14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00202068","article-title":"IL-6 cytokine family and signal transduction: a model of the cytokine system.","volume":"74","author":"Hibi","year":"1996","journal-title":"J Mol Med."},{"key":"2020021223165323700_B15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/hon.2900130302","article-title":"IL6 and IL6 receptor expression in Burkitt's lymphoma and lymphoblastoid cell lines: promotion of IL6 receptor expression by EBV.","volume":"13","author":"Klein","year":"1995","journal-title":"Hematol Oncol."},{"key":"2020021223165323700_B16","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1002\/eji.1830251240","article-title":"Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies.","volume":"25","author":"Wijdenes","year":"1995","journal-title":"Eur J Immunol."},{"key":"2020021223165323700_B17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.8272872","article-title":"Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.","volume":"263","author":"Lu\u0308tticken","year":"1994","journal-title":"Science."},{"key":"2020021223165323700_B18","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1126\/science.8272873","article-title":"Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.","volume":"263","author":"Stahl","year":"1994","journal-title":"Science."},{"key":"2020021223165323700_B19","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.277.5332.1630","article-title":"STATs and gene regulation.","volume":"277","author":"Darnell","year":"1997","journal-title":"Science."},{"key":"2020021223165323700_B20","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1101\/gad.9.8.984","article-title":"A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.","volume":"9","author":"Horvath","year":"1995","journal-title":"Genes Dev."},{"key":"2020021223165323700_B21","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1128\/MCB.17.8.4677","article-title":"Mutational analysis of acute-phase response factor\/Stat3 activation and dimerization.","volume":"17","author":"Sasse","year":"1997","journal-title":"Mol Cell Biol."},{"key":"2020021223165323700_B22","doi-asserted-by":"crossref","first-page":"12991","DOI":"10.1074\/jbc.271.22.12991","article-title":"Differential activation of acute phase response factor\/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130, I: definition of a novel phosphotyrosine motif mediating STAT1 activation.","volume":"271","author":"Gerhartz","year":"1996","journal-title":"J Biol Chem."},{"key":"2020021223165323700_B23","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1182\/blood.V88.3.809.809","article-title":"Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines.","volume":"88","author":"Weber-Nordt","year":"1996","journal-title":"Blood."},{"key":"2020021223165323700_B24","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1182\/blood.V87.5.1692.1692","article-title":"STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients.","volume":"87","author":"Gouilleux","year":"1996","journal-title":"Blood."},{"key":"2020021223165323700_B25","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/379645a0","article-title":"Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor.","volume":"379","author":"Meydan","year":"1996","journal-title":"Nature."},{"key":"2020021223165323700_B26","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.4049\/jimmunol.159.10.4720","article-title":"Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients.","volume":"159","author":"Chai","year":"1997","journal-title":"J Immunol."},{"key":"2020021223165323700_B27","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.278.5341.1309","article-title":"A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia.","volume":"278","author":"Lacronique","year":"1997","journal-title":"Science."},{"key":"2020021223165323700_B28","doi-asserted-by":"crossref","first-page":"6764","DOI":"10.1073\/pnas.94.13.6764","article-title":"Constitutive activation of a slowly migrating isoform of Stat3 in mycosisfungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosisfungoides tumor cell lines.","volume":"94","author":"Nielsen","year":"1997","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021223165323700_B29","first-page":"3173","article-title":"Expression of signal transducers and activators of transcription proteins in acute myeloid leukemia blasts.","volume":"58","author":"Xia","year":"1998","journal-title":"Cancer Res."},{"key":"2020021223165323700_B30","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/ijc.2910400223","article-title":"Phenotype versus immunoglobulin and T-cell receptor genotype of Hodgkin-derived cell lines: activation of immature lymphoid cells in Hodgkin's disease.","volume":"40","author":"Falk","year":"1987","journal-title":"Int J Cancer."},{"key":"2020021223165323700_B31","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1182\/blood.V87.8.3418.bloodjournal8783418","article-title":"Peripheral blood mononuclear cells of a patient with advanced Hodgkin's lymphoma give rise to permanently growing Hodgkin-Reed Sternberg cells.","volume":"87","author":"Wolf","year":"1996","journal-title":"Blood."},{"key":"2020021223165323700_B32","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1432-1033.1995.661_b.x","article-title":"Soluble human interleukin-6 receptor: expression in insect cells, purification and characterization.","volume":"234","author":"Weiergra\u0308ber","year":"1995","journal-title":"Eur J Biochem."},{"key":"2020021223165323700_B33","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1128\/JVI.73.2.1630-1636.1999","article-title":"Expression of Epstein-Barr virus nuclear antigen 1 is associated with enhanced expression of CD25 in the Hodgkin cell line L428.","volume":"73","author":"Kube","year":"1999","journal-title":"J Virol."},{"key":"2020021223165323700_B34","doi-asserted-by":"crossref","first-page":"10117","DOI":"10.1073\/pnas.95.17.10117","article-title":"Isolation of viable Hodgkin and Reed-Sternberg cells from Hodgkin disease tissues.","volume":"95","author":"Irsch","year":"1998","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021223165323700_B35","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1128\/MCB.14.5.3186","article-title":"The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family.","volume":"14","author":"Wegenka","year":"1994","journal-title":"Mol Cell Biol."},{"key":"2020021223165323700_B36","first-page":"985","article-title":"Transcriptional regulation of the junB promoter: analysis of STAT-mediated signal transduction.","volume":"10","author":"Coffer","year":"1995","journal-title":"Oncogene."},{"key":"2020021223165323700_B37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/10428199209049781","article-title":"Hodgkin and Reed-Sternberg cells express interleukin 6 and interleukin 6 receptors.","volume":"7","author":"Tesch","year":"1992","journal-title":"Leuk Lymphoma."},{"key":"2020021223165323700_B38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/10428199709058334","article-title":"Activated Stat related transcription factors in acute leukemia.","volume":"28","author":"Gouilleux","year":"1997","journal-title":"Leuk Lymphoma."},{"key":"2020021223165323700_B39","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0092-8674(00)81959-5","article-title":"Stat3 as an oncogene.","volume":"98","author":"Bromberg","year":"1999","journal-title":"Cell."},{"key":"2020021223165323700_B40","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1126\/science.278.5344.1803","article-title":"Specific inhibition of Stat3 signal transduction by PIAS3.","volume":"278","author":"Chung","year":"1997","journal-title":"Science."},{"key":"2020021223165323700_B41","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/43219","article-title":"Structure and function of a new STAT-induced STAT inhibitor.","volume":"387","author":"Naka","year":"1997","journal-title":"Nature."},{"key":"2020021223165323700_B42","doi-asserted-by":"crossref","first-page":"18198","DOI":"10.1074\/jbc.273.29.18198","article-title":"Identification of a membrane-associated inhibitor(s) of epidermal growth factor-induced signal transducer and activator of transcription activation.","volume":"273","author":"Iwamoto","year":"1998","journal-title":"J Biol Chem."},{"key":"2020021223165323700_B43","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1126\/science.7541555","article-title":"Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein.","volume":"269","author":"Yu","year":"1995","journal-title":"Science."},{"key":"2020021223165323700_B44","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1128\/MCB.17.6.3295","article-title":"Abrogation of interleukin-3 dependence of myeloid cells by the v-srconcogene requires SH2 and SH3 domains which specify activation of STATs.","volume":"17","author":"Chaturvedi","year":"1997","journal-title":"Mol Cell Biol."},{"key":"2020021223165323700_B45","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.4049\/jimmunol.159.11.5206","article-title":"Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase.","volume":"159","author":"Yu","year":"1997","journal-title":"J Immunol."},{"key":"2020021223165323700_B46","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.1074\/jbc.273.12.7072","article-title":"Activation of STAT3 by the c-Fes protein-tyrosine kinase.","volume":"273","author":"Nelson","year":"1998","journal-title":"J Biol Chem."},{"key":"2020021223165323700_B47","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1126\/science.7569929","article-title":"Jak-STAT signaling induced by the v-abl oncogene.","volume":"269","author":"Danial","year":"1995","journal-title":"Science."},{"key":"2020021223165323700_B48","doi-asserted-by":"crossref","first-page":"9148","DOI":"10.1073\/pnas.93.17.9148","article-title":"Activation of Jak\/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.","volume":"93","author":"Zhang","year":"1996","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021223165323700_B49","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1182\/blood.V90.11.4341","article-title":"The Bmx tyrosine kinase induces activation of the STAT signaling pathway, which is specifically inhibited by protein kinase C delta.","volume":"90","author":"Saharinen","year":"1997","journal-title":"Blood."},{"key":"2020021223165323700_B50","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/hon.2900080404","article-title":"Heterogeneous expression of proto-oncogenes in Hodgkin's disease derived cell lines.","volume":"8","author":"Ju\u0308cker","year":"1990","journal-title":"Hematol Oncol."},{"key":"2020021223165323700_B51","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1182\/blood.V77.6.1298.1298","article-title":"Cytogenetic studies in untreated Hodgkin\u2032s disease.","volume":"77","author":"Tilly","year":"1991","journal-title":"Blood."},{"key":"2020021223165323700_B52","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1172\/JCI119849","article-title":"Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.","volume":"100","author":"Bargou","year":"1997","journal-title":"J Clin Invest."},{"key":"2020021223165323700_B53","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/sj.onc.1202351","article-title":"Molecular mechanisms of constitutive NF-kappaB\/Rel activation in Hodgkin\/Reed-Sternberg cells.","volume":"18","author":"Krappmann","year":"1999","journal-title":"Oncogene."},{"key":"2020021223165323700_B54","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1038\/sj.onc.1201735","article-title":"Defective I\u03baB\u03b1 in Hodgkin cell lines with constitutively active NF-\u03baB.","volume":"16","author":"Wood","year":"1998","journal-title":"Oncogene."},{"key":"2020021223165323700_B55","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1074-7613(00)80501-4","article-title":"Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.","volume":"5","author":"Fukada","year":"1996","journal-title":"Immunity."},{"key":"2020021223165323700_B56","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S1074-7613(00)80145-4","article-title":"Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.","volume":"11","author":"Shirogane","year":"1999","journal-title":"Immunity."},{"key":"2020021223165323700_B57","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1038\/sj.onc.1202708","article-title":"Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27\/Kip1.","volume":"18","author":"Kortylewski","year":"1999","journal-title":"Oncogene."},{"key":"2020021223165323700_B58","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1359-6101(98)80005-1","article-title":"Signaling mechanisms through gp130: a model of the cytokine system.","volume":"8","author":"Hirano","year":"1997","journal-title":"Cytokine Growth Factor Rev."},{"key":"2020021223165323700_B59","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1093\/emboj\/17.22.6670","article-title":"STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition.","volume":"17","author":"Fukada","year":"1998","journal-title":"EMBO J."},{"key":"2020021223165323700_B60","first-page":"549","article-title":"Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells.","volume":"60","author":"Joos","year":"2000","journal-title":"Cancer Res."}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/98\/3\/762\/1676153\/h8150100762.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/98\/3\/762\/1676153\/h8150100762.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T20:11:24Z","timestamp":1682280684000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/98\/3\/762\/53300\/STAT3-is-constitutively-activated-in-Hodgkin-cell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8,1]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,8,1]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.v98.3.762","relation":{},"ISSN":["1528-0020","0006-4971"],"issn-type":[{"value":"1528-0020","type":"electronic"},{"value":"0006-4971","type":"print"}],"subject":[],"published":{"date-parts":[[2001,8,1]]}}}